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Volumn 389, Issue 8, 2008, Pages 1067-1074

Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model

Author keywords

Pharmacokinetics; Protease inhibitor; Therapy

Indexed keywords

ANTINEOPLASTIC AGENT; CATHEPSIN; COLLAGEN TYPE 1; JPM OET; UNCLASSIFIED DRUG;

EID: 50849133244     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2008.115     Document Type: Conference Paper
Times cited : (40)

References (28)
  • 1
    • 0029950355 scopus 로고    scopus 로고
    • Expression, subcellular distribution and plasma membrane binding of catwhepsin B and gelatinases in bone metastatic tissue
    • Arkona, C. and Wiederanders, B. (1996). Expression, subcellular distribution and plasma membrane binding of catwhepsin B and gelatinases in bone metastatic tissue. Biol. Chem. 377, 695-702.
    • (1996) Biol. Chem , vol.377 , pp. 695-702
    • Arkona, C.1    Wiederanders, B.2
  • 2
    • 0039552134 scopus 로고    scopus 로고
    • Negative regulation of epidermal growth factor signaling by selective proteolytic mechanisms in the endosome mediated by cathepsin
    • Authier, F., Metioui, M., Bell, A.W., and Mort, J.S. (1999). Negative regulation of epidermal growth factor signaling by selective proteolytic mechanisms in the endosome mediated by cathepsin B. J. Biol. Chem. 274, 33723-33731.
    • (1999) B. J. Biol. Chem , vol.274 , pp. 33723-33731
    • Authier, F.1    Metioui, M.2    Bell, A.W.3    Mort, J.S.4
  • 3
    • 34547640302 scopus 로고    scopus 로고
    • Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer
    • Bell-McGuinn, K.M., Garfall, A.L., Bogyo, M., Hanahan, D., and Joyce, J.A. (2007). Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer. Cancer Res. 67, 7378-7385.
    • (2007) Cancer Res , vol.67 , pp. 7378-7385
    • Bell-McGuinn, K.M.1    Garfall, A.L.2    Bogyo, M.3    Hanahan, D.4    Joyce, J.A.5
  • 4
    • 25844457673 scopus 로고    scopus 로고
    • Cathepsins B and D activity and activity ratios in normal ovaries, benign ovarian neoplasms, and epithelial ovarian cancer
    • Downs, L.S. Jr, Lima, P.H., Bliss, R.L., and Blomquist, C.H. (2005). Cathepsins B and D activity and activity ratios in normal ovaries, benign ovarian neoplasms, and epithelial ovarian cancer. J. Soc. Gynecol. Invest. 12, 539-544.
    • (2005) J. Soc. Gynecol. Invest , vol.12 , pp. 539-544
    • Downs Jr, L.S.1    Lima, P.H.2    Bliss, R.L.3    Blomquist, C.H.4
  • 5
    • 0026072872 scopus 로고
    • Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: Experience from a large study with long-term follow-up
    • Elston, C.W. and Ellis, I.O. (1991). Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19, 403-410.
    • (1991) Histopathology , vol.19 , pp. 403-410
    • Elston, C.W.1    Ellis, I.O.2
  • 7
    • 34548217651 scopus 로고    scopus 로고
    • Maximizing mouse cancer models
    • Frese, K.K. and Tuveson, D.A. (2007). Maximizing mouse cancer models. Nat. Rev. Cancer 7, 645-658.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 645-658
    • Frese, K.K.1    Tuveson, D.A.2
  • 8
    • 33846643454 scopus 로고    scopus 로고
    • Cysteine cathepsins and the cutting edge of cancer invasion
    • Gocheva, V. and Joyce, J.A. (2007). Cysteine cathepsins and the cutting edge of cancer invasion. Cell Cycle 6, 60-64.
    • (2007) Cell Cycle , vol.6 , pp. 60-64
    • Gocheva, V.1    Joyce, J.A.2
  • 10
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • Gottesman, M.M., Fojo, T., and Bates, S.E. (2002). Multidrug resistance in cancer: role of ATP-dependent transporters. Nat. Rev. Cancer 2, 48-58.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 11
    • 34548689404 scopus 로고    scopus 로고
    • Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation
    • Goulet, B., Sansregret, L., Leduy, L., Bogyo, M., Weber, E., Chauhan, S.S., and Nepveu, A. (2007). Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation. Mol. Cancer Res. 5, 899-907.
    • (2007) Mol. Cancer Res , vol.5 , pp. 899-907
    • Goulet, B.1    Sansregret, L.2    Leduy, L.3    Bogyo, M.4    Weber, E.5    Chauhan, S.S.6    Nepveu, A.7
  • 12
    • 0026587657 scopus 로고
    • Induction of mammary tumors by expression of polyomavirus middle T oncogene: A transgenic mouse model for metastatic disease
    • Guy, C.T., Cardiff, R.D., and Muller, W.J. (1992). Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol. Cell. Biol. 12, 954-961.
    • (1992) Mol. Cell. Biol , vol.12 , pp. 954-961
    • Guy, C.T.1    Cardiff, R.D.2    Muller, W.J.3
  • 15
    • 0035902141 scopus 로고    scopus 로고
    • The microenvironment of the tumour-host interface
    • Liotta, L.A. and Kohn, E.C. (2001). The microenvironment of the tumour-host interface. Nature 411, 375-379.
    • (2001) Nature , vol.411 , pp. 375-379
    • Liotta, L.A.1    Kohn, E.C.2
  • 16
    • 0034725119 scopus 로고    scopus 로고
    • Human procathepsin B interacts with the annexin II tetramer on the surface of tumor cells
    • Mai, J., Finley, R.L. Jr, Waisman, D.M., and Sloane, B.F. (2000). Human procathepsin B interacts with the annexin II tetramer on the surface of tumor cells. J. Biol. Chem. 275, 12806-12812.
    • (2000) J. Biol. Chem , vol.275 , pp. 12806-12812
    • Mai, J.1    Finley Jr, R.L.2    Waisman, D.M.3    Sloane, B.F.4
  • 17
    • 0029744988 scopus 로고    scopus 로고
    • Mechanistic studies on the inactivation of papain by epoxysuccinyl inhibitors
    • Meara, J.P. and Rich, D.H. (1996). Mechanistic studies on the inactivation of papain by epoxysuccinyl inhibitors. J. Med. Chem. 39, 3357-3366.
    • (1996) J. Med. Chem , vol.39 , pp. 3357-3366
    • Meara, J.P.1    Rich, D.H.2
  • 18
    • 33749017931 scopus 로고    scopus 로고
    • Cysteine cathepsins: Multifunctional enzymes in cancer
    • Mohamed, M.M. and Sloane, B.F. (2006). Cysteine cathepsins: multifunctional enzymes in cancer. Nat. Rev. Cancer 6, 764-775.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 764-775
    • Mohamed, M.M.1    Sloane, B.F.2
  • 22
    • 34248549740 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of in vivo potency and selectivity of epoxysuccinyl-based inhibitors of papain-family cysteine proteases
    • Sadaghiani, A.M., Verhelst, S.H., Gocheva, V., Hill, K., Majerova, E., Stinson, S., Joyce, J.A., and Bogyo, M. (2007). Design, synthesis, and evaluation of in vivo potency and selectivity of epoxysuccinyl-based inhibitors of papain-family cysteine proteases. Chem. Biol. 14, 499-511.
    • (2007) Chem. Biol , vol.14 , pp. 499-511
    • Sadaghiani, A.M.1    Verhelst, S.H.2    Gocheva, V.3    Hill, K.4    Majerova, E.5    Stinson, S.6    Joyce, J.A.7    Bogyo, M.8
  • 23
    • 33746255613 scopus 로고    scopus 로고
    • Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice
    • Sevenich, L., Pennacchio, L.A., Peters, C., and Reinheckel, T. (2006). Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice. Biol. Chem. 387, 885-891.
    • (2006) Biol. Chem , vol.387 , pp. 885-891
    • Sevenich, L.1    Pennacchio, L.A.2    Peters, C.3    Reinheckel, T.4
  • 26
    • 38649084746 scopus 로고    scopus 로고
    • Dual contrasting roles of cysteine cathepsins in cancer progression: Apoptosis versus tumour invasion
    • Vasiljeva, O. and Turk, B. (2008). Dual contrasting roles of cysteine cathepsins in cancer progression: apoptosis versus tumour invasion. Biochimie 90, 380-386.
    • (2008) Biochimie , vol.90 , pp. 380-386
    • Vasiljeva, O.1    Turk, B.2
  • 28
    • 33846164404 scopus 로고    scopus 로고
    • Emerging roles of cysteine cathepsins in disease and their potential as drug targets
    • Vasiljeva, O., Reinheckel, T., Peters, C., Turk, D., Turk, V., and Turk, B. (2007). Emerging roles of cysteine cathepsins in disease and their potential as drug targets. Curr. Pharm. Des. 13, 385-401.
    • (2007) Curr. Pharm. Des , vol.13 , pp. 385-401
    • Vasiljeva, O.1    Reinheckel, T.2    Peters, C.3    Turk, D.4    Turk, V.5    Turk, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.