Bioreversibly crosslinked polyplexes of PEI and high molecular weight PEG show extended circulation times in vivo

Journal of Controlled Release

Volumn 124, Issue 1-2, 2007, Pages 69-80

  Neu, Michael ^a   Germershaus, Oliver ^a   Behe, Martin ^a   Kissel, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Crosslinking; Gene delivery; Pharmacokinetics; Poly(ethylene glycol); Poly(ethylene imine)

Indexed keywords

GENE DELIVERY; HEMOLYTIC ACTIVITY; PLASMIDS; POLYPLEXES;

CROSSLINKING; CYTOTOXICITY; DNA; MOLECULAR WEIGHT; PHARMACOKINETICS; POLYETHYLENE GLYCOLS;

COPOLYMERS;

COPOLYMER; DNA; MACROGOL; POLYETHYLENEIMINE; POLYMIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOCOMPATIBILITY; BIODEGRADABILITY; CELL STRAIN L 929; COMPLEX FORMATION; CONTROLLED STUDY; CROSS LINKING; DRUG CYTOTOXICITY; DRUG SYNTHESIS; GENE TARGETING; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PLASMID; PRIORITY JOURNAL; SURFACE PROPERTY;

BIOCOMPATIBLE MATERIALS; CELL LINE, TUMOR; CELL SURVIVAL; CROSS-LINKING REAGENTS; DNA; ELECTROPHORESIS, AGAR GEL; FLOW CYTOMETRY; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; HUMANS; LUCIFERASES; MICROSCOPY, CONFOCAL; MOLECULAR WEIGHT; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; TIME FACTORS; TRANSFECTION;

EID: 36049034316     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2007.08.009     Document Type: Article

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