Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma

Journal of Translational Medicine

Volumn 7, Issue , 2009, Pages

  Kashiwagi, Hiroyuki ^a   McDunn, Jonathan E ^a   Simon Jr , Peter O ^a   Goedegebuure, Peter S ^a,b   Vangveravong, Suwanna ^a   Chang, Katherine ^a   Hotchkiss, Richard S ^a   Mach, Robert H ^a   Hawkins, William G ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; GEMCITABINE; PACLITAXEL; SIGMA 2 OPIATE RECEPTOR; SIGMA RECEPTOR LIGAND; SV 119; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DEOXYCYTIDINE; DRUG DERIVATIVE; LIGAND; SIGMA OPIATE RECEPTOR; SIGMA-2 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; C57BL 6 MOUSE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENTIATION; DRUG TOLERABILITY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LIGAND BINDING; MOUSE; NICK END LABELING; NONHUMAN; PANCREAS ADENOCARCINOMA; ADENOCARCINOMA; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECT; FEMALE; INTERPHASE; METABOLISM; PANCREAS TUMOR; PATHOLOGY; SURVIVAL; TUMOR CELL LINE;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CELL LINE, TUMOR; DEOXYCYTIDINE; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; INTERPHASE; LIGANDS; MICE; MICE, INBRED C57BL; PACLITAXEL; PANCREATIC NEOPLASMS; RECEPTORS, SIGMA; SURVIVAL ANALYSIS;

EID: 65349102411     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-7-24     Document Type: Article

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