Inhibition of fructose-6-phosphate,2-kinase by N-bromoacetylethanolamine phosphate in vitro and in vivo

Journal of Biochemistry

Volumn 121, Issue 4, 1997, Pages 724-730

  Harada, Yuhki ^a   Tominaga, Nobuaki ^a   Watanabe, Mitsuaki ^a   Shimokawa, Ryoko ^a   Ishiguro, Masatsune ^a   Sakakibara, Ryuzo ^a,b  

^a NAGASAKI UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Bifunctional enzyme; Fructose 2,6 bisphosphatase; Fructose 6 phosphate,2 kinase; Glycolysis; Inhibitor

Indexed keywords

6 PHOSPHOFRUCTO 2 KINASE; ENZYME INHIBITOR; ETHANOLAMINE DERIVATIVE; FRUCTOSE 1,6 BISPHOSPHATE; FRUCTOSE 2,6 BISPHOSPHATASE; GLUCOSE; LACTIC ACID; LIVER ENZYME; TRIOSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; GLYCOLYSIS; LIVER METABOLISM; NONHUMAN; RAT; WEIGHT GAIN;

ANIMALIA; MAMMALIA;

EID: 0030893045     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a021646     Document Type: Article

References (37)

1. Uyeda, K., Furuya, E., and Luby, L.J. (1981) The effect of natural and synthetic p-fructose 2,6-bisphosphate on the reguIntory kinetic properties of liver and muscle phophofructokinases. J. Biol. Chem. 256, 8394-8399
2. Van Schaftingen, E., Jett. M.F., Hue, L. and Hers, H.G. (1981) Control of liver (liver 6-phosphofructokinase by fructose 2,6-bisphosphate and other effectors, Proc. Natl. Acad. Sci. USA 78, 3483-3486
3. Pilkis, S.J., El-Maghrabi, M.R., Pilkis, J., Claus, T.H., and Cumming, D.A. (1981) Fructose 2,6-bisphosphate la new activator of phosphofructokinase). J. Biol. Chem. 256, 3171-3174
4. Van Schaftingen, E. and Hers, H.G. (1981) Inhibition of fructose-1.6-bisphosphatase by fructose 2,6-bisphosphate. Proc Natl. Acad. Sci. USA 78, 2861-2863
5. Pilkis, S.J., El-Maghrabi, M.R., Pilkis, J., and Claus. T.H. (1981) Inhibition of fructose-1,6-bisphosphatase by fructose- 2,6-bisphosphate J. Biol. Chem. 256, 3619-3622
6. Van Schaftingen, E., Davies, D.R., and Hers, H.G. (1982) Fructose 2,6-bisphophatase from rat liver. Eur. J. Biochem. 124, 143-149
7. El-Maghrabi, M.R., Claus, T.H., Pilkis, J., Fox, E., and Pilkis. S.J. (1982) Regulation of Rat liver fructose 2,6-bisphosphatase. J. Biol. Chem. 257, 7603-7607
8. Sakakibara, R., Kitajima, S., and Uyeda, K. (1984) Differences in kinetic properties of phospho and duphuspho forms of fructose6-phosphate,2-kinase and fructose-2,6-bisphosphatase. J. Biol. Chem. 259, 41-46
9. Colosia, A.D., Lively, M., El-Maghrabi, M.R., and Pilkis, S.J. (1987) Isolation of a cDNA clone for rat liver 6-phosphofructo-2-kinase fructose 2,6-bisphosphatase, Biochem. Biophys. Res. Commun. 143, 1092-1098
10. Van Schaftingen, E. and Hers, H.G.(1986) Purification and properties of phosphofructokinase 2 fructose 2,6-bisphosphatase from chicken liver and from pigeon muscle. Eur. J. Biochem. 159, 359-365
11. Kitamura, K., Uyeda, K., Kangawa, K., and Matsuo, H. (1989) Purification and characterization of rat muscle fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase. J. Biol. Chem. 264, 9799-9800
12. Sakata, J. and Uyeda, K. (1990) Bovine heart fructose-6-phosphate,2-kinase fructose-2,6-bisphosphatase: Complete amino acid sequence and localization of phosphorylation sites. Proc. Natl, Avad. Sci. USA 87, 4951-4955
13. Sakata, J., Abe, Y., and Uyeda, K. (1991) Molecular cloning of the DNA and expression and characterization of rat test is fructose-6-phosphate ,2-kinase: fructose-2,6-bisphosphatase. J. Biol. Chem. 266, 15764-15770
14. Sakai, A., Kato, M., Fukasawa, M., Ishiguro. M., Furuya, E., and Sakakibara, R. (1996) Cloning of cDNA encoding for a novel isozyme of fructose 6-phoaphate,2-kinase 'fructose, 2,6-bisphosphatase. from human placenta. J. Biochem. 119, 506-511
15. Uyeda, K., Furuya, E., Richards, C.S., and Yokoyama, M. (1982) Fructose 2.6-P2. chemistry und biological function. Mol. Cell. Biochem. 18, 97-120
16. Pilkis, S. J. Christman , T., Burgress, B., Megrane, M., Colosia, M.M., Pilkis, J., Claus, T.H., and El-Maghrabi, M.R, (1985) Rat hepatic 6-phosphofructo-2-kinase fructose 2,6-bisphosphatase: a unique bifunctional enzyme. Adv. Enzyme Regul. 21, 147-17
17. Van Schaltingen, R. (1987) Frutose-2,6-bisphosphate in Adcances in Enzymology and Related Areas of Molecular Biology (Mcistor, A., ed.) Vol. 59, pp. 315-395, John Wiloy & Sons, New York
18. Nishimura, M., Fedorov, S., and Uyeda, K. (1991) Glucosistimulated synthesis of fructose 2,6-bisphosphate in rat liver: Dephoxphorylation of fructose 6-phosphate,2-kinase:fructose 2,6-bisphosphataso and activation by a sugar phosphate. J. Biol. Chem. 269, 26100-25106
19. Nishimura, M. and Uyeda, K. (1995) Purification and characterization of a novel xylulose 5-phosphate-activated protein phosphiitusc catalyzing dephosphorylation of fructose-6-phosphate. 2-kinase:fructose-2,6-bisphospnatase. J. Biol. Chem. 270, 26341-26346
20. Hartman, K.C., Suh. B., Welch, M.H., and Harkor, R. (1973) Inactivition of class I fructose diphosphnte aldolase by the substrate analog N-bromoacctylcthanolamine phosphate. J. Biol. Chem. 248, 8233-8259
21. Sakukibari, R., Kitajima, S., Hartman. F.C., and Uyedii. K. (1984) Herxose phosphate binding sites of fructose-6-phosphate. 2-kinas: fructose-2,6-bisphosphatase Interaction with N-biximoacetylethalamoine phosplate and 3-bromo-1. 4-dihydroxy-2-butanone 1,4-bisphosphate. J. Biol. Chem. 259, 14023-14028
22. Kitamura, K., Uyeda, K., Hartman, F.C., Kungawa, K., and Matsuo, H. (1989) Catalytic site of rat liver and bovine heart fructose-6-phosphiite,2-kinase: fructose-2,6-bisphosphatase: Identification of fructose, 6-phosphate binding site. J. Biol. Chem. 264, 6344-6348
23. Uyeda, K., Miyatake, A., Luby, L.J.. and Richards. EG. (1978) Isolation and characterization of muscle phospluifructokinase with varying degrees of phosphorylation. J. Biol. Chem. 253, 8319-81527
24. Tuminga, N., Minami, Y., Sakakibara, K., and Uyeda. K (1993) Significance of the amino terminus of rat testis fructose-6- phosphate, 2-kinase:fructose-2,6-bisphosphatase. J. Biol. Chem 288, 15951-15957
25. Rajkumur, T.V., Woodfin, B.M., and Rutter, W.J. (1981) Aldolasc B from (Adult) rabbit liver, in Methods in Enzymolo (Wood, W.A., ed.) Vol. 9, pp. 491-498, Academic Press, New York and Lpondon
26. Michal, G. (1984) in Methods of Enzymatic Analysis, Third ed. (Bursmeyer, H.U., ed.) Vol. 6, pp. 191-198, Academic Press, New York and London
27. Michal, G. (1984) in Methods of Emymatic Analysis, Third ed, (Bersmeyer, H.U., ed.) Vol. 6, pp. 342-350, Academic Press, New York and London
28. Noll, F. (1984) in Methods of Emymatic Analysis, Third ed. (Bergmeyer, H.U., ed.) Vol. 6, pp. 582-588, Academic Press, Now York and London
29. Bradford, M.M. (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254
30. Hue, L. and Kider, M.H. (1987) Koto of fructose 2,6-bisphos- phato in the control of glycolysis in mammalian tissues. Biochem.. J. 245, 313-324
31. Pilkis, S.J., El-Maghrabi, M.R., and Claus, T.H. (1988) Hor- monal regulation of hepatic glucogenesis and glycolysis. Annu. Rev. Biochem. 57, 755-783
32. Uyeda, K. (1991) Phosphofructokinase and fructose 6-phos- phate,2-kinase:fructose 2.6-bisphosphatase in CRC Review (Kuby, S.A., ed.) Vol. II. pp, 445-450. CRC Press, Boston
33. Richard, C.S., Furuya, E., und Ueyda. K. (1981) Regulation of fructose 2,6-P in isolated hepatocytes. Biochim. Biophys. Res. Commun. 100, 1673-1679
34. Furuya, E., Yokoyarna, M., and Uyeda, K. (1982) Regulation of fructose-o-phosphate 2-kinase by phosphurylation and dephos- phorylation: Possible mechanism for cixirdinated control of glycolysis and glycogensis. Proc Natl. Acad J. Sci. USA 79, 325-329
35. Hems, D.A., Math, K.A., and Verrindor. T.R. (1975) Fatty acid synthesis in liver and adiposo tissue of normul and genetically obese (ob obi mice during the 24-hour cycle. Biochem, J. 150, 167-173
36. Jennrcnaud, B., Froychet, P., Assmncopnolos-Jeannet, F., Le Marchand, Y., and Karakash, C. (1997) Regulation of liver lipid nietabolism in experimental obesity. Biochem. Soc. Trans. 5, 890-894
37. Hue, I., and van de Werve, G. (1982) Increased concentration of fructose 2,6-bisphospte in livers of genetically obese mice. FEBS Lett. 145, 263-266