Heat shock protein 90 and role of its chemical inhibitors in treatment of hematologic malignancies

Pharmaceuticals

Volumn 5, Issue 8, 2012, Pages 779-801

  Ho, Ngoc ^a   Li, Adam ^b   Li, Shaoguang ^a   Zhang, Haojian ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b Xaverian Brothers High School   (United States)

Author keywords

Chemical inhibitors; Heat shock protein 90; Hematologic malignancies

Indexed keywords

5 (2,4 DIHYDROXY 5 ISOPROPYLPHENYL) 4 (4 MORPHOLINOMETHYLPHENYL) 3 ISOXAZOLECARBOXYLIC ACID ETHYLAMIDE; ALVESPIMYCIN; ANSAMYCIN DERIVATIVE; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; AT 13387; BIIB 021; CD135 ANTIGEN; CNF 2024; GANETESPIB; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; HERBIMYCIN A; IMATINIB; IPI 493; JANUS KINASE 2; KF 58333; KW 2478; NVP HSP 990; PROTEIN TYROSINE KINASE INHIBITOR; RADICICOL; RETASPIMYCIN; RETINOIC ACID; RUXOLITINIB; SNX 2112; SNX 5422; TANESPIMYCIN; THEOPHYLLINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALPROIC ACID; XL 888;

ACETYLATION; ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOCYTIC LEUKEMIA; AMINO TERMINAL SEQUENCE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CARBOXY TERMINAL SEQUENCE; CELL CYCLE PROGRESSION; CHRONIC LYMPHATIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; DIMERIZATION; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG SAFETY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG TOLERABILITY; HEMATOLOGIC MALIGNANCY; HUMAN; HYDROLYSIS; LARGE CELL LYMPHOMA; LEUKEMIA CELL; MANTLE CELL LYMPHOMA; MOLECULAR DYNAMICS; MULTIPLE MYELOMA; MYELOFIBROSIS; MYELOID LEUKEMIA; MYELOID METAPLASIA; MYELOPROLIFERATIVE NEOPLASM; NITROSYLATION; NONHODGKIN LYMPHOMA; NONHUMAN; POLYCYTHEMIA VERA; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; THROMBOCYTHEMIA;

EID: 84865374278     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph5080779     Document Type: Review

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