A structure-based strategy for discovery of small ligands binding to functionally unknown proteins: Combination of in silico screening and surface plasmon resonance measurements

Proteomics

Volumn 5, Issue 6, 2005, Pages 1472-1480

  Yoshitani, Naoei ^a   Satou, Kazuhito ^a   Saito, Kazuki ^a   Suzuki, Sakura ^a   Hatanaka, Hideki ^a   Seki, Motoaki ^a   Shinozaki, Kazuo ^a   Hirota, Hiroshi ^a   Yokoyama, Shigeyuki ^a,b,c  

^a RIKEN YOKOHAMA INSTITUTE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c RIKEN HARIMA INSTITUTE   (Japan)

Author keywords

In Silico screening; Lead compound search; Protein three dimensional structure; Structure based ligand screening; Surface plasmon resonance

Indexed keywords

LIGAND; PROTEIN;

ARABIDOPSIS; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; DISSOCIATION CONSTANT; LIGAND BINDING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN IMMOBILIZATION; PROTEIN STRUCTURE; ROBOTICS; SURFACE PLASMON RESONANCE; X RAY CRYSTALLOGRAPHY;

ARABIDOPSIS PROTEINS; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEINS; SURFACE PLASMON RESONANCE;

EID: 17844374364     PISSN: 16159853     EISSN: None     Source Type: Journal    
DOI: 10.1002/pmic.200401032     Document Type: Article

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