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Volumn 6, Issue AUG, 2013, Pages

Circulating microRNAs in Alzheimer's disease: The search for novel biomarkers

Author keywords

Alzheimer's disease; Biomarker; Diagnosis; microRNA; Mild cognitive impairment

Indexed keywords

AMYLOID PROTEIN; MICRORNA; TAU PROTEIN; UNTRANSLATED RNA;

EID: 84885070998     PISSN: 16625099     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnmol.2013.00024     Document Type: Article
Times cited : (51)

References (54)
  • 1
    • 84871609151 scopus 로고    scopus 로고
    • MicroRNAs and neurodegeneration: Role and impact
    • doi: 10.1016/j.tcb.2012.08.013
    • Abe, M., and Bonini, N. M. (2013). MicroRNAs and neurodegeneration: role and impact. Trends Cell Biol. 23, 30-36. doi: 10.1016/j.tcb.2012.08.013
    • (2013) Trends Cell Biol. , vol.23 , pp. 30-36
    • Abe, M.1    Bonini, N.M.2
  • 2
    • 84871695724 scopus 로고    scopus 로고
    • microRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF)
    • Alexandrov, P. N., Dua, P., Hill, J. M., Bhattacharjee, S., Zhao, Y., and Lukiw, W. J. (2012). microRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF). Int. J. Biochem. Mol. Biol. 3, 365-373.
    • (2012) Int. J. Biochem. Mol. Biol. , vol.3 , pp. 365-373
    • Alexandrov, P.N.1    Dua, P.2    Hill, J.M.3    Bhattacharjee, S.4    Zhao, Y.5    Lukiw, W.J.6
  • 3
    • 84880564516 scopus 로고    scopus 로고
    • MicroRNA in Alzheimer's disease: An exploratory study in brain, cerebrospinal fluid and plasma
    • doi: 10.3109/1354750X.2013.814073
    • Bekris, L. M., Lutz, F., Montine, T. J., Yu, C. E., Tsuang, D., Peskind, E. R., et al. (2013). MicroRNA in Alzheimer's disease: an exploratory study in brain, cerebrospinal fluid and plasma. Biomarkers 18, 455-466. doi: 10.3109/1354750X.2013.814073
    • (2013) Biomarkers , vol.18 , pp. 455-466
    • Bekris, L.M.1    Lutz, F.2    Montine, T.J.3    Yu, C.E.4    Tsuang, D.5    Peskind, E.R.6
  • 4
    • 84877263242 scopus 로고    scopus 로고
    • A microRNA miR-34a-regulated bimodal switch targets notch in colon cancer stem cells
    • doi: 10.1016/j.stem.2013.03.002
    • Bu, P., Chen, K. Y., Chen, J. H., Wang, L., Walters, J., Shin, Y. J., et al. (2013). A microRNA miR-34a-regulated bimodal switch targets notch in colon cancer stem cells. Cell Stem Cell 12, 602-615. doi: 10.1016/j.stem.2013.03.002
    • (2013) Cell Stem Cell , vol.12 , pp. 602-615
    • Bu, P.1    Chen, K.Y.2    Chen, J.H.3    Wang, L.4    Walters, J.5    Shin, Y.J.6
  • 5
    • 37549008310 scopus 로고    scopus 로고
    • Widespread microRNA repression by Myc contributes to tumorigenesis
    • doi: 10.1038/ng.2007.30
    • Chang, T. C., Yu, D., Lee, Y. S., Wentzel, E. A., Arking, D. E., West, K. M., et al. (2008). Widespread microRNA repression by Myc contributes to tumorigenesis. Nat. Genet. 40, 43-50. doi: 10.1038/ng.2007.30
    • (2008) Nat. Genet. , vol.40 , pp. 43-50
    • Chang, T.C.1    Yu, D.2    Lee, Y.S.3    Wentzel, E.A.4    Arking, D.E.5    West, K.M.6
  • 6
    • 84885028399 scopus 로고    scopus 로고
    • Biomarkers in Alzheimer's disease: A review
    • doi: 10.5402/2012/984786
    • Chintamaneni, M., and Bhaskar, M. (2012). Biomarkers in Alzheimer's disease: a review. ISRN Pharmacol. 2012, 984786. doi: 10.5402/2012/984786
    • (2012) ISRN Pharmacol. , vol.2012 , pp. 984786
    • Chintamaneni, M.1    Bhaskar, M.2
  • 7
    • 47849124269 scopus 로고    scopus 로고
    • Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways
    • Cogswell, J. P., Ward, J., Taylor, I. A., Waters, M., Shi, Y., Cannon, B., et al. (2008). Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways. J. Alzheimers Dis. 14, 27-41.
    • (2008) J. Alzheimers Dis. , vol.14 , pp. 27-41
    • Cogswell, J.P.1    Ward, J.2    Taylor, I.A.3    Waters, M.4    Shi, Y.5    Cannon, B.6
  • 8
    • 49749150980 scopus 로고    scopus 로고
    • A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene
    • doi: 10.1158/1541-7786.MCR-07-2102
    • Cole, K. A., Attiyeh, E. F., Mosse, Y. P., Laquaglia, M. J., Diskin, S. J., Brodeur, G. M., et al. (2008). A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene. Mol. Cancer Res. 6, 735-742. doi: 10.1158/1541-7786.MCR-07-2102
    • (2008) Mol. Cancer Res. , vol.6 , pp. 735-742
    • Cole, K.A.1    Attiyeh, E.F.2    Mosse, Y.P.3    Laquaglia, M.J.4    Diskin, S.J.5    Brodeur, G.M.6
  • 9
    • 84859503786 scopus 로고    scopus 로고
    • MicroRNAs in Alzheimer's disease
    • doi: 10.1016/j.nbd.2012.01.003
    • Delay, C., Mandemakers, W., and Hebert, S. S. (2012). MicroRNAs in Alzheimer's disease. Neurobiol. Dis. 46, 285-290. doi: 10.1016/j.nbd.2012.01.003
    • (2012) Neurobiol. Dis. , vol.46 , pp. 285-290
    • Delay, C.1    Mandemakers, W.2    Hebert, S.S.3
  • 10
    • 84865442904 scopus 로고    scopus 로고
    • Gene network and pathway analysis of mice with conditional ablation of dicer in post-mitotic neurons
    • doi: 10.1371/journal.pone.0044060
    • Dorval, V., Smith, P. Y., Delay, C., Calvo, E., Planel, E., Zommer, N., et al. (2012). Gene network and pathway analysis of mice with conditional ablation of dicer in post-mitotic neurons. PLoS ONE 7:e44060. doi: 10.1371/journal.pone.0044060
    • (2012) PLoS ONE , vol.7
    • Dorval, V.1    Smith, P.Y.2    Delay, C.3    Calvo, E.4    Planel, E.5    Zommer, N.6
  • 11
    • 80054025163 scopus 로고    scopus 로고
    • MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid beta, novel targets in sporadic Alzheimer's disease
    • doi: 10.1523/JNEUROSCI.3883-11.2011
    • Geekiyanage, H., and Chan, C. (2011). MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid beta, novel targets in sporadic Alzheimer's disease. J. Neurosci. 31, 14820-14830. doi: 10.1523/JNEUROSCI.3883-11.2011
    • (2011) J. Neurosci. , vol.31 , pp. 14820-14830
    • Geekiyanage, H.1    Chan, C.2
  • 12
    • 84860369464 scopus 로고    scopus 로고
    • Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease
    • doi: 10.1016/j.expneurol.2011.11.026
    • Geekiyanage, H., Jicha, G. A., Nelson, P. T., and Chan, C. (2012). Blood serum miRNA: non-invasive biomarkers for Alzheimer's disease. Exp. Neurol. 235, 491-496. doi: 10.1016/j.expneurol.2011.11.026
    • (2012) Exp. Neurol. , vol.235 , pp. 491-496
    • Geekiyanage, H.1    Jicha, G.A.2    Nelson, P.T.3    Chan, C.4
  • 13
    • 0029979798 scopus 로고    scopus 로고
    • Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease
    • Gomez-Isla, T., Price, J. L., Mckeel, D. W., Jr., Morris, J. C., Growdon, J. H., and Hyman, B. T. (1996). Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J. Neurosci. 16, 4491-4500.
    • (1996) J. Neurosci. , vol.16 , pp. 4491-4500
    • Gomez-Isla, T.1    Price, J.L.2    McKeel Jr., D.W.3    Morris, J.C.4    Growdon, J.H.5    Hyman, B.T.6
  • 14
    • 54049100454 scopus 로고    scopus 로고
    • Imaging amyloid deposition in Lewy body diseases
    • doi: 10.1212/01.wnl.0000326146.60732.d6
    • Gomperts, S. N., Rentz, D. M., Moran, E., Becker, J. A., Locascio, J. J., Klunk, W. E., et al. (2008). Imaging amyloid deposition in Lewy body diseases. Neurology 71, 903-910. doi: 10.1212/01.wnl.0000326146.60732.d6
    • (2008) Neurology , vol.71 , pp. 903-910
    • Gomperts, S.N.1    Rentz, D.M.2    Moran, E.3    Becker, J.A.4    Locascio, J.J.5    Klunk, W.E.6
  • 15
    • 34250851115 scopus 로고    scopus 로고
    • A microRNA component of the p53 tumour suppressor network
    • doi: 10.1038/nature05939
    • He, L., He, X., Lim, L. P., De Stanchina, E., Xuan, Z., Liang, Y., et al. (2007). A microRNA component of the p53 tumour suppressor network. Nature 447, 1130-1134. doi: 10.1038/nature05939
    • (2007) Nature , vol.447 , pp. 1130-1134
    • He, L.1    He, X.2    Lim, L.P.3    de Stanchina, E.4    Xuan, Z.5    Liang, Y.6
  • 16
    • 77957735016 scopus 로고    scopus 로고
    • Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration
    • doi: 10.1093/hmg/ddq311
    • Hebert, S. S., Papadopoulou, A. S., Smith, P., Galas, M. C., Planel, E., Silahtaroglu, A. N., et al. (2010). Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration. Hum. Mol. Genet. 19, 3959-3969. doi: 10.1093/hmg/ddq311
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 3959-3969
    • Hebert, S.S.1    Papadopoulou, A.S.2    Smith, P.3    Galas, M.C.4    Planel, E.5    Silahtaroglu, A.N.6
  • 17
    • 84877117884 scopus 로고    scopus 로고
    • A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with Lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls
    • doi: 10.3233/JAD-122350
    • Hebert, S. S., Wang, W. X., Zhu, Q., and Nelson, P. T. (2013). A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with Lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls. J. Alzheimers Dis. 35, 335-348. doi: 10.3233/JAD-122350
    • (2013) J. Alzheimers Dis. , vol.35 , pp. 335-348
    • Hebert, S.S.1    Wang, W.X.2    Zhu, Q.3    Nelson, P.T.4
  • 18
    • 0033817466 scopus 로고    scopus 로고
    • Tau promoter confers neuronal specificity and binds Sp1 and AP-2
    • doi: 10.1046/j.1471-4159.2000.0751408.x
    • Heicklen-Klein, A., and Ginzburg, I. (2000). Tau promoter confers neuronal specificity and binds Sp1 and AP-2. J. Neurochem. 75, 1408-1418. doi: 10.1046/j.1471-4159.2000.0751408.x
    • (2000) J. Neurochem. , vol.75 , pp. 1408-1418
    • Heicklen-Klein, A.1    Ginzburg, I.2
  • 19
    • 80955151917 scopus 로고    scopus 로고
    • CSF biomarkers for Alzheimer's disease: Current utility and potential future use
    • doi: 10.1016/j.neurobiolaging.2011.09.003
    • Holtzman, D. M. (2011). CSF biomarkers for Alzheimer's disease: current utility and potential future use. Neurobiol. Aging 32(Suppl.1), S4-S9. doi: 10.1016/j.neurobiolaging.2011.09.003
    • (2011) Neurobiol. Aging , vol.32 , Issue.SUPPL. 1
    • Holtzman, D.M.1
  • 20
    • 84869212180 scopus 로고    scopus 로고
    • Exosomal miRNAs: Biological properties and therapeutic potential
    • doi: 10.3389/fgene.2012.00056
    • Hu, G., Drescher, K. M., and Chen, X. M. (2012). Exosomal miRNAs: biological properties and therapeutic potential. Front. Genet. 3:56. doi: 10.3389/fgene.2012.00056
    • (2012) Front. Genet. , vol.3 , pp. 56
    • Hu, G.1    Drescher, K.M.2    Chen, X.M.3
  • 21
    • 84856002055 scopus 로고    scopus 로고
    • National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease
    • doi: 10.1016/j.jalz.2011.10.007
    • Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., et al. (2012). National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimers Dement. 8, 1-13. doi: 10.1016/j.jalz.2011.10.007
    • (2012) Alzheimers Dement. , vol.8 , pp. 1-13
    • Hyman, B.T.1    Phelps, C.H.2    Beach, T.G.3    Bigio, E.H.4    Cairns, N.J.5    Carrillo, M.C.6
  • 23
    • 33646437238 scopus 로고    scopus 로고
    • Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia
    • doi: 10.1001/archneur.63.5.674
    • Jicha, G. A., Parisi, J. E., Dickson, D. W., Johnson, K., Cha, R., Ivnik, R. J., et al. (2006). Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia. Arch. Neurol. 63, 674-681. doi: 10.1001/archneur.63.5.674
    • (2006) Arch. Neurol. , vol.63 , pp. 674-681
    • Jicha, G.A.1    Parisi, J.E.2    Dickson, D.W.3    Johnson, K.4    Cha, R.5    Ivnik, R.J.6
  • 24
    • 20044395613 scopus 로고    scopus 로고
    • RAS is regulated by the let-7 microRNA family
    • doi: 10.1016/j.cell.2005.01.014
    • Johnson, S. M., Grosshans, H., Shingara, J., Byrom, M., Jarvis, R., Cheng, A., et al. (2005). RAS is regulated by the let-7 microRNA family. Cell 120, 635-647. doi: 10.1016/j.cell.2005.01.014
    • (2005) Cell , vol.120 , pp. 635-647
    • Johnson, S.M.1    Grosshans, H.2    Shingara, J.3    Byrom, M.4    Jarvis, R.5    Cheng, A.6
  • 25
    • 0023105114 scopus 로고
    • The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
    • doi: 10.1038/325733a0
    • Kang, J., Lemaire, H. G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K. H., et al. (1987). The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733-736. doi: 10.1038/325733a0
    • (1987) Nature , vol.325 , pp. 733-736
    • Kang, J.1    Lemaire, H.G.2    Unterbeck, A.3    Salbaum, J.M.4    Masters, C.L.5    Grzeschik, K.H.6
  • 26
    • 77952920881 scopus 로고    scopus 로고
    • Secretory mechanisms and intercellular transfer of microRNAs in living cells
    • doi: 10.1074/jbc.M110.107821
    • Kosaka, N., Iguchi, H., Yoshioka, Y., Takeshita, F., Matsuki, Y., and Ochiya, T. (2010). Secretory mechanisms and intercellular transfer of microRNAs in living cells. J. Biol. Chem. 285, 17442-17452. doi: 10.1074/jbc.M110.107821
    • (2010) J. Biol. Chem. , vol.285 , pp. 17442-17452
    • Kosaka, N.1    Iguchi, H.2    Yoshioka, Y.3    Takeshita, F.4    Matsuki, Y.5    Ochiya, T.6
  • 27
    • 84863647710 scopus 로고    scopus 로고
    • Mechanisms of age-related cognitive change and targets for intervention: Epigenetics
    • doi: 10.1093/gerona/gls110
    • Kosik, K. S., Rapp, P. R., Raz, N., Small, S. A., Sweatt, J. D., and Tsai, L. H. (2012). Mechanisms of age-related cognitive change and targets for intervention: epigenetics. J. Gerontol. A Biol. Sci. Med. Sci. 67, 741-746. doi: 10.1093/gerona/gls110
    • (2012) J. Gerontol. A Biol. Sci. Med. Sci. , vol.67 , pp. 741-746
    • Kosik, K.S.1    Rapp, P.R.2    Raz, N.3    Small, S.A.4    Sweatt, J.D.5    Tsai, L.H.6
  • 28
    • 0024542108 scopus 로고
    • Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene
    • doi: 10.1016/0006-291X(89)92437-6
    • La Fauci, G., Lahiri, D. K., Salton, S. R., and Robakis, N. K. (1989). Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene. Biochem. Biophys. Res. Commun. 159, 297-304. doi: 10.1016/0006-291X(89)92437-6
    • (1989) Biochem. Biophys. Res. Commun. , vol.159 , pp. 297-304
    • la Fauci, G.1    Lahiri, D.K.2    Salton, S.R.3    Robakis, N.K.4
  • 29
    • 34250877841 scopus 로고    scopus 로고
    • A mammalian microRNA expression atlas based on small RNA library sequencing
    • doi: 10.1016/j.cell.2007.04.040
    • Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., et al. (2007). A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 129, 1401-1414. doi: 10.1016/j.cell.2007.04.040
    • (2007) Cell , vol.129 , pp. 1401-1414
    • Landgraf, P.1    Rusu, M.2    Sheridan, R.3    Sewer, A.4    Iovino, N.5    Aravin, A.6
  • 30
    • 84861577379 scopus 로고    scopus 로고
    • An unconventional role for miRNA: Let-7 activates Toll-like receptor 7 and causes neurodegeneration
    • doi: 10.1038/nn.3113
    • Lehmann, S. M., Kruger, C., Park, B., Derkow, K., Rosenberger, K., Baumgart, J., et al. (2012). An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat. Neurosci. 15, 827-835. doi: 10.1038/nn.3113
    • (2012) Nat. Neurosci. , vol.15 , pp. 827-835
    • Lehmann, S.M.1    Kruger, C.2    Park, B.3    Derkow, K.4    Rosenberger, K.5    Baumgart, J.6
  • 31
    • 84880956260 scopus 로고    scopus 로고
    • A blood based 12-miRNA signature of Alzheimer disease patients
    • doi: 10.1186/gb-2013-14-7-r78 [Epub ahead of print]
    • Leidinger, P., Backes, C., Deutscher, S., Schmitt, K., Muller, S. C., Frese, K., et al. (2013). A blood based 12-miRNA signature of Alzheimer disease patients. Genome Biol. 14, R78. doi: 10.1186/gb-2013-14-7-r78 [Epub ahead of print].
    • (2013) Genome Biol. , vol.14
    • Leidinger, P.1    Backes, C.2    Deutscher, S.3    Schmitt, K.4    Muller, S.C.5    Frese, K.6
  • 32
    • 79957687792 scopus 로고    scopus 로고
    • MicroRNA 802 stimulates ROMK channels by suppressing caveolin-1
    • doi: 10.1681/ASN.2010090927
    • Lin, D. H., Yue, P., Pan, C., Sun, P., and Wang, W. H. (2011). MicroRNA 802 stimulates ROMK channels by suppressing caveolin-1. J. Am. Soc. Nephrol. 22, 1087-1098. doi: 10.1681/ASN.2010090927
    • (2011) J. Am. Soc. Nephrol. , vol.22 , pp. 1087-1098
    • Lin, D.H.1    Yue, P.2    Pan, C.3    Sun, P.4    Wang, W.H.5
  • 33
    • 45549103746 scopus 로고    scopus 로고
    • MicroRNAs and the immune response
    • doi: 10.1016/j.it.2008.04.004
    • Lindsay, M. A. (2008). MicroRNAs and the immune response. Trends Immunol. 29, 343-351. doi: 10.1016/j.it.2008.04.004
    • (2008) Trends Immunol. , vol.29 , pp. 343-351
    • Lindsay, M.A.1
  • 34
    • 84855806746 scopus 로고    scopus 로고
    • MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice
    • doi: 10.1016/j.neurobiolaging.2010.04.034
    • Liu, W., Liu, C., Zhu, J., Shu, P., Yin, B., Gong, Y., et al. (2012). MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice. Neurobiol. Aging 33, 522-534. doi: 10.1016/j.neurobiolaging.2010.04.034
    • (2012) Neurobiol. Aging , vol.33 , pp. 522-534
    • Liu, W.1    Liu, C.2    Zhu, J.3    Shu, P.4    Yin, B.5    Gong, Y.6
  • 35
    • 68649092030 scopus 로고    scopus 로고
    • MicroRNA: Implications for Alzheimer disease and other human CNS disorders
    • doi: 10.2174/138920209788185252
    • Maes, O. C., Chertkow, H. M., Wang, E., and Schipper, H. M. (2009). MicroRNA: implications for Alzheimer disease and other human CNS disorders. Curr. Genomics 10, 154-168. doi: 10.2174/138920209788185252
    • (2009) Curr. Genomics , vol.10 , pp. 154-168
    • Maes, O.C.1    Chertkow, H.M.2    Wang, E.3    Schipper, H.M.4
  • 36
    • 70349952140 scopus 로고    scopus 로고
    • MicroRNA isolation and stability in stored RNA samples
    • doi: 10.1016/j.bbrc.2009.09.061
    • Mraz, M., Malinova, K., Mayer, J., and Pospisilova, S. (2009). MicroRNA isolation and stability in stored RNA samples. Biochem. Biophys. Res. Commun. 390, 1-4. doi: 10.1016/j.bbrc.2009.09.061
    • (2009) Biochem. Biophys. Res. Commun. , vol.390 , pp. 1-4
    • Mraz, M.1    Malinova, K.2    Mayer, J.3    Pospisilova, S.4
  • 37
    • 84860215480 scopus 로고    scopus 로고
    • Correlation of Alzheimer disease neuropathologic changes with cognitive status: A review of the literature
    • doi: 10.1097/NEN.0b013e31825018f7
    • Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., et al. (2012). Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J. Neuropathol. Exp. Neurol. 71, 362-381. doi: 10.1097/NEN.0b013e31825018f7
    • (2012) J. Neuropathol. Exp. Neurol. , vol.71 , pp. 362-381
    • Nelson, P.T.1    Alafuzoff, I.2    Bigio, E.H.3    Bouras, C.4    Braak, H.5    Cairns, N.J.6
  • 38
    • 64049098761 scopus 로고    scopus 로고
    • Neuropathology and cognitive impairment in Alzheimer disease: A complex but coherent relationship
    • doi: 10.1097/NEN.0b013e3181919a48
    • Nelson, P. T., Braak, H., and Markesbery, W. R. (2009). Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship. J. Neuropathol. Exp. Neurol. 68, 1-14. doi: 10.1097/NEN.0b013e3181919a48
    • (2009) J. Neuropathol. Exp. Neurol. , vol.68 , pp. 1-14
    • Nelson, P.T.1    Braak, H.2    Markesbery, W.R.3
  • 39
    • 84858005054 scopus 로고    scopus 로고
    • miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes
    • doi: 10.1016/j.mito.2011.09.001
    • Ouyang, Y. B., Lu, Y., Yue, S., and Giffard, R. G. (2012). miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes. Mitochondrion 12, 213-219. doi: 10.1016/j.mito.2011.09.001
    • (2012) Mitochondrion , vol.12 , pp. 213-219
    • Ouyang, Y.B.1    Lu, Y.2    Yue, S.3    Giffard, R.G.4
  • 40
    • 15744377208 scopus 로고    scopus 로고
    • MicroRNAs: A developing story
    • doi: 10.1016/j.gde.2005.01.002
    • Pasquinelli, A. E., Hunter, S., and Bracht, J. (2005). MicroRNAs: a developing story. Curr. Opin. Genet. Dev. 15, 200-205. doi: 10.1016/j.gde.2005.01.002
    • (2005) Curr. Opin. Genet. Dev. , vol.15 , pp. 200-205
    • Pasquinelli, A.E.1    Hunter, S.2    Bracht, J.3
  • 41
    • 33646830919 scopus 로고    scopus 로고
    • Mild Cognitive Impairment (MCI) in medical practice: A critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimer's Disease
    • doi: 10.1136/jnnp.2005.085332
    • Portet, F., Ousset, P. J., Visser, P. J., Frisoni, G. B., Nobili, F., Scheltens, P., et al. (2006). Mild Cognitive Impairment (MCI) in medical practice: a critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimer's Disease. J. Neurol. Neurosurg. Psychiatry 77, 714-718. doi: 10.1136/jnnp.2005.085332
    • (2006) J. Neurol. Neurosurg. Psychiatry , vol.77 , pp. 714-718
    • Portet, F.1    Ousset, P.J.2    Visser, P.J.3    Frisoni, G.B.4    Nobili, F.5    Scheltens, P.6
  • 42
    • 79960104144 scopus 로고    scopus 로고
    • MicroRNAs in development and disease
    • doi: 10.1152/physrev.00006.2010
    • Sayed, D., and Abdellatif, M. (2011). MicroRNAs in development and disease. Physiol. Rev. 91, 827-887. doi: 10.1152/physrev.00006.2010
    • (2011) Physiol. Rev. , vol.91 , pp. 827-887
    • Sayed, D.1    Abdellatif, M.2
  • 43
    • 67649578152 scopus 로고    scopus 로고
    • Biomarker potential of heme oxygenase-1 in Alzheimer's disease and mild cognitive impairment
    • doi: 10.2217/17520363.1.3.375
    • Schipper, H. M. (2007). Biomarker potential of heme oxygenase-1 in Alzheimer's disease and mild cognitive impairment. Biomark. Med. 1, 375-385. doi: 10.2217/17520363.1.3.375
    • (2007) Biomark. Med. , vol.1 , pp. 375-385
    • Schipper, H.M.1
  • 45
    • 77955919746 scopus 로고    scopus 로고
    • Biomarkers in translational research of Alzheimer's disease
    • doi: 10.1016/j.neuropharm.2010.04.006
    • Tarawneh, R., and Holtzman, D. M. (2010). Biomarkers in translational research of Alzheimer's disease. Neuropharmacology 59, 310-322. doi: 10.1016/j.neuropharm.2010.04.006
    • (2010) Neuropharmacology , vol.59 , pp. 310-322
    • Tarawneh, R.1    Holtzman, D.M.2
  • 46
    • 84887264718 scopus 로고    scopus 로고
    • MicroRNAs in the brain: It's regulatory role in neuroinflammation
    • doi: 10.1007/s12035-013-8400-3
    • Thounaojam, M. C., Kaushik, D. K., and Basu, A. (2013). MicroRNAs in the brain: it's regulatory role in neuroinflammation. Mol. Neurobiol. 47, 1034-1044. doi: 10.1007/s12035-013-8400-3
    • (2013) Mol. Neurobiol. , vol.47 , pp. 1034-1044
    • Thounaojam, M.C.1    Kaushik, D.K.2    Basu, A.3
  • 47
    • 84859318003 scopus 로고    scopus 로고
    • Regulation of microRNA biogenesis and function
    • doi: 10.1160/TH11-12-0836
    • Treiber, T., Treiber, N., and Meister, G. (2012). Regulation of microRNA biogenesis and function. Thromb. Haemost. 107, 605-610. doi: 10.1160/TH11-12-0836
    • (2012) Thromb. Haemost. , vol.107 , pp. 605-610
    • Treiber, T.1    Treiber, N.2    Meister, G.3
  • 48
    • 84885071935 scopus 로고    scopus 로고
    • MicroRNA analysis in the spinal fluid of Alzheimer patients: A methodological feasibility study
    • in, ed. P. B. Gahan (Dordrecht: Springer Netherlands)
    • van Harten, A., Mulders, J., Çevik, C., Kester, M., Scheltens, P., Flier, W. V. D., et al. (2011). "MicroRNA analysis in the spinal fluid of Alzheimer patients: a methodological feasibility study, " in Circulating Nucleic Acids in Plasma and Serum, ed. P. B. Gahan (Dordrecht: Springer Netherlands), 275-282.
    • (2011) Circulating Nucleic Acids in Plasma and Serum , pp. 275-282
    • van Harten, A.1    Mulders, J.2    Çevik, C.3    Kester, M.4    Scheltens, P.5    Flier, W.V.D.6
  • 49
    • 79953301730 scopus 로고    scopus 로고
    • MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
    • doi: 10.1038/ncb2210
    • Vickers, K. C., Palmisano, B. T., Shoucri, B. M., Shamburek, R. D., and Remaley, A. T. (2011). MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat. Cell Biol. 13, 423-433. doi: 10.1038/ncb2210
    • (2011) Nat. Cell Biol. , vol.13 , pp. 423-433
    • Vickers, K.C.1    Palmisano, B.T.2    Shoucri, B.M.3    Shamburek, R.D.4    Remaley, A.T.5
  • 50
    • 84880244044 scopus 로고    scopus 로고
    • Expression of the transcription factor Sp1 and its regulatory hsa-miR-29b in peripheral blood mononuclear cells from patients with Alzheimer's disease
    • doi: 10.3233/JAD-122263
    • Villa, C., Ridolfi, E., Fenoglio, C., Ghezzi, L., Vimercati, R., Clerici, F., et al. (2013). Expression of the transcription factor Sp1 and its regulatory hsa-miR-29b in peripheral blood mononuclear cells from patients with Alzheimer's disease. J. Alzheimers Dis. 35, 487-494. doi: 10.3233/JAD-122263
    • (2013) J. Alzheimers Dis. , vol.35 , pp. 487-494
    • Villa, C.1    Ridolfi, E.2    Fenoglio, C.3    Ghezzi, L.4    Vimercati, R.5    Clerici, F.6
  • 51
    • 0028122463 scopus 로고
    • Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
    • doi: 10.1016/S0140-6736(94)92338-8
    • West, M. J., Coleman, P. D., Flood, D. G., and Troncoso, J. C. (1994). Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet 344, 769-772. doi: 10.1016/S0140-6736(94)92338-8
    • (1994) Lancet , vol.344 , pp. 769-772
    • West, M.J.1    Coleman, P.D.2    Flood, D.G.3    Troncoso, J.C.4
  • 52
    • 33745614108 scopus 로고    scopus 로고
    • The gamma-secretase complex: Membrane-embedded proteolytic ensemble
    • doi: 10.1021/bi060799c
    • Wolfe, M. S. (2006). The gamma-secretase complex: membrane-embedded proteolytic ensemble. Biochemistry 45, 7931-7939. doi: 10.1021/bi060799c
    • (2006) Biochemistry , vol.45 , pp. 7931-7939
    • Wolfe, M.S.1
  • 53
    • 7444243756 scopus 로고    scopus 로고
    • MicroRNAs and the regulation of cell death
    • doi: 10.1016/j.tig.2004.09.010
    • Xu, P., Guo, M., and Hay, B. A. (2004). MicroRNAs and the regulation of cell death. Trends Genet. 20, 617-624. doi: 10.1016/j.tig.2004.09.010
    • (2004) Trends Genet. , vol.20 , pp. 617-624
    • Xu, P.1    Guo, M.2    Hay, B.A.3
  • 54
    • 77449127999 scopus 로고    scopus 로고
    • Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection
    • doi: 10.1126/scisignal.2000610
    • Zernecke, A., Bidzhekov, K., Noels, H., Shagdarsuren, E., Gan, L., Denecke, B., et al. (2009). Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Sci. Signal. 2, ra81. doi: 10.1126/scisignal.2000610
    • (2009) Sci. Signal. , vol.2
    • Zernecke, A.1    Bidzhekov, K.2    Noels, H.3    Shagdarsuren, E.4    Gan, L.5    Denecke, B.6


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