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Volumn 9, Issue 10, 2013, Pages 1566-1578

Progesterone receptor membrane component 1/ Sigma-2 receptor associates with MAP1LC3B and promotes autophagy

Author keywords

Autophagy; Metabolism; Therapeutics; TOR; Ubiquitin

Indexed keywords

ADENYLATE KINASE; CYTOCHROME; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE PROTEIN; MICROTUBULE PROTEIN; PROGESTERONE RECEPTOR MEMBRANE COMPONENT 1; PROTEIN MAP1LC3B; PROTEIN TSC1; ROTEIN UVRAG; S6 KINASE; STAT5A PROTEIN; STAT5B PROTEIN; TUBERIN; UNCLASSIFIED DRUG; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAP1LC3B PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; PROGESTERONE RECEPTOR; SIGMA OPIATE RECEPTOR; SIGMA-2 RECEPTOR; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SQSTM1 PROTEIN, HUMAN;

EID: 84885646346     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.25889     Document Type: Article
Times cited : (69)

References (73)
  • 1
    • 80053634368 scopus 로고    scopus 로고
    • The dynamic nature of autophagy in cancer
    • PMID:21979913
    • Kimmelman AC. The dynamic nature of autophagy in cancer. Genes Dev 2011; 25:1999-2010; PMID:21979913; http://dx.doi.org/10.1101/gad.17558811
    • (2011) Genes Dev , vol.25 , pp. 1999-2010
    • Kimmelman, A.C.1
  • 2
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • PMID:18191218
    • Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132:27-42; PMID:18191218; http://dx.doi.org/10.1016/j.cell.2007.12.018
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 3
    • 65549142204 scopus 로고    scopus 로고
    • A role for ubiquitin in selective autophagy
    • PMID:19450525
    • Kirkin V, McEwan DG, Novak I, Dikic I. A role for ubiquitin in selective autophagy. Mol Cell 2009; 34:259-69; PMID:19450525; http://dx.doi.org/10.1016/j. molcel.2009.04.026
    • (2009) Mol Cell , vol.34 , pp. 259-269
    • Kirkin, V.1    McEwan, D.G.2    Novak, I.3    Dikic, I.4
  • 4
    • 0034676037 scopus 로고    scopus 로고
    • The reversible modification regulates the membrane-binding state of apg8/aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway
    • PMID:11038174
    • Kirisako T, Ichimura Y, Okada H, Kabeya Y, Mizushima N, Yoshimori T, Ohsumi M, Takao T, Noda T, Ohsumi Y. The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J Cell Biol 2000; 151:263-76; PMID:11038174; http://dx.doi.org/10.1083/jcb.151.2.263
    • (2000) J Cell Biol , vol.151 , pp. 263-276
    • Kirisako, T.1    Ichimura, Y.2    Okada, H.3    Kabeya, Y.4    Mizushima, N.5    Yoshimori, T.6    Ohsumi, M.7    Takao, T.8    Noda, T.9    Ohsumi, Y.10
  • 6
    • 77954237882 scopus 로고    scopus 로고
    • Network organization of the human autophagy system
    • PMID:20562859
    • Behrends C, Sowa ME, Gygi SP, Harper JW. Network organization of the human autophagy system. Nature 2010; 466:68-76; PMID:20562859; http://dx.doi.org/10.1038/nature09204
    • (2010) Nature , vol.466 , pp. 68-76
    • Behrends, C.1    Sowa, M.E.2    Gygi, S.P.3    Harper, J.W.4
  • 7
    • 77953543377 scopus 로고    scopus 로고
    • The beclin 1-vps34 complex-at the crossroads of autophagy and beyond
    • PMID:20356743
    • Funderburk SF, Wang QJ, Yue Z. The Beclin 1-VPS34 complex-at the crossroads of autophagy and beyond. Trends Cell Biol 2010; 20:355-62; PMID:20356743; http://dx.doi.org/10.1016/j.tcb.2010.03.002
    • (2010) Trends Cell Biol , vol.20 , pp. 355-362
    • Funderburk, S.F.1    Wang, Q.J.2    Yue, Z.3
  • 8
    • 78049271501 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase class iii sub-complex containing vps15, vps34, beclin 1, uvrag and bif-1 regulates cytokinesis and degradative endocytic traffic
    • PMID:20643123
    • Thoresen SB, Pedersen NM, Liestøl K, Stenmark H. A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic. Exp Cell Res 2010; 316:3368-78; PMID:20643123; http://dx.doi.org/10. 1016/j.yexcr.2010.07.008
    • (2010) Exp Cell Res , vol.316 , pp. 3368-3378
    • Thoresen, S.B.1    Pedersen, N.M.2    Liestøl, K.3    Stenmark, H.4
  • 9
    • 46449120732 scopus 로고    scopus 로고
    • Beclin1-binding uvrag targets the class c vps complex to coordinate autophagosome maturation and endocytic trafficking
    • PMID:18552835
    • Liang C, Lee JS, Inn KS, Gack MU, Li Q, Roberts EA, Vergne I, Deretic V, Feng P, Akazawa C, et al. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol 2008; 10:776-87; PMID:18552835; http://dx.doi.org/10.1038/ncb1740
    • (2008) Nat Cell Biol , vol.10 , pp. 776-787
    • Liang, C.1    Lee, J.S.2    Inn, K.S.3    Gack, M.U.4    Li, Q.5    Roberts, E.A.6    Vergne, I.7    Deretic, V.8    Feng, P.9    Akazawa, C.10
  • 10
    • 79960099287 scopus 로고    scopus 로고
    • Identification of the pgrmc1 protein complex as the putative sigma-2 receptor binding site
    • PMID:21730960
    • Xu J, Zeng C, Chu W, Pan F, Rothfuss JM, Zhang F, Tu Z, Zhou D, Zeng D, Vangveravong S, et al. Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nat Commun 2011; 2:380; PMID:21730960; http://dx.doi.org/10.1038/ncomms1386
    • (2011) Nat Commun , vol.2 , pp. 380
    • Xu, J.1    Zeng, C.2    Chu, W.3    Pan, F.4    Rothfuss, J.M.5    Zhang, F.6    Tu, Z.7    Zhou, D.8    Zeng, D.9    Vangveravong, S.10
  • 11
    • 0038313119 scopus 로고    scopus 로고
    • Membrane-bound progesterone receptors contain a cytochrome b5-like ligand-binding domain
    • PMID:12537557
    • Mifsud W, Bateman A. Membrane-bound progesterone receptors contain a cytochrome b5-like ligand-binding domain. Genome Biol 2002; 3:H0068; PMID:12537557; http://dx.doi.org/10.1186/gb-2002-3-12-research0068
    • (2002) Genome Biol , vol.3
    • Mifsud, W.1    Bateman, A.2
  • 13
    • 57749085501 scopus 로고    scopus 로고
    • Pgrmc1 (progesterone receptor membrane component 1): A targetable protein with multiple functions in steroid signaling,p450 activation and drug binding
    • PMID:18992768
    • Rohe HJ, Ahmed IS, Twist KE, Craven RJ. PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding. Pharmacol Ther 2009; 121:14-9; PMID:18992768; http://dx.doi.org/10.1016/j.pharmthera.2008.09.006
    • (2009) Pharmacol Ther , vol.121 , pp. 14-19
    • Rohe, H.J.1    Ahmed, I.S.2    Twist, K.E.3    Craven, R.J.4
  • 14
    • 0030569560 scopus 로고    scopus 로고
    • Full-length cdna sequence of a progesterone membrane-binding protein from porcine vascular smooth muscle cells
    • PMID:8954087
    • Falkenstein E, Meyer C, Eisen C, Scriba PC, Wehling M. Full-length cDNA sequence of a progesterone membrane-binding protein from porcine vascular smooth muscle cells. Biochem Biophys Res Commun 1996; 229:86-9; PMID:8954087; http://dx.doi.org/10.1006/bbrc.1996.1761
    • (1996) Biochem Biophys Res Commun , vol.229 , pp. 86-89
    • Falkenstein, E.1    Meyer, C.2    Eisen, C.3    Scriba, P.C.4    Wehling, M.5
  • 16
    • 0031871382 scopus 로고    scopus 로고
    • Cloning and tissue expression of two putative steroid membrane receptors
    • PMID:9705155
    • Gerdes D, Wehling M, Leube B, Falkenstein E. Cloning and tissue expression of two putative steroid membrane receptors. Biol Chem 1998; 379:907-11; PMID:9705155
    • (1998) Biol Chem , vol.379 , pp. 907-911
    • Gerdes, D.1    Wehling, M.2    Leube, B.3    Falkenstein, E.4
  • 17
    • 84861632585 scopus 로고    scopus 로고
    • Elevated progesterone receptor membrane component 1/sigma-2 receptor levels in lung tumors and plasma from lung cancer patients
    • PMID:21918976
    • Mir SU, Ahmed IS, Arnold S, Craven RJ. Elevated progesterone receptor membrane component 1/sigma-2 receptor levels in lung tumors and plasma from lung cancer patients. Int J Cancer 2012; 131:E1-9; PMID:21918976; http://dx.doi.org/10.1002/ijc.26432
    • (2012) Int J Cancer , vol.131
    • Mir, S.U.1    Ahmed, I.S.2    Arnold, S.3    Craven, R.J.4
  • 18
    • 43249120558 scopus 로고    scopus 로고
    • Regulation of ovarian cancer cell viability and sensitivity to cisplatin by progesterone receptor membrane component-1
    • PMID:18319313
    • Peluso JJ, Liu X, Saunders MM, Claffey KP, Phoenix K. Regulation of ovarian cancer cell viability and sensitivity to cisplatin by progesterone receptor membrane component-1. J Clin Endocrinol Metab 2008; 93:1592-9; PMID:18319313; http://dx.doi.org/10.1210/jc.2007-2771
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1592-1599
    • Peluso, J.J.1    Liu, X.2    Saunders, M.M.3    Claffey, K.P.4    Phoenix, K.5
  • 19
    • 33644958757 scopus 로고    scopus 로고
    • Characterization of a novel iodinated sigma-2 receptor ligand as a cell proliferation marker
    • PMID:16546674
    • Hou C, Tu Z, Mach R, Kung HF, Kung MP. Characterization of a novel iodinated sigma-2 receptor ligand as a cell proliferation marker. Nucl Med Biol 2006; 33:203-9; PMID:16546674; http://dx.doi.org/10.1016/j.nucmedbio.2005.10.001
    • (2006) Nucl Med Biol , vol.33 , pp. 203-209
    • Hou, C.1    Tu, Z.2    Mach, R.3    Kung, H.F.4    Kung, M.P.5
  • 21
    • 78549265187 scopus 로고    scopus 로고
    • Novel sigma-2 receptor ligand sw43 stabilizes pancreas cancer progression in combination with gemcitabine
    • PMID:21092190
    • Hornick JR, Xu J, Vangveravong S, Tu Z, Mitchem JB, Spitzer D, Goedegebuure P, Mach RH, Hawkins WG. The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine. Mol Cancer 2010; 9:298; PMID:21092190; http://dx.doi.org/10.1186/1476-4598-9-298
    • (2010) Mol Cancer , vol.9 , pp. 298
    • Hornick, J.R.1    Xu, J.2    Vangveravong, S.3    Tu, Z.4    Mitchem, J.B.5    Spitzer, D.6    Goedegebuure, P.7    Mach, R.H.8    Hawkins, W.G.9
  • 24
    • 29244483674 scopus 로고    scopus 로고
    • Hpr6 (heme-1 domain protein) regulates the susceptibility of cancer cells to chemotherapeutic drugs
    • PMID:16234411
    • Crudden G, Chitti RE, Craven RJ. Hpr6 (heme-1 domain protein) regulates the susceptibility of cancer cells to chemotherapeutic drugs. J Pharmacol Exp Ther 2006; 316:448-55; PMID:16234411; http://dx.doi.org/10.1124/jpet.105.094631
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 448-455
    • Crudden, G.1    Chitti, R.E.2    Craven, R.J.3
  • 25
    • 0038397236 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae dap1p, a novel dna damage response protein related to the mammalian membraneassociated progesterone receptor
    • PMID:12684380
    • Hand RA, Jia N, Bard M, Craven RJ. Saccharomyces cerevisiae Dap1p, a novel DNA damage response protein related to the mammalian membraneassociated progesterone receptor. Eukaryot Cell 2003; 2:306-17; PMID:12684380; http://dx.doi.org/10.1128/EC.2.2.306-317.2003
    • (2003) Eukaryot Cell , vol.2 , pp. 306-317
    • Hand, R.A.1    Jia, N.2    Bard, M.3    Craven, R.J.4
  • 26
    • 14044252188 scopus 로고    scopus 로고
    • Dap1p, a heme-binding protein that regulates the cytochrome p450 protein erg11p/cyp51p in saccharomyces cerevisiae
    • PMID:15713626
    • Mallory JC, Crudden G, Johnson BL, Mo C, Pierson CA, Bard M, Craven RJ. Dap1p, a heme-binding protein that regulates the cytochrome P450 protein Erg11p/Cyp51p in Saccharomyces cerevisiae. Mol Cell Biol 2005; 25:1669-79; PMID:15713626; http://dx.doi.org/10.1128/MCB.25.5.1669-1679.2005
    • (2005) Mol Cell Biol , vol.25 , pp. 1669-1679
    • Mallory, J.C.1    Crudden, G.2    Johnson, B.L.3    Mo, C.4    Pierson, C.A.5    Bard, M.6    Craven, R.J.7
  • 27
    • 37549014195 scopus 로고    scopus 로고
    • Regulation of iron homeostasis mediated by the heme-binding protein dap1 (damage resistance protein 1) via the p450 protein erg11/cyp51
    • PMID:17954932
    • Craven RJ, Mallory JC, Hand RA. Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51. J Biol Chem 2007; 282:36543-51; PMID:17954932; http://dx.doi.org/10.1074/jbc. M706770200
    • (2007) J Biol Chem , vol.282 , pp. 36543-36551
    • Craven, R.J.1    Mallory, J.C.2    Hand, R.A.3
  • 29
    • 77951084376 scopus 로고    scopus 로고
    • Progesterone receptor membrane component 1 (pgrmc1): A heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule
    • PMID:20164297
    • Ahmed IS, Rohe HJ, Twist KE, Mattingly MN, Craven RJ. Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule. J Pharmacol Exp Ther 2010; 333:564-73; PMID:20164297; http://dx.doi.org/10.1124/jpet.109.164210
    • (2010) J Pharmacol Exp Ther , vol.333 , pp. 564-573
    • Ahmed, I.S.1    Rohe, H.J.2    Twist, K.E.3    Mattingly, M.N.4    Craven, R.J.5
  • 30
    • 0141919706 scopus 로고    scopus 로고
    • Hpr6.6 protein mediates cell death from oxidative damage in mcf-7 human breast cancer cells
    • PMID:14523988
    • Hand RA, Craven RJ. Hpr6.6 protein mediates cell death from oxidative damage in MCF-7 human breast cancer cells. J Cell Biochem 2003; 90:534-47; PMID:14523988; http://dx.doi.org/10.1002/jcb.10648
    • (2003) J Cell Biochem , vol.90 , pp. 534-547
    • Hand, R.A.1    Craven, R.J.2
  • 31
    • 77955295885 scopus 로고    scopus 로고
    • Pgrmc1 (progesterone receptor membrane component 1) associates with epidermal growth factor receptor and regulates erlotinib sensitivity
    • PMID:20538600
    • Ahmed IS, Rohe HJ, Twist KE, Craven RJ. Pgrmc1 (progesterone receptor membrane component 1) associates with epidermal growth factor receptor and regulates erlotinib sensitivity. J Biol Chem 2010; 285:24775-82; PMID:20538600; http://dx.doi.org/10.1074/jbc.M110.134585
    • (2010) J Biol Chem , vol.285 , pp. 24775-24782
    • Ahmed, I.S.1    Rohe, H.J.2    Twist, K.E.3    Craven, R.J.4
  • 32
    • 77949566861 scopus 로고    scopus 로고
    • Progesterone inhibits apoptosis in part by pgrmc1-regulated gene expression
    • PMID:20144686
    • Peluso JJ, Liu X, Gawkowska A, Lodde V, Wu CA. Progesterone inhibits apoptosis in part by PGRMC1-regulated gene expression. Mol Cell Endocrinol 2010; 320:153-61; PMID:20144686; http://dx.doi.org/10.1016/j.mce.2010.02.005
    • (2010) Mol Cell Endocrinol , vol.320 , pp. 153-161
    • Peluso, J.J.1    Liu, X.2    Gawkowska, A.3    Lodde, V.4    Wu, C.A.5
  • 33
    • 33646806787 scopus 로고    scopus 로고
    • Progesterone membrane receptor component 1 expression in the immature rat ovary and its role in mediating progesterone's antiapoptotic action
    • PMID:16513825
    • Peluso JJ, Pappalardo A, Losel R, Wehling M. Progesterone membrane receptor component 1 expression in the immature rat ovary and its role in mediating progesterone's antiapoptotic action. Endocrinology 2006; 147:3133-40; PMID:16513825; http://dx.doi.org/10.1210/en.2006-0114
    • (2006) Endocrinology , vol.147 , pp. 3133-3140
    • Peluso, J.J.1    Pappalardo, A.2    Losel, R.3    Wehling, M.4
  • 34
    • 38549114147 scopus 로고    scopus 로고
    • Progesterone receptor membrane component-1 (pgrmc1) is the mediator of progesterone's antiapoptotic action in spontaneously immortalized granulosa cells as revealed by pgrmc1 small interfering ribonucleic acid treatment and functional analysis of pgrmc1 mutations
    • PMID:17991724
    • Peluso JJ, Romak J, Liu X. Progesterone receptor membrane component-1 (PGRMC1) is the mediator of progesterone's antiapoptotic action in spontaneously immortalized granulosa cells as revealed by PGRMC1 small interfering ribonucleic acid treatment and functional analysis of PGRMC1 mutations. Endocrinology 2008; 149:534-43; PMID:17991724; http://dx.doi.org/10.1210/en. 2007-1050
    • (2008) Endocrinology , vol.149 , pp. 534-543
    • Peluso, J.J.1    Romak, J.2    Liu, X.3
  • 36
    • 25444483322 scopus 로고    scopus 로고
    • Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress
    • PMID:16204071
    • Ostenfeld MS, Fehrenbacher N, Høyer-Hansen M, Thomsen C, Farkas T, Jäättelä M. Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress. Cancer Res 2005; 65:8975-83; PMID:16204071; http://dx.doi.org/10.1158/0008-5472.CAN-05-0269
    • (2005) Cancer Res , vol.65 , pp. 8975-8983
    • Ostenfeld, M.S.1    Fehrenbacher, N.2    Høyer-Hansen, M.3    Thomsen, C.4    Farkas, T.5    Jäättelä, M.6
  • 38
    • 33947235679 scopus 로고    scopus 로고
    • Vincristine induces dramatic lysosomal changes and sensitizes cancer cells to lysosome-destabilizing siramesine
    • PMID:17332352
    • Groth-Pedersen L, Ostenfeld MS, Høyer-Hansen M, Nylandsted J, Jäättelä M. Vincristine induces dramatic lysosomal changes and sensitizes cancer cells to lysosome-destabilizing siramesine. Cancer Res 2007; 67:2217-25; PMID:17332352; http://dx.doi.org/10.1158/0008-5472.CAN-06-3520
    • (2007) Cancer Res , vol.67 , pp. 2217-2225
    • Groth-Pedersen, L.1    Ostenfeld, M.S.2    Høyer-Hansen, M.3    Nylandsted, J.4    Jäättelä, M.5
  • 39
    • 0028989833 scopus 로고
    • Sigma binding site ligands inhibit cell proliferation in mammary and colon carcinoma cell lines and melanoma cells in culture
    • PMID:7671999
    • Brent PJ, Pang GT. Sigma binding site ligands inhibit cell proliferation in mammary and colon carcinoma cell lines and melanoma cells in culture. Eur J Pharmacol 1995; 278:151-60; PMID:7671999; http://dx.doi.org/10.1016/0014- 2999(95)00115-2
    • (1995) Eur J Pharmacol , vol.278 , pp. 151-160
    • Brent, P.J.1    Pang, G.T.2
  • 40
    • 0036141493 scopus 로고    scopus 로고
    • Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines
    • PMID:11782394
    • Crawford KW, Bowen WD. Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines. Cancer Res 2002; 62:313-22; PMID:11782394
    • (2002) Cancer Res , vol.62 , pp. 313-322
    • Crawford, K.W.1    Bowen, W.D.2
  • 41
    • 84855392178 scopus 로고    scopus 로고
    • Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling
    • PMID:22065721
    • Spitzer D, Simon PO Jr., Kashiwagi H, Xu J, Zeng C, Vangveravong S, Zhou D, Chang K, McDunn JE, Hornick JR, et al. Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling. Cancer Res 2012; 72:201-9; PMID:22065721; http://dx.doi.org/10.1158/0008-5472. CAN-11-1354
    • (2012) Cancer Res , vol.72 , pp. 201-209
    • Spitzer, D.1    Simon Jr., P.O.2    Kashiwagi, H.3    Xu, J.4    Zeng, C.5    Vangveravong, S.6    Zhou, D.7    Chang, K.8    McDunn, J.E.9    Hornick, J.R.10
  • 42
    • 17844374364 scopus 로고    scopus 로고
    • A structure-based strategy for discovery of small ligands binding to functionally unknown proteins: Combination of in silico screening and surface plasmon resonance measurements
    • PMID:15798990
    • Yoshitani N, Satou K, Saito K, Suzuki S, Hatanaka H, Seki M, Shinozaki K, Hirota H, Yokoyama S. A structure-based strategy for discovery of small ligands binding to functionally unknown proteins: combination of in silico screening and surface plasmon resonance measurements. Proteomics 2005; 5:1472-80; PMID:15798990; http://dx.doi.org/10.1002/pmic.200401032
    • (2005) Proteomics , vol.5 , pp. 1472-1480
    • Yoshitani, N.1    Satou, K.2    Saito, K.3    Suzuki, S.4    Hatanaka, H.5    Seki, M.6    Shinozaki, K.7    Hirota, H.8    Yokoyama, S.9
  • 43
    • 84862786208 scopus 로고    scopus 로고
    • Haloperidol and clozapine block formation of autophagolysosomes in rat primary neurons
    • PMID:22390943
    • Park J, Chung S, An H, Kim J, Seo J, Kim DH, Yoon SY. Haloperidol and clozapine block formation of autophagolysosomes in rat primary neurons. Neuroscience 2012; 209:64-73; PMID:22390943; http://dx.doi.org/10.1016/j. neuroscience.2012.02.035
    • (2012) Neuroscience , vol.209 , pp. 64-73
    • Park, J.1    Chung, S.2    An, H.3    Kim, J.4    Seo, J.5    Kim, D.H.6    Yoon, S.Y.7
  • 44
    • 84859422467 scopus 로고    scopus 로고
    • Effects of lipofectamine 2000/sirna complexes on autophagy in hepatoma cells
    • PMID:21660602
    • Mo RH, Zaro JL, Ou JH, Shen WC. Effects of Lipofectamine 2000/siRNA complexes on autophagy in hepatoma cells. Mol Biotechnol 2012; 51:1-8; PMID:21660602; http://dx.doi.org/10.1007/s12033-011-9422-6
    • (2012) Mol Biotechnol , vol.51 , pp. 1-8
    • Mo, R.H.1    Zaro, J.L.2    Ou, J.H.3    Shen, W.C.4
  • 45
    • 0025776523 scopus 로고
    • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
    • PMID:1715094
    • Heitman J, Movva NR, Hall MN. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 1991; 253:905-9; PMID:1715094; http://dx.doi.org/10.1126/science.1715094
    • (1991) Science , vol.253 , pp. 905-909
    • Heitman, J.1    Movva, N.R.2    Hall, M.N.3
  • 46
    • 0028239893 scopus 로고
    • Raft1: A mammalian protein that binds to fkbp12 in a rapamycin-dependent fashion and is homologous to yeast tors
    • PMID:7518356
    • Sabatini DM, Erdjument-Bromage H, Lui M, Tempst P, Snyder SH. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 1994; 78:35-43; PMID:7518356; http://dx.doi.org/10.1016/0092-8674(94)90570-3
    • (1994) Cell , vol.78 , pp. 35-43
    • Sabatini, D.M.1    Erdjument-Bromage, H.2    Lui, M.3    Tempst, P.4    Snyder, S.H.5
  • 47
    • 0028360374 scopus 로고
    • A mammalian protein targeted by g1-arresting rapamycin-receptor complex
    • PMID:8008069
    • Brown EJ, Albers MW, Shin TB, Ichikawa K, Keith CT, Lane WS, Schreiber SL. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 1994; 369:756-8; PMID:8008069; http://dx.doi.org/10.1038/369756a0
    • (1994) Nature , vol.369 , pp. 756-758
    • Brown, E.J.1    Albers, M.W.2    Shin, T.B.3    Ichikawa, K.4    Keith, C.T.5    Lane, W.S.6    Schreiber, S.L.7
  • 48
    • 78650510609 scopus 로고    scopus 로고
    • Mtor: From growth signal integration to cancer, diabetes and ageing
    • PMID:21157483
    • Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011; 12:21-35; PMID:21157483; http://dx.doi.org/10.1038/nrm3025
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 49
    • 79956088595 scopus 로고    scopus 로고
    • The long and winding road to rational treatment of cancer associated with lkb1/ampk/tsc/mtorc1 signaling
    • PMID:21258412
    • van Veelen W, Korsse SE, van de Laar L, Peppelenbosch MP. The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling. Oncogene 2011; 30:2289-303; PMID:21258412; http://dx.doi.org/10.1038/onc.2010.630
    • (2011) Oncogene , vol.30 , pp. 2289-2303
    • Van Veelen, W.1    Korsse, S.E.2    Van De Laar, L.3    Peppelenbosch, M.P.4
  • 50
    • 0042701991 scopus 로고    scopus 로고
    • Tuberous sclerosis complex gene products, tuberin and hamartin, control mtor signaling by acting as a gtpase-activating protein complex toward rheb
    • PMID:12906785
    • Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 2003; 13:1259-68; PMID:12906785; http://dx.doi.org/10.1016/S0960-9822(03)00506-2
    • (2003) Curr Biol , vol.13 , pp. 1259-1268
    • Tee, A.R.1    Manning, B.D.2    Roux, P.P.3    Cantley, L.C.4    Blenis, J.5
  • 51
    • 0037108750 scopus 로고    scopus 로고
    • Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mtor)-mediated downstream signaling
    • PMID:12271141
    • Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci U S A 2002; 99:13571-6; PMID:12271141; http://dx.doi.org/10.1073/pnas. 202476899
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 13571-13576
    • Tee, A.R.1    Fingar, D.C.2    Manning, B.D.3    Kwiatkowski, D.J.4    Cantley, L.C.5    Blenis, J.6
  • 52
    • 0345167800 scopus 로고    scopus 로고
    • Tsc2 mediates cellular energy response to control cell growth and survival
    • PMID:14651849
    • Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003; 115:577-90; PMID:14651849; http://dx.doi.org/10.1016/S0092-8674(03)00929-2
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 53
    • 0028289946 scopus 로고
    • Molecular characterization of light chain 3. A microtubule binding subunit of map1a and map1b
    • PMID:7908909
    • Mann SS, Hammarback JA. Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B. J Biol Chem 1994; 269:11492-7; PMID:7908909
    • (1994) J Biol Chem , vol.269 , pp. 11492-11497
    • Mann, S.S.1    Hammarback, J.A.2
  • 54
    • 34548259958 scopus 로고    scopus 로고
    • P62/sqstm1 binds directly to atg8/lc3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    • PMID:17580304
    • Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Øvervatn A, Bjørkøy G, Johansen T. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 2007; 282:24131-45; PMID:17580304; http://dx.doi.org/10.1074/jbc. M702824200
    • (2007) J Biol Chem , vol.282 , pp. 24131-24145
    • Pankiv, S.1    Clausen, T.H.2    Lamark, T.3    Brech, A.4    Bruun, J.A.5    Outzen HØvervatn, A.6    Bjørkøy, G.7    Johansen, T.8
  • 55
    • 0027424777 scopus 로고
    • Isolation and characterization of autophagy-defective mutants of saccharomyces cerevisiae
    • PMID:8224160
    • Tsukada M, Ohsumi Y. Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 1993; 333:169-74; PMID:8224160; http://dx.doi.org/10.1016/0014-5793(93)80398-E
    • (1993) FEBS Lett , vol.333 , pp. 169-1674
    • Tsukada, M.1    Ohsumi, Y.2
  • 56
    • 0032512636 scopus 로고    scopus 로고
    • Tor a phosphatidylinositol kinase homologue, controls autophagy in yeast
    • PMID:9461583
    • Noda T, Ohsumi Y. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Biol Chem 1998; 273:3963-6; PMID:9461583; http://dx.doi.org/10.1074/jbc.273.7.3963
    • (1998) J Biol Chem , vol.273 , pp. 3963-3966
    • Noda, T.1    Ohsumi, Y.2
  • 57
    • 65549145048 scopus 로고    scopus 로고
    • An atp-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mtorc1
    • PMID:19150980
    • Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, Gray NS. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem 2009; 284:8023-32; PMID:19150980; http://dx.doi.org/10.1074/jbc. M900301200
    • (2009) J Biol Chem , vol.284 , pp. 8023-8032
    • Thoreen, C.C.1    Kang, S.A.2    Chang, J.W.3    Liu, Q.4    Zhang, J.5    Gao, Y.6    Reichling, L.J.7    Sim, T.8    Sabatini, D.M.9    Gray, N.S.10
  • 58
    • 0034683568 scopus 로고    scopus 로고
    • Tor-mediated induction of autophagy via an apg1 protein kinase complex
    • PMID:10995454
    • Kamada Y, Funakoshi T, Shintani T, Nagano K, Ohsumi M, Ohsumi Y. Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol 2000; 150:1507-13; PMID:10995454; http://dx.doi.org/10.1083/jcb.150.6.1507
    • (2000) J Cell Biol , vol.150 , pp. 1507-1513
    • Kamada, Y.1    Funakoshi, T.2    Shintani, T.3    Nagano, K.4    Ohsumi, M.5    Ohsumi, Y.6
  • 59
    • 84856800302 scopus 로고    scopus 로고
    • Role of ampk-mtor-ulk12 in the regulation of autophagy: Cross talk shortcuts and feedbacks
    • PMID:22025673
    • Alers S, Löffler AS, Wesselborg S, Stork B. Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks. Mol Cell Biol 2012; 32:2-11; PMID:22025673; http://dx.doi.org/10.1128/MCB.06159-11
    • (2012) Mol Cell Biol , vol.32 , pp. 2-11
    • Alers, S.1    Löffler, A.S.2    Wesselborg, S.3    Stork, B.4
  • 60
    • 34648828532 scopus 로고    scopus 로고
    • Amp-activated/snf1 protein kinases: Conserved guardians of cellular energy
    • PMID:17712357
    • Hardie DG. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol 2007; 8:774-85; PMID:17712357; http://dx.doi.org/10.1038/nrm2249
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 774-785
    • Hardie, D.G.1
  • 61
    • 80052511813 scopus 로고    scopus 로고
    • Ampk signalling pathway coordinates cell growth, autophagy and metabolism
    • PMID:21892142
    • Mihaylova MM, Shaw RJ. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 2011; 13:1016-23; PMID:21892142; http://dx.doi.org/10.1038/ncb2329
    • (2011) Nat Cell Biol , vol.13 , pp. 1016-1023
    • Mihaylova, M.M.1    Shaw, R.J.2
  • 62
    • 0043127125 scopus 로고    scopus 로고
    • Rheb gtpase is a direct target of tsc2 gap activity and regulates mtor signaling
    • PMID:12869586
    • Inoki K, Li Y, Xu T, Guan KL. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 2003; 17:1829-34; PMID:12869586; http://dx.doi.org/10.1101/gad.1110003
    • (2003) Genes Dev , vol.17 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.L.4
  • 64
    • 0038141979 scopus 로고    scopus 로고
    • Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
    • PMID:12771962
    • Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol 2003; 5:578-81; PMID:12771962; http://dx.doi.org/10.1038/ncb999
    • (2003) Nat Cell Biol , vol.5 , pp. 578-581
    • Zhang, Y.1    Gao, X.2    Saucedo, L.J.3    Ru, B.4    Edgar, B.A.5    Pan, D.6
  • 65
    • 60149098492 scopus 로고    scopus 로고
    • The pivotal role of c-jun nh2-terminal kinase-mediated beclin 1 expression during anticancer agents-induced autophagy in cancer cells
    • PMID:19060920
    • Li DD, Wang LL, Deng R, Tang J, Shen Y, Guo JF, Wang Y, Xia LP, Feng GK, Liu QQ, et al. The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells. Oncogene 2009; 28:886-98; PMID:19060920; http://dx.doi.org/10.1038/onc.2008.441
    • (2009) Oncogene , vol.288 , pp. 86-98
    • Li, D.D.1    Wang, L.L.2    Deng, R.3    Tang, J.4    Shen, Y.5    Guo, J.F.6    Wang, Y.7    Xia, L.P.8    Feng, G.K.9    Liu, Q.Q.10
  • 66
    • 70149114818 scopus 로고    scopus 로고
    • C-jun nh2-terminal kinase activation is essential for dram-dependent induction of autophagy and apoptosis in 2-methoxyestradiol-treated ewing sarcoma cells
    • PMID:19706754
    • Lorin S, Borges A, Ribeiro Dos Santos L, Souquère S, Pierron G, Ryan KM, Codogno P, Djavaheri-Mergny M. c-Jun NH2-terminal kinase activation is essential for DRAM-dependent induction of autophagy and apoptosis in 2-methoxyestradiol-treated Ewing sarcoma cells. Cancer Res 2009; 69:6924-31; PMID:19706754; http://dx.doi.org/10.1158/0008-5472.CAN-09-1270
    • (2009) Cancer Res , vol.69 , pp. 6924-6931
    • Lorin, S.1    Borges, A.2    Ribeiro Dos Santos, L.3    Souquère, S.4    Pierron, G.5    Ryan, K.M.6    Codogno, P.7    Djavaheri-Mergny, M.8
  • 67
    • 84860352374 scopus 로고    scopus 로고
    • Neutrophil gelatinaseassociated lipocalin (ngal) expression is dependent on the tumor-associated sigma-2 receptor s2rpgrmc1
    • PMID:22418433
    • Mir SU, Jin L, Craven RJ. Neutrophil gelatinaseassociated lipocalin (NGAL) expression is dependent on the tumor-associated sigma-2 receptor S2RPgrmc1. J Biol Chem 2012; 287:14494-501; PMID:22418433; http://dx.doi.org/10. 1074/jbc.M111.324921
    • (2012) J Biol Chem , vol.287 , pp. 14494-14501
    • Mir, S.U.1    Jin, L.2    Craven, R.J.3
  • 68
    • 25444459083 scopus 로고    scopus 로고
    • A genomic screen for yeast vacuolar membrane atpase mutants
    • PMID:15937126
    • Sambade M, Alba M, Smardon AM, West RW, Kane PM. A genomic screen for yeast vacuolar membrane ATPase mutants. Genetics 2005; 170:1539-51; PMID:15937126; http://dx.doi.org/10.1534/genetics.105.042812
    • (2005) Genetics , vol.170 , pp. 1539-1551
    • Sambade, M.1    Alba, M.2    Smardon, A.M.3    West, R.W.4    Kane, P.M.5
  • 69
    • 0029809134 scopus 로고    scopus 로고
    • P62, a phosphotyrosine-independent ligand of the sh2 domain of p56lck, belongs to a new class of ubiquitinbinding proteins
    • PMID:8702753
    • Vadlamudi RK, Joung I, Strominger JL, Shin J. p62, a phosphotyrosine- independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitinbinding proteins. J Biol Chem 1996; 271:20235-7; PMID:8702753; http://dx.doi.org/10.1074/jbc.271.34.20235
    • (1996) J Biol Chem , vol.271 , pp. 20235-20237
    • Vadlamudi, R.K.1    Joung, I.2    Strominger, J.L.3    Shin, J.4
  • 70
    • 84860345815 scopus 로고    scopus 로고
    • Lysosomal membrane permeabilization is an early event in sigma-2 receptor ligand mediated cell death in pancreatic cancer
    • PMID:22551149
    • Hornick JR, Vangveravong S, Spitzer D, Abate C, Berardi F, Goedegebuure P, Mach RH, Hawkins WG. Lysosomal membrane permeabilization is an early event in Sigma-2 receptor ligand mediated cell death in pancreatic cancer. J Exp Clin Cancer Res 2012; 31:41; PMID:22551149; http://dx.doi.org/10.1186/1756-9966-31-41
    • (2012) J Exp Clin Cancer Res , vol.31 , pp. 41
    • Hornick, J.R.1    Vangveravong, S.2    Spitzer, D.3    Abate, C.4    Berardi, F.5    Goedegebuure, P.6    Mach, R.H.7    Hawkins, W.G.8
  • 71
    • 33746576243 scopus 로고    scopus 로고
    • Haloperidol induces apoptosis via the sigma2 receptor system and bcl-xs
    • PMID:16462815
    • Wei Z, Mousseau DD, Dai Y, Cao X, Li XM. Haloperidol induces apoptosis via the sigma2 receptor system and Bcl-XS. Pharmacogenomics J 2006; 6:279-88; PMID:16462815
    • (2006) Pharmacogenomics J , vol.6 , pp. 279-288
    • Wei, Z.1    Mousseau, D.D.2    Dai, Y.3    Cao, X.4    Li, X.M.5
  • 72
    • 0034080806 scopus 로고    scopus 로고
    • Sigma receptors: Recent advances and new clinical potentials
    • PMID:10812960
    • Bowen WD. Sigma receptors: recent advances and new clinical potentials. Pharm Acta Helv 2000; 74:211-8; PMID:10812960; http://dx.doi.org/10.1016/S0031- 6865(99)00034-5
    • (2000) Pharm Acta Helv , vol.74 , pp. 211-218
    • Bowen, W.D.1


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