Subcellular effects of myocyte-specific androgen receptor overexpression in mice

Journal of Endocrinology

Volumn 210, Issue 1, 2011, Pages 93-104

  Musa, Mutaz ^a   Fernando, Shannon M ^a   Chatterjee, Diptendu ^b   Monks, D Ashley ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; GLYCOGEN; TESTOSTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ATROPHY; CELL STRUCTURE; CONTROLLED STUDY; ELECTRON TRANSPORT; EXTENSOR DIGITORUM LONGUS MUSCLE; FEMALE; GENE OVEREXPRESSION; GLYCOGEN METABOLISM; HYPERMETABOLISM; MALE; MITOCHONDRIAL VOLUME; MOUSE; MUSCLE ATROPHY; MUSCLE FIBRIL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ANIMALS; ATROPHY; BASAL METABOLISM; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; FEMALE; GENE DOSAGE; GENE EXPRESSION; GLYCOGEN; MALE; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA, MUSCLE; MUSCLE PROTEINS; MUSCLE, SKELETAL; MYOFIBRILS; NEUROMUSCULAR DISEASES; RECEPTORS, ANDROGEN; SEX FACTORS; TESTOSTERONE;

EID: 79960287252     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-11-0071     Document Type: Article

References (51)

1. Arnold AP. 2009 The organizational-activational hypothesis as the foundation for a unified theory of sexual differentiation of all mammalian tissues. Hormones and Behavior 55 570-578.
2. Basaria S, Lieb J II, Tang AM, DeWeese T, Carducci M, Eisenberger M & Dobs AS. 2002 Long-term effects of androgen deprivation therapy in prostate cancer patients. Clinical Endocrinology 56 779-786.
3. Basaria S, Coviello AD, Travison TG, Storer TW, Farwell WR, Jette AM, Eder R, Tennstedt S, Ulloor J, Zhang A et al.. 2010 Adverse events associated with testosterone administration. New England Journal of Medicine 363 109-122.
4. Beauchemin AM, Gottlieb B, Beitel LK, Elhaji YA, Pinsky L & Trifiro MA. 2001 Cytochrome c oxidase subunit Vb interacts with human androgen receptor: a potential mechanism for neurotoxicity in spinobulbar muscular atrophy. Brain Research Bulletin 56 285-297.
5. Bergamini E. 1975 Different mechanisms in testosterone action on glycogen metabolism in rat perineal and skeletal muscles. Endocrinology 96 77-84.
6. Bhasin S, Storer TW, Berman N, Callegari C, Clevenger B, Phillips J, Bunnell TJ, Tricker R, Shirazi A & Casaburi R. 1996 The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men. New England Journal of Medicine 335 1-7.
7. Bhasin S, Woodhouse L, Casaburi R, Singh AB, Mac RP, Lee M, Yarasheski KE, Sinha-Hikim I, Dzekov C, Dzekov J et al.. 2005 Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle. Journal of Clinical Endocrinology and Metabolism 90 678-688.
8. Chambon C, Duteil D, Vignaud A, Ferry A, Messaddeq N, Malivindi R, Kato S, Chambon P. & Metzger D 2010 Myocytic androgen receptor controls the strength but not the mass of limb muscles. PNAS 107 14327-14332.
9. Cunha TS, Tanno AP, Costa Sampaio Moura MJ & Marcondes FK. 2005 Influence of high-intensity exercise training and anabolic androgenic steroid treatment on rat tissue glycogen content. Life Sciences 77 1030-1043.
10. Duteil D, Chambon C, Ali F, Malivindi R, Zoll J, Kato S, Geny B, Chambon P & Metzger D. 2010 The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles. Cell Metabolism 12 496-508.
11. Fairchild TJ & Fournier PA. 2004 Glycogen determination using periodic acid-Schiff: artifact of muscle preparation. Medicine and Science in Sports and Exercise 36. 2053-2058.
12. Ferrando AA, Sheffield-Moore M, Yeckel CW, Gilkison C, Jiang J, Achacosa A, Lieberman SA, Tipton K, Wolfe RR & Urban RJ. 2002 Testosterone administration to older men improves muscle function: molecular and physiological mechanisms. American Journal of Physiology. Endocrinology and Metabolism 282 E601-E607.
13. Ferrando AA, Sheffield-Moore M, Paddon-Jones D, Wolfe RR & Urban RJ. 2003 Differential anabolic effects of testosterone and amino acid feeding in older men. Journal of Clinical Endocrinology and Metabolism 88 358-362.
14. Fernando SM, Rao P, Niel L, Chatterjee D, Stagljar M & Monks DA. 2010 Myocyte androgen receptors increase metabolic rate and improve body composition by reducing fat mass. Endocrinology 151 3125-3132.
15. Forbes GB, Porta CR, Herr BE & Griggs RC. 1992 Sequence of changes in body composition induced by testosterone and reversal of changes after drug is stopped. Journal of the American Medical Association 267 397-399.
16. Hartgens F, van Straaten H, Fideldij S, Rietjens G, Keizer HA & Kuipers H. 2002 Misuse of androgenic-anabolic steroids and human deltoid muscle fibers: differences between polydrug regimens and single drug administration. European Journal of Applied Physiology 86 233-239.
17. Herbst KL & Bhasin S. 2004 Testosterone action on skeletal muscle. Current Opinion in Clinical Nutrition and Metabolic Care 7 271-277.
18. Huguenard AL, Fernando SM, Monks DA & Sengelaub DR. 2011 Overexpression of androgen receptors in target musculature confers androgen sensitivity to motoneuron dendrites. Endocrinology 152 639-650.
19. Johansen JA, Yu Z, Mo K, Monks DA, Lieberman AP, Breedlove SM & Jordan CL. 2009 Recovery of function in a myogenic mouse model of spinal bulbar muscular atrophy. Neurobiology of Disease 34 113-120.
20. Kirby DM, Thorburn DR, Turnbull DM & Taylor RW. 2007 Biochemical assays of respiratory chain complex activity. Methods in Cell Biology 80 93-119.
21. Koenig H, Goldstone A & Lu CY. 1980 Androgens regulate mitochondrial cytochrome c oxidase and lysosomal hydrolases in mouse skeletal muscle. Biochemical Journal. 192 349-353.
22. van der Laarse WJ, van Noort P & Diegenbach PC. 1992 Calibration of quantitative histochemical methods: estimation of glycogen content of muscle fibers using the PAS reaction. Biotechnic and Histochemistry 67 303-308.
23. Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN et al.. 2002 Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 418 797-801.
24. MacLean HE, Chiu WS, Notini AJ, Axell AM, Davey RA, McManus JF, Ma C, Plant DR, Lynch GS & Zajac JD. 2008 Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice. FASEB Journal 22 2676-2689.
25. MacLean HE & Handelsman DJ. 2009 Unraveling androgen action in muscle: genetic tools probing cellular mechanisms. Endocrinology 150 3437-3439.
26. Marin P, Krotkiewski M & Bjorntorp P. 1992 Androgen treatment of middleaged, obese men: effects on metabolism, muscle and adipose tissues. European Journal of Medicine 1 329-336.
27. Mauras N, Hayes V, Welch S, Rini A, Helgeson K, Dokler M, Veldhuis JD & Urban RJ. 1998 Testosterone deficiency in young men: marked alterations in whole body protein kinetics, strength, and adiposity. Journal of Clinical Endocrinology and Metabolism 83 1886-1892.
28. Milanesi L, Vasconsuelo A, de Boland AR & Boland R. 2009 Expression and subcellular distribution of native estrogen receptor beta in murine C2C12 cells and skeletal muscle tissue. Steroids 74 489-497.
29. Mo K, Razak Z, Rao PR, Yu Z, Adachi H, Katsuno M, Sobue G, Lieberman AP, Westwood JT & Monks DA. 2010 Microarray analysis of gene expression by skeletal muscle of three mouse models of Kennedy disease/spinal bulbar muscular atrophy. PLoS ONE 5 1-8.
30. Monks DA, O'Bryant EL & Jordan CL. 2004 Androgen receptor immunoreactivity in skeletal muscle: enrichment at the neuromuscular junction. Journal of Comparative Neurology 473 59-72.
31. Monks DA, Johansen JA, Mo K, Rao P, Eagleson B, Yu Z, Lieberman AP, Breedlove SM & Jordan CL. 2007 Overexpression of wild-type androgen receptor in muscle recapitulates polyglutamine disease. PNAS 104 18259-18264.
32. Monks DA, Rao P, Mo K, Johansen J, Lewis G & Kemp M. 2008 Androgen receptor and Kennedy disease/spinal bulbar muscular atrophy. Hormones and Behavior 53 729-740.
33. Niel L, Shah AH, Lewis GA, Mo K, Chatterjee D, Fernando SM, Hong MH, Chang WY, Vollmayr P, Rosen J et al.. 2009 Sexual differentiation of the spinal nucleus of the bulbocavernosus is not mediated solely by androgen receptors in muscle fibers. Endocrinology 150 3207-3213.
34. Oner J, Oner H, Sahin Z, Demir R & Ustunel I. 2008 Melatonin is as effective as testosterone in the prevention of soleus muscle atrophy induced by castration in rats. Anatomical Record 291 448-455.
35. Ophoff J, Van Proeyen K, Callewaert F, De Gendt K, De Bock K, Van den Bosch A, Verhoeven G, Hespel P & Vanderschueren D. 2009 Androgen signaling in myocytes contributes to the maintenance of muscle mass and fiber type regulation but not to muscle strength or fatigue. Endocrinology 150 3558-3566.
36. Orr R & Fiatarone SinghM .2004 The anabolic androgenic steroid oxandrolone in the treatment of wasting and catabolic disorders: review of efficacy and safety. Drugs 64 725-750.
37. Pansarasa O, D'Antona G, Gualea MR, Marzani B, Pellegrino MA & Marzatico F. 2002 "Oxidative stress": effects of mild endurance training and testosterone treatment on rat gastrocnemius muscle. European Journal of Applied Physiology 87 550-555.
38. Pitteloud N, Mootha VK, Dwyer AA, Hardin M, Lee H, Eriksson KF, Tripathy D, Yialamas M, Groop L, Elahi D et al.. 2005 Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men. Diabetes Care 28 1636-1642.
39. Rabiee A, Dwyer AA, Caronia LM, Hayes FJ, Yialamas MA, Andersen DK, Thomas B, Torriani M & Elahi D. 2010 Impact of acute biochemical castration on insulin sensitivity in healthy adult men. Endocrine Research 35 71-84.
40. Scheller K, Sekeris CE, Krohne G, Hock R, Hansen IA & Scheer U. 2000 Localization of glucocorticoid hormone receptors in mitochondria of human cells. European Journal of Cell Biology 79 299-307.
41. Schroeder ET, Singh A, Bhasin S, Storer TW, Azen C, Davidson T, Martinez C, Sinha-Hikim I, Jaque SV, Terk M et al.. 2003 Effects of an oral androgen on muscle and metabolism in older, community-dwelling men. American Journal of Physiology. Endocrinology and Metabolism 284 E120-E128.
42. Storer TW, Magliano L, Woodhouse L, Lee ML, Dzekov C, Dzekov J, Casaburi R & Bhasin S. 2003 Testosterone dose-dependently increases maximal voluntary strength and leg power, but does not affect fatigability or specific tension. Journal of Clinical Endocrinology and Metabolism 88 1478-1485.
43. Storer TW, Woodhouse L, Magliano L, Singh AB, Dzekov C, Dzekov J & Bhasin S. 2008 Changes in muscle mass, muscle strength, and power but not physical function are related to testosterone dose in healthy older men. Journal of the American Geriatrics Society 56. 1991-1999.
44. Ustunel I, Akkoyunlu G & Demir R. 2003 The effect of testosterone on gastrocnemius muscle fibres in growing and adult male and female rats: a histochemical, morphometric and ultrastructural study. Anatomia, Histologia, Embryologia 32 70-79.
45. Venable JH. 1966 Morphology of the cells of normal, testosterone-deprived and testosterone-stimulated levator ani muscles. American Journal of Anatomy 119 271-301.
46. Wang C, Cunningham G, Dobs A, Iranmanesh A, Matsumoto AM, Snyder PJ, Weber T, Berman N, Hull L & Swerdloff RS. 2004 Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men. Journal of Clinical Endocrinology and Metabolism 89. 2085-2098.
47. Weber K, Bruck P, Mikes Z, Küpper JH, Klingenspor M & Wiesner RJ. 2002 Glucocorticoid hormone stimulates mitochondrial biogenesis specifically in skeletal muscle. Endocrinology 143 177-184.
48. Weibel ER. 1979 Stereological methods, volume 1, practical methods for Biological morphometry. London: Academic Press.
49. Welle S, Jozefowicz R, Forbes G & Griggs RC. 1992 Effect of testosterone on metabolic rate and body composition in normal men and men with muscular dystrophy. Journal of Clinical Endocrinology and Metabolism 74 332-335.
50. Welle S, Tawil R & Thornton CA. 2008 Sex-related differences in gene expression in human skeletal muscle. PLoS ONE 3 e1385.
51. Woodhouse LJ, Reisz-Porszasz S, Javanbakht M, Storer TW, Lee M, Zerounian H & Bhasin S. 2003 Development of models to predict anabolic response to testosterone administration in healthy young men. American Journal of Physiology. Endocrinology and Metabolism 284 E1009-E1017.