An integrated computational and experimental study for overproducing fatty acids in Escherichia coli

Metabolic Engineering

Volumn 14, Issue 6, 2012, Pages 687-704

  Ranganathan, Sridhar ^a   Tee, Ting Wei ^b   Chowdhury, Anupam ^c   Zomorrodi, Ali R ^c   Yoon, Jong Moon ^b   Fu, Yanfen ^b   Shanks, Jacqueline V ^b   Maranas, Costas D ^c  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b Iowa State University of Science and Technology   (United States)

^c The Pennsylvania State University   (United States)

Author keywords

Computational strain design; Fatty acids overproduction; Metabolic flux analysis

Indexed keywords

ACYL-ACP; BIO-PRODUCTION; BIOSYNTHETIC PATHWAY; CATALYTIC PRODUCTION; E. COLI; EXPERIMENTAL STUDIES; FATTY ACID CHAINS; FLUX ANALYSIS; FREE FATTY ACID; GENETIC MANIPULATIONS; HIGHER YIELD; METABOLIC FLUX ANALYSIS; METABOLIC PATHWAYS; MICROBIAL PRODUCTION; PRIORITIZATION; RECOMBINANT STRAINS; THEORETICAL YIELD; THIOESTERASES; WILD TYPES;

AMINO ACIDS; BIOFUELS; CHAIN LENGTH; DESIGN; ESCHERICHIA COLI; GENETIC ENGINEERING; GLUCOSE; ITERATIVE METHODS; METABOLIC ENGINEERING; METABOLISM;

FATTY ACIDS;

DECANOIC ACID; FATTY ACID; HEXANOIC ACID; OCTANOIC ACID;

ACYL CARRIER PROTEIN THIOESTERASE GENE; ARTICLE; BACTERIAL GENE; ESCHERICHIA COLI; EXPERIMENTAL STUDY; FABZ GENE; FADD GENE; FATTY ACID SYNTHESIS; GENE DELETION; GENETIC MANIPULATION; LIPID COMPOSITION; METABOLIC ENGINEERING; NONHUMAN; PRIORITY JOURNAL; UPREGULATION;

COMPUTER SIMULATION; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FATTY ACIDS; GENETIC ENHANCEMENT; METABOLOME; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; SYSTEMS INTEGRATION; UP-REGULATION;

ESCHERICHIA COLI;

EID: 84869027982     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2012.08.008     Document Type: Article

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