Geranylgeranyltransferase i regulates HIF-1α promoting glioblastoma cell migration and invasion

Journal of Neuro-Oncology

Volumn 112, Issue 3, 2013, Pages 365-374

  Zhou, Xiuping ^a   Liu, Zhi ^a   Shi, Qiong ^a   Jiao, Jiantong ^a   Bian, Wenbin ^a   Song, Xu ^a   Mo, Jianbing ^a   Sang, Ben ^a   Xu, Yinfu ^a   Qian, Jinming ^a   Chao, Yuewen ^a   Yu, Rutong ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Geranylgeranyltransferase I; Glioma; Hypoxia inducible factor 1 ; Invasion; Migration

Indexed keywords

GERANYLGERANYLTRANSFERASE I; GERANYLGERANYLTRANSFERASE I BETA; HYPOXIA INDUCIBLE FACTOR 1ALPHA; TRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CELL MIGRATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; ENZYME REGULATION; ENZYME SUBUNIT; GENE SILENCING; GLIOBLASTOMA; HYPOXIA; PROTEIN INDUCTION; PROTEIN PRENYLATION; TUMOR INVASION;

ALKYL AND ARYL TRANSFERASES; BLOTTING, WESTERN; BRAIN NEOPLASMS; CELL HYPOXIA; CELL LINE, TUMOR; CELL MOVEMENT; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; GLIOBLASTOMA; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NEOPLASM INVASIVENESS; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84885080490     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-013-1081-y     Document Type: Article

References (46)

1. Clarke J, Butowski N, Chang S (2010) Recent advances in therapy for glioblastoma. Arch Neurol 67:279-283
2. Meyer MA (2008) Malignant gliomas in adults. N Engl J Med 359:1850 (author reply 1850)
3. Minniti G, De Sanctis V, Muni R, Filippone F, Bozzao A, Valeriani M, Osti MF, De Paula U, Lanzetta G, Tombolini V, Maurizi Enrici R (2008) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma in elderly patients. J Neurooncol 88:97-103
4. Wilson WR, Hay MP (2011) Targeting hypoxia in cancer therapy. Nat Rev Cancer 11:393-410
5. Vordermark D (2005) Significance of hypoxia in malignant glioma. Re: Evans et al. Hypoxia is important in the biology and aggression of human glial brain tumors. Clin Cancer Res 2004;10:8177-8184; Clin Cancer Res 11:3966-3967 (author reply 3967-3968)
6. Kaur B, Khwaja FW, Severson EA, Matheny SL, Brat DJ, Van Meir EG (2005) Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis. Neuro Oncol 7:134-153
7. Kessler J, Hahnel A, Wichmann H, Rot S, Kappler M, Bache M, Vordermark D (2010) HIF-1alpha inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression. BMC Cancer 10:605
8. Tao BB, Zhang CC, Liu SY, Zhu YC (2012) Involvement of HIF-1 in the migration-promoting effects of hydrogen sulfide in vascular endothelial cells under normoxic conditions. Sheng Li Xue Bao 64:129-134
9. Jans J, van Dijk JH, van Schelven S, van der Groep P, Willems SH, Jonges TN, van Diest PJ, Bosch JL (2010) Expression and localization of hypoxia proteins in prostate cancer: prognostic implications after radical prostatectomy. Urology 75:786-792
10. Schwab LP, Peacock DL, Majumdar D, Ingels JF, Jensen LC, Smith KD, Cushing RC, Seagroves TN (2012) Hypoxia-inducible factor 1alpha promotes primary tumor growth and tumor-initiating cell activity in breast cancer. Breast Cancer Res 14:R6
11. Wong CC, Zhang H, Gilkes DM, Chen J, Wei H, Chaturvedi P, Hubbi ME, Semenza GL (2012) Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. J Mol Med (Berl) 90(7):803-815. doi: 10.1007/s00109-011-0855-y
12. Dai S, Huang ML, Hsu CY, Chao KS (2003) Inhibition of hypoxia inducible factor 1alpha causes oxygen-independent cytotoxicity and induces p53 independent apoptosis in glioblastoma cells. Int J Radiat Oncol Biol Phys 55:1027-1036
13. Lu H, Li Y, Shu M, Tang J, Huang Y, Zhou Y, Liang Y, Yan G (2009) Hypoxia-inducible factor-1alpha blocks differentiation of malignant gliomas. FEBS J 276:7291-7304
14. Gillespie DL, Flynn JR, Ragel BT, Arce-Larreta M, Kelly DA, Tripp SR, Jensen RL (2009) Silencing of HIF-1alpha by RNA interference in human glioma cells in vitro and in vivo. Methods Mol Biol 487:283-301
15. Reymond N, Riou P, Ridley AJ (2012) Rho GTPases and cancer cell transendothelial migration. Methods Mol Biol 827:123-142
16. Khalil BD, El-Sibai M (2012) Rho GTPases in primary brain tumor malignancy and invasion. J Neurooncol 108(3):333-339. doi: 10.1007/s11060-012- 0866-8
17. Zhou J, Li K, Gu Y, Feng B, Ren G, Zhang L, Wang Y, Nie Y, Fan D (2011) Transcriptional up-regulation of RhoE by hypoxia-inducible factor (HIF)-1 promotes epithelial to mesenchymal transition of gastric cancer cells during hypoxia. Biochem Biophys Res Commun 415:348-354
18. Xue Y, Li NL, Yang JY, Chen Y, Yang LL, Liu WC (2011) Phosphatidylinositol 3′-kinase signaling pathway is essential for Rac1-induced hypoxia-inducible factor-1(alpha) and vascular endothelial growth factor expression. Am J Physiol Heart Circ Physiol 300:H2169-H2176
19. Zhang P, Zhang X, Hao X, Wang Y, Hui Y, Wang H, Hu D, Zhou J (2009) Rac1 activates HIF-1 in retinal pigment epithelium cells under hypoxia. Graefes Arch Clin Exp Ophthalmol 247:633-639
20. Waheed F, Speight P, Dan Q, Garcia-Mata R, Szaszi K (2012) Affinity precipitation of active Rho-GEFs using a GST-tagged mutant Rho protein (GST-RhoA(G17A)) from epithelial cell lysates. J Vis Exp. doi: 10.3791/3932
21. Zhou XP, Wu KY, Liang B, Fu XQ, Luo ZG (2008) TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis. Proc Natl Acad Sci USA 105:17181-17186
22. Luo ZG, Je HS, Wang Q, Yang F, Dobbins GC, Yang ZH, Xiong WC, Lu B, Mei L (2003) Implication of geranylgeranyltransferase I in synapse formation. Neuron 40:703-717
23. Berndt N, Hamilton AD, Sebti SM (2011) Targeting protein prenylation for cancer therapy. Nat Rev Cancer 11:775-791
24. Ghavami S, Mutawe MM, Schaafsma D, Yeganeh B, Unruh H, Klonisch T, Halayko AJ (2012) Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 302:L420-L428
25. Lu J, Chan L, Fiji HD, Dahl R, Kwon O, Tamanoi F (2009) In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I. Mol Cancer Ther 8:1218-1226
26. Zhou X, Hua L, Zhang W, Zhu M, Shi Q, Li F, Zhang L, Song C, Yu R (2012) FRK controls migration and invasion of human glioma cells by regulating JNK/c-Jun signaling. J Neurooncol 110:9-19
27. Zhou X, Xu X, Meng Q, Hu J, Zhi T, Shi Q, Yu R (2012) Bex2 is critical for migration and invasion in malignant glioma cells. J Mol Neurosci. doi: 10.1007/s12031-012-9864-8
28. Zhou X, Ma L, Li J, Gu J, Shi Q, Yu R (2012) Effects of SEMA3G on migration and invasion of glioma cells. Oncol Rep 28:269-275
29. Tremblay P, Beaudet MJ, Tremblay E, Rueda N, Thomas T, Vallieres L (2011) Matrix metalloproteinase 2 attenuates brain tumour growth, while promoting macrophage recruitment and vascular repair. J Pathol 224:222-233
30. Koul D, Parthasarathy R, Shen R, Davies MA, Jasser SA, Chintala SK, Rao JS, Sun Y, Benvenisite EN, Liu TJ, Yung WK (2001) Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN. Oncogene 20:6669-6678
31. Turcotte S, Desrosiers RR, Beliveau R (2003) HIF-1alpha mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma. J Cell Sci 116:2247-2260
32. Wu KY, Zhou XP, Luo ZG (2010) Geranylgeranyltransferase I is essential for dendritic development of cerebellar Purkinje cells. Mol Brain 3:18
33. Chen JK, Hu LJ, Wang J, Lamborn KR, Kong EL, Deen DF (2005) Hypoxia-induced BAX overexpression and radiation killing of hypoxic glioblastoma cells. Radiat Res 163:644-653
34. Advani SH (2010) Targeting mTOR pathway: a new concept in cancer therapy. Indian J Med Paediatr Oncol 31:132-136
35. Yuan G, Nanduri J, Khan S, Semenza GL, Prabhakar NR (2008) Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR. J Cell Physiol 217:674-685
36. Koh MY, Spivak-Kroizman TR, Powis G (2010) HIF-1alpha and cancer therapy. Recent Results Cancer Res 180:15-34
37. Kim JW, Gao P, Liu YC, Semenza GL, Dang CV (2007) Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol 27:7381-7393
38. Rathinam R, Berrier A, Alahari SK (2012) Role of Rho GTPases and their regulators in cancer progression. Front Biosci 17:2561-2571
39. Struckhoff AP, Rana MK, Worthylake RA (2011) RhoA can lead the way in tumor cell invasion and metastasis. Front Biosci 16:1915-1926
40. Kikuchi K, Li X, Zheng Y, Takano Y (2011) Invasion of breast cancer cells into collagen matrix requires TGF-alpha and Cdc42 signaling. FEBS Lett 585:286-290
41. Chen B, Gao Y, Jiang T, Ding J, Zeng Y, Xu R, Jiang X (2011) Inhibition of tumor cell migration and invasion through knockdown of Rac1 expression in medulloblastoma cells. Cell Mol Neurobiol 31:251-257
42. Gao Y, Xie M, He ZP, Zhang X, Zheng JQ (2010) The effect of hypoxia on the expression of RHO/RHO signaling pathway and CTGF of human embryonic fibroblasts. Sichuan Da Xue Xue Bao Yi Xue Ban 41:946-950
43. Lau CP, Huang L, Tsui SK, Ng PK, Leung PY, Kumta SM (2011) Pamidronate, farnesyl transferase, and geranylgeranyl transferase-I inhibitors affects cell proliferation, apoptosis, and OPG/RANKL mRNA expression in stromal cells of giant cell tumor of bone. J Orthop Res 29:403-413
44. van de Donk NW, Schotte D, Kamphuis MM, van Marion AM, van Kessel B, Bloem AC, Lokhorst HM (2003) Protein geranylgeranylation is critical for the regulation of survival and proliferation of lymphoma tumor cells. Clin Cancer Res 9:5735-5748
45. Sane KM, Mynderse M, Lalonde DT, Dean IS, Wojtkowiak JW, Fouad F, Borch RF, Reiners JJ Jr, Gibbs RA, Mattingly RR (2010) A novel geranylgeranyl transferase inhibitor in combination with lovastatin inhibits proliferation and induces autophagy in STS-26T MPNST cells. J Pharmacol Exp Ther 333:23-33
46. Unlu S, Mason CD, Schachter M, Hughes AD (2000) Perillyl alcohol, an inhibitor of geranylgeranyl transferase, induces apoptosis of immortalized human vascular smooth muscle cells in vitro. J Cardiovasc Pharmacol 35:341-344