Bex2 is critical for migration and invasion in malignant glioma cells

Journal of Molecular Neuroscience

Volumn 50, Issue 1, 2013, Pages 78-87

  Zhou, Xiuping ^a   Xu, Xuebin ^a   Meng, Qingming ^a   Hu, Jinxia ^a   Zhi, Tongle ^a   Shi, Qiong ^a   Yu, Rutong ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Bex2; Glioblastoma; Invasion; Metalloproteinase 2; Migration; N cadherin

Indexed keywords

GELATINASE A; NERVE CELL ADHESION MOLECULE;

ARTICLE; BRAIN EXPRESSED X LINKED GENE 2; CANCER GROWTH; CANCER INVASION; CELL ADHESION; CELL COUNT; CELL DENSITY; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; GLIOBLASTOMA; GLIOMA CELL; METASTASIS; ONCOGENE; OPEN READING FRAME; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE;

BRAIN NEOPLASMS; CADHERINS; CELL LINE, TUMOR; CELL MOVEMENT; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; HUMANS; MATRIX METALLOPROTEINASE 2; NEOPLASM INVASIVENESS; NERVE TISSUE PROTEINS; RNA, SMALL INTERFERING;

EID: 84876115150     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-012-9864-8     Document Type: Article

References (46)

1. Alvarez E, Zhou W, Witta SE, Freed CR (2005) Characterization of the Bex gene family in humans, mice, and rats. Gene 357(1):18-28 (Pubitemid 41267311)
2. Asano K, Kubo O, Tajika Y, Takakura K, Suzuki S (2000) Expression of cadherin and CSF dissemination in malignant astrocytic tumours. Neurosurg Rev 23:39-44 (Pubitemid 30249527)
3. Asano K, Duntsch CD, Zhou Q, Weimar JD, Bordelon D, Robertson JH, Pourmotabbed T (2004) Correlation of N-cadherin expression in high grade gliomas with tissue invasion. J Neurooncol 70(1):3-15 (Pubitemid 39193992)
4. Aubert M, Badoual M, Fereol S, Christov C, Grammaticos B (2006) A cellular automaton model for the migration of glioma cells. Phys Biol 3(2):93-100 (Pubitemid 44043089)
5. Barami K, Lewis-Tuffin L, Anastasiadis PZ (2006) The role of cadherins and catenins in gliomagenesis. Neurosurg Focus 21(4):E13
6. Baumann F, Leukel P, Doerfelt A, Beier CP, Dettmer K, Oefner PJ, Kastenberger M, Kreutz M, Nickl-Jockschat T, Bogdahn U, Bosserhoff AK, Hau P (2009) Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2. Neuro Oncol 11(4):368-380
7. Bharadwaj AG, Goodrich NP, McAtee CO, Haferbier K, Oakley GG, Wahl JK 3rd, Simpson MA (2011) Hyaluronan suppresses prostate tumor cell proliferation through diminished expression of N-cadherin and aberrant growth factor receptor signaling. Exp Cell Res 317(8):1214-1225
8. Bozzuto G, Ruggieri P, Molinari A (2010) Molecular aspects of tumor cell migration and invasion. Ann Ist Super Sanita 46(1):66-80
9. Buckner JC, Brown PD, O'Neill BP, Meyer FB, Wetmore CJ, Uhm JH (2007) Central nervous system tumors. Mayo Clin Proc 82(10):1271-1286 (Pubitemid 47502884)
10. Cavallaro U, Christofori G (2004) Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer 4(2):118-132 (Pubitemid 38198740)
11. Chaw KC, Manimaran M, Tay FE, Swaminathan S (2007) Matrigel coated polydimethylsiloxane based microfluidic devices for studying metastatic and non-metastatic cancer cell invasion and migration. Biomed Microdevices 9(4):597-602
12. Derycke LD, Bracke ME (2004) N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling. Int J Dev Biol 48(5-6):463-476 (Pubitemid 39360397)
13. Drivalos A, Papatsoris AG, Chrisofos M, Efstathiou E, Dimopoulos MA (2011) The role of the cell adhesion molecules (integrins/cadherins) in prostate cancer. Int Braz J Urol 37(3):302-306
14. Foltz G, Ryu GY, Yoon JG, Nelson T, Fahey J, Frakes A, Lee H, Field L, Zander K, Sibenaller Z, Ryken TC, Vibhakar R, Hood L, Madan A (2006) Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. Cancer Res 66(13):6665-6674 (Pubitemid 44085623)
15. Gabelloni P, Da Pozzo E, Bendinelli S, Costa B, Nuti E, Casalini F, Orlandini E, Da Settimo F, Rossello A, Martini C (2010) Inhibition of metalloproteinases derived from tumours: new insights in the treatment of human glioblastoma. Neuroscience 168(2):514-522
16. Han C, Liu H, Liu J, Yin K, Xie Y, Shen X, Wang Y, Yuan J, Qiang B, Liu YJ, Peng X (2005) Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex. Nucleic Acids Res 33(20):6555-6565 (Pubitemid 41806420)
17. Hirohashi S, Kanai Y (2003) Cell adhesion system and human cancer morphogenesis. Cancer Sci 94(7):575-581 (Pubitemid 36975010)
18. Hu B, Jarzynka MJ, Guo P, Imanishi Y, Schlaepfer DD, Cheng SY (2006) Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway. Cancer Res 66(2):775-783 (Pubitemid 43165942)
19. Itoh Y, Palmisano R, Anilkumar N, Nagase H, Miyawaki A, Seiki M (2011) Dimerization of MT1-MMP during cellular invasion detected by fluorescence resonance energy transfer. Biochem J 440(3):319-326
20. Jeanes A, Gottardi CJ, Yap AS (2008) Cadherins and cancer: how does cadherin dysfunction promote tumor progression? Oncogene 27(55):6920-6929
21. Kargiotis O, Chetty C, Gondi CS, Tsung AJ, Dinh DH, Gujrati M, Lakka SS, Kyritsis AP, Rao JS (2008) Adenovirus-mediated transfer of siRNA against MMP-2 mRNA results in impaired invasion and tumor-induced angiogenesis, induces apoptosis in vitro and inhibits tumor growth in vivo in glioblastoma. Oncogene 27(35):4830-4840
22. Kislin KL, McDonough WS, Eschbacher JM, Armstrong BA, Berens ME (2009) NHERF-1: modulator of glioblastoma cell migration and invasion. Neoplasia 11(4):377-387
23. Kotb AM, Hierholzer A, Kemler R (2011) Replacement of E-cadherin by N-cadherin in the mammary gland leads to fibrocystic changes and tumor formation. Breast Cancer Res 13(5):R104
24. Lacroix M, Abi-Said D, Fourney DR, Gokaslan ZL, Shi W, DeMonte F, Lang FF, McCutcheon IE, Hassenbusch SJ, Holland E, Hess K, Michael C, Miller D, Sawaya R (2001) A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg 95(2):190-198 (Pubitemid 32799739)
25. Lee LY, Wu CM, Wang CC, Yu JS, Liang Y, Huang KH, Lo CH, Hwang TL (2008) Expression of matrix metalloproteinases MMP-2 and MMP-9 in gastric cancer and their relation to claudin-4 expression. Histol Histopathol 23(5):515-521 (Pubitemid 351552337)
26. Leinonen T, Pirinen R, Bohm J, Johansson R, Kosma VM (2008) Increased expression of matrix metalloproteinase-2 (MMP-2) predicts tumour recurrence and unfavourable outcome in non-small cell lung cancer. Histol Histopathol 23(6):693-700 (Pubitemid 351552354)
27. Mendes O, Kim HT, Stoica G (2005) Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model. Clin Exp Metastasis 22(3):237-246 (Pubitemid 41298005)
28. Munaut C, Noel A, Hougrand O, Foidart JM, Boniver J, Deprez M (2003) Vascular endothelial growth factor expression correlates with matrix metalloproteinases MT1-MMP, MMP-2 and MMP-9 in human glioblastomas. Int J Cancer 106(6):848-855 (Pubitemid 37071662)
29. Naderi A, Teschendorff A, Beigel J et al (2007) BEX2 is overexpressed in a subset of primary breast cancers and mediates nerve growth factor/nuclear factor-kappaB inhibition of apoptosis in breast cancer cell lines. Cancer Res 67(14):6725-6736 (Pubitemid 47105519)
30. Naderi A, Liu J, Bennett I (2010a) BEX2 regulates mitochondrial apoptosis and G1 cell cycle in breast cancer. Int J Cancer 126(7):1596-1610
31. Naderi A, Liu J, Hughes-Davies L (2010b) Bex2 has a functional interplay with c-Jun/JNK and p65/RelA in breast cancer. Mol Cancer 9:111
32. Nakopoulou L, Tsirmpa I, Alexandrou P, Louvrou A, Ampela C, Markaki S, Davaris PS (2003) MMP-2 protein in invasive breast cancer and the impact of MMP-2/TIMP-2 phenotype on overall survival. Breast Cancer Res Treat 77(2):145-155 (Pubitemid 36197615)
33. Perego C, Vanoni C, Massari S, Raimondi A, Pola S, Cattaneo MG, Francolini M, Vicentini LM, Pietrini G (2002) Invasive behaviour of glioblastoma cell lines is associated with altered organisation of the cadherin-catenin adhesion system. J Cell Sci 115(16):3331-3340 (Pubitemid 34960185)
34. Petrie RJ, Doyle AD, Yamada KM (2009) Random versus directionally persistent cell migration. Nat Rev Mol Cell Biol 10(8):538-549
35. Rampling R, James A, Papanastassiou V (2004) The present and future management of malignant brain tumours: surgery, radiotherapy, chemotherapy. J Neurol Neurosurg Psychiatry 75(Suppl 2):ii24-ii30 (Pubitemid 41652838)
36. Rappl A, Piontek G, Schlegel J (2008) EGFR-dependent migration of glial cells is mediated by reorganisation of N-cadherin. J Cell Sci 121(Pt 24):4089-4097
37. Sabeh F, Shimizu-Hirota R, Weiss SJ (2009) Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited. J Cell Biol 185(1):11-19
38. Schmalfeldt B, Prechtel D, Harting K, Spathe K, Rutke S, Konik E, Fridman R, Berger U, Schmitt M, Kuhn W, Lengyel E (2001) Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinase-type plasminogen activator is associated with progression from benign to advanced ovarian cancer. Clin Cancer Res 7(8):2396-2404 (Pubitemid 32751641)
39. Seznec J, Weit S, Naumann U (2010) Gene expression profile in a glioma cell line resistant to cell death induced by the chimeric tumor suppressor-1 (CTS-1), a dominant-positive variant of p53 - the role of NFkappaB. Carcinogenesis 31(3):411-418
40. Shinoura N, Paradies NE, Warnick RE, Chen H, Larson JJ, Tew JJ, Simon M, Lynch RA, Kanai Y, Hirohashi S et al (1995) Expression of N-cadherin and alpha-catenin in astrocytomas and glioblastomas. Br J Cancer 72(3):627-633
41. Siebzehnrubl FA, Reynolds BA, Vescovi A, Steindler DA, Deleyrolle LP (2011) The origins of glioma: e pluribus unum? Glia 59(8):1135-1147
42. Su Y, Li J, Witkiewicz AK, Brennan D, Neill T, Talarico J, Radice GL (2011) N-cadherin haploinsufficiency increases survival in a mouse model of pancreatic cancer. Oncogene 12. doi: 10.1038/onc.2011.574 [Epub ahead of print]
43. Utsuki S, Sato Y, Oka H, Tsuchiya B, Suzuki S, Fujii K (2002) Relationship between the expression of E-, N-cadherins and beta-catenin and tumor grade in astrocytomas. J Neurooncol 57(3):187-192 (Pubitemid 34692627)
44. Yagita Y, Sakurai T, Tanaka H, Kitagawa K, Colman DR, Shan W (2009) N-cadherin mediates interaction between precursor cells in the subventricular zone and regulates further differentiation. J Neurosci Res 87(15):3331-3342
45. Zhou X, Hua L, Zhang W, Zhu M, Shi Q, Li F, Zhang L, Song C, Yu R (2012a) FRK controls migration and invasion of human glioma cells by regulating JNK/c-Jun signaling. J Neuro Oncol 13. doi: 10.1007/s11060-012-0933-1 [Epub ahead of print]
46. Zhou X, Ma L, Li J, Gu J, Shi Q, Yu R (2012b) Effects of SEMA3G on migration and invasion of glioma cells. Oncol Rep 28(1):269-275