Metabolic analyses elucidate non-trivial gene targets for amplifying dihydroartemisinic acid production in yeast

Frontiers in Microbiology

Volumn 4, Issue JUL, 2013, Pages

  Misra, Ashish ^a,d   Conway, Matthew F ^a,e   Johnnie, Joseph ^b   Qureshi, Tabish M ^a   Lige, Bao ^c   Derrick, Anne M ^c   Agbo, Eddy C ^c   Sriram, Ganesh ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c Fyodor Biotechnologies   (United States)

^d INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^e Department of Chemical Engineering Columbia University ^*  (United States)

Author keywords

Artemisinin; Extreme pathway; Flux balance analysis; Isotope labeling; Metabolic engineering; Metabolic flux analysis; Metabolic pathway; Minimization of metabolic adjustment

Indexed keywords

ARTEMISININ; ASPARTATE AMINOTRANSFERASE; DIHYDROARTEMISINIC ACID; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; MALATE DEHYDROGENASE (NADP); NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BIOMASS PRODUCTION; CELL CULTURE; ENZYME ACTIVITY; GENE AMPLIFICATION; GENE INACTIVATION; GENETIC ANALYSIS; METABOLIC ENGINEERING; METABOLIC REGULATION; MICROBIAL COMMUNITY; MICROBIAL METABOLISM; MOLECULAR BIOLOGY; NONHUMAN; PENTOSE PHOSPHATE CYCLE; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; SYNTHETIC BIOLOGY; YEAST;

EID: 84885352221     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2013.00200     Document Type: Article

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