F 11782, a novel catalytic inhibitor of topoisomerases I and II, induces atypical, yet cytotoxic DNA double-strand breaks in CHO-K1 cells

Anticancer Research

Volumn 22, Issue 1 A, 2002, Pages 187-192

  Barret, Jean Marc ^a   Etiévant, Chantal ^a   Baudouin, Caroline ^a   Skov, Kirsten ^a   Charvéron, Marie ^a   Hill, Bridget T ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

Catalytic topoisomerase inhibitor; DNA damage; DNA recombination; DNA strand breaks; F 11782

Indexed keywords

2'',3'' BISPENTAFLUOROPHENOXYACETYL 4',6' ETHYLIDENE BETA DEXTRO GLUCOSIDE; DNA TOPOISOMERASE INHIBITOR; EPIPODOPHYLLOTOXIN DERIVATIVE; ETOPOSIDE; F 11782; GLUCOSIDE; GYRASE INHIBITOR; NAVELBINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CATALYSIS; CHO CELL; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DNA STRAND BREAKAGE; DRUG MECHANISM; ENZYME ACTIVITY; FLUORINATION; GENETIC RECOMBINATION; IN VITRO STUDY; MOLECULAR STABILITY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CHO CELLS; COMET ASSAY; CRICETINAE; DNA; DNA DAMAGE; DNA REPAIR; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; ENZYME INHIBITORS; ETOPOSIDE; INHIBITORY CONCENTRATION 50; NAPHTHALENES; PYRANS;

EID: 0036244606     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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