-
1
-
-
0036168150
-
Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis
-
Adkison AM, Raptis SZ, Kelley DG, Pham CT. 2002. Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis. J Clin Invest 109: 363-371.
-
(2002)
J Clin Invest
, vol.109
, pp. 363-371
-
-
Adkison, A.M.1
Raptis, S.Z.2
Kelley, D.G.3
Pham, C.T.4
-
2
-
-
84858011122
-
Delineating protease functions during cancer development
-
Affara NI, Andreu P, Coussens LM. 2009. Delineating protease functions during cancer development. Methods Mol Biol 539: 1-32.
-
(2009)
Methods Mol Biol
, vol.539
, pp. 1-32
-
-
Affara, N.I.1
Andreu, P.2
Coussens, L.M.3
-
3
-
-
76349088502
-
FcRg activation regulates inflammation-associated squamous carcinogenesis
-
Andreu P, Johansson M, Affara NI, Pucci F, Tan T, Junankar S, Korets L, Lam J, Tawfik D, DeNardo DG, et al. 2010. FcRg activation regulates inflammation-associated squamous carcinogenesis. Cancer Cell 17: 121-134.
-
(2010)
Cancer Cell
, vol.17
, pp. 121-134
-
-
Andreu, P.1
Johansson, M.2
Affara, N.I.3
Pucci, F.4
Tan, T.5
Junankar, S.6
Korets, L.7
Lam, J.8
Tawfik, D.9
Denardo, D.G.10
-
4
-
-
17644394616
-
Smoldering and polarized inflammation in the initiation and promotion of malignant disease
-
Balkwill F, Charles KA, Mantovani A. 2005. Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 7: 211-217.
-
(2005)
Cancer Cell
, vol.7
, pp. 211-217
-
-
Balkwill, F.1
Charles, K.A.2
Mantovani, A.3
-
5
-
-
84858150882
-
Protective role of cathepsin L in mouse skin carcinogenesis
-
Benavides F, Perez C, Blando J, Contreras O, Shen J, Coussens LM, Fischer SM, Kusewitt DF, Digiovanni J, Conti CJ. 2012. Protective role of cathepsin L in mouse skin carcinogenesis. Mol Carcinog 51: 352-361.
-
(2012)
Mol Carcinog
, vol.51
, pp. 352-361
-
-
Benavides, F.1
Perez, C.2
Blando, J.3
Contreras, O.4
Shen, J.5
Coussens, L.M.6
Fischer, S.M.7
Kusewitt, D.F.8
Digiovanni, J.9
Conti, C.J.10
-
6
-
-
36949011597
-
Loss of cathepsin L activity promotes claudin-1 overexpression and intestinal neoplasia
-
Boudreau F, Lussier CR, Mongrain S, Darsigny M, Drouin JL, Doyon G, Suh ER, Beaulieu JF, Rivard N, Perreault N. 2007. Loss of cathepsin L activity promotes claudin-1 overexpression and intestinal neoplasia. FASEB J 21: 3853-3865.
-
(2007)
FASEB J
, vol.21
, pp. 3853-3865
-
-
Boudreau, F.1
Lussier, C.R.2
Mongrain, S.3
Darsigny, M.4
Drouin, J.L.5
Doyon, G.6
Suh, E.R.7
Beaulieu, J.F.8
Rivard, N.9
Perreault, N.10
-
7
-
-
84872086179
-
Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth
-
Bruchard M, Mignot G, Derangere V, Chalmin F, Chevriaux A, Vegran F, Boireau W, Simon B, Ryffel B, Connat JL, et al. 2013. Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth. Nat Med 19: 57-64.
-
(2013)
Nat Med
, vol.19
, pp. 57-64
-
-
Bruchard, M.1
Mignot, G.2
Derangere, V.3
Chalmin, F.4
Chevriaux, A.5
Vegran, F.6
Boireau, W.7
Simon, B.8
Ryffel, B.9
Connat, J.L.10
-
8
-
-
0026575258
-
Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissues
-
Buck MR, Karustis DG, Day NA, Honn KV, Sloane BF. 1992. Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissues. Biochem J 282: 273-278.
-
(1992)
Biochem J
, vol.282
, pp. 273-278
-
-
Buck, M.R.1
Karustis, D.G.2
Day, N.A.3
Honn, K.V.4
Sloane, B.F.5
-
9
-
-
0037102412
-
Promotion of tumor growth by murine fibroblast activation protein, a serine protease, in an animal model
-
Cheng JD, Dunbrack RL, Valianou M, Rogatko A, Alpaugh RK, Weiner LM. 2002. Promotion of tumor growth by murine fibroblast activation protein, a serine protease, in an animal model. Cancer Res 62: 4767-4772.
-
(2002)
Cancer Res
, vol.62
, pp. 4767-4772
-
-
Cheng, J.D.1
Dunbrack, R.L.2
Valianou, M.3
Rogatko, A.4
Alpaugh, R.K.5
Weiner, L.M.6
-
10
-
-
0029844435
-
Genetic predisposition and parameters of malignant progression in K14- HPV16 transgenic mice
-
Coussens LM, Hanahan D, Arbeit JM. 1996. Genetic predisposition and parameters of malignant progression in K14- HPV16 transgenic mice. Am J Pathol 149: 1899-1917.
-
(1996)
Am J Pathol
, vol.149
, pp. 1899-1917
-
-
Coussens, L.M.1
Hanahan, D.2
Arbeit, J.M.3
-
11
-
-
0033151608
-
Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis
-
Coussens LM, Raymond WW, Bergers G, Laig-Webster M Behrendtsen O, Werb Z, Caughey GH, Hanahan D. 1999. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev 13: 13821397.
-
(1999)
Genes Dev
, vol.13
, pp. 13821397
-
-
Coussens, L.M.1
Raymond, W.W.2
Bergers, G.3
Laig-Webster, M.4
Behrendtsen, O.5
Werb, Z.6
Caughey, G.H.7
Hanahan, D.8
-
12
-
-
0037192458
-
Matrix metalloproteinase inhibitors and cancer: Trials and tribulations
-
Coussens LM, Fingleton B, Matrisian LM. 2002. Matrix metalloproteinase inhibitors and cancer: Trials and tribulations. Science 295: 2387-2392.
-
(2002)
Science
, vol.295
, pp. 2387-2392
-
-
Coussens, L.M.1
Fingleton, B.2
Matrisian, L.M.3
-
13
-
-
0035852855
-
Human recombinant pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processing
-
Dahl SW, Halkier T, Lauritzen C, Dolenc I, Pedersen J, Turk V, Turk B. 2001. Human recombinant pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processing. Biochemistry 40: 1671-1678.
-
(2001)
Biochemistry
, vol.40
, pp. 1671-1678
-
-
Dahl, S.W.1
Halkier, T.2
Lauritzen, C.3
Dolenc, I.4
Pedersen, J.5
Turk, V.6
Turk, B.7
-
16
-
-
84866784798
-
Leukocyte complexity in breast cancer predicts overall survival and functionally regulates response to chemotherapy
-
DeNardo DG, Brennan D, Rexhapaj E, Ruffell B, Shiao S, Gallagher WM, Wadhani N, Kial SD, Junaid SA, Rugo HS, et al. 2011. Leukocyte complexity in breast cancer predicts overall survival and functionally regulates response to chemotherapy. Cancer Discov 1: 54-67.
-
(2011)
Cancer Discov
, vol.1
, pp. 54-67
-
-
Denardo, D.G.1
Brennan, D.2
Rexhapaj, E.3
Ruffell, B.4
Shiao, S.5
Gallagher, W.M.6
Wadhani, N.7
Kial, S.D.8
Junaid, S.A.9
Rugo, H.S.10
-
17
-
-
77949656494
-
Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis
-
Dennemarker J, Lohmuller T, Mayerle J, Tacke M, Lerch MM, Coussens LM, Peters C, Reinheckel T. 2010. Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis. Oncogene 29: 1611-1621.
-
(2010)
Oncogene
, vol.29
, pp. 1611-1621
-
-
Dennemarker, J.1
Lohmuller, T.2
Mayerle, J.3
Tacke, M.4
Lerch, M.M.5
Coussens, L.M.6
Peters, C.7
Reinheckel, T.8
-
18
-
-
19344365408
-
De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent
-
De Visser KE, Korets LV, Coussens LM. 2005. De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell 7: 411-423.
-
(2005)
Cancer Cell
, vol.7
, pp. 411-423
-
-
de Visser, K.E.1
Korets, L.V.2
Coussens, L.M.3
-
19
-
-
0036512208
-
New functions for the matrix metalloproteinases in cancer progression
-
Egeblad M, Werb Z. 2002. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2: 161-174.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 161-174
-
-
Egeblad, M.1
Werb, Z.2
-
20
-
-
76349096670
-
Cancerassociated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kBdependent manner
-
Erez N, Truitt M, Olson P, Arron ST, Hanahan D. 2010. Cancerassociated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kBdependent manner. Cancer Cell 17: 135-147.
-
(2010)
Cancer Cell
, vol.17
, pp. 135-147
-
-
Erez, N.1
Truitt, M.2
Olson, P.3
Arron, S.T.4
Hanahan, D.5
-
21
-
-
33846167705
-
Activity based probes for proteases: Applications to biomarker discovery, molecular imaging and drug screening
-
Fonovic M, Bogyo M. 2007. Activity based probes for proteases: Applications to biomarker discovery, molecular imaging and drug screening. Curr Pharm Des 13: 253-261.
-
(2007)
Curr Pharm Des
, vol.13
, pp. 253-261
-
-
Fonovic, M.1
Bogyo, M.2
-
22
-
-
8744314149
-
Cathepsin C involvement in the aetiology of Papillon-Lefevre syndrome
-
Frezzini C, Leao JC, Porter S. 2004. Cathepsin C involvement in the aetiology of Papillon-Lefevre syndrome. Int J Paediatr Dent 14: 466-467.
-
(2004)
Int J Paediatr Dent
, vol.14
, pp. 466-467
-
-
Frezzini, C.1
Leao, J.C.2
Porter, S.3
-
23
-
-
33846643454
-
Cysteine cathepsins and the cutting edge of cancer invasion
-
Gocheva V, Joyce JA. 2007. Cysteine cathepsins and the cutting edge of cancer invasion. Cell Cycle 6: 60-64.
-
(2007)
Cell Cycle
, vol.6
, pp. 60-64
-
-
Gocheva, V.1
Joyce, J.A.2
-
24
-
-
33644784910
-
Distinct roles for cysteine cathepsin genes in multistage tumorigenesis
-
Gocheva V, Zeng W, Ke D, Klimstra D, Reinheckel T, Peters C, Hanahan D, Joyce JA. 2006. Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes Dev 20: 543-556.
-
(2006)
Genes Dev
, vol.20
, pp. 543-556
-
-
Gocheva, V.1
Zeng, W.2
Ke, D.3
Klimstra, D.4
Reinheckel, T.5
Peters, C.6
Hanahan, D.7
Joyce, J.A.8
-
25
-
-
76149146398
-
IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion
-
Gocheva V, Wang HW, Gadea BB, Shree T, Hunter KE, Garfall AL, Berman T, Joyce JA. 2010. IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev 24: 241-255.
-
(2010)
Genes Dev
, vol.24
, pp. 241-255
-
-
Gocheva, V.1
Wang, H.W.2
Gadea, B.B.3
Shree, T.4
Hunter, K.E.5
Garfall, A.L.6
Berman, T.7
Joyce, J.A.8
-
26
-
-
9144231998
-
RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas
-
Gondi CS, Lakka SS, Dinh DH, Olivero WC, Gujrati M, Rao JS. 2004. RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas. Oncogene 23: 8486-8496.
-
(2004)
Oncogene
, vol.23
, pp. 8486-8496
-
-
Gondi, C.S.1
Lakka, S.S.2
Dinh, D.H.3
Olivero, W.C.4
Gujrati, M.5
Rao, J.S.6
-
27
-
-
84860557204
-
Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice
-
Gopinathan A, Denicola GM, Frese KK, Cook N, Karreth FA, Mayerle J, Lerch MM, Reinheckel T, Tuveson DA. 2012. Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice. Gut 61: 877-884.
-
(2012)
Gut
, vol.61
, pp. 877-884
-
-
Gopinathan, A.1
Denicola, G.M.2
Frese, K.K.3
Cook, N.4
Karreth, F.A.5
Mayerle, J.6
Lerch, M.M.7
Reinheckel, T.8
Tuveson, D.A.9
-
28
-
-
51449115025
-
Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth
-
Gounaris E, Tung CH, Restaino C, Maehr R, Kohler R, Joyce JA, Ploegh HL, Barrett TA, Weissleder R, Khazaie K. 2008. Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. PLoS ONE 3: e2916.
-
(2008)
PLoS ONE
, vol.3
-
-
Gounaris, E.1
Tung, C.H.2
Restaino, C.3
Maehr, R.4
Kohler, R.5
Joyce, J.A.6
Ploegh, H.L.7
Barrett, T.A.8
Weissleder, R.9
Khazaie, K.10
-
29
-
-
77952475301
-
Therapeutic utility and medicinal chemistry of cathepsin C inhibitors
-
Guay D, Beaulieu C, Percival MD. 2010. Therapeutic utility and medicinal chemistry of cathepsin C inhibitors. Curr Top Med Chem 10: 708-716.
-
(2010)
Curr Top Med Chem
, vol.10
, pp. 708-716
-
-
Guay, D.1
Beaulieu, C.2
Percival, M.D.3
-
30
-
-
0026587657
-
Induction of mammary tumors by expression of polyomavirus middle T oncogene: A transgenic mouse model for metastatic disease
-
Guy CT, Cardiff RD, Muller WJ. 1992. Induction of mammary tumors by expression of polyomavirus middle T oncogene: A transgenic mouse model for metastatic disease. Mol Cell Biol 12: 954-961.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 954-961
-
-
Guy, C.T.1
Cardiff, R.D.2
Muller, W.J.3
-
31
-
-
0033795691
-
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis
-
Halangk W, Lerch MM, Brandt-Nedelev B, Roth W, Ruthenbuerger M, Reinheckel T, Domschke W, Lippert H, Peters C, Deussing J. 2000. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest 106: 773-781.
-
(2000)
J Clin Invest
, vol.106
, pp. 773-781
-
-
Halangk, W.1
Lerch, M.M.2
Brandt-Nedelev, B.3
Roth, W.4
Ruthenbuerger, M.5
Reinheckel, T.6
Domschke, W.7
Lippert, H.8
Peters, C.9
Deussing, J.10
-
32
-
-
0034056862
-
Haim-Munk syndrome and Papillon-Lefevre syndrome are allelic mutations in cathepsin C
-
Hart TC, Hart PS, Michalec MD, Zhang Y, Firatli E, Van Dyke TE, Stabholz A, Zlotogorski A, Shapira L, Soskolne WA. 2000. Haim-Munk syndrome and Papillon-Lefevre syndrome are allelic mutations in cathepsin C. J Med Genet 37: 88-94.
-
(2000)
J Med Genet
, vol.37
, pp. 88-94
-
-
Hart, T.C.1
Hart, P.S.2
Michalec, M.D.3
Zhang, Y.4
Firatli, E.5
van Dyke, T.E.6
Stabholz, A.7
Zlotogorski, A.8
Shapira, L.9
Soskolne, W.A.10
-
33
-
-
47849097202
-
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
-
Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E. 2008. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 9: 847-856.
-
(2008)
Nat Immunol
, vol.9
, pp. 847-856
-
-
Hornung, V.1
Bauernfeind, F.2
Halle, A.3
Samstad, E.O.4
Kono, H.5
Rock, K.L.6
Fitzgerald, K.A.7
Latz, E.8
-
34
-
-
17144394796
-
Multiple roles for cysteine cathep-sins in cancer
-
Joyce JA, Hanahan D. 2004. Multiple roles for cysteine cathep-sins in cancer. Cell Cycle 3: 1516-1519.
-
(2004)
Cell Cycle
, vol.3
, pp. 1516-1519
-
-
Joyce, J.A.1
Hanahan, D.2
-
35
-
-
2342603891
-
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis
-
Joyce JA, Baruch A, Chehade K, Meyer-Morse N, Giraudo E, Tsai FY, Greenbaum DC, Hager JH, Bogyo M, Hanahan D. 2004. Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell 5: 443-453.
-
(2004)
Cancer Cell
, vol.5
, pp. 443-453
-
-
Joyce, J.A.1
Baruch, A.2
Chehade, K.3
Meyer-Morse, N.4
Giraudo, E.5
Tsai, F.Y.6
Greenbaum, D.C.7
Hager, J.H.8
Bogyo, M.9
Hanahan, D.10
-
37
-
-
70450265558
-
Mast cells contribute to the stromal microenvironment in mammary gland branching morphogenesis
-
Lilla JN, Werb Z. 2010. Mast cells contribute to the stromal microenvironment in mammary gland branching morphogenesis. Dev Biol 337: 124-133.
-
(2010)
Dev Biol
, vol.337
, pp. 124-133
-
-
Lilla, J.N.1
Werb, Z.2
-
38
-
-
0035911221
-
Colonystimulating factor 1 promotes progression of mammary tumors to malignancy
-
Lin EY, Nguyen AV, Russell RG, Pollard JW. 2001. Colonystimulating factor 1 promotes progression of mammary tumors to malignancy. J Exp Med 193: 727-740.
-
(2001)
J Exp Med
, vol.193
, pp. 727-740
-
-
Lin, E.Y.1
Nguyen, A.V.2
Russell, R.G.3
Pollard, J.W.4
-
39
-
-
0038230415
-
The macro-phage growth factor CSF-1 in mammary gland development and tumor progression
-
Lin E, Gouon-Evans V, Nguyen A, Pollard J. 2002. The macro-phage growth factor CSF-1 in mammary gland development and tumor progression. J Mammary Gland Biol Neoplasia 7: 147-162.
-
(2002)
J Mammary Gland Biol Neoplasia
, vol.7
, pp. 147-162
-
-
Lin, E.1
Gouon-Evans, V.2
Nguyen, A.3
Pollard, J.4
-
40
-
-
33745837774
-
Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake
-
Loeffler M, Kruger JA, Niethammer AG, Reisfeld RA. 2006. Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake. J Clin Invest 116: 1955-1962.
-
(2006)
J Clin Invest
, vol.116
, pp. 1955-1962
-
-
Loeffler, M.1
Kruger, J.A.2
Niethammer, A.G.3
Reisfeld, R.A.4
-
41
-
-
34648815810
-
Emerging roles of proteases in tumour suppression
-
Lopez-Otin C, Matrisian LM. 2007. Emerging roles of proteases in tumour suppression. Nat Rev Cancer 7: 800-808.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 800-808
-
-
Lopez-Otin, C.1
Matrisian, L.M.2
-
42
-
-
1642337351
-
Mast cell dipeptidyl peptidase I mediates survival from sepsis
-
Mallen SCJ, Pham CT, Villalta SA, Caughey GH, Wolters PJ. 2004. Mast cell dipeptidyl peptidase I mediates survival from sepsis. J Clin Invest 113: 628-634.
-
(2004)
J Clin Invest
, vol.113
, pp. 628-634
-
-
Mallen, S.C.J.1
Pham, C.T.2
Villalta, S.A.3
Caughey, G.H.4
Wolters, P.J.5
-
43
-
-
79953163995
-
Proteolytic networks in cancer
-
Mason SD, Joyce JA. 2011. Proteolytic networks in cancer. Trends Cell Biol 21: 228-237.
-
(2011)
Trends Cell Biol
, vol.21
, pp. 228-237
-
-
Mason, S.D.1
Joyce, J.A.2
-
44
-
-
80052587306
-
Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment
-
Mikhaylov G, Mikac U, Magaeva AA, Itin VI, Naiden EP, Psakhye I, Babes L, Reinheckel T, Peters C, Zeiser R, et al. 2011. Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. Nat Nanotechnol 6: 594-602.
-
(2011)
Nat Nanotechnol
, vol.6
, pp. 594-602
-
-
Mikhaylov, G.1
Mikac, U.2
Magaeva, A.A.3
Itin, V.I.4
Naiden, E.P.5
Psakhye, I.6
Babes, L.7
Reinheckel, T.8
Peters, C.9
Zeiser, R.10
-
45
-
-
33749017931
-
Cysteine cathepsins: Multifunctional enzymes in cancer
-
Mohamed MM, Sloane BF. 2006. Cysteine cathepsins: Multifunctional enzymes in cancer. Nat Rev Cancer 6: 764-775.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 764-775
-
-
Mohamed, M.M.1
Sloane, B.F.2
-
46
-
-
2442701902
-
Novel mutations in the cathepsin C gene in patients with pre-pubertal aggressive periodontitis and Papillon-Lefevre syndrome
-
Noack B, Gorgens H, Hoffmann T, Fanghanel J, Kocher T, Eickholz P, Schackert HK. 2004. Novel mutations in the cathepsin C gene in patients with pre-pubertal aggressive periodontitis and Papillon-Lefevre syndrome. J Dent Res 83: 368-370.
-
(2004)
J Dent Res
, vol.83
, pp. 368-370
-
-
Noack, B.1
Gorgens, H.2
Hoffmann, T.3
Fanghanel, J.4
Kocher, T.5
Eickholz, P.6
Schackert, H.K.7
-
47
-
-
51649087512
-
Effective immunoconjugate therapy in cancer models targeting a serine protease of tumor fibroblasts
-
Ostermann E, Garin-Chesa P, Heider KH, Kalat M, Lamche H, Puri C, Kerjaschki D, Rettig WJ, Adolf GR. 2008. Effective immunoconjugate therapy in cancer models targeting a serine protease of tumor fibroblasts. Clin Cancer Res 14: 45844592.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 45844592
-
-
Ostermann, E.1
Garin-Chesa, P.2
Heider, K.H.3
Kalat, M.4
Lamche, H.5
Puri, C.6
Kerjaschki, D.7
Rettig, W.J.8
Adolf, G.R.9
-
48
-
-
37549070672
-
Cysteine cathepsin proteases as pharmacological targets in cancer
-
Palermo C, Joyce JA. 2008. Cysteine cathepsin proteases as pharmacological targets in cancer. Trends Pharmacol Sci 29: 22-28.
-
(2008)
Trends Pharmacol Sci
, vol.29
, pp. 22-28
-
-
Palermo, C.1
Joyce, J.A.2
-
49
-
-
0033579444
-
Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts
-
Park JE, Lenter MC, Zimmermann RN, Garin-Chesa P, Old LJ, Rettig WJ. 1999. Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts. J Biol Chem 274: 36505-36512.
-
(1999)
J Biol Chem
, vol.274
, pp. 36505-36512
-
-
Park, J.E.1
Lenter, M.C.2
Zimmermann, R.N.3
Garin-Chesa, P.4
Old, L.J.5
Rettig, W.J.6
-
50
-
-
0033587689
-
Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo
-
Pham CT, Ley TJ. 1999. Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo. Proc Natl Acad Sci 96: 8627-8632.
-
(1999)
Proc Natl Acad Sci
, vol.96
, pp. 8627-8632
-
-
Pham, C.T.1
Ley, T.J.2
-
51
-
-
10344234724
-
Papillon-Lefevre syndrome: Correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans
-
Pham CT, Ivanovich JL, Raptis SZ, Zehnbauer B, Ley TJ. 2004. Papillon-Lefevre syndrome: Correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans. J Immunol 173: 72777281.
-
(2004)
J Immunol
, vol.173
, pp. 72777281
-
-
Pham, C.T.1
Ivanovich, J.L.2
Raptis, S.Z.3
Zehnbauer, B.4
Ley, T.J.5
-
52
-
-
1642377561
-
ONCOMINE: A cancer microarray database and integrated data-mining platform
-
Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A, Chinnaiyan AM. 2004. ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia 6: 1-6.
-
(2004)
Neoplasia
, vol.6
, pp. 1-6
-
-
Rhodes, D.R.1
Yu, J.2
Shanker, K.3
Deshpande, N.4
Varambally, R.5
Ghosh, D.6
Barrette, T.7
Pandey, A.8
Chinnaiyan, A.M.9
-
53
-
-
84880687861
-
Depletion of stromal cells expressing fibroblast activation protein-a from skeletal muscle and bone marrow results in cachexia and anemia
-
Roberts EW, Deonarine A, Jones JO, Denton AE, Feig C, Lyons SK, Espeli M, Kraman M, McKenna B, Wells RJ, et al. 2013. Depletion of stromal cells expressing fibroblast activation protein-a from skeletal muscle and bone marrow results in cachexia and anemia. J Exp Med 210: 1137-1151.
-
(2013)
J Exp Med
, vol.210
, pp. 1137-1151
-
-
Roberts, E.W.1
Deonarine, A.2
Jones, J.O.3
Denton, A.E.4
Feig, C.5
Lyons, S.K.6
Espeli, M.7
Kraman, M.8
McKenna, B.9
Wells, R.J.10
-
54
-
-
0026664252
-
Rat procathepsin B. Proteolytic processing to the mature form in vitro
-
Rowan AD, Mason P, Mach L, Mort JS. 1992. Rat procathepsin B. Proteolytic processing to the mature form in vitro. J Biol Chem 267: 15993-15999.
-
(1992)
J Biol Chem
, vol.267
, pp. 15993-15999
-
-
Rowan, A.D.1
Mason, P.2
Mach, L.3
Mort, J.S.4
-
55
-
-
84857391089
-
Leukocyte composition in human breast cancer
-
Ruffell B, Au A, Rugo HS, Esserman LJ, Hwang ES, Coussens LM. 2012. Leukocyte composition in human breast cancer. Proc Natl Acad Sci 109: 2796-2801.
-
(2012)
Proc Natl Acad Sci
, vol.109
, pp. 2796-2801
-
-
Ruffell, B.1
Au, A.2
Rugo, H.S.3
Esserman, L.J.4
Hwang, E.S.5
Coussens, L.M.6
-
56
-
-
72849125358
-
Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice
-
Santos AM, Jung J, Aziz N, Kissil JL, Pure E. 2009. Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice. J Clin Invest 119: 3613-3625.
-
(2009)
J Clin Invest
, vol.119
, pp. 3613-3625
-
-
Santos, A.M.1
Jung, J.2
Aziz, N.3
Kissil, J.L.4
Pure, E.5
-
57
-
-
0028286026
-
Molecular cloning of fibroblast activation protein a, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers
-
Scanlan MJ, Raj BK, Calvo B, Garin-Chesa P, Sanz-Moncasi MP, Healey JH, Old LJ, Rettig WJ. 1994. Molecular cloning of fibroblast activation protein a, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers. Proc Natl Acad Sci 91: 5657-5661.
-
(1994)
Proc Natl Acad Sci
, vol.91
, pp. 5657-5661
-
-
Scanlan, M.J.1
Raj, B.K.2
Calvo, B.3
Garin-Chesa, P.4
Sanz-Moncasi, M.P.5
Healey, J.H.6
Old, L.J.7
Rettig, W.J.8
-
58
-
-
50849133244
-
Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model
-
Schurigt U, Sevenich L, Vannier C, Gajda M, Schwinde A, Werner F, Stahl A, von Elverfeldt D, Becker AK, Bogyo M, et al. 2008. Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model. Biol Chem 389: 1067-1074.
-
(2008)
Biol Chem
, vol.389
, pp. 1067-1074
-
-
Schurigt, U.1
Sevenich, L.2
Vannier, C.3
Gajda, M.4
Schwinde, A.5
Werner, F.6
Stahl, A.7
von Elverfeldt, D.8
Becker, A.K.9
Bogyo, M.10
-
59
-
-
0037459360
-
Deficiency of the cysteine protease cathepsin S impairs microvessel growth
-
Shi GP, Sukhova GK, Kuzuya M, Ye Q, Du J, Zhang Y, Pan JH, Lu ML, Cheng XW, Iguchi A, et al. 2003. Deficiency of the cysteine protease cathepsin S impairs microvessel growth. Circ Res 92: 493-500.
-
(2003)
Circ Res
, vol.92
, pp. 493-500
-
-
Shi, G.P.1
Sukhova, G.K.2
Kuzuya, M.3
Ye, Q.4
Du, J.5
Zhang, Y.6
Pan, J.H.7
Lu, M.L.8
Cheng, X.W.9
Iguchi, A.10
-
60
-
-
82955189189
-
Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer
-
Shree T, Olson OC, Elie BT, Kester JC, Garfall AL, Simpson K, Bell-McGuinn KM, Zabor EC, Brogi E, Joyce JA. 2011. Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer. Genes Dev 25: 2465-2479.
-
(2011)
Genes Dev
, vol.25
, pp. 2465-2479
-
-
Shree, T.1
Olson, O.C.2
Elie, B.T.3
Kester, J.C.4
Garfall, A.L.5
Simpson, K.6
Bell-McGuinn, K.M.7
Zabor, E.C.8
Brogi, E.9
Joyce, J.A.10
-
61
-
-
84874615947
-
Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome
-
Tholen S, Biniossek ML, Gansz M, Gomez-Auli A, Bengsch F, Noel A, Kizhakkedathu JN, Boerries M, Busch H, Reinheckel T, et al. 2013. Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome. Mol Cell Proteomics 12: 611-625.
-
(2013)
Mol Cell Proteomics
, vol.12
, pp. 611-625
-
-
Tholen, S.1
Biniossek, M.L.2
Gansz, M.3
Gomez-Auli, A.4
Bengsch, F.5
Noel, A.6
Kizhakkedathu, J.N.7
Boerries, M.8
Busch, H.9
Reinheckel, T.10
-
62
-
-
84880656055
-
Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia
-
Tran E, Chinnasamy D, Yu Z, Morgan RA, Lee CC, Restifo NP, Rosenberg SA. 2013. Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia. J Exp Med 210: 1125-1135.
-
(2013)
J Exp Med
, vol.210
, pp. 1125-1135
-
-
Tran, E.1
Chinnasamy, D.2
Yu, Z.3
Morgan, R.A.4
Lee, C.C.5
Restifo, N.P.6
Rosenberg, S.A.7
-
63
-
-
33748308883
-
Targeting proteases: Successes, failures and future prospects
-
Turk B. 2006. Targeting proteases: Successes, failures and future prospects. Nat Rev Drug Discov 5: 785-799.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 785-799
-
-
Turk, B.1
-
64
-
-
0345310073
-
Revised definition of substrate binding sites of papain-like cysteine proteases
-
Turk D, Guncar G, Podobnik M, Turk B. 1998. Revised definition of substrate binding sites of papain-like cysteine proteases. Biol Chem 379: 137-147.
-
(1998)
Biol Chem
, vol.379
, pp. 137-147
-
-
Turk, D.1
Guncar, G.2
Podobnik, M.3
Turk, B.4
-
65
-
-
17944366493
-
Structure of human dipeptidyl peptidase I (cathepsin C): Exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases
-
Turk D, Janjic V, Stern I, Podobnik M, Lamba D, Dahl SW, Lauritzen C, Pedersen J, Turk V, Turk B. 2001. Structure of human dipeptidyl peptidase I (cathepsin C): Exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases. EMBO J 20: 6570-6582.
-
(2001)
EMBO J
, vol.20
, pp. 6570-6582
-
-
Turk, D.1
Janjic, V.2
Stern, I.3
Podobnik, M.4
Lamba, D.5
Dahl, S.W.6
Lauritzen, C.7
Pedersen, J.8
Turk, V.9
Turk, B.10
-
66
-
-
2342551977
-
Cysteine cathepsins (proteases)-on the main stage of cancer?
-
Turk V, Kos J, Turk B. 2004. Cysteine cathepsins (proteases)-on the main stage of cancer? Cancer Cell 5: 409-410.
-
(2004)
Cancer Cell
, vol.5
, pp. 409-410
-
-
Turk, V.1
Kos, J.2
Turk, B.3
-
67
-
-
78650034777
-
Towards a knowledge-based Human Protein Atlas
-
Uhlen M, Oksvold P, Fagerberg L, Lundberg E, Jonasson K, Forsberg M, Zwahlen M, Kampf C, Wester K, Hober S, et al. 2010. Towards a knowledge-based Human Protein Atlas. Nat Biotechnol 28: 1248-1250.
-
(2010)
Nat Biotechnol
, vol.28
, pp. 1248-1250
-
-
Uhlen, M.1
Oksvold, P.2
Fagerberg, L.3
Lundberg, E.4
Jonasson, K.5
Forsberg, M.6
Zwahlen, M.7
Kampf, C.8
Wester, K.9
Hober, S.10
-
69
-
-
33744917827
-
Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer
-
Vasiljeva O, Papazoglou A, Kruger A, Brodoefel H, Korovin M, Deussing J, Augustin N, Nielsen BS, Almholt K, Bogyo M, et al. 2006. Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. Cancer Res 66: 5242-5250.
-
(2006)
Cancer Res
, vol.66
, pp. 5242-5250
-
-
Vasiljeva, O.1
Papazoglou, A.2
Kruger, A.3
Brodoefel, H.4
Korovin, M.5
Deussing, J.6
Augustin, N.7
Nielsen, B.S.8
Almholt, K.9
Bogyo, M.10
-
70
-
-
0035947568
-
Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice
-
Wolters PJ, Pham CT, Muilenburg DJ, Ley TJ, Caughey GH. 2001. Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice. J Biol Chem 276: 18551-18566.
-
(2001)
J Biol Chem
, vol.276
, pp. 18551-18566
-
-
Wolters, P.J.1
Pham, C.T.2
Muilenburg, D.J.3
Ley, T.J.4
Caughey, G.H.5
-
71
-
-
33646594411
-
A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C
-
Yuan F, Verhelst SH, Blum G, Coussens LM, Bogyo M. 2006. A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C. J Am Chem Soc 128: 5616-5617.
-
(2006)
J Am Chem Soc
, vol.128
, pp. 5616-5617
-
-
Yuan, F.1
Verhelst, S.H.2
Blum, G.3
Coussens, L.M.4
Bogyo, M.5
|