Biochemical determination of enzyme-bound metabolites: Preferential accumulation of a programmed octaketide on the enediyne polyketide synthase CalE8

Journal of the American Chemical Society

Volumn 135, Issue 38, 2013, Pages 14339-14348

  Belecki, Katherine ^a   Townsend, Craig A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITUMOR ANTIBIOTICS; BIOSYNTHETIC PATHWAY; CARRIER PROTEINS; CHEMICAL RELEASE; CORE CONSTRUCTION; NONRIBOSOMAL PEPTIDE; POLYKETIDE SYNTHASES; SENSITIVE SYSTEMS;

BIOCHEMISTRY; ENZYMES; KETONES;

ORGANIC COMPOUNDS;

CALICHEAMICIN; CARRIER PROTEIN; ENEDIYNE; MERCAPTAMINE; POLYKETIDE SYNTHASE;

ABSORPTION SPECTROSCOPY; ARTICLE; CHEMICAL ANALYSIS; DERIVATIZATION; DRUG SYNTHESIS; ENZYME ACTIVITY; FERMENTATION; HETEROLOGOUS EXPRESSION; LIGHT EXPOSURE; METABOLITE; PHOTOOXIDATION; PHOTOREACTIVITY;

ANTIBIOTICS, ANTINEOPLASTIC; CYSTEAMINE; ENEDIYNES; ESCHERICHIA COLI; HYDROLYSIS; LIGHT; POLYKETIDE SYNTHASES; POLYKETIDES; RECOMBINANT PROTEINS;

EID: 84884871087     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja406697t     Document Type: Article

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