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Volumn 31, Issue 4, 2010, Pages 132-136

Targeting mTOR pathway: A new concept in cancer therapy

Author keywords

Angiogenesis; bioenergetics; everolimus

Indexed keywords

CYCLIN D1; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EVEROLIMUS; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 2ALPHA; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN TYROSINE KINASE INHIBITOR; TRANSFORMING GROWTH FACTOR ALPHA; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN;

EID: 79551691852     PISSN: 09715851     EISSN: 09752129     Source Type: Journal    
DOI: 10.4103/0971-5851.76197     Document Type: Review
Times cited : (74)

References (43)
  • 1
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • DOI 10.1101/gad.1212704
    • Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004;18:1926-45. (Pubitemid 39071573)
    • (2004) Genes and Development , vol.18 , Issue.16 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 2
    • 34250619165 scopus 로고    scopus 로고
    • The mammalian target of rapamycin signaling pathway: Twists and turns in the road to cancer therapy
    • DOI 10.1158/1078-0432.CCR-06-2798
    • Abraham RT, Gibbons JJ. The mammalian target of rapamycin signaling pathway: twists and turns in the road to cancer therapy. Clin Cancer Res 2007;13:3109-14. (Pubitemid 46944891)
    • (2007) Clinical Cancer Research , vol.13 , Issue.11 , pp. 3109-3114
    • Abraham, R.T.1    Gibbons, J.J.2
  • 3
    • 33751162384 scopus 로고    scopus 로고
    • Therapeutic targets: MTOR and related pathways
    • Dancey JE. Therapeutic targets: mTOR and related pathways. Cancer Biol Ther 2006;5:1065-73. (Pubitemid 44773684)
    • (2006) Cancer Biology and Therapy , vol.5 , Issue.9 , pp. 1065-1073
    • Dancey, J.E.1
  • 4
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • DOI 10.1016/j.cell.2006.01.016, PII S0092867406001085
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006;124:471-84. (Pubitemid 43199434)
    • (2006) Cell , vol.124 , Issue.3 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 5
    • 0037423288 scopus 로고    scopus 로고
    • Evidence that cyclin D1 mediates both growth and proliferation downstream of TOR in hepatocytes
    • DOI 10.1074/jbc.M209374200
    • Nelsen CJ, Rickheim DG, Tucker MM, Hansen LK, Albrecht JH. Evidence that cyclin D1 mediates both growth and proliferation downstream of TOR in hepatocytes. J Biol Chem 2003;278:3656-63. (Pubitemid 36801089)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.6 , pp. 3656-3663
    • Nelsen, C.J.1    Rickheim, D.G.2    Tucker, M.M.3    Hansen, L.K.4    Albrecht, J.H.5
  • 6
    • 9444236895 scopus 로고    scopus 로고
    • Minireview: Cyclin D1: Normal and abnormal functions
    • DOI 10.1210/en.2004-0959
    • Fu M, Wang C, Li Z, Sakamaki T, Pestell RG. Minireview: Cyclin D1: Normal and abnormal functions. Endocrinology 2004;145:5439-47 (Pubitemid 39564581)
    • (2004) Endocrinology , vol.145 , Issue.12 , pp. 5439-5447
    • Fu, M.1    Wang, C.2    Li, Z.3    Sakamaki, T.4    Pestell, R.G.5
  • 7
    • 0037454409 scopus 로고    scopus 로고
    • Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma
    • DOI 10.1016/S0140-6736(03)13044-9
    • El-Hashemite N, Zhang H, Henske EP, Kwiatkowski DJ. Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma. Lancet 2003;361:1348-9. (Pubitemid 36514870)
    • (2003) Lancet , vol.361 , Issue.9366 , pp. 1348-1349
    • El-Hashemite, N.1    Zhang, H.2    Henske, E.P.3    Kwiatkowski, D.J.4
  • 11
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003;3:721-32. (Pubitemid 37328811)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.10 , pp. 721-732
    • Semenza, G.L.1
  • 12
    • 0033770179 scopus 로고    scopus 로고
    • Pancreatic involvement in von Hippel-Lindau disease
    • The Groupe Francophone d'Etude de la Maladie de von Hippel-Lindau
    • Hammel PR, Vilgrain V, Terris B, Penfornis A, Sauvanet A, Correas JM, et al. Pancreatic involvement in von Hippel-Lindau disease. The Groupe Francophone d'Etude de la Maladie de von Hippel-Lindau. Gastroenterology 2000;119:1087-95.
    • (2000) Gastroenterology , vol.119 , pp. 1087-1095
    • Hammel, P.R.1    Vilgrain, V.2    Terris, B.3    Penfornis, A.4    Sauvanet, A.5    Correas, J.M.6
  • 13
    • 33749642343 scopus 로고    scopus 로고
    • Mammalian Target of Rapamycin Inhibitors in Renal Cell Carcinoma: Current Status and Future Applications
    • DOI 10.1053/j.seminoncol.2006.06.002, PII S0093775406002685, Renal Cell Carcinoma
    • Pantuck AJ, Thomas G, Belldegrun AS, Figlin RA. Mammalian target of rapamycin inhibitors in renal cell carcinoma: current status and future applications. Semin Oncol 2006; 33:607-13. (Pubitemid 44540210)
    • (2006) Seminars in Oncology , vol.33 , Issue.5 , pp. 607-613
    • Pantuck, A.J.1    Thomas, G.2    Belldegrun, A.S.3    Figlin, R.A.4
  • 14
    • 33750619348 scopus 로고    scopus 로고
    • Glucose metabolism and cancer
    • DOI 10.1016/j.ceb.2006.10.005, PII S095506740600158X
    • Shaw RJ. Glucose metabolism and cancer. Curr Opin Cell Biol 2006;18:598-608. (Pubitemid 44692479)
    • (2006) Current Opinion in Cell Biology , vol.18 , Issue.6 , pp. 598-608
    • Shaw, R.J.1
  • 15
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signalling controls tumour cell growth
    • DOI 10.1038/nature04869, PII NATURE04869
    • Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 2006;441:424-30. (Pubitemid 44050136)
    • (2006) Nature , vol.441 , Issue.7092 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 16
    • 34247474846 scopus 로고    scopus 로고
    • Regulation of survivin expression by IGF-1/mTOR signaling
    • DOI 10.1038/sj.onc.1210094, PII 1210094
    • Vaira V, Lee CW, Goel HL, Bosari S, Languino LR, Altieri DC. Regulation of survivin expression by IGF-1/mTOR signaling. Oncogene 2007;26:2678-84. (Pubitemid 46663841)
    • (2007) Oncogene , vol.26 , Issue.19 , pp. 2678-2684
    • Vaira, V.1    Lee, C.W.2    Goel, H.L.3    Bosari, S.4    Languino, L.R.5    Altieri, D.C.6
  • 17
    • 36549057831 scopus 로고    scopus 로고
    • Emerging drugs for the treatment of metastatic renal cancer
    • DOI 10.1517/14728214.12.4.605
    • Samlowski WE, Vogelzang NJ. Emerging drugs for the treatment of metastatic renal cancer. Expert Opin Emerg Drugs 2007;12:605-18. (Pubitemid 350189126)
    • (2007) Expert Opinion on Emerging Drugs , vol.12 , Issue.4 , pp. 605-618
    • Samlowski, W.E.1    Vogelzang, N.J.2
  • 18
    • 0036275356 scopus 로고    scopus 로고
    • Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR) -dependent signaling
    • DOI 10.1096/fj.01-0658com
    • Humar R, Kiefer FN, Berns H, Resink TJ, Battegay EJ. Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling. FASEB J 2002;16:771-80. (Pubitemid 34615125)
    • (2002) FASEB Journal , vol.16 , Issue.8 , pp. 771-780
    • Humar, R.O.K.1    Kiefer, F.N.2    Berns, H.3    Resink, T.J.4    Battegay, E.J.5
  • 20
    • 25144432015 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and activated epidermal growth factor receptor expression in gastrointestinal carcinoids and pancreatic endocrine carcinomas
    • DOI 10.1038/modpathol.3800427, PII 3800427
    • Papouchado B, Erickson LA, Rohlinger AL, Hobday TJ, Erlichman C, Ames MM, et al. Epidermal growth factor receptor and activated epidermal growth factor receptor expression in gastrointestinal carcinoids and pancreatic endocrine carcinomas. Mod Pathol 2005;18:1329-35. (Pubitemid 41348651)
    • (2005) Modern Pathology , vol.18 , Issue.10 , pp. 1329-1335
    • Papouchado, B.1    Erickson, L.A.2    Rohlinger, A.L.3    Hobday, T.J.4    Erlichman, C.5    Ames, M.M.6    Lloyd, R.V.7
  • 21
    • 0036787462 scopus 로고    scopus 로고
    • Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells
    • McDaniel ML, Marshall CA, Pappan KL, Kwon G. Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells. Diabetes 2002;51:2877-85.
    • (2002) Diabetes , vol.51 , pp. 2877-2885
    • McDaniel, M.L.1    Marshall, C.A.2    Pappan, K.L.3    Kwon, G.4
  • 22
    • 34247162696 scopus 로고    scopus 로고
    • Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression-free survival among patients with low-grade neuroendocrine tumors
    • DOI 10.1002/cncr.22554
    • Zhang J, Jia Z, Li Q, Wang L, Rashid A, Zhu Z, et al. Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progressionfree survival among patients with low-grade neuroendocrine tumors. Cancer 2007;109:1478-86. (Pubitemid 46595681)
    • (2007) Cancer , vol.109 , Issue.8 , pp. 1478-1486
    • Zhang, J.1    Jia, Z.2    Li, Q.3    Wang, L.4    Rashid, A.5    Zhu, Z.6    Evans, D.B.7    Vauthey, J.-N.8    Xie, K.9    Yao, J.C.10
  • 25
    • 49749136104 scopus 로고    scopus 로고
    • Morphoproteomic profile of mTOR, Ras/Raf kinase/ERK, and NF-kappaB pathways in human gastric adenocarcinoma
    • Feng W, Brown RE, Trung CD, Li W, Wang L, Khoury T, et al. Morphoproteomic profile of mTOR, Ras/Raf kinase/ERK, and NF-kappaB pathways in human gastric adenocarcinoma. Ann Clin Lab Sci 2008;38:195-209.
    • (2008) Ann Clin Lab Sci , vol.38 , pp. 195-209
    • Feng, W.1    Brown, R.E.2    Trung, C.D.3    Li, W.4    Wang, L.5    Khoury, T.6
  • 26
    • 42649133793 scopus 로고    scopus 로고
    • EGFR in gastric carcinomas: Prognostic significance of protein overexpression and high gene copy number
    • DOI 10.1111/j.1365-2559.2008.03021.x
    • Kim MA, Lee HS, Lee HE, Jeon YK, Yang HK, Kim WH. EGFR in gastric carcinomas: Prognostic significance of protein overexpression and high gene copy number. Histopathology 2008;52:738-46. (Pubitemid 351600058)
    • (2008) Histopathology , vol.52 , Issue.6 , pp. 738-746
    • Kim, M.A.1    Lee, H.S.2    Lee, H.E.3    Jeon, Y.K.4    Yang, H.K.5    Kim, W.H.6
  • 27
    • 38049177080 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) is an independent prognostic indicator of worse outcome in gastric cancer patients
    • Lieto E, Ferraraccio F, Orditura M, Castellano P, Mura AL, Pinto M, et al. Expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) is an independent prognostic indicator of worse outcome in gastric cancer patients. Ann Surg Oncol 2008;15:69-79.
    • (2008) Ann Surg Oncol , vol.15 , pp. 69-79
    • Lieto, E.1    Ferraraccio, F.2    Orditura, M.3    Castellano, P.4    Mura, A.L.5    Pinto, M.6
  • 28
    • 0842265105 scopus 로고    scopus 로고
    • P53 and VEGF expression are independent predictors of tumour recurrence and survival following curative resection of gastric cancer
    • DOI 10.1038/sj.bjc.6601455
    • Fondevila C, Metges JP, Fuster J, Grau JJ, Palacín A, Castells A, et al. p53 and VEGF expression are independent predictors of tumour recurrence and survival following curative resection of gastric cancer. Br J Cancer 2004;90:206-15. (Pubitemid 38174963)
    • (2004) British Journal of Cancer , vol.90 , Issue.1 , pp. 206-215
    • Fondevila, C.1    Metges, J.P.2    Fuster, J.3    Grau, J.J.4    Palacin, A.5    Castells, A.6    Volant, A.7    Pera, M.8
  • 37
    • 58149234169 scopus 로고    scopus 로고
    • Molecular therapy for the treatment of hepatocellular carcinoma
    • Greten TF, Korangy F, Manns MP, Malek NP. Molecular therapy for the treatment of hepatocellular carcinoma. Br J Cancer 2009;100:19-23.
    • (2009) Br J Cancer , vol.100 , pp. 19-23
    • Greten, T.F.1    Korangy, F.2    Manns, M.P.3    Malek, N.P.4
  • 38
    • 39849105376 scopus 로고    scopus 로고
    • Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular cancer
    • DOI 10.3748/wjg.14.1
    • Höpfner M, Schuppan D, Scherübl H. Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular cancer. World J Gastroenterol 2008;14:1-14. (Pubitemid 351314320)
    • (2008) World Journal of Gastroenterology , vol.14 , Issue.1 , pp. 1-14
    • Hopfner, M.1    Schuppan, D.2    Scherubl, H.3
  • 39
    • 68149103802 scopus 로고    scopus 로고
    • American Cancer Society [last accessed on 2010 Oct 25]
    • American Cancer Society. Detailed guide: lymphoma, non- Hodgkin type. Available from: http://www.cancer.org [last accessed on 2010 Oct 25].
    • Detailed Guide: Lymphoma, Non- Hodgkin Type
  • 40
    • 40349095131 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) pathway signalling in lymphomas
    • Drakos E, Rassidakis GZ, Medeiros LJ. Mammalian target of rapamycin (mTOR) pathway signalling in lymphomas. Expert Rev Mol Med 2008;10:e4.
    • (2008) Expert Rev Mol Med , vol.10
    • Drakos, E.1    Rassidakis, G.Z.2    Medeiros, L.J.3
  • 41
    • 33748194240 scopus 로고    scopus 로고
    • Recent developments in targeting the mammalian target of rapamycin (mTOR) kinase pathway
    • PII 0000181320060600000001
    • Smolewski P. Recent developments in targeting the mammalian target of rapamycin (mTOR) kinase pathway. Anticancer Drugs 2006;17:487-94. (Pubitemid 44309964)
    • (2006) Anti-Cancer Drugs , vol.17 , Issue.5 , pp. 487-494
    • Smolewski, P.1
  • 43
    • 0346362997 scopus 로고    scopus 로고
    • Rapamycins: Mechanism of action and cellular resistance
    • Huang S, Bjornsti MA, Houghton PJ. Rapamycins: Mechanism of action and cellular resistance. Cancer Biol Ther 2003;2:222-32.
    • (2003) Cancer Biol Ther , vol.2 , pp. 222-232
    • Huang, S.1    Ma, B.2    Houghton, P.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.