Sarcopenia and age-related endocrine function

International Journal of Endocrinology

Volumn 2012, Issue , 2012, Pages

  Sakuma, Kunihiro ^a   Yamaguchi, Akihiko ^b  

^a TOYOHASHI UNIVERSITY OF TECHNOLOGY   (Japan)

^b HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; ESTROGEN; GHRELIN; GLUCOCORTICOID; GROWTH HORMONE; HUMAN MYOSTATIN ANTIBODY; IBUTAMOREN; INTERLEUKIN 6; MYOSTATIN; PLACEBO; PRASTERONE; PROTEIN ANTIBODY; SOMATOMEDIN C; TESTOSTERONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VITAMIN D;

AGING; APOPTOSIS; ARTHRALGIA; CACHEXIA; CALORIC INTAKE; CARPAL TUNNEL SYNDROME; CATABOLISM; DRUG MEGADOSE; EDEMA; ENDOCRINE FUNCTION; GYNECOMASTIA; HORMONAL THERAPY; HUMAN; LEAN BODY WEIGHT; MUSCLE ATROPHY; MUSCLE MASS; MUSCLE STRENGTH; MUSCLE WEAKNESS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RESISTANCE TRAINING; REVIEW; SLEEP APNEA SYNDROME; SOFT TISSUE EDEMA; TESTOSTERONE SUPPLEMENTATION; THROMBOSIS; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION;

EID: 84862279391     PISSN: 16878337     EISSN: 16878345     Source Type: Journal    
DOI: 10.1155/2012/127362     Document Type: Review

References (128)

1. Melton L. J. III, Khosla S., Crowson C. S., O'Connor M. K., O'Fallon W. M., Riggs B. L., Epidemiology of sarcopenia Journal of the American Geriatrics Society 2000 48 6 625 630 (Pubitemid 30390451)
2. Baumgartner R. N., Waters D. L., Gallagher D., Morley J. E., Garry P. J., Predictors of skeletal muscle mass in elderly men and women Mechanisms of Ageing and Development 1999 107 2 123 136 (Pubitemid 29138849)
3. Short K. R., Nair K. S., The effect of age on protein metabolism Current Opinion in Clinical Nutrition and Metabolic Care 2000 3 1 39 44 (Pubitemid 30469103)
4. Short K. R., Vittone J. L., Bigelow M. L., Proctor D. N., Nair K. S., Age and aerobic exercise training effects on whole body and muscle protein metabolism American Journal of Physiology 2004 286 1 E92 E101
5. Lexell J., Human aging, muscle mass, and fiber type composition Journals of Gerontology 1995 50 11 16
6. Lexell J., Ageing and human muscle: observations from Sweden Canadian Journal of Applied Physiology 1993 18 1 2 18
7. Roubenoff R., Hughes V. A., Sarcopenia: current concepts Journals of Gerontology 2000 55 12 M716 M724
8. Sakuma K., Akiho M., Nakashima H., Akima H., Yasuhara M., Age-related reductions in expression of serum response factor and myocardin-related transcription factor A in mouse skeletal muscles Biochimica et Biophysica Acta 2008 1782 78 453 461
9. Sakuma K., Yamaguchi A., Molecular mechanisms in aging and current strategies to counteract sarcopenia Current Aging Science 2010 3 2 90 101
10. Sakuma K., Yamaguchi A., Sarcopenia: molecular mechanisms and current therapeutic strategy Cell Aging 2011 New York, NY, USA Nova Science 93 152
11. Thomson D. M., Gordon S. E., Impaired overload-induced muscle growth is associated with diminished translational signalling in aged rat fast-twitch skeletal muscle Journal of Physiology 2006 574 1 291 305 (Pubitemid 43905813)
12. Degens H., The role of systemic inflammation in age-related muscle weakness and wasting Scandinavian Journal of Medicine and Science in Sports 2010 20 1 28 38
13. Grounds M. D., Reasons for the degeneration of ageing skeletal muscle: a central role for IGF-1 signalling Biogerontology 2002 3 12 19 24 (Pubitemid 34284971)
14. Schaap L. A., Pluijm S. M. F., Deeg D. J. H., Visser M., Inflammatory markers and loss of muscle mass (sarcopenia) and strength American Journal of Medicine 2006 119 6 526.e9 526.e17
15. Drey M., Sarcopenia-pathophysiology and clinical relevance Wiener Medizinische Wochenschrift 2011 161 1718 402 408
16. Sakuma K., Yamaguchi A., Sarcopenia and cachexia: the adaptations of negative regulators of skeletal muscle mass. Journal of Cachexia, Sarcopenia and Muscle. In press
17. Sattler F. R., Castaneda-Sceppa C., Binder E. F., Schroeder E. T., Wang Y., Bhasin S., Kawakubo M., Stewart Y., Yarasheski K. E., Ulloor J., Colletti P., Roubenoff R., Azen S. P., Testosterone and growth hormone improve body composition and muscle performance in older men Journal of Clinical Endocrinology and Metabolism 2009 94 6 1991 2001
18. Thomas D. R., Loss of skeletal muscle mass in aging: examining the relationship of starvation, sarcopenia and cachexia Clinical Nutrition 2007 26 4 389 399 (Pubitemid 47091483)
19. Giovannini S., Marzetti E., Borst S. E., Leeuwenburgh C., Modulation of GH/IGF-1 axis: potential strategies to counteract sarcopenia in older adults Mechanisms of Ageing and Development 2008 129 10 593 601
20. Nass R., Johannsson G., Christiansen J. S., Kopchick J. J., Thorner M. O., The aging populationis there a role for endocrine interventions? Growth Hormone and IGF Research 2009 19 2 89 100
21. Roubenoff R., Catabolism of aging: is it an inflammatory process? Current Opinion in Clinical Nutrition and Metabolic Care 2003 6 3 295 299 (Pubitemid 40684606)
22. Schaap L. A., Pluijm S. M. F., Deeg D. J. H., Harris T. B., Kritchevsky S. B., Newman A. B., Colbert L. H., Pahor M., Rubin S. M., Tylavsky F. A., Visser M., Higher inflammatory marker levels in older persons: associations with 5-year change in muscle mass and muscle strength Journals of Gerontology 2009 64 11 1183 1189
23. Rieu I., Magne H., Savary-Auzeloux I., Averous J., Bos C., Peyron M. A., Combaret L., Dardevet D., Reduction of low grade inflammation restores blunting of postprandial muscle anabolism and limits sarcopenia in old rats Journal of Physiology 2009 587 22 5483 5492
24. Chung H. Y., Cesari M., Anton S., Marzetti E., Giovannini S., Seo A. Y., Carter C., Yu B. P., Leeuwenburgh C., Molecular inflammation: underpinnings of aging and age-related diseases Ageing Research Reviews 2009 8 1 18 30
25. Reid M. B., Li Y. P., Tumor necrosis factor- and muscle wasting: a cellular perspective Respiratory Research 2001 2 5 269 272 (Pubitemid 34189649)
26. Aoi W., Sakuma K., Oxidative stress and skeletal muscle dysfunction with aging Current Aging Science 2011 4 2 101 109
27. Meng S. J., Yu L. J., Oxidative stress, molecular inflammation and sarcopenia International Journal of Molecular Sciences 2010 11 4 1509 1526
28. Bar-Shai M., Carmeli E., Coleman R., Rozen N., Perek S., Fuchs D., Reznick A. Z., The effect of hindlimb immobilization on acid phosphatase, metalloproteinases and nuclear factor- B in muscles of young and old rats Mechanisms of Ageing and Development 2005 126 2 289 297 (Pubitemid 40038350)
29. Philips T., Leeuwenburgh C., Muscle fiber specific apoptosis and TNF- signaling in sarcopenia are attenuated by life-long calorie restriction The FASEB Journal 2005 19 6 668 670 (Pubitemid 40471280)
30. Marzetti E., Carter C. S., Wohlgemuth S. E., Lees H. A., Giovannini S., Anderson B., Quinn L. S., Leeuwenburgh C., Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction Mechanisms of Ageing and Development 2009 130 4 272 280
31. Pistilli E. E., Jackson J. R., Alway S. E., Death receptor-associated pro-apoptotic signaling in aged skeletal muscle Apoptosis 2006 11 12 2115 2126 (Pubitemid 44885388)
32. Lee S. J., Regulation of muscle mass by myostatin Annual Review of Cell and Developmental Biology 2004 20 61 86
33. Zimmers T. A., Davies M. V., Koniaris L. G., Haynes P., Esquela A. F., Tomkinson K. N., McPherron A. C., Wolfman N. M., Lee S. J., Induction of cachexia in mice by systemically administered myostatin Science 2002 296 5572 1486 1488 (Pubitemid 34553097)
34. Wolfman N. M., McPherron A. C., Pappano W. N., Davies M. V., Song K., Tomkinson K. N., Wright J. F., Zhao L., Sebald S. M., Greenspan D. S., Lee S. J., Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases Proceedings of the National Academy of Sciences of the United States of America 2003 100 26 15842 15846 (Pubitemid 38021077)
35. Langley B., Thomas M., Bishop A., Sharma M., Gilmour S., Kambadur R., Myostatin inhibits myoblast differentiation by down-regulating MyoD expression Journal of Biological Chemistry 2002 277 51 49831 49840 (Pubitemid 36014431)
36. Thomas M., Langley B., Berry C., Sharma M., Kirk S., Bass J., Kambadur R., Myostatin, a negative regulator of muscle growth, functions by inhibiting myoblast proliferation Journal of Biological Chemistry 2000 275 51 40235 40243 (Pubitemid 32064654)
37. Yang W., Zhang Y., Li Y., Wu Z., Zhu D., Myostatin induces cyclin D1 degradation to cause cell cycle arrest through a phosphatidylinositol 3-kinase/AKT/GSK-3 pathway and is antagonized by insulin-like growth factor 1 Journal of Biological Chemistry 2007 282 6 3799 3808 (Pubitemid 47084479)
38. Allen D. L., Unterman T. G., Regulation of myostatin expression and myoblast differentiation by FoxO and SMAD transcription factors American Journal of Physiology 2007 292 1 C188 C199
39. Trendelenburg A. U., Meyer A., Rohner D., Boyle J., Hatakeyama S., Glass D. J., Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size American Journal of Physiology 2009 296 6 C1258 C1270
40. Sartori R., Milan G., Patron M., Mammucari C., Blaauw B., Abraham R., Sandri M., Smad2 and 3 transcription factors control muscle mass in adulthood American Journal of Physiology 2009 296 6 C1248 C1257
41. LeBrasseur N. K., Schelhorn T. M., Bernardo B. L., Cosgrove P. G., Loria P. M., Brown T. A., Myostatin inhibition enhances the effects of exercise on performance and metabolic outcomes in aged mice Journals of Gerontology 2009 64 9 940 948
42. Murphy K. T., Koopman R., Naim T., Léger B., Trieu J., Ibebunjo C., Lynch G. S., Antibody-directed myostatin inhibition in 21-mo-old mice reveals novel roles for myostatin signaling in skeletal muscle structure and function The FASEB Journal 2010 24 11 4433 4442
43. Ratkevicius A., Joyson A., Selmer I., Serum concentrations of myostatin and myostatin-interacting proteins do not differ between young and sarcopenic elderly men Journals of Gerontology 2011 66 6 620 626
44. Ferrando A. A., Stuart C. A., Sheffield-Moore M., Wolfe R. R., Inactivity amplifies the catabolic response of skeletal muscle to cortisol Journal of Clinical Endocrinology and Metabolism 1999 84 10 3515 3521 (Pubitemid 30645199)
45. Carballo-Jane E., Pandit S., Santoro J. C., Freund C., Luell S., Harris G., Forrest M. J., Sitlani A., Skeletal muscle: a dual system to measure glucocorticoid-dependent transactivation and transrepression of gene regulation Journal of Steroid Biochemistry and Molecular Biology 2004 88 2 191 201 (Pubitemid 38482036)
46. Sacheck J. M., Ohtsuka A., McLary S. C., Goldberg A. L., IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1 American Journal of Physiology 2004 287 4 E591 E601
47. Dardevet D., Sornet C., Taillandier D., Savary I., Attaix D., Grizard J., Sensitivity and protein turnover response to glucocorticoids are different in skeletal muscle from adult and old rats. Lack of regulation of the ubiquitin-proteasome proteolytic pathway in aging Journal of Clinical Investigation 1995 96 5 2113 2119
48. Savary I., Debras E., Dardevet D., Sornet C., Capitan P., Prugnaud J., Patureau Mirand P., Grizard J., Effect of glucocorticoid excess on skeletal muscle and heart protein synthesis in adult and old rats British Journal of Nutrition 1998 79 3 297 304 (Pubitemid 28142615)
49. Rieu I., Sornet C., Grizard J., Dardevet D., Glucocorticoid excess induces a prolonged leucine resistance on muscle protein synthesis in old rats Experimental Gerontology 2004 39 9 1315 1321 (Pubitemid 39360372)
50. Ershler W. B., Keller E. T., Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty Annual Review of Medicine 2000 51 245 270 (Pubitemid 30216036)
51. Krabbe K. S., Pedersen M., Bruunsgaard H., Inflammatory mediators in the elderly Experimental Gerontology 2004 39 5 687 699 (Pubitemid 38586809)
52. Cappola A. R., Xue Q. L., Ferrucci L., Guralnik J. M., Volpato S., Fried L. P., Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women Journal of Clinical Endocrinology and Metabolism 2003 88 5 2019 2025 (Pubitemid 36549871)
53. Taaffe D. R., Harris T. B., Ferrucci L., Rowe J., Seeman T. E., Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging Journals of Gerontology 2000 55 12 M709 M715
54. Hamer M., Molloy G. J., Association of C-reactive protein and muscle strength in the English Longitudinal Study of Ageing Age 2009 31 3 171 177
55. Haddad F., Zaldivar F., Cooper D. M., Adams G. R., IL-6-induced skeletal muscle atrophy Journal of Applied Physiology 2005 98 3 911 917 (Pubitemid 40283672)
56. Kohut M. L., McCann D. A., Russell D. W., Konopka D. N., Cunnick J. E., Franke W. D., Castillo M. C., Reighard A. E., Vanderah E., Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of -blockers, BMI, and psychosocial factors in older adults Brain, Behavior, and Immunity 2006 20 3 201 209
57. Stewart L. K., Flynn M. G., Campbell W. W., Craig B. A., Robinson J. P., Timmerman K. L., McFarlin B. K., Coen P. M., Talbert E., The influence of exercise training on inflammatory cytokines and C-reactive protein Medicine and Science in Sports and Exercise 2007 39 10 1714 1719 (Pubitemid 47511477)
58. Feldman H. A., Longcope C., Derby C. A., Johannes C. B., Araujo A. B., Coviello A. D., Bremner W. J., McKinlay J. B., Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts Male Aging Study Journal of Clinical Endocrinology and Metabolism 2002 87 2 589 598 (Pubitemid 34158223)
59. Morley J. E., Kaiser F. E., Perry H. M., Patrick P., Morley P. M. K., Stauber P. M., Vellas B., Baumgartner R. N., Garry P. J., Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men Metabolism 1997 46 4 410 413 (Pubitemid 27172090)
60. Morley J. E., Perry H. M., Androgens and women at the menopause and beyond Journals of Gerontology 2003 58 5 M409 M416
61. Urban R. J., Bodenburg Y. H., Gilkison C., Foxworth J., Coggan A. R., Wolfe R. R., Ferrando A., Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis American Journal of Physiology 1995 269 5 E820 E826
62. Bhasin S., Woodhouse L., Storer T. W., Proof of the effect of testosterone on skeletal muscle Journal of Endocrinology 2001 170 1 27 38 (Pubitemid 32677563)
63. Bakhshi V., Elliott M., Gentili A., Godschalk M., Mulligan T., Testosterone improves rehabilitation outcomes in ill older men Journal of the American Geriatrics Society 2000 48 5 550 553 (Pubitemid 30263108)
64. Ferrando A. A., Sheffield-Moore M., Yeckel C. W., Gilkison C., Jiang J., Achacosa A., Lieberman S. A., Tipton K., Wolfe R. R., Urban R. J., Testosterone administration to older men improves muscle function: molecular and physiological mechanisms American Journal of Physiology 2002 282 3 E601 E607
65. Morley J. E., Perry H. M. III, Androgen deficiency in aging men: role of testosterone replacement therapy Journal of Laboratory and Clinical Medicine 2000 135 5 370 378
66. Snyder P. J., Peachey H., Hannoush P., Berlin J. A., Loh L., Lenrow D. A., Holmes J. H., Dlewati A., Santanna J., Rosen C. J., Strom B. L., Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age Journal of Clinical Endocrinology and Metabolism 1999 84 8 2647 2653 (Pubitemid 30641987)
67. Bhasin S., Calof O. M., Storer T. W., Lee M. L., Mazer N. A., Jasuja R., Montori V. M., Gao W., Dalton J. T., Drug insight: testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging Nature Clinical Practice Endocrinology and Metabolism 2006 2 3 146 159
68. Sinha-Hikim I., Cornford M., Gaytan H., Lee M. L., Bhasin S., Effects of testosterone supplementation on skeletal muscle fiber hypertrophy and satellite cells in community-dwelling older men Journal of Clinical Endocrinology and Metabolism 2006 91 8 3024 3033 (Pubitemid 44271751)
69. Mudali S., Dobs A. S., Effects of testosterone on body composition of the aging male Mechanisms of Ageing and Development 2004 125 4 297 304 (Pubitemid 38438509)
70. Cadilla R. P., Turnbull P., Selective androgen receptor modulators in drug discovery: medicinal chemistry and therapeutic potential Current Topics in Medicinal Chemistry 2006 6 3 245 270
71. Labrie F., Luu-The V., Bélanger A., Lin S. X., Simard J., Pelletier G., Labrie C., Is dehydroepiandrosterone a hormone? Journal of Endocrinology 2005 187 2 169 196 (Pubitemid 41685178)
72. Baulieu E. E., Thomas G., Legrain S., Lahlou N., Roger M., Debuire B., Faucounau V., Girard L., Hervy M. P., Latour F., Leaud M. C., Mokrane A., Pitti-Ferrandi H., Trivalle C., De Lacharrire O., Nouveau S., Rakoto-Arison B., Souberbielle J. C., Raison J., Le Bouc Y., Raynaud A., Girerd X., Forette F., Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge study to a sociobiomedical issue Proceedings of the National Academy of Sciences of the United States of America 2000 97 8 4279 4284 (Pubitemid 30226124)
73. Dayal M., Sammel M. D., Zhao J., Hummel A. C., Vandenbourne K., Barnhart K. T., Supplementation with DHEA: effect on muscle size, strength, quality of life, and lipids Journal of Women's Health 2005 14 5 391 400 (Pubitemid 41052037)
74. Van Geel T. A. C. M., Geusen P. P., Winkens B., Sels J. P. J. E., Dinant G. J., Measures of bioavailable serum testosterone and estradiol and their relationships with muscle mass, muscle strength and bone mineral density in postmenopausal women: a cross-sectional study European Journal of Endocrinology 2009 160 4 681 687
75. Iannuzzi-Sucich M., Prestwood K. M., Kenny A. M., Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women Journals of Gerontology 2002 57 12 M772 M777
76. Baumgartner R. N., Waters D. L., Gallagher D., Morley J. E., Garry P. J., Predictors of skeletal muscle mass in elderly men and women Mechanisms of Ageing and Development 1999 107 2 123 136 (Pubitemid 29138849)
77. Roubenoff R., Catabolism of aging: is it an inflammatory process? Current Opinion in Clinical Nutrition and Metabolic Care 2003 6 3 295 299 (Pubitemid 40684606)
78. Brown M., Skeletal muscle and bone: effect of sex steroids and aging Advances in Physiology Education 2008 32 2 120 126
79. Falk R. T., Rossi S. C., Fears T. R., Sepkovic D. W., Migella A., Adlercreutz H., Donaldson J., Bradlow H. L., Ziegler R. G., A new ELISA kit for measuring urinary 2-hydroxyestrone, 16 -hydroxyestrone, and their ratio: reproducibility, validity, and assay performance after freeze-thaw cycling and preservation by boric acid Cancer Epidemiology Biomarkers and Prevention 2000 9 1 81 87 (Pubitemid 30062913)
80. Florini J. R., Ewton D. Z., Coolican S. A., Growth hormone and the insulin-like growth factor system in myogenesis Endocrine Reviews 1996 17 5 481 517 (Pubitemid 26346639)
81. Ho K. Y., Veldhuis J. D., Johnson M. L., Furlanetto R., Evans W. S., Alberti K. G. M. M., Thorner M. O., Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man Journal of Clinical Investigation 1988 81 4 968 975
82. Giustina A., Mazziotti G., Canalis E., Growth hormone, insulin-like growth factors, and the skeleton Endocrine Reviews 2008 29 5 535 559
83. Moran A., Jacobs D. R., Steinberger J., Cohen P., Hong C. P., Prineas R., Sinaiko A. R., Association between the insulin resistance of puberty and the insulin-like growth factor-I/growth hormone axis Journal of Clinical Endocrinology and Metabolism 2002 87 10 4817 4820 (Pubitemid 35247081)
84. Hermann M., Berger P., Hormonal changes in aging men: a therapeutic indication? Experimental Gerontology 2001 36 7 1075 1082 (Pubitemid 32515221)
85. Ryall J. G., Schertzer J. D., Lynch G. S., Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness Biogerontology 2008 9 4 213 228
86. Veldhuis J. D., Iranmanesh A., Physiological regulation of the human growth hormone (GH)-insulin-like growth factor type I (IGF-I) axis: predominant impact of age, obesity, gonadal function, and sleep Sleep 1996 19 10 S221 S224
87. Le Roith D., Bondy C., Yakar S., Liu J. L., Butler A., The somatomedin hypothesis Endocrine Reviews 2001 22 1 53 74
88. Andersen N. B., Andreassen T. T., Orskov H., Oxlund H., Growth hormone and mild exercise in combination increases markedly muscle mass and tetanic tension in old rats European Journal of Endocrinology 2000 143 3 409 418
89. Blackman M. R., Sorkin J. D., Mnzer T., Bellantoni M. F., Busby-Whitehead J., Stevens T. E., Jayme J., O'Connor K. G., Christmas C., Tobin J. D., Stewart K. J., Cottrell E., Clair C. S., Pabst K. M., Harman S. M., Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial Journal of the American Medical Association 2002 288 18 2282 2292 (Pubitemid 35291758)
90. Giannoulis M. G., Sonksen P. H., Umpleby M., Breen L., Pentecost C., Whyte M., McMillan C. V., Bradley C., Martin F. C., The effects of growth hormone and/or testosterone in healthy elderly men: a randomized controlled trial Journal of Clinical Endocrinology and Metabolism 2006 91 2 477 484 (Pubitemid 43236912)
91. Marcell T. J., Harman S. M., Urban R. J., Metz D. D., Rodgers B. D., Blackman M. R., Comparison of GH, IGF-I, and testosterone with mRNA of receptors and myostatin in skeletal muscle in older men American Journal of Physiology 2001 281 6 E1159 E1164
92. Ferrucci L., Penninx B. W. J. H., Volpato S., Harris T. B., Bandeen-Roche K., Balfour J., Leveille S. G., Fried L. P., Guralnik J. M., Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels Journal of the American Geriatrics Society 2002 50 12 1947 1954 (Pubitemid 35462439)
93. Philippou A., Maridaki M., Halapas A., Koutsilieris M., The role of the insulin-like growth factor 1 (IGF-1) in skeletal muscle physiology In Vivo 2007 21 1 45 54 (Pubitemid 46359198)
94. Butterfield G. E., Thompson J., Rennie M. J., Marcus R., Hintz R. L., Hoffman A. R., Effect of rhGH and rhIGF-I treatment on protein utilization in elderly women American Journal of Physiology 1997 272 1 E94 E99
95. Evans W. J., Paolisso G., Abbatecola A. M., Corsonello A., Bustacchini S., Strollo F., Lattanzio F., Frailty and muscle metabolism dysregulation in the elderly Biogerontology 2010 11 5 527 536
96. Dardevet D., Sornet C., Attaix D., Baracos V. E., Grizard J., Insulin-like growth factor-1 and insulin resistance in skeletal muscles of adult and old rats Endocrinology 1994 134 3 1475 1484 (Pubitemid 24085607)
97. Martineau L. C., Chadan S. G., Parkhouse W. S., Age-associated alterations in cardiac and skeletal muscle glucose transporters, insulin and IGF-1 receptors, and PI3-kinase protein contents in the C57BL/6 mouse Mechanisms of Ageing and Development 1999 106 3 217 232 (Pubitemid 29083086)
98. Arvat E., Broglio F., Ghigo E., Insulin-like growth factor I: implications in aging Drugs and Aging 2000 16 1 29 40 (Pubitemid 30052707)
99. Wilkes E. A., Selby A. L., Atherton P. J., Patel R., Rankin D., Smith K., Rennie M. J., Blunting of insulin inhibition of proteolysis in legs of older subjects may contribute to age-related sarcopenia American Journal of Clinical Nutrition 2009 90 5 1343 1350
100. Kojima M., Kangawa K., Ghrelin: structure and function Physiological Reviews 2005 85 2 495 522 (Pubitemid 40404635)
101. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K., Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 1999 402 6762 656 660 (Pubitemid 129516334)
102. Dixit V. D., Schaffer E. M., Pyle R. S., Collins G. D., Sakthivel S. K., Palaniappan R., Lillard J. W., Taub D. D., Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells Journal of Clinical Investigation 2004 114 1 57 66 (Pubitemid 39071644)
103. Akamizu T., Kangawa K., Ghrelin for cachexia Journal of Cachexia, Sarcopenia, and Muscle 2010 1 2 169 176
104. Nagaya N., Itoh T., Murakami S., Oya H., Uematsu M., Miyatake K., Kangawa K., Treatment of cachexia with ghrelin in patients with COPD Chest 2005 128 3 1187 1193 (Pubitemid 41324394)
105. Nagaya N., Moriya J., Yasumura Y., Uematsu M., Ono F., Shimizu W., Ueno K., Kitakaze M., Miyatake K., Kangawa K., Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure Circulation 2004 110 24 3674 3679 (Pubitemid 39665256)
106. Bach M. A., Rockwood K., Zetterberg C., Thamsborg G., Hébert R., Devogelaer J. P., Christiansen J. S., Rizzoli R., Ochsner J. L., Beisaw N., Gluck O., Yu L., Schwab T., Farrington J., Taylor A. M., Ng J., Fuh V., The Effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture Journal of the American Geriatrics Society 2004 52 4 516 523 (Pubitemid 38480627)
107. Holick M. F., Vitamin D deficiency New England Journal of Medicine 2007 357 3 266 281
108. DeLuca H. F., Overview of general physiologic features and functions of vitamin D The American Journal of Clinical Nutrition 2004 80 6 1689S 1696S
109. Gloth F. M. III, Gundberg C. M., Hollis B. W., Haddad J. G., Tobin J. D., Vitamin D deficiency in homebound elderly persons Journal of the American Medical Association 1995 274 21 1683 1686
110. Goldray D., Mizrahi-Sasson E., Merdler C., Edelstein-Singer M., Algoetti A., Eisenberg Z., Jaccard N., Weisman Y., Vitamin D deficiency in elderly patients in a general hospital Journal of the American Geriatrics Society 1989 37 7 589 592 (Pubitemid 19167803)
111. Wicherts I. S., Van Schoor N. M., Boeke A. J. P., Visser M., Deeg D. J. H., Smit J., Knol D. L., Lips P., Vitamin D status predicts physical performance and its decline in older persons Journal of Clinical Endocrinology and Metabolism 2007 92 6 2058 2065 (Pubitemid 46997101)
112. Bischoff-Ferrari H. A., Borchers M., Gudat F., Drmller U., Sthelin H. B., Dick W., Vitamin D receptor expression in human muscle tissue decreases with age Journal of Bone and Mineral Research 2004 19 2 265 269 (Pubitemid 38116740)
113. Sato Y., Iwamoto J., Kanoko T., Satoh K., Low-dose vitamin D prevents muscular atrophy and reduces falls and hip fractures in women after stroke: a randomized controlled trial Cerebrovascular Diseases 2005 20 3 187 192 (Pubitemid 41254180)
114. Montero-Odasso M., Duque G., Vitamin D in the aging musculoskeletal system: an authentic strength preserving hormone Molecular Aspects of Medicine 2005 26 3 203 219 (Pubitemid 40462027)
115. Yoshikawa S., Nakamura T., Tanabe H., Imamura T., Osteomalacic myopathy Endocinological Japan 1979 26 65 72
116. Sorensen O. H., Lund Bi., Saltin B., Myopathy in bone loss of ageing: improvement by treatment with 1 -hydroxycholecalciferol and calcium Clinical Science 1979 56 2 157 161 (Pubitemid 10072237)
117. Faulkner K. A., Cauley J. A., Zmuda J. M., Landsittel D. P., Newman A. B., Studenski S. A., Redfern M. S., Ensrud K. E., Fink H. A., Lane N. E., Nevitt M. C., Higher 1, 25-dihydroxyvitamin D3 concentrations associated with lower fall rates in older community-dwelling women Osteoporosis International 2006 17 9 1318 1328 (Pubitemid 44127318)
118. Flicker L., Mead K., MacInnis R. J., Nowson C., Scherer S., Stein M. S., Thomas J., Hopper J. L., Wark J. D., Serum vitamin D and falls in older women in residential care in Australia Journal of the American Geriatrics Society 2003 51 11 1533 1538 (Pubitemid 37409586)
119. Snijder M. B., Van Schoor N. M., Pluijm S. M. F., Van Dam R. M., Visser M., Lips P., Vitamin D status in relation to one-year risk of recurrent falling in older men and women Journal of Clinical Endocrinology and Metabolism 2006 91 8 2980 2985 (Pubitemid 44271745)
120. Annweiler C., Schott A. M., Berrut G., Fantino B., Beauchet O., Vitamin D-related changes in physical performance: a systematic review Journal of Nutrition, Health and Aging 2009 13 10 893 898
121. Bischoff-Ferrari H. A., Dawson-Hughes B., Staehelin H. B., Orav J. E., Stuck A. E., Theiler R., Wong J. B., Egli A., Kiel D. P., Henschkowski J., Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials British Medical Journal 2009 339 b3692
122. Ceglia L., Vitamin D and its role in skeletal muscle Current Opinion in Clinical Nutrition and Metabolic Care 2009 12 6 628 633
123. Dawson-Hughes B., Serum 25-hydroxyvitamin D and functional outcomes in the elderly American Journal of Clinical Nutrition 2008 88 2 537S 540S
124. Pfeifer M., Begerow B., Minne H. W., Suppan K., Fahrleitner-Pammer A., Dobnig H., Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals Osteoporosis International 2009 20 2 315 322
125. Jackson C., Gaugris S., Sen S. S., Hosking D., The effect of cholecalciferol (vitamin D3) on the risk of fall and fracture: a meta-analysis Quarterly Journal of Medicine 2007 100 4 185 192 (Pubitemid 47061686)
126. Latham N. K., Anderson C. S., Reid I. R., Effects of vitamin D supplementation on strength, physical performance, and falls in older persons: a systematic review Journal of the American Geriatrics Society 2003 51 9 1219 1226 (Pubitemid 37093570)
127. Sanders K. M., Stuart A. L., Williamson E. J., Simpson J. A., Kotowicz M. A., Young D., Nicholson G. C., Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial Journal of the American Medical Association 2010 303 18 1815 1822
128. Cesari M., Incalzi R. A., Zamboni V., Pahor M., Vitamin D hormone: a multitude of actions potentially influencing the physical function decline in older persons Geriatrics and Gerontology International 2011 11 2 133 142