Antitumor agents. 163. Three-dimensional quantitative structure-activity relationship study of 4′-O-demethylepipodophyllotoxin analogs using the modified CoMFA/q2-GRS approach

Journal of Medicinal Chemistry

Volumn 39, Issue 7, 1996, Pages 1383-1395

  Cho, Sung Jin ^a   Tropsha, Alexander ^a   Sufness, Matthew ^b   Cheng, Yung Chi ^c   Lee, Kuo Hsiung ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4' NOREPIPODOPHYLLOTOXIN; ANTINEOPLASTIC AGENT; DAUNORUBICIN; ETOPOSIDE DERIVATIVE; GYRASE INHIBITOR; NOGALAMYCIN; PLANT EXTRACT; PODOPHYLLOTOXIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DNA PROTEIN COMPLEX; DRUG ACTIVITY; DRUG STRUCTURE; MOLECULAR MODEL; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STEREOCHEMISTRY; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; COMPUTER GRAPHICS; DNA; DNA TOPOISOMERASES, TYPE I; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NUCLEIC ACID CONFORMATION; PODOPHYLLOTOXIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0001056916     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9503052     Document Type: Article

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