Inhibition of hypoxia inducible factor 1α causes oxygen-independent cytotoxicity and induces p53 independent apoptosis in glioblastoma cells

International Journal of Radiation Oncology Biology Physics

Volumn 55, Issue 4, 2003, Pages 1027-1036

  Dai, Simon ^a   Huang, Mary Lin ^a   Hsu, Chang Y ^a   Chao, K S Clifford ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Antisense; Apoptosis; Chemotherapy; Hypoxia inducible factor 1; Malignant glioma

Indexed keywords

BIOASSAY; CELLS; CHEMOTHERAPY; COLORIMETRY; NITROGEN; TUMORS;

HYPOXIA;

BIOLOGICAL RADIATION EFFECTS;

3 (4,5 DIMETHYLTHIAZOL 2 YL) 5 (3 CARBOXYMETHOXYPHENYL) 2 (4 SULFOPHENYL) 2H TETRAZOLIUM; ANTISENSE PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDE; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CARBON DIOXIDE; CASPASE 3; CASPASE INHIBITOR; CISPLATIN; ETOPOSIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LUCIFERASE; NITROGEN; OLIGODEOXYNUCLEOTIDE DERIVATIVE; OXYGEN; PROTEIN P53; TETRAZOLIUM; UNCLASSIFIED DRUG; VINCRISTINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTE; CANCER THERAPY; CATALYSIS; CELL ASSAY; CELL LINE; CELL SURVIVAL; CELL VIABILITY; COLORIMETRY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME ASSAY; FIBROBLAST; GLIOBLASTOMA; GLIOMA; GLIOMA CELL; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOBLOTTING; INCUBATOR; MICROTITER PLATE ASSAY; NICK END LABELING; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; TIME; TRANSACTIVATION; TREATMENT INDICATION; TUMOR CELL;

EID: 0037443494     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(02)04507-8     Document Type: Article

References (25)

1. Maher E., Furnari F., Bachoo R., et al. Malignant glioma Genetics and biology of a grave matter. Genes Dev. 15:2001;1311-1333.
2. Chao K.S.C., Bosch W.R., Mutic S., et al. A novel approach to overcome hypoxic tumor resistance - ATSM-guided intensity modulated radiation therapy. Int J Radiat Oncol Biol Phys. 49:2001;1171-1182.
3. Semenza G. HIF-1 Using two hands to flip the angiogenic switch. Cancer Metastasis Rev. 19:2000;59-65.
4. Wiener C., Booth G., Semenza G. In vivo expression of mRNAs encoding hypoxia-inducible factor 1. Biochem Biophys Res Commun. 225:1996;485-488.
5. 2 tension. Am J Physiol. 271:1996;C1172-C1180.
6. Jewell U., Kvietikova I., Scheid A., et al. Induction of HIF-1alpha in response to hypoxia is instantaneous. FASEB J. 15:2001;1312-1314.
7. 2 sensing. Science. 292:2001;464-468.
8. 2-regulated prolyl hydroxylation. Science. 292:2001;468-472.
9. Epstein A., Gleadle J., McNeill L., et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. 107:2001;43-54.
10. Zagzag D., Zhong H., Scalzitti J., et al. Expression of hypoxia-inducible factor 1alpha in brain tumors Association with angiogenesis, invasion, and progression. Cancer. 88:2000;2606-2618.
11. Caniggia I., Mostachfi H., Winter J., et al. Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3). J Clin Invest. 105:2000;577-587.
12. Ryan H., Lo J., Johnson R. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J. 17:1998;3005-3015.
13. Baker B., Monia B. Novel mechanisms for antisense-mediated regulation of gene expression. Biochim Biophys Acta. 1489:1999;3-18.
14. Weller M., Rieger J., Grimmel C., et al. Predicting chemoresistance in human malignant glioma cells The role of molecular genetic analyses. Int J Cancer. 79:1998;640-644.
15. Suzuki H., Tomida A., Tsuruo T. Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia. Oncogene. 20:2001;5779-5788.
16. Sowter H., Ratcliffe P., Watson P., et al. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3, and NIX in human tumors. Cancer Res. 61:2001;6669-6673.
17. Jiang H., Guo R., Powell-Coffman J. The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia. Proc Natl Acad Sci USA. 98:2001;7916-7921.
18. Drutel G., Kathmann M., Heron A., et al. Two splice variants of the hypoxia-inducible factor HIF-1alpha as potential dimerization partners of ARNT2 in neurons. Eur J Neurosci. 12:2000;3701-3708.
19. Carmeliet P., Dor Y., Herbert J., et al. Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation, and tumour angiogenesis. Nature. 394:1998;485-490.
20. Cerrato J., Yung W., Liu T. Introduction of mutant p53 into a wild-type p53-expressing glioma cell line confers sensitivity to Ad-p53-induced apoptosis. Neuro-oncol. 3:2001;113-122.
21. Bruick R. Expression of the gene encoding the proapoptotic Nip3 protein is induced under hypoxia. Proc Natl Acad Sci. 97:2000;9082-9087.
22. Dong Z., Venkatachalam M., Wang J., et al. Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia Hif-1-independent mechanisms. J Biol Chem. 276:2001;18702-18709.
23. Kung A., Wang S., Klco J., et al. Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nat Med. 6:2000;1335-1340.
24. Sun X., Kanwar J., Leung E., et al. Gene transfer of antisense hypoxia inducible factor-1 alpha enhances the therapeutic efficacy of cancer immunotherapy. Gene Ther. 8:2001;638-645.
25. Zhong H., DeMarzo A., Laughner E., et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 59:1999;5830-5835.