Phosphatidylinositol 3′-kinase signaling pathway is essential for Rac1-induced hypoxia-inducible factor-1α and vascular endothelial growth factor expression

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 300, Issue 6, 2011, Pages

  Xue, Yan ^a   Li, Nan Lin ^a   Yang, Jing Yue ^a   Chen, Yan ^a   Yang, Lu Lu ^a   Liu, Wen Chao ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Angiogenesis; Signal transduction; Tumor suppressor genes

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P53; RAC1 PROTEIN; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; ENZYME INHIBITOR; HIF1A PROTEIN, HUMAN; MORPHOLINE DERIVATIVE; RAC1 PROTEIN, HUMAN; VASCULOTROPIN A;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYPOXIA; MOLECULAR INTERACTION; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; UPREGULATION; ANOXIA; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; STOMACH TUMOR; TUMOR CELL LINE;

ANOXIA; CELL LINE, TUMOR; CHROMONES; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MORPHOLINES; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHATIDYLINOSITOL 3-KINASES; RAC1 GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 79958076969     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00970.2010     Document Type: Article

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