Synthesis and cytotoxic activity on human cancer cells of carbamate derivatives of 4β-(1,2,3-triazol-1-yl)podophyllotoxin

European Journal of Medicinal Chemistry

Volumn 64, Issue , 2013, Pages 621-628

  Liu, Jian Fei ^a   Sang, Chun Yan ^a   Xu, Xiao Hui ^a   Zhang, Lin Lin ^a   Yang, Xuan ^a   Hui, Lin ^b   Zhang, Jin Bang ^a   Chen, Shi Wu ^a,c  

^a LANZHOU UNIVERSITY   (China)

^b LANZHOU GENERAL HOSPITAL   (China)

^c LANZHOU UNIVERSITY   (China)

Author keywords

Microtubules; Podophyllotoxin; Topoisomerase II; Triazole

Indexed keywords

4 NITROPHENYL PIPERAZINYL N [1 OXYL (4' O DEMETHYL 4BETA [(4 HYDROXY METHYL) 1,2,3 TRIAZOL 1 YL] 4 DESOXYPODOPHYLLIC)]LEVO METHINE AMIDE; 4' O DEMETHYL 4' BENZYLOXYCARBONYL 4BETA [(4 HYDROXY METHYL) 1,2,3 TRIAZOL 1 YL] 4 DESOXYPODOPHYLLOTOXIN; 4' O DEMETHYL 4BETA [(4 HYDROXY METHYL) 1,2,3 TRIAZOL 1 YL] 4 DESOXYPODOPHYLLOTOXIN 1 (4 NITROPHENYL PIPERAZINYL)CARBAMATE; 4' O DEMETHYL 4BETA [(4 HYDROXY METHYL) 1,2,3 TRIAZOL 1 YL] 4 DESOXYPODOPHYLLOTOXIN CYLCOPENTYL CARBAMATE; 4' O DEMETHYL 4BETA [(4 HYDROXY METHYL) 1,2,3 TRIAZOL 1 YL] 4 DESOXYPODOPHYLLOTOXIN MORPHOLINO CARBAMATE; 4' O DEMETHYL 4BETA [(4 HYDROXY METHYL) 1,2,3 TRIAZOL 1 YL] 4 DESOXYPODOPHYLLOTOXIN PROPYL CARBAMATE; 4' O DEMETHYL 4BETA [(4 HYDROXYMETHYL) 1,2,3 TRIAZOL 1 YL] 4 DEOXYPODOPHYLLOTOXIN CYCLOPENTYL CARBAMATE; 40-DEMETHYL 4' BENZYLOXYCARBONYL 4BETA [(4 HYDROXY METHYL) 1,2,3 TRIAZOL 1 YL] 4 DESOXYPODOPHYLLOTOXIN 4 NITROPHENYL CARBONATE; 4BETA (1,2,3 TRIAZOL 1 YL)PODOPHYLLOTOXIN DERIVATIVE; 4BETA [(4 HYDROXY METHYL) 1,2,3 TRIAZOL 1 YL] 4 DESOXYPODOPHYLLOTOXIN; 4BETA [(4 HYDROXY METHYL) 1,2,3 TRIAZOL 1 YL] 4 DESOXYPODOPHYLLOTOXIN 1 (4 CYCLOPENTYL PIPERAZINYL)CARBAMATE; 4BETA [(4 HYDROXY METHYL) 1,2,3 TRIAZOL 1 YL] 4 DESOXYPODOPHYLLOTOXIN 1 (4 FLUOROPHENYL PIPERAZINYL)CARBAMATE; 4BETA [(4 HYDROXY METHYL) 1,2,3 TRIAZOL 1 YL] 4 DESOXYPODOPHYLLOTOXIN 4 NITROPHENYL CARBONATE; 4BETA [(4 HYDROXY METHYL) 1,2,3 TRIAZOL 1 YL] 4 DESOXYPODOPHYLLOTOXIN CYCLOPENTYL CARBAMATE; 4BETA [(4 HYDROXY METHYL) 1,2,3 TRIAZOL 1 YL] 4 DESOXYPODOPHYLLOTOXIN N MORPHOLINO CARBAMATE; 4BETA [(4 HYDROXY METHYL) 1,2,3 TRIAZOL 1 YL] 4 DESOXYPODOPHYLLOTOXIN PROPYL CARBAMATE; ANTINEOPLASTIC AGENT; CARBAMIC ACID DERIVATIVE; ETOPOSIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CLICK CHEMISTRY; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; LUNG CANCER; MICROTUBULE; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARBAMATES; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HL-60 CELLS; HUMANS; MOLECULAR STRUCTURE; PODOPHYLLOTOXIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84878164013     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.03.068     Document Type: Article

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