Synthesis and biological evaluation of novel conjugates of podophyllotoxin and 5-FU as antineoplastic agents

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 8, 2009, Pages 3111-3117

  Chen, Shi Wu ^a   Xiang, Rong ^a,b   Liu, Jian ^a   Tian, Xuan ^a  

^a LANZHOU UNIVERSITY   (China)

^b Lanzhou Hospital of Traditional Chinese Medicine Traumatocomium   (China)

Author keywords

5 FU; Antineoplastic agents; Calf thymus DNA; Podophyllotoxin

Indexed keywords

1 (OMEGA BROMOBUTYL) 5 FLUOROURACIL; 1 (OMEGA BROMOPENTYL) 5 FLUOROURACIL; 1 (OMEGA BROMOPROPYL) 5 FLUOROURACIL; 4 O DEMETHYL 4 BETA N [(5 FLUOROURACIL N 1 ) BUTYLALANYL] 4 DESOXY PODOPHYLLOTOXIN; 4 O DEMETHYL 4 BETA N [(5 FLUOROURACIL N 1 ) BUTYLLEUCYL] 4 DESOXY PODOPHYLLOTOXIN; 4 O DEMETHYL 4 BETA N [(5 FLUOROURACIL N 1 ) PENTYLLEUCYL] 4 DESOXY PODOPHYLLOTOXIN; 4 O DEMETHYL 4 BETA N [(5 FLUOROURACIL N 1 ) PENTYLPHENYLALANYL] 4 DESOXY PODOPHYLLOTOXIN; 4 O DEMETHYL 4 BETA N [(5 FLUOROURACIL N 1 ) PROPYLALANYL] 4 DESOXY PODOPHYLLOTOXIN; 4 O DEMETHYL 4 BETA N [(5 FLUOROURACIL N 1 ) PROPYLISOLEUCYL] 4 DESOXY PODOPHYLLOTOXIN; 4 O DEMETHYL 4 BETA N [(5 FLUOROURACIL N 1 ) PROPYLLEUCYL] 4 DESOXY PODOPHYLLOTOXIN; 4 O DEMETHYL 4 BETA N [(5 FLUOROURACIL N 1 ) PROPYLMETHIONYL] 4 DESOXY PODOPHYLLOTOXIN; 4 O DEMETHYL 4 BETA N [(5 FLUOROURACIL N 1 ) PROPYLPHENYLALANYL] 4 DESOXY PODOPHYLLOTOXIN; 4 O DEMETHYL 4 BETA N [(5 FLUOROURACIL N 1 ) PROPYLTHREONYL] 4 DESOXY PODOPHYLLOTOXIN; 4 O DEMETHYL 4 BETA N [(5 FLUOROURACIL N 1 ) PROPYLTYROSYL] 4 DESOXY PODOPHYLLOTOXIN; 4 O DEMETHYL 4 BETA N [(5 FLUOROURACIL N 1 ) PROPYLVALINYL] 4 DESOXY PODOPHYLLOTOXIN; ANTINEOPLASTIC AGENT; ETOPOSIDE; FLUOROURACIL DERIVATIVE; PODOPHYLLOTOXIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; CELL LINE, TUMOR; DNA; DRUG DESIGN; FLUOROURACIL; HL-60 CELLS; HUMANS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PODOPHYLLOTOXIN;

EID: 64049110824     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.03.009     Document Type: Article

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