Improved intratumoral nanoparticle extravasation and penetration by mild hyperthermia

Journal of Controlled Release

Volumn 167, Issue 2, 2013, Pages 130-137

  Li, Li ^a   Ten Hagen, Timo L M ^a   Bolkestein, Michiel ^a   Gasselhuber, Astrid ^b   Yatvin, Jeremy ^b   Van Rhoon, Gerard C ^a   Eggermont, Alexander M M ^a,c   Haemmerich, Dieter ^b   Koning, Gerben A ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

Hyperpermeable tumorvasculature; Intravital confocal microscopy; Liposome extravasation; Mild hyperthermia; Nanoparticle drug delivery; Whole body optical imaging

Indexed keywords

DRUG DELIVERY SYSTEM; HYPERPERMEABLE TUMORVASCULATURE; INTERSTITIAL FLUID FLOW; INTRATUMORAL DRUG DELIVERIES; LIPOSOME EXTRAVASATION; MILD HYPERTHERMIA; OPTICAL IMAGING; VASCULAR PERMEABILITY;

C (PROGRAMMING LANGUAGE); CONFOCAL MICROSCOPY; DRUG DELIVERY; LIPOSOMES; NANOPARTICLES; OPTICAL IMAGE STORAGE;

TUMORS;

LIPOSOME; NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EXTRAVASATION; DRUG PENETRATION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HYPERTHERMIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN FLAP; TUMOR VASCULARIZATION;

ANIMALS; CAPILLARY PERMEABILITY; CARCINOMA, LEWIS LUNG; CELL LINE, TUMOR; HUMANS; HYPERTHERMIA, INDUCED; LIPIDS; LIPOSOMES; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICE, NUDE; NANOPARTICLES; SKIN NEOPLASMS;

EID: 84874397479     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.01.026     Document Type: Article

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