Mesenchymal stem cells play a potential role in regulating the establishment and maintenance of epithelial-mesenchymal transition in MCF7 human breast cancer cells by paracrine and induced autocrine TGF-β

International Journal of Oncology

Volumn 41, Issue 3, 2012, Pages 959-968

  Xu, Qilin ^a   Wang, Liang ^a,b   Li, Hongling ^a   Han, Qin ^a   Li, Jing ^a   Qu, Xuebin ^a   Huang, Shan ^a   Zhao, Robert Chunhua ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b Department of Health Care   (China)

Author keywords

Autocrine TGF ; Epithelial mesenchymal transition; Mesenchymal stem cells; Metastasis; Paracrine TGF ; ZEB miR 200 regulatory loop

Indexed keywords

MICRORNA 200; MICRORNA 200B; MICRORNA 200C; TRANSFORMING GROWTH FACTOR BETA1;

ADIPOSE TISSUE; ARTICLE; AUTOCRINE EFFECT; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL FUNCTION; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; HUMAN TISSUE; MESENCHYMAL STEM CELL; MORPHOLOGY; PARACRINE SIGNALING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; UPREGULATION;

AUTOCRINE COMMUNICATION; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DOWN-REGULATION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; MESENCHYMAL STROMAL CELLS; MICRORNAS; PARACRINE COMMUNICATION; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84864979988     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1541     Document Type: Article

References (35)

1. Gupta GP and Massague J: Cancer metastasis: building a framework. Cell 127: 679-695, 2006. (Pubitemid 44781029)
2. Weigelt B, Peterse JL and van't Veer LJ: Breast cancer metastasis: markers and models. Nat Rev Cancer 5: 591-602, 2005. (Pubitemid 41081385)
3. Guarino M, Rubino B and Ballabio G: The role of epithelial-mesenchymal transition in cancer pathology. Pathology 39: 305-318, 2007. (Pubitemid 46897605)
4. Kang Y and Massague J: Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 118: 277-279, 2004. (Pubitemid 39061108)
5. Trimboli AJ, Fukino K, de Bruin A, et al: Direct evidence for epithelial-mesenchymal transitions in breast cancer. Cancer Res 68: 937-945, 2008. (Pubitemid 351206773)
6. Baum B, Settleman J and Quinlan MP: Transitions between epithelial and mesenchymal states in development and disease. Semin Cell Dev Biol 19: 294-308, 2008.
7. Hugo H, Ackland ML, Blick T, et al: Epithelial-mesenchymal and mesenchymal - epithelial transitions in carcinoma progression. J Cell Physiol 213: 374-383, 2007. (Pubitemid 47509716)
8. Thiery JP and Sleeman JP: Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7: 131-142, 2006. (Pubitemid 43278296)
9. Yang J and Weinberg RA: Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 14: 818-829, 2008. (Pubitemid 351757205)
10. Brabletz T, Jung A, Spaderna S, Hlubek F and Kirchner T: Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat Rev Cancer 5: 744-749, 2005. (Pubitemid 41486367)
11. Mani SA, Guo W, Liao MJ, et al: The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133: 704-715, 2008. (Pubitemid 351636299)
12. Gupta PB, Chaffer CL and Weinberg RA: Cancer stem cells: mirage or reality? Nat Med 15: 1010-1012, 2009.
13. Polyak K and Weinberg RA: Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9: 265-273, 2009.
14. Hu M and Polyak K: Molecular characterisation of the tumour microenvironment in breast cancer. Eur J Cancer 44: 2760-2765, 2008.
15. Fierro FA, Sierralta WD, Epunan MJ and Minguell JJ: Marrow-derived mesenchymal stem cells: role in epithelial tumor cell determination. Clin Exp Metastasis 21: 313-319, 2004. (Pubitemid 39434541)
16. Hombauer H and Minguell JJ: Selective interactions between epithelial tumour cells and bone marrow mesenchymal stem cells. Br J Cancer 82: 1290-1296, 2000. (Pubitemid 30145347)
17. Sasser AK, Mundy BL, Smith KM, et al: Human bone marrow stromal cells enhance breast cancer cell growth rates in a cell line-dependent manner when evaluated in 3D tumor environments. Cancer Lett 254: 255-264, 2007. (Pubitemid 47161104)
18. Chen J, Zhang ZG, Li Y, et al: Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res 92: 692-699, 2003. (Pubitemid 36417705)
19. Kumar S, Chanda D and Ponnazhagan S: Therapeutic potential of genetically modified mesenchymal stem cells. Gene Ther 15: 711-715, 2008. (Pubitemid 351627354)
20. Karnoub AE, Dash AB, Vo AP, et al: Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449: 557-563, 2007. (Pubitemid 47525152)
21. Dwyer RM, Potter-Beirne SM, Harrington KA, et al: Monocyte chemotactic protein-1 secreted by primary breast tumors stimulates migration of mesenchymal stem cells. Clin Cancer Res 13: 5020-5027, 2007. (Pubitemid 47502066)
22. Molloy AP, Martin FT, Dwyer RM, et al: Mesenchymal stem cell secretion of chemokines during differentiation into osteoblasts, and their potential role in mediating interactions with breast cancer cells. Int J Cancer 124: 326-332, 2009.
23. Zeisberg M and Kalluri R: The role of epithelial-to-mesenchymal transition in renal fibrosis. J Mol Med 82: 175-181, 2004. (Pubitemid 38392167)
24. Pardali K and Moustakas A: Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer. Biochim Biophys Acta 1775: 21-62, 2007. (Pubitemid 44881193)
25. Derynck R and Akhurst RJ: Differentiation plasticity regulated by TGF-beta family proteins in development and disease. Nat Cell Biol 9: 1000-1004, 2007. (Pubitemid 47338137)
26. Thiery JP, Acloque H, Huang RY and Nieto MA: Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890, 2009.
27. Peinado H, Olmeda D and Cano A: Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7: 415-428, 2007. (Pubitemid 46809165)
28. Burk U, Schubert J, Wellner U, et al: A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep 9: 582-589, 2008. (Pubitemid 351772923)
29. Gregory PA, Bert AG, Paterson EL, et al: The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 10: 593-601, 2008. (Pubitemid 351627379)
30. Park SM, Gaur AB, Lengyel E and Peter ME: The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 22: 894-907, 2008. (Pubitemid 351482843)
31. Bracken CP, Gregory PA, Kolesnikoff N, et al: A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res 68: 7846-7854, 2008.
32. Gregory PA, Bracken CP, Bert AG and Goodall GJ: MicroRNAs as regulators of epithelial-mesenchymal transition. Cell Cycle 7: 3112-3118, 2008.
33. Cao Y, Sun Z, Liao L, Meng Y, Han Q and Zhao RC: Human adipose tissue-derived stem cells differentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo. Biochem Biophys Res Commun 332: 370-379, 2005. (Pubitemid 40724988)
34. Gregory PA, Bracken CP, Smith E, et al: An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Mol Biol Cell 22: 1686-1698, 2011.
35. Brabletz S and Brabletz T: The ZEB/miR-200 feedback loop - a motor of cellular plasticity in development and cancer? EMBO Rep 11: 670-677, 2010.