Glucose-6-phosphate dehydrogenase, NADPH, and cell survival

IUBMB Life

Volumn 64, Issue 5, 2012, Pages 362-369

  Stanton, Robert C ^a,b,c  

^a JOSLIN DIABETES CENTER   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Antioxidants; Nitric oxide; Oxidative stress; Reactive oxygen species; Signaling

Indexed keywords

ALDOSTERONE; ANTIOXIDANT; CATALASE; CYTOCHROME P450; CYTOCHROME P450 REDUCTASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

CELL SURVIVAL; CELLULAR DISTRIBUTION; DIABETES MELLITUS; ENDOTHELIAL DYSFUNCTION; GENETIC TRANSCRIPTION; GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY; HEMOLYSIS; HUMAN; LIPID METABOLISM; NEOPLASM; NONHUMAN; PATHOPHYSIOLOGY; PENTOSE PHOSPHATE CYCLE; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; TRANSLATION REGULATION;

ANIMALS; CELL SURVIVAL; DIABETES MELLITUS; ENZYME ACTIVATION; GLUCOSEPHOSPHATE DEHYDROGENASE; HUMANS; NADP; PENTOSE PHOSPHATE PATHWAY;

EID: 84859787172     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.1017     Document Type: Review

References (57)

1. Kornberg, A. and Horecker, B. L. (1956) Glucose-6-phosphate dehydrogenase. Methods Enzymol. 1, 323-327.
2. Horton, J. D. (2002) Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis. Biochem. Soc. Trans. 30, 1091-1095.
3. Nkhoma, E. T., Poole, C., Vannappagari, V., Hall, S. A., and Beutler, E. (2009) The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis. Blood Cells Mol. Dis. 42, 267-278.
4. Minucci, A., Giardina, B., Zuppi, C., and Capoluongo, E. (2009) Glucose-6-phosphate dehydrogenase laboratory assay: how, when, and why? IUBMB Life 61, 27-34.
5. Au, S. W., Gover, S., Lam, V. M., and Adams, M. J. (2000) Human glucose-6-phosphate dehydrogenase: the crystal structure reveals a structural NADP(+) molecule and provides insights into enzyme deficiency. Structure 8, 293-303. (Pubitemid 30148695)
6. Kletzien, R. F., Harris, P. K., and Foellmi, L. A. (1994) Glucose-6-phosphate dehydrogenase: a "housekeeping" enzyme subject to tissue-specific regulation by hormones, nutrients, and oxidant stress. FASEB J. 8, 174-181.
7. Wood, T. (1986) Physiological functions of the pentose phosphate pathway. Cell Biochem. Funct. 4, 241-247.
8. Ho, H. Y., Cheng, M. L., and Chiu, D. T. (2005) G6PD - an old bottle with new wine. Chang Gung Med. J. 28, 606-612.
9. Holten, D., Procsal, D., and Chang, H. L. (1976) Regulation of pentose phosphate pathway dehydrogenases by NADP1/NADPH ratios. Biochem. Biophys. Res. Commun. 68, 436-441.
10. Shapiro, B. M. (1991) The control of oxidant stress at fertilization. Science 252, 533-536.
11. Swezey, R. R. and Epel, D. (1988) Enzyme stimulation upon fertilization is revealed in electrically permeabilized sea urchin eggs. Proc. Natl. Acad. Sci. USA 85, 812-816.
12. Cosentino, C., Grieco, D., and Costanzo, V. (2011) ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair. EMBO J. 30, 546-555.
13. Jiang, P., Du, W., Wang, X., Mancuso, A., Gao, X., et al. (2011) p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat. Cell Biol. 13, 310-316.
14. Stanton, R. C., Seifter, J. L., Boxer, D. C., Zimmerman, E., and Cantley, L. C. (1991) Rapid release of bound glucose-6-phosphate dehydrogenase by growth factors. Correlation with increased enzymatic activity. J. Biol. Chem. 266, 12442-12448. (Pubitemid 21907114)
15. Tian, W. N., Pignatare, J. N., and Stanton, R. C. (1994) Signal transduction proteins that associate with the platelet-derived growth factor (PDGF) receptor mediate the PDGF-induced release of glucose-6-phosphate dehydrogenase from permeabilized cells. J. Biol. Chem. 269, 14798-14805. (Pubitemid 24194048)
16. Pan, S., World, C. J., Kovacs, C. J., and Berk, B. C. (2009) Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells. Arterioscler. Thromb. Vasc. Biol. 29, 895-901.
17. Bao, B. Y., Ting, H. J., Hsu, J. W., and Lee, Y. F. (2008) Protective role of 1 alpha, 25-dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells. Int. J. Cancer 122, 2699-2706.
18. Duvel, K., Yecies, J. L., Menon, S., Raman, P., Lipovsky, A. I., et al. (2010) Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol. Cell 39, 171-183.
19. Wagle, A., Jivraj, S., Garlock, G. L., and Stapleton, S. R. (1998) Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires phosphatidylinositol 3-kinase. J. Biol. Chem. 273, 14968-14974. (Pubitemid 28272789)
20. Zhang, H. S. and Wang, S. Q. (2007) Nrf2 is involved in the effect of tanshinone IIA on intracellular redox status in human aortic smooth muscle cells. Biochem. Pharmacol. 73, 1358-1366.
21. Bensaad, K., Tsuruta, A., Selak, M. A., Vidal, M. N., Nakano, K., et al. (2006) TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 126, 107-120. (Pubitemid 44040989)
22. 2metabolism. Evidence for cyclic AMP-dependent protein kinase mediated inhibition of glucose-6-phosphate dehydrogenase and activation of NADP+-dependent 'malic' enzyme. Biochem. J. 310(Part 2), 709-714.
23. Xu, Y., Osborne, B. W., and Stanton, R. C. (2005) Diabetes causes inhibition of glucose-6-phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex. Am. J. Physiol. Renal. Physiol. 289, F1040-F1047. (Pubitemid 41447059)
24. Zhang, Z., Apse, K., Pang, J., and Stanton, R. C. (2000) High glucose inhibits glucose-6-phosphate dehydrogenase via cAMP in aortic endothelial cells. J. Biol. Chem. 275, 40042-40047. (Pubitemid 32064628)
25. Leopold, J. A., Dam, A., Maron, B. A., Scribner, A. W., Liao, R., et al. (2007) Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nat. Med. 13, 189-197.
26. Talukdar, I., Szeszel-Fedorowicz, W., and Salati, L. M. (2005) Arachidonic acid inhibits the insulin induction of glucose-6-phosphate dehydrogenase via p38 MAP kinase. J. Biol. Chem. 280, 40660-40667. (Pubitemid 41780557)
27. Boros, L. G., Brandes, J. L., Yusuf, F. I., Cascante, M., Williams, R. D., et al. (1998) Inhibition of the oxidative and nonoxidative pentose phosphate pathways by somatostatin: a possible mechanism of antitumor action. Med. Hypotheses 50, 501-506. (Pubitemid 28307913)
28. Frederiks, W. M., Bosch, K. S., Hoeben, K. A., van Marle, J., and Langbein, S. (2010) Renal cell carcinoma and oxidative stress: the lack of peroxisomes. Acta Histochem. 112, 364-371.
29. Frederiks, W. M., Vizan, P., Bosch, K. S., Vreeling-Sindelarova, H., Boren, J., et al. (2008) Elevated activity of the oxidative and non-oxidative pentose phosphate pathway in (pre)neoplastic lesions in rat liver. Int. J. Exp. Pathol. 89, 232-240. (Pubitemid 352019178)
30. Tian, W. N., Braunstein, L. D., Pang, J., Stuhlmeier, K. M., Xi, Q. C., et al. (1998) Importance of glucose-6-phosphate dehydrogenase activity for cell growth. J. Biol. Chem. 273, 10609-10617. (Pubitemid 28227673)
31. Tian, W. N., Braunstein, L. D., Apse, K., Pang, J., Rose, M., et al. (1999) Importance of glucose-6-phosphate dehydrogenase activity in cell death. Am. J. Physiol. 276, C1121-C1131. (Pubitemid 29244667)
32. Pandolfi, P. P., Sonati, F., Rivi, R., Mason, P., Grosveld, F., et al. (1995) Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress. EMBO J. 14, 5209-5215.
33. Longo, L., Vanegas, O. C., Patel, M., Rosti, V., Li, H., et al. (2002) Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethal. EMBO J. 21, 4229-4239.
34. Kuo, W., Lin, J., and Tang, T. K. (2000) Human glucose-6-phosphate dehydrogenase (G6PD) gene transforms NIH 3T3 cells and induces tumors in nude mice. Int. J. Cancer 85, 857-864. (Pubitemid 30131478)
35. Ho, H. Y., Cheng, M. L., Lu, F. J., Chou, Y. H., Stern, A., et al. (2000) Enhanced oxidative stress and accelerated cellular senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts. Free Radic. Biol. Med. 29, 156-169.
36. Zhang, Z., Liew, C. W., Handy, D. E., Zhang, Y., Leopold, J. A., et al. (2010) High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis. FASEB J. 24, 1497-1505.
37. Leopold, J. A., Walker, J., Scribner, A. W., Voetsch, B., Zhang, Y. Y., et al. (2003) Glucose-6-phosphate dehydrogenase modulates vascular endothelial growth factor-mediated angiogenesis. J. Biol. Chem. 278, 32100-32106. (Pubitemid 37048399)
38. Leopold, J. A., Zhang, Y. Y., Scribner, A. W., Stanton, R. C., and Loscalzo, J. (2003) Glucose-6-phosphate dehydrogenase overexpression decreases endothelial cell oxidant stress and increases bioavailable nitric oxide. Arterioscler. Thromb. Vasc. Biol. 23, 411-417. (Pubitemid 36337216)
39. Guzik, T. J. and Griendling, K. K. (2009) NADPH oxidases: molecular understanding finally reaching the clinical level? Antioxid Redox Signal 11, 2365-2370.
40. Forman, H. J. and Torres, M. (2002) Reactive oxygen species and cell signaling: respiratory burst in macrophage signaling. Am. J. Respir. Crit. Care Med. 166, S4-S8. (Pubitemid 36015930)
41. Iyanagi, T. (2007) Molecular mechanism of phase I and phase II drug-metabolizing enzymes: implications for detoxification. Int. Rev. Cytol. 260, 35-112.
42. Hui, L., Hong, Y., Jingjing, Z., Yuan, H., Qi, C., et al. (2010) HGF suppresses high glucose-mediated oxidative stress in mesangial cells by activation of PKG and inhibition of PKA. Free Radic. Biol. Med. 49, 467-473.
43. Ramudu, S. K., Korivi, M., Kesireddy, N., Lee, L. C., Cheng, I. S., et al. (2011) Nephro-protective effects of a ginger extract on cytosolic and mitochondrial enzymes against streptozotocin (STZ)-induced diabetic complications in rats. Chin. J. Physiol. 54, 79-86.
44. Sanders, S., Smith, D. P., Thomas, G. A., and Williams, E. D. (1997) A glucose-6-phosphate dehydrogenase (G6PD) splice site consensus sequence mutation associated with G6PD enzyme deficiency. Mutat. Res. 374, 79-87. (Pubitemid 27093139)
45. Xu, Y., Zhang, Z., Hu, J., Stillman, I. E., Leopold, J. A., et al. (2010) Glucose-6-phosphate dehydrogenase-deficient mice have increased renal oxidative stress and increased albuminuria. FASEB J. 24, 609-616.
46. Perner, A., Nielsen, S. E., and Rask-Madsen, J. (2003) High glucose impairs superoxide production from isolated blood neutrophils. Intensive Care Med. 29, 642-645. (Pubitemid 36523682)
47. Diaz-Flores, M., Ibanez-Hernandez, M. A., Galvan, R. E., Gutierrez, M., Duran-Reyes, G., et al. (2006) Glucose-6-phosphate dehydrogenase activity and NADPH/NADP+ ratio in liver and pancreas are dependent on the severity of hyperglycemia in rat. Life Sci. 78, 2601-2607.
48. Katare, R., Caporali, A., Emanueli, C., and Madeddu, P. (2010) Benfotiamine improves functional recovery of the infarcted heart via activation of pro-survival G6PD/Akt signaling pathway and modulation of neurohormonal response. J. Mol. Cell Cardiol. 49, 625-638.
49. Rees, D. A. and Alcolado, J. C. (2005) Animal models of diabetes mellitus. Diabet. Med. 22, 359-370. (Pubitemid 40516231)
50. Serpillon, S., Floyd, B. C., Gupte, R. S., George, S., Kozicky, M., et al. (2009) Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH. Am. J. Physiol. Heart Circ. Physiol. 297, H153-H162.
51. Gupte, R. S., Floyd, B. C., Kozicky, M., George, S., Ungvari, Z. I., et al. (2009) Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver. Free Radic. Biol. Med. 47, 219-228.
52. Lee, J. W., Choi, A. H., Ham, M., Kim, J. W., Choe, S. S., et al. (2011) G6PD up-regulation promotes pancreatic beta-cell dysfunction. Endocrinology 152, 793-803.
53. Rajasekaran, N. S., Connell, P., Christians, E. S., Yan, L. J., Taylor, R. P., et al. (2007) Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice. Cell 130, 427-439. (Pubitemid 47208522)
54. Niazi, G. A. (1991) Glucose-6-phosphate dehydrogenase deficiency and diabetes mellitus. Int. J. Hematol. 54, 295-298.
55. Saeed, T. K., Hamamy, H. A., and Alwan, A. A. (1985) Association of glucose-6-phosphate dehydrogenase deficiency with diabetes mellitus. Diabet. Med. 2, 110-112. (Pubitemid 15109135)
56. Cappai, G., Songini, M., Doria, A., Cavallerano, J. D., and Lorenzi, M. (2011) Increased prevalence of proliferative retinopathy in patients with type 1 diabetes who are deficient in glucose-6-phosphate dehydrogenase. Diabetologia 54, 1539-1542.
57. Gaskin, R. S., Estwick, D., and Peddi, R. (2001) G6PD deficiency: its role in the high prevalence of hypertension and diabetes mellitus. Ethn. Dis. 11, 749-754.