Mitochondrial dysfunction and sarcopenia of aging: From signaling pathways to clinical trials

International Journal of Biochemistry and Cell Biology

Volumn 45, Issue 10, 2013, Pages 2288-2301

  Marzetti, Emanuele ^a   Calvani, Riccardo ^b   Cesari, Matteo ^c   Buford, Thomas W ^d,e   Lorenzi, Maria ^a   Behnke, Bradley J ^e   Leeuwenburgh, Christiaan ^d  

^a CATHOLIC UNIVERSITY   (Italy)

^b CNR   (Italy)

^c Faculté de Médecine Centre Hospitalo universitaire   (France)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF FLORIDA   (United States)

Author keywords

Apoptosis; Biomarkers; Fusion and fission; Mitophagy; Vascular dysfunction

Indexed keywords

LIPOFUSCIN; MESSENGER RNA;

AGING; APOPTOSIS; CHRONIC INFLAMMATION; HUMAN; MITOCHONDRIAL DNA DISORDER; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL TARGETING SIGNAL; MUSCLE CELL; MUSCLE MITOCHONDRION; MUSCLE REGENERATION; NONHUMAN; OXIDATIVE STRESS; QUALITY CONTROL; REVIEW; SARCOPENIA; SIGNAL TRANSDUCTION;

(31)P NUCLEAR MAGNETIC RESONANCE; (31)P-NMR; AIF; ANGII; ANGIOTENSIN II; APOPTOSIS; APOPTOSIS-INDUCING FACTOR; ATG PROTEIN; AUTOPHAGY-RELATED PROTEIN; B-CELL LEUKEMIA-2; BCL-2; BIOMARKERS; CHRONIC OBSTRUCTIVE PULMONARY DISEASE; COPD; COX; CROSS-SECTIONAL AREA; CSA; CYTOCHROME C OXIDASE; DRP1; DYNAMIN-RELATED PROTEIN 1; ELECTRON TRANSPORT CHAIN; ENDOG; ENDONUCLEASE G; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENOS; ETC; FIS1; FISSION PROTEIN 1; FORKHEAD BOX O3; FOXO3; FUSION AND FISSION; GH; GROWTH HORMONE; IFM; IGF-1; INDUCIBLE NITRIC OXIDE SYNTHASE; INOS; INSULIN-LIKE GROWTH FACTOR-1; INTERFIBRILLAR MITOCHONDRIA; LAMP-2; LC3; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2; MFN; MFRTA; MICROTUBULE-ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; MITOCHONDRIAL DNA; MITOCHONDRIAL FREE RADICAL THEORY OF AGING; MITOCHONDRIAL QUALITY CONTROL; MITOCHONDRIAL TRANSCRIPTION FACTOR A; MITOFUSIN; MITOPHAGY; MQC; MTDNA; NEURONAL NITRIC OXIDE SYNTHASE; NF-ΚB; NITRIC OXIDE SYNTHASE; NNOS; NOS; NUCLEAR FACTOR ΚB; OMM; OUTER MITOCHONDRIAL MEMBRANE; OXIDATIVE PHOSPHORYLATION; OXPHOS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-Γ COACTIVATOR-1Α; PGC-1Α; RANDOMIZED CONTROLLED TRIAL; RCT; REACTIVE OXYGEN SPECIES; ROS; SDH; SSM; SUBSARCOLEMMAL MITOCHONDRIA; SUCCINATE DEHYDROGENASE; TA; TFAM; TIBIALIS ANTERIOR; TNF-Α; TUMOR-NECROSIS FACTOR Α; UBIQUITIN-PROTEASOME SYSTEM; UPS; VASCULAR DYSFUNCTION; VASTUS LATERALIS; VDR; VITAMIN D RECEPTOR; VL;

AGED; AGING; ANIMALS; APOPTOSIS; HUMANS; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; OXIDATIVE STRESS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SARCOPENIA; SIGNAL TRANSDUCTION;

EID: 84885181506     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2013.06.024     Document Type: Review

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