Expression of the transcription factor Sp1 and its regulatory hsa-miR-29b in peripheral blood mononuclear cells from patients with alzheimer's disease

Journal of Alzheimer's Disease

Volumn 35, Issue 3, 2013, Pages 487-494

  Villa, Chiara ^a   Ridolfi, Elisa ^a   Fenoglio, Chiara ^a   Ghezzi, Laura ^a   Vimercati, Roberto ^a   Clerici, Francesca ^b   Marcone, Alessandra ^c   Gallone, Salvatore ^d   Serpente, Maria ^a   Cantoni, Claudia ^a   Bonsi, Rossana ^a   Cioffi, Sara ^a   Cappa, Stefano ^c,e   Franceschi, Massimo ^f   Rainero, Innocenzo ^d   Mariani, Claudio ^b   Scarpini, Elio ^a   Galimberti, Daniela ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c SAN RAFFAELE HOSPITAL   (Italy)

^d UNIVERSITY OF TURIN   (Italy)

^e VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^f IRCCS MULTIMEDICA   (Italy)

Author keywords

Alzheimer's disease; expression; gene regulation; microRNAs; peripheral blood mononuclear cells; risk factor; Sp1

Indexed keywords

MICRORNA 29B; TRANSCRIPTION FACTOR SP1;

AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL DEMENTIA RATING; COGNITIVE DEFECT; CONTROLLED STUDY; DNA ISOLATION; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC VARIABILITY; GENOTYPING TECHNIQUE; HUMAN; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; NEUROLOGIC EXAMINATION; ONSET AGE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; WESTERN BLOTTING;

EID: 84880244044     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-122263     Document Type: Article

References (25)

1. Black AR, Jensen D, Lin SY, Azizkhan JC (1999) Growth/cell cycle regulation of Sp1 phosphorylation. J Biol Chem 274, 1207-1215.
2. Duyckaerts C, Dickson DW (2003) Neuropathology of Alzheimer's disease. In Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders, Dickson D, edi. ISN Neuropath Press, Basel, pp. 47-65.
3. Docagne F, Gabriel C, Lebeurrier N, Lesn'e S, Hommet Y, Plawinski L, Mackenzie ET, Vivien D (2004) Sp1 and Smad transcription factors co-operate to mediate TGF-betadependent activation of amyloid-beta precursor protein gene transcription. Biochem J 383, 393-399.
4. Christensen MA, Zhou W, Qing H, Lehman A, Philipsen S, Song W (2004) Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1. Mol Cell 24, 865-874.
5. Heicklen-Klein A, Ginzburg I (2000) Tau promoter confers neuronal specificity and binds Sp1 and AP-2. J Neurochem 75, 1408-1418.
6. Santpere G, Nieto M, Puig B, Ferrer I (2006) Abnormal Sp1 transcription factor expression in Alzheimer disease and tauopathies. Neurosci Lett 397, 30-34.
7. Ryu H, Lee J, Zaman K, Kubilis J, Ferrante RJ, Ross BD, Neve R, Ratan RR (2003) Sp1 and Sp3 are oxidative stressinducible, anti-death transcription factors in cortical neurons. J Neurosci 23, 3597-3606.
8. Citron BA, Dennis JS, Zeitlin RS, Echeverria V (2008) Transcription factor Sp1 dysregulation in Alzheimer's disease. J Neurosci Res 86, 2499-2504.
9. Villa C, Ghezzi L, Fenoglio C, Clerici F, Marcone A, Benussi L, Ghidoni R, Gallone S, Serpente M, Cantoni C, Ridolfi E, Bonsi R, Cerami C, Cappa S, Binetti G, FranceschiM,Rainero I, Mariani C, Bresolin N, Scarpini E, Galimberti D (2012) Genetics and expression analysis of the transcription factor Sp4 in patients with Alzheimer's disease and frontotemporal lobar degeneration. J Alzheimers Dis 31, 537-542.
10. Satoh J (2010) MicroRNAs and their therapeutic potential for human diseases: Aberrant microRNA expression in Alzheimer's disease brains. J Pharmacol Sci 114, 269-275.
11. Bartel DP (2004) MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116, 281-297.
12. Li N, Cui J, Duan X, Chen H, Fan F (2012) Suppression of type I collagen expression by miR-29b via PI3K, Akt, and Sp1 pathway in human tenon's fibroblasts. Invest Ophthalmol Vis Sci 53, 1670-1678.
13. Wang F, Li Y, Zhou J, Xu J, Peng C, Ye F, Shen Y, LuW,Wan X, Xie X (2011) miR-375 is down-regulated in squamous cervical cancer and inhibits cell migration and invasion via targeting transcription factor SP1. Am J Pathol 179, 2580-2588.
14. Wierstra I (2008) Sp1: Emerging roles-beyond constitutive activation of TATA-less housekeeping genes. Biochem Biophys Res Commun 372, 1-13.
15. Maes OC, Schipper HM, Chertkow HM, Wang E (2009) Methodology for discovery of Alzheimer's disease bloodbased biomarkers. J Gerontol A Biol Sci Med Sci 64, 636-645.
16. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDAWork Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944.
17. Del Bo R, Comi GP, Bresolin N, Castelli E, Conti E, Degiuli A, Ausenda CD, Scarlato G (1997) The apolipoprotein E epsilon4 allele causes a faster decline of cognitive performances in Down's syndrome subjects. J Neurol Sci 145, 87-91.
18. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25, 402-408.
19. Fratiglioni L, Viitanen M, von Strauss E, Tontodonati V, Herlitz A, Winblad B (1997) Very old women at highest risk of dementia and Alzheimer's disease: Incidence data from the Kungnsholmen Project, Stockholm. Neurology 48, 132-138.
20. Pirskanen M, Hiltunen M, Mannermaa A, Helisalmi S, Lehtovirta M,Hänninen T, SoininenH(2005) Estrogen receptor beta gene variants are associated with increased risk of Alzheimer's disease in women. Eur J Hum Genet 13, 1000-1006.
21. Wang YT, Yang WB, Chang WC, Hung JJ (2011) Interplay of posttranslational modifications in Sp1 mediates Sp1 stability during cell cycle progression. J Mol Biol 414, 1-14.
22. Huang Q, Figueiredo-Pereira ME (2010) Ubiquitin/proteasome pathway impairment in neurodegeneration: Therapeutic implications. Apoptosis 15, 1292-1311.
23. Takahashi K, Ishida M, Komano H, Takahashi H (2008) SUMO-1 immunoreactivity co-localizes with phospho-Tau in APP transgenic mice but not in mutant Tau transgenic mice. Neurosci Lett 441, 90-93.
24. Temp'e D, Piechaczyk M, Bossis G (2008) SUMO under stress. Biochem Soc Trans 36, 874-878.
25. Sullivan PF, Fan C, Perou CM (2006) Evaluating the comparability of gene expression in blood and brain. Am J Med Genet B Neuropsychiatr Genet 141B, 261-268.