메뉴 건너뛰기




Volumn 19, Issue 4, 2013, Pages 631-640

HSP90: Chaperone-me-not

Author keywords

Cancer hallmarks; Client proteins; Hsp90; Hsp90 inhibitors; Inhibitor classes; Tumor selectivity

Indexed keywords

ALVESPIMYCIN; ANSAMYCIN DERIVATIVE; BORTEZOMIB; CELL CYCLE PROTEIN; CHAPERONE; CISPLATIN; CNF 1010; COUMARIN DERIVATIVE; DIHYDROINDAZOLONE DERIVATIVE; EPIGALLOCATECHIN GALLATE; GANETESPIB; GEDUNIN; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; ISOFLAVONE DERIVATIVE; ISOXAZOLE DERIVATIVE; PACLITAXEL; POCHONIN A; PROTEIN KINASE; PURINE DERIVATIVE; PYRAZOLE DERIVATIVE; RADICICOL DERIVATIVE; REGULATOR PROTEIN; RETASPIMYCIN; SANSALVAMIDE A; SORAFENIB; STEROID RECEPTOR; TANESPIMYCIN; TRANSCRIPTION FACTOR; TRASTUZUMAB; TRIPTERINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84885180767     PISSN: 12194956     EISSN: 15322807     Source Type: Journal    
DOI: 10.1007/s12253-013-9675-4     Document Type: Review
Times cited : (25)

References (73)
  • 1
    • 0742287264 scopus 로고    scopus 로고
    • Heat shock protein 90
    • 14624223 1:CAS:528:DC%2BD3sXptVCmsbg%3D
    • Neckers L, Ivy SP (2003) Heat shock protein 90. Curr Opin Oncol 15:419-424
    • (2003) Curr Opin Oncol , vol.15 , pp. 419-424
    • Neckers, L.1    Ivy, S.P.2
  • 3
    • 0042885973 scopus 로고    scopus 로고
    • The Hsp90 chaperone complex as a novel target for cancer therapy
    • 12881371 1:STN:280:DC%2BD3szkvVaktA%3D%3D
    • Goetz MP, Toft DO, Ames MM, Erichman C (2003) The Hsp90 chaperone complex as a novel target for cancer therapy. Ann Oncol 14:1169-1176
    • (2003) Ann Oncol , vol.14 , pp. 1169-1176
    • Goetz, M.P.1    Toft, D.O.2    Ames, M.M.3    Erichman, C.4
  • 4
    • 62949238913 scopus 로고    scopus 로고
    • New developments in Hsp90 inhibitors as anti-cancer therapeutics: Mechanisms, clinical perspective and more potential
    • 19179103 1:CAS:528:DC%2BD1MXjvVans78%3D
    • Li Y, Zhang T, Sun D (2009) New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential. Drug Resist Updat 12(1-2):17-27
    • (2009) Drug Resist Updat , vol.12 , Issue.1-2 , pp. 17-27
    • Li, Y.1    Zhang, T.2    Sun, D.3
  • 5
    • 49649117517 scopus 로고    scopus 로고
    • The Hsp90 chaperone machinery
    • 10.1074/jbc.R800007200 18442971 1:CAS:528:DC%2BD1cXnsl2rtb0%3D
    • Wandinger SK, Richter K, Buchner J (2008) The Hsp90 chaperone machinery. J Biol Chem 283:18473-18477. doi: 10.1074/jbc.R800007200
    • (2008) J Biol Chem , vol.283 , pp. 18473-18477
    • Wandinger, S.K.1    Richter, K.2    Buchner, J.3
  • 7
    • 41149111451 scopus 로고    scopus 로고
    • The Hsp90 molecular chaperone: An open and shut case for treatment
    • 18290764 1:CAS:528:DC%2BD1cXisVWgtrs%3D
    • Pearl LH, Prodromou C, Workman P (2008) The Hsp90 molecular chaperone: an open and shut case for treatment. Biochem J 410:439-453
    • (2008) Biochem J , vol.410 , pp. 439-453
    • Pearl, L.H.1    Prodromou, C.2    Workman, P.3
  • 8
    • 34948893963 scopus 로고    scopus 로고
    • Structures of GRP94-nucleotide complexes reveal mechanistic differences between the hsp90 chaperones
    • 17936703 1:CAS:528:DC%2BD2sXht1Kmsr%2FL
    • Dollins ED, Warren JJ, Immormino RM, Gewirth DT (2007) Structures of GRP94-nucleotide complexes reveal mechanistic differences between the hsp90 chaperones. Mol Cell 28:41-56
    • (2007) Mol Cell , vol.28 , pp. 41-56
    • Dollins, E.D.1    Warren, J.J.2    Immormino, R.M.3    Gewirth, D.T.4
  • 9
    • 84857994615 scopus 로고    scopus 로고
    • HSP90 inhibition: Two-pronged exploitation of cancer dependencies
    • (in press)
    • Travers J, Sharp S, Workman P (2012) HSP90 inhibition: two-pronged exploitation of cancer dependencies. Drug Discov Today 00 (00) (in press)
    • (2012) Drug Discov Today 00 (00)
    • Travers, J.1    Sharp, S.2    Workman, P.3
  • 10
    • 1542322900 scopus 로고    scopus 로고
    • Why target apoptosis in cancer treatment?
    • 12813137 1:CAS:528:DC%2BD3sXlslWktL8%3D
    • Kasibhatla S, Tseng B (2003) Why target apoptosis in cancer treatment? Mol Cancer Ther 2:573-580
    • (2003) Mol Cancer Ther , vol.2 , pp. 573-580
    • Kasibhatla, S.1    Tseng, B.2
  • 11
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • 10647931 1:CAS:528:DC%2BD3cXks1CktA%3D%3D
    • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57-70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 12
    • 79952284127 scopus 로고    scopus 로고
    • The hallmarks of cancer: The next generation
    • 10.1016/j.cell.2011.02.013 21376230 1:CAS:528:DC%2BC3MXjsFeqtrk%3D
    • Hanahan D, Weinberg RA (2011) The hallmarks of cancer: the next generation. Cell 144:646-674. doi: 10.1016/j.cell.2011.02.013
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 13
    • 4143095430 scopus 로고    scopus 로고
    • Altered Hsp90 function in cancer: A unique therapeutic opportunity
    • 15299085 1:CAS:528:DC%2BD2cXmtleksL4%3D
    • Bagatell R, Whitesell L (2004) Altered Hsp90 function in cancer: a unique therapeutic opportunity. Mol Cancer Ther 3(8):1021-1030
    • (2004) Mol Cancer Ther , vol.3 , Issue.8 , pp. 1021-1030
    • Bagatell, R.1    Whitesell, L.2
  • 15
    • 35348890981 scopus 로고    scopus 로고
    • Drugging the cancer chaperone HSP90: Combinatorial therapeutic exploitation of oncogene addiction and tumor stress
    • 17513464 1:CAS:528:DC%2BD2sXhsVanurfF
    • Workman P, Burrows F, Neckers L, Rosen N (2007) Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress. Ann N Y Acad Sci 1113:202-216
    • (2007) Ann N y Acad Sci , vol.1113 , pp. 202-216
    • Workman, P.1    Burrows, F.2    Neckers, L.3    Rosen, N.4
  • 16
    • 65449120730 scopus 로고    scopus 로고
    • Extracellular Hsp90: An emerging target for cancer therapy
    • 1:CAS:528:DC%2BD1MXkvVSntrg%3D
    • Sidera K, Patsavoudi E (2009) Extracellular Hsp90: an emerging target for cancer therapy. Curr Signal Transduct Ther 4:51-58
    • (2009) Curr Signal Transduct Ther , vol.4 , pp. 51-58
    • Sidera, K.1    Patsavoudi, E.2
  • 17
    • 1642268986 scopus 로고    scopus 로고
    • Hsp90 isoforms: Functions, expression and clinical importance
    • 15069952
    • Sreedhar AS, Kalmar E, Csermely P, Shen YF (2004) Hsp90 isoforms: functions, expression and clinical importance. FEBS Lett 562:11-15
    • (2004) FEBS Lett , vol.562 , pp. 11-15
    • Sreedhar, A.S.1    Kalmar, E.2    Csermely, P.3    Shen, Y.F.4
  • 18
    • 0036219609 scopus 로고    scopus 로고
    • Hsp90 inhibitors as novel cancer chemotherapeutic agents
    • 11927289 1:CAS:528:DC%2BD38XitlGhsb4%3D
    • Neckers L (2002) Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol Med 8:S55-S61
    • (2002) Trends Mol Med , vol.8
    • Neckers, L.1
  • 19
    • 1542298267 scopus 로고    scopus 로고
    • Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone
    • 15013520 1:CAS:528:DC%2BD2cXhvFaiu7s%3D
    • Workman P (2004) Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone. Cancer Lett 206:149-157
    • (2004) Cancer Lett , vol.206 , pp. 149-157
    • Workman, P.1
  • 20
    • 0031895351 scopus 로고    scopus 로고
    • The Hsp90 based chaperone system: Involvement in signal transduction from a variety of hormone and growth factor receptors
    • 9521088 1:CAS:528:DyaK1cXitVWlsr0%3D
    • Pratt WB (1998) The Hsp90 based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors. Proc Soc Exp Biol Med 217:420-434
    • (1998) Proc Soc Exp Biol Med , vol.217 , pp. 420-434
    • Pratt, W.B.1
  • 21
    • 34248187981 scopus 로고    scopus 로고
    • Heat shock protein 90: The cancer chaperone
    • 17536171 1:CAS:528:DC%2BD2sXmsFamu7k%3D
    • Neckers L (2007) Heat shock protein 90: the cancer chaperone. J Biosci 32:517-530
    • (2007) J Biosci , vol.32 , pp. 517-530
    • Neckers, L.1
  • 22
    • 0038668000 scopus 로고    scopus 로고
    • Escaping cell death: Survival proteins in cancer
    • 10094811 1:CAS:528:DyaK1MXitVWns7k%3D
    • Jaattela M (1999) Escaping cell death: survival proteins in cancer. Exp Cell Res 248:30-43
    • (1999) Exp Cell Res , vol.248 , pp. 30-43
    • Jaattela, M.1
  • 23
    • 41149084179 scopus 로고    scopus 로고
    • Eph-ephrin bi-directional signaling in physiology and disease
    • 18394988 1:CAS:528:DC%2BD1cXkslOlu7o%3D
    • Pasquale EB (2008) Eph-ephrin bi-directional signaling in physiology and disease. Cell 133(1):38-52
    • (2008) Cell , vol.133 , Issue.1 , pp. 38-52
    • Pasquale, E.B.1
  • 24
    • 77955348541 scopus 로고    scopus 로고
    • Hsp90 as a gatekeeper of tumor angiogenesis: Clinical promise and potential pitfalls
    • 10.1155/2010/412985 20628489
    • Bohonowych JE, Gopal U, Issacs JS (2010) Hsp90 as a gatekeeper of tumor angiogenesis: clinical promise and potential pitfalls. J Oncol. doi: 10.1155/2010/412985
    • (2010) J Oncol
    • Bohonowych, J.E.1    Gopal, U.2    Issacs, J.S.3
  • 25
    • 33846861747 scopus 로고    scopus 로고
    • Targeting the multiple signaling pathways by heat shock protein 90 molecular chaperone inhibitors
    • Powers MV, Workman P (2006) Targeting the multiple signaling pathways by heat shock protein 90 molecular chaperone inhibitors. Endocr Relat Cancer 13(1):125-135
    • (2006) Endocr Relat Cancer , vol.13 , Issue.1 , pp. 125-135
    • Powers, M.V.1    Workman, P.2
  • 26
    • 33746379315 scopus 로고    scopus 로고
    • Using natural product inhibitors to validate HSP90 as a molecular target in cancer
    • 1:CAS:528:DC%2BD28Xpt1ejtL4%3D
    • Neckers L (2006) Using natural product inhibitors to validate HSP90 as a molecular target in cancer. Curr Med Chem 6:1163-1171
    • (2006) Curr Med Chem , vol.6 , pp. 1163-1171
    • Neckers, L.1
  • 27
    • 4344674482 scopus 로고    scopus 로고
    • Targeting multiple signal transduction pathways through inhibition of Hsp90
    • 15168026 1:CAS:528:DC%2BD2cXmt1Kktrs%3D
    • Zhang H, Burrows F (2004) Targeting multiple signal transduction pathways through inhibition of Hsp90. J Mol Med 82:488-499
    • (2004) J Mol Med , vol.82 , pp. 488-499
    • Zhang, H.1    Burrows, F.2
  • 28
    • 65549114190 scopus 로고    scopus 로고
    • Human 90Kda Heat shock protein Hsp90 as a target for cancer therapeutics
    • 1:CAS:528:DC%2BD1MXks1Cgtrg%3D
    • Gava LM, Ramos CHI (2009) Human 90Kda Heat shock protein Hsp90 as a target for cancer therapeutics. Curr Chem Biol 3:330-341
    • (2009) Curr Chem Biol , vol.3 , pp. 330-341
    • Gava, L.M.1    Ramos, C.H.I.2
  • 29
    • 21244446219 scopus 로고    scopus 로고
    • Heat shock protein 90 inhibitors in antineoplastic therapy: Is it all wrapped up?
    • Issacs JS (2005) Heat shock protein 90 inhibitors in antineoplastic therapy: is it all wrapped up? Expert Opin Investig Drugs 14(6):569-589
    • (2005) Expert Opin Investig Drugs , vol.14 , Issue.6 , pp. 569-589
    • Issacs, J.S.1
  • 30
    • 33747886236 scopus 로고    scopus 로고
    • Molecular biology of cancer
    • 2nd edn. Oxford University Press
    • Pecorino L (2008) Molecular biology of cancer. Mechanisms, targets and therpeutics, 2nd edn. Oxford University Press
    • (2008) Mechanisms, Targets and Therpeutics
    • Pecorino, L.1
  • 32
    • 0141484615 scopus 로고    scopus 로고
    • A high-affinity conformation of Hsp90 confers tumor selectivity on Hsp90 inhibitors
    • 14508491 1:CAS:528:DC%2BD3sXnsV2kt7w%3D
    • Kamal A, Thao L, Sensintaffar J, Zhang L, Boehm MF, Fritz LC, Burrows FJ (2003) A high-affinity conformation of Hsp90 confers tumor selectivity on Hsp90 inhibitors. Nature 425:407-410
    • (2003) Nature , vol.425 , pp. 407-410
    • Kamal, A.1    Thao, L.2    Sensintaffar, J.3    Zhang, L.4    Boehm, M.F.5    Fritz, L.C.6    Burrows, F.J.7
  • 33
    • 0043269344 scopus 로고    scopus 로고
    • Auditing the pharmacological accounts for hsp90 molecular chaperone inhibitors: Unfolding the relationship between pharmacokinetics and pharmacodynamics
    • 12589030 1:CAS:528:DC%2BD3sXht1Wktb0%3D
    • Workman P (2003) Auditing the pharmacological accounts for hsp90 molecular chaperone inhibitors: unfolding the relationship between pharmacokinetics and pharmacodynamics. Mol Cancer Ther 2:131-138
    • (2003) Mol Cancer Ther , vol.2 , pp. 131-138
    • Workman, P.1
  • 34
    • 0141596941 scopus 로고    scopus 로고
    • Overview: Translating Hsp90 biology into Hsp90 drugs
    • 14529382 1:CAS:528:DC%2BD3sXnsV2isro%3D
    • Workman P (2003) Overview: translating Hsp90 biology into Hsp90 drugs. Curr Cancer Drug Targets 3:297-300
    • (2003) Curr Cancer Drug Targets , vol.3 , pp. 297-300
    • Workman, P.1
  • 35
    • 33845302853 scopus 로고    scopus 로고
    • Tumor selectivity of Hsp90 inhibitors - The explanat-ion remains elusive
    • 17163756 1:CAS:528:DC%2BD28XmtFSiur8%3D
    • Chiosis G, Neckers L (2006) Tumor selectivity of Hsp90 inhibitors - the explanat-ion remains elusive. ACS Chem Biol 1:279-284
    • (2006) ACS Chem Biol , vol.1 , pp. 279-284
    • Chiosis, G.1    Neckers, L.2
  • 36
    • 33646345860 scopus 로고    scopus 로고
    • Dihydroquinone ansamycins: Toward resolving the conflict between low in vitro affinity and high cellular potency of geldanamycin derivatives
    • 16634649 1:CAS:528:DC%2BD28Xjt1Wls7Y%3D
    • Maroney AC et al (2006) Dihydroquinone ansamycins: toward resolving the conflict between low in vitro affinity and high cellular potency of geldanamycin derivatives. Biochemistry 45:5678-5685
    • (2006) Biochemistry , vol.45 , pp. 5678-5685
    • Maroney, A.C.1
  • 37
    • 33746417580 scopus 로고    scopus 로고
    • Hsp90: A novel target for cancer therapy
    • 16842157 1:CAS:528:DC%2BD28Xpt1ejtLo%3D
    • Solit DB, Rosen N (2006) Hsp90: a novel target for cancer therapy. Curr Top Med Chem 6:1205-1214
    • (2006) Curr Top Med Chem , vol.6 , pp. 1205-1214
    • Solit, D.B.1    Rosen, N.2
  • 38
    • 33845804718 scopus 로고    scopus 로고
    • Loss of Hsp90 association up-regulates Src dependent ErbB2 activity
    • 17030621 1:CAS:528:DC%2BD2sXjs1Ol
    • Xu W, Yuan X, Beebe K et al (2007) Loss of Hsp90 association up-regulates Src dependent ErbB2 activity. Mol Cell Biol 27:220-228
    • (2007) Mol Cell Biol , vol.27 , pp. 220-228
    • Xu, W.1    Yuan, X.2    Beebe, K.3
  • 39
    • 0032554763 scopus 로고    scopus 로고
    • Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol
    • 9632140 1:CAS:528:DyaK1cXjsFKjsrY%3D
    • Sharma S et al (1998) Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol. Oncogene 16:2639-2645
    • (1998) Oncogene , vol.16 , pp. 2639-2645
    • Sharma, S.1
  • 40
    • 41849084518 scopus 로고    scopus 로고
    • Development of Novobiocin analogues that manifest anti-proliferative activity against several cancer cell lines
    • Burlingson JA et al (2007) Development of Novobiocin analogues that manifest anti-proliferative activity against several cancer cell lines. J Org Chem 73:2130-2137
    • (2007) J Org Chem , vol.73 , pp. 2130-2137
    • Burlingson, J.A.1
  • 41
    • 61649098007 scopus 로고    scopus 로고
    • Novobiocin and Hsp90 inhibitors of C terminal nucleotide binding pocket
    • 18991631 1:CAS:528:DC%2BD1cXhtlWiur3M
    • Donnelly A, Blagg BSJ (2008) Novobiocin and Hsp90 inhibitors of C terminal nucleotide binding pocket. Curr Med Chem 15(26):2702-2717
    • (2008) Curr Med Chem , vol.15 , Issue.26 , pp. 2702-2717
    • Donnelly, A.1    Blagg, B.S.J.2
  • 42
    • 79952752856 scopus 로고    scopus 로고
    • STA-9090 A small molecule Hsp90 inhibitor for the potential treatment of cancer
    • Wangl Y et al (2010) STA-9090 A small molecule Hsp90 inhibitor for the potential treatment of cancer. Curr Opin Investig Drugs 11(12):1466-1476
    • (2010) Curr Opin Investig Drugs , vol.11 , Issue.12 , pp. 1466-1476
    • Wangl, Y.1
  • 43
    • 40949091876 scopus 로고    scopus 로고
    • Synthesis and evaluation of Derrubone and select analogues
    • 18154304 1:CAS:528:DC%2BD2sXhsVOntb3P
    • Hastings JM, Hadden MK, Blagg BSJ (2008) Synthesis and evaluation of Derrubone and select analogues. J Org Chem 73:369-373
    • (2008) J Org Chem , vol.73 , pp. 369-373
    • Hastings, J.M.1    Hadden, M.K.2    Blagg, B.S.J.3
  • 44
  • 46
    • 65449155145 scopus 로고    scopus 로고
    • Natural product inhibitors of Hsp90: Potential leads for drug discovery
    • 19200020 1:CAS:528:DC%2BD1MXks1ChsLs%3D
    • Amolins MW, Blagg BSJ (2009) Natural product inhibitors of Hsp90: potential leads for drug discovery. Mini Rev Med Chem 9(2):140-152
    • (2009) Mini Rev Med Chem , vol.9 , Issue.2 , pp. 140-152
    • Amolins, M.W.1    Blagg, B.S.J.2
  • 47
    • 77956640526 scopus 로고    scopus 로고
    • Mechanistic studies of Sansalvamide A-Amide: An allosteric modulator of Hsp90
    • 20730035 1:CAS:528:DC%2BC3cXhs12isg%3D%3D
    • Vasko RC et al (2010) Mechanistic studies of Sansalvamide A-Amide: an allosteric modulator of Hsp90. ACS Med Chem Lett 1:4-8
    • (2010) ACS Med Chem Lett , vol.1 , pp. 4-8
    • Vasko, R.C.1
  • 48
    • 54549105458 scopus 로고    scopus 로고
    • Gedunin, a novel Hsp90 inhibitor: Semi synthesis of derivatives and preliminary structure activity relationships
    • 10.1021/jm8007486 18816111 1:CAS:528:DC%2BD1cXhtFKlurrI
    • Brandt GEL et al (2008) Gedunin, a novel Hsp90 inhibitor: semi synthesis of derivatives and preliminary structure activity relationships. J Med Chem 51(20):6495-6502. doi: 10.1021/jm8007486
    • (2008) J Med Chem , vol.51 , Issue.20 , pp. 6495-6502
    • Brandt, G.E.L.1
  • 49
    • 33845481603 scopus 로고    scopus 로고
    • Chemistry and biology of resorcyclic acid lactones
    • doi: 10.1039/b610344h
    • Winssinger N, Barluenga S (2007) Chemistry and biology of resorcyclic acid lactones. Chem Commun:22-36. doi: 10.1039/b610344h
    • (2007) Chem Commun , pp. 22-36
    • Winssinger, N.1    Barluenga, S.2
  • 50
    • 77953843722 scopus 로고    scopus 로고
    • Structure-activity of Sansalvamide A derivatives and their apoptotic activity in pancreatic cancer cell line PL-45
    • 1:CAS:528:DC%2BD1MXhvFersrw%3D
    • Rodriguez RA (2008) Structure-activity of Sansalvamide A derivatives and their apoptotic activity in pancreatic cancer cell line PL-45. Mex Chem Soc 52(3):201-211
    • (2008) Mex Chem Soc , vol.52 , Issue.3 , pp. 201-211
    • Rodriguez, R.A.1
  • 51
    • 58149144382 scopus 로고    scopus 로고
    • A novel class of small molecule inhibitors of Hsp90
    • 18785742 1:CAS:528:DC%2BD1cXhtFSrsrjE
    • Yi F, Regan L (2008) A novel class of small molecule inhibitors of Hsp90. ACS Chem Biol 3(10):645-654
    • (2008) ACS Chem Biol , vol.3 , Issue.10 , pp. 645-654
    • Yi, F.1    Regan, L.2
  • 52
    • 77953605309 scopus 로고    scopus 로고
    • Hsp90 inhibitors: A potential treatement for latent EBV infection?
    • 20404505 1:CAS:528:DC%2BC3cXht12itrzE
    • Sun X, Kenney SC (2010) Hsp90 inhibitors: a potential treatement for latent EBV infection? Cell Cycle 9(9):1665-1666
    • (2010) Cell Cycle , vol.9 , Issue.9 , pp. 1665-1666
    • Sun, X.1    Kenney, S.C.2
  • 53
    • 84860307774 scopus 로고    scopus 로고
    • Geldanamycin and its derivatives as Hsp90 inhibitors
    • Gorska M et al (2012) Geldanamycin and its derivatives as Hsp90 inhibitors. Front Biosci 17:2269-2277
    • (2012) Front Biosci , vol.17 , pp. 2269-2277
    • Gorska, M.1
  • 55
    • 77954945333 scopus 로고    scopus 로고
    • Targeting the dynamic Hsp90 complex in cancer
    • 10.1038/nrc2887 20651736 1:CAS:528:DC%2BC3cXpt1GjtLs%3D
    • Trepel J et al (2010) Targeting the dynamic Hsp90 complex in cancer. Nat Rev Cancer 10:537-549. doi: 10.1038/nrc2887
    • (2010) Nat Rev Cancer , vol.10 , pp. 537-549
    • Trepel, J.1
  • 56
    • 80054995372 scopus 로고    scopus 로고
    • Development and characterization of novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells
    • 22039910 1:CAS:528:DC%2BC3MXhsFSrurzN
    • Eskew JD (2011) Development and characterization of novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells. BMC Cancer 11:468
    • (2011) BMC Cancer , vol.11 , pp. 468
    • Eskew, J.D.1
  • 57
    • 80053207751 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate (EGCG) for clinical trials: More pitfalls than promises?
    • 10.3390/ijms12095592 22016611 1:CAS:528:DC%2BC3MXht1entbzP
    • Mereles D, Hunstein W (2011) Epigallocatechin-3-gallate (EGCG) for clinical trials: more pitfalls than promises? Int J Mol Sci 12:5592-5603. doi: 10.3390/ijms12095592
    • (2011) Int J Mol Sci , vol.12 , pp. 5592-5603
    • Mereles, D.1    Hunstein, W.2
  • 58
    • 73149102557 scopus 로고    scopus 로고
    • KU135 A novel novobiocin derived C-terminal inhibitor of 90 Kda heat shock protein exerts potent anti-proliferative effects on human luekemic cells
    • 19741006 1:CAS:528:DC%2BD1MXhsFajtbzK
    • Shelton SN et al (2009) KU135 A novel novobiocin derived C-terminal inhibitor of 90 Kda heat shock protein exerts potent anti-proliferative effects on human luekemic cells. Mol Pharmacol 76(6):1314-1322
    • (2009) Mol Pharmacol , vol.76 , Issue.6 , pp. 1314-1322
    • Shelton, S.N.1
  • 59
    • 0036836964 scopus 로고    scopus 로고
    • Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase
    • 12213470 1:CAS:528:DC%2BD38Xms12isr8%3D
    • Chiosis G et al (2002) Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase. Bioorg Med Chem 10:3555-3564
    • (2002) Bioorg Med Chem , vol.10 , pp. 3555-3564
    • Chiosis, G.1
  • 60
    • 84865374278 scopus 로고    scopus 로고
    • Heat shock protein 90 and role of its chemical inhibitors in treatment of hematologic malignancies
    • 10.3390/ph5080779 1:CAS:528:DC%2BC38XhtFGgtrzE
    • Ho N, Li A, Li S, Zhang H (2012) Heat shock protein 90 and role of its chemical inhibitors in treatment of hematologic malignancies. Pharmaceuticals 5:779-801. doi: 10.3390/ph5080779
    • (2012) Pharmaceuticals , vol.5 , pp. 779-801
    • Ho, N.1    Li, A.2    Li, S.3    Zhang, H.4
  • 61
    • 80455131276 scopus 로고    scopus 로고
    • Mechanisms of resistance to Hsp90 inhibitor drugs: A complex mosaic emerges
    • 1:CAS:528:DC%2BC38XjvV2kuw%3D%3D
    • Piper PW, Millson SH (2011) Mechanisms of resistance to Hsp90 inhibitor drugs: a complex mosaic emerges. Pharmaceuticals 4:1400-1422
    • (2011) Pharmaceuticals , vol.4 , pp. 1400-1422
    • Piper, P.W.1    Millson, S.H.2
  • 62
    • 21244505104 scopus 로고    scopus 로고
    • Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design
    • 15974572 1:CAS:528:DC%2BD2MXkslSnsbg%3D
    • Dymock BW, Barrill X, Brough PA et al (2005) Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design. J Med Chem 48:4212-4215
    • (2005) J Med Chem , vol.48 , pp. 4212-4215
    • Dymock, B.W.1    Barrill, X.2    Brough, P.A.3
  • 63
    • 49449105426 scopus 로고    scopus 로고
    • Signalling profile and anti-tumor activity of the novel Hsp90 inhibitor NVP-AUY922 in multiple myeloma
    • 18480838 1:STN:280:DC%2BD1crhtlCjtA%3D%3D
    • Stuhmer T et al (2008) Signalling profile and anti-tumor activity of the novel Hsp90 inhibitor NVP-AUY922 in multiple myeloma. Leukemia 22:1604-1612
    • (2008) Leukemia , vol.22 , pp. 1604-1612
    • Stuhmer, T.1
  • 64
    • 79960983822 scopus 로고    scopus 로고
    • AUY922 a novel Hsp90 inhibitor: Final results of a first-in-human study in patients with advanced solid malignancies
    • Samuel T et al (2010) AUY922 a novel Hsp90 inhibitor: final results of a first-in-human study in patients with advanced solid malignancies. Am Soc Clin Oncol Ann Meet 46:Abs 2528
    • (2010) Am Soc Clin Oncol Ann Meet , vol.46 , pp. 2528
    • Samuel, T.1
  • 65
    • 59649086503 scopus 로고    scopus 로고
    • SNX-2112, a selective hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signalling via Akt and Erk
    • 18948577 1:CAS:528:DC%2BD1MXhtlGhtLw%3D
    • Okawa Y et al (2009) SNX-2112, a selective hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signalling via Akt and Erk. Blood 113:846-855
    • (2009) Blood , vol.113 , pp. 846-855
    • Okawa, Y.1
  • 66
    • 77955141041 scopus 로고    scopus 로고
    • 20618337 1:CAS:528:DC%2BC3cXhtFCru77J
    • Richardson et al (2010) Br J Haematol 150:438-445
    • (2010) Br J Haematol , vol.150 , pp. 438-445
    • Richardson1
  • 67
    • 84855457952 scopus 로고    scopus 로고
    • Hsp90 molecular chaperone inhibitors: Are we there yet?
    • 10.1158/1078-0432.CCR-11-1000 22215907 1:CAS:528:DC%2BC38XhvFWmsw%3D%3D
    • Neckers L, Workman P (2012) Hsp90 molecular chaperone inhibitors: are we there yet? Clin Cancer Res 18(1):64-76. doi: 10.1158/1078-0432.CCR-11-1000
    • (2012) Clin Cancer Res , vol.18 , Issue.1 , pp. 64-76
    • Neckers, L.1    Workman, P.2
  • 68
    • 33745086222 scopus 로고    scopus 로고
    • Identification of new biomarkers for clinical trials of Hsp90 inhibitors
    • 10.1158/1535-7163.MCT-05-0537 16731758 1:CAS:528:DC%2BD28XltVWmsrw%3D
    • Zhang H, Chung D, Yang YC (2006) Identification of new biomarkers for clinical trials of Hsp90 inhibitors. Mol Cancer Ther 5:1256-1264. doi: 10.1158/1535-7163.MCT-05-0537
    • (2006) Mol Cancer Ther , vol.5 , pp. 1256-1264
    • Zhang, H.1    Chung, D.2    Yang, Y.C.3
  • 69
    • 33745574028 scopus 로고    scopus 로고
    • Early tumor response to Hsp90 therapy using HER2 PET: Comparison with 18F-FDG PET
    • 16644749 1:CAS:528:DC%2BD28XltFaiurs%3D
    • Smith-Jones PM et al (2006) Early tumor response to Hsp90 therapy using HER2 PET: comparison with 18F-FDG PET. J Nucl Med 47:793-796
    • (2006) J Nucl Med , vol.47 , pp. 793-796
    • Smith-Jones, P.M.1
  • 70
    • 37649024109 scopus 로고    scopus 로고
    • Development and applications of Hsp90 inhibitors
    • 18190862 1:CAS:528:DC%2BD1cXlsVWhug%3D%3D
    • Solit DB, Chiosis G (2008) Development and applications of Hsp90 inhibitors. Drug Discov Today 13(1/2):38-43
    • (2008) Drug Discov Today , vol.13 , Issue.12 , pp. 38-43
    • Solit, D.B.1    Chiosis, G.2
  • 71
    • 70349775512 scopus 로고    scopus 로고
    • Evaluation of prostate-specific antigen as a novel biomarker of Hsp90 inhibition
    • Oikonomopoulou K et al (2009) Evaluation of prostate-specific antigen as a novel biomarker of Hsp90 inhibition. Clin Biochem 42(8):16-17
    • (2009) Clin Biochem , vol.42 , Issue.8 , pp. 16-17
    • Oikonomopoulou, K.1
  • 72
    • 84886365429 scopus 로고    scopus 로고
    • Hsp90 inhibitors as selective anticancer drugs
    • Adeela K, Burrows FJ (2009) Hsp90 inhibitors as selective anticancer drugs. Discov Med. http://www.discoverymedicine.com/Adeela-Kamal/2009/07/12/ hsp90-inhibitors-as-selectable-anticancer-drugs/
    • (2009) Discov Med.
    • Adeela, K.1    Burrows, F.J.2
  • 73
    • 0030016274 scopus 로고    scopus 로고
    • Drug resistance against gemcitabine and topotecan mediated by constitutive Hsp70 overexpression in vitro: Implication of quercetin as sensitizer in chemotherapy
    • 8688318 1:CAS:528:DyaK28XltFSqs74%3D
    • Sliutz G, Karlseder J, Tempfer C, Orel L, Holzer G, Simon M (1996) Drug resistance against gemcitabine and topotecan mediated by constitutive Hsp70 overexpression in vitro: implication of quercetin as sensitizer in chemotherapy. Br J Cancer 74:172-177
    • (1996) Br J Cancer , vol.74 , pp. 172-177
    • Sliutz, G.1    Karlseder, J.2    Tempfer, C.3    Orel, L.4    Holzer, G.5    Simon, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.