Synthesis and evaluation of the apoptosis inducing and CT DNA interaction properties of a series of 4β-carbamoyl 4′-O- demethylepipodophyllotoxins

European Journal of Medicinal Chemistry

Volumn 70, Issue , 2013, Pages 59-67

  Sang, Chun Yan ^a   Liu, Jian Fei ^a   Qin, Wen Wen ^a   Zhao, Jie ^a   Hui, Lin ^b   Jin, Yong Xin ^c   Chen, Shi Wu ^a  

^a LANZHOU UNIVERSITY   (China)

^b LANZHOU GENERAL HOSPITAL   (China)

^c GANSU PROVINCIAL HOSPITAL   (China)

Author keywords

Apoptosis; Carbamates; CT DNA; Cytotoxicity; Podophyllotoxin

Indexed keywords

1 (4 NITROPHENYL)PIPERAZINYL CARBAMATE; 2'' DEOXY 2'' (DIMETHYLAMINO)ETOPOSIDE; 4BETA CARBAMOYL 4 2 DEMETHYLEPIPODOPHYLLOTOXIN; CARBAMIC ACID DERIVATIVE; CASPASE 3; DNA; EPIPODOPHYLLOTOXIN DERIVATIVE; ETOPOFOS; ETOPOSIDE; PROTEIN BAX; PROTEIN P53; TAFLUPOSIDE; TENIPOSIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CALF (BOVINE); CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CONFORMATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DNA INTERACTION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVATION; HELA CELL; HUMAN; HUMAN CELL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; THYMUS; TUMOR SUPPRESSOR GENE;

APOPTOSIS; CARBAMATES; CT DNA; CYTOTOXICITY; PODOPHYLLOTOXIN;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARBAMATES; CATTLE; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HL-60 CELLS; HUMANS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84885495357     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.09.053     Document Type: Article

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