PGRMC1 (progesterone receptor membrane component 1): A targetable protein with multiple functions in steroid signaling, P450 activation and drug binding

Pharmacology and Therapeutics

Volumn 121, Issue 1, 2009, Pages 14-19

  Rohe, Hannah J ^a   Ahmed, Ikhlas S ^a   Twist, Katherine E ^a   Craven, Rolf J ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Carcinogenicity; Chemotherapy; Cholesterol; P450 proteins; Progesterone

Indexed keywords

CYTOCHROME P450; DRUG BINDING PROTEIN; HEME; PROGESTERONE; PROGESTERONE RECEPTOR; PROGESTERONE RECEPTOR MEMBRANE COMPONENT 1; STEROID; STEROL 14ALPHA DEMETHYLASE; UNCLASSIFIED DRUG;

BINDING AFFINITY; CANCER THERAPY; CARDIOVASCULAR DISEASE; CELL SURVIVAL; CHOLESTEROL SYNTHESIS; DRUG BINDING; DRUG METABOLISM; DRUG TARGETING; ENZYME ACTIVATION; HORMONE SYNTHESIS; HUMAN; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN; CELL SURVIVAL; CHOLESTEROL; CYTOCHROME P-450 ENZYME SYSTEM; DNA DAMAGE; DRUG DISCOVERY; HEME; HUMANS; MEMBRANE PROTEINS; RECEPTORS, PROGESTERONE; STEROIDS;

EID: 57749085501     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2008.09.006     Document Type: Review

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