Matrix metalloproteinases: Potential therapy to prevent the development of second malignancies after breast radiotherapy

Surgical Oncology

Volumn 21, Issue 3, 2012, Pages

  Artacho Cordon F ^a,b   Rios Arrabal S ^a,b   Lara, P C ^c   Artacho Cordon A ^a   Calvente, I ^a,b   Nunez M I ^a,b  

^a UNIVERSITY OF GRANADA   (Spain)

^b HOSPITAL UNIVERSITARIO SAN CECILIO   (Spain)

^c HOSPITAL UNIVERSITARIO DE GRAN CANARIA DR NEGRÍN   (Spain)

Author keywords

Breast cancer; Histone deacetylases; Ionizing radiation; MMP; Radiation induced carcinogenesis; Second malignancy; Tumour microenvironment; Tumour progression

Indexed keywords

COLLAGENASE; DEATH RECEPTOR; GELATINASE; HISTONE DEACETYLASE; MACROPHAGE ELASTASE; MATRILYSIN; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 15; MATRIX METALLOPROTEINASE 16; MATRIX METALLOPROTEINASE 17; MATRIX METALLOPROTEINASE 20; MATRIX METALLOPROTEINASE 21; MATRIX METALLOPROTEINASE 24; MATRIX METALLOPROTEINASE 25; MATRIX METALLOPROTEINASE 27; OSTHOLE; STROMELYSIN; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BREAST CANCER; CANCER CELL; CANCER RADIOTHERAPY; CANCER RISK; CANCER SURVIVAL; CARCINOGENESIS; DRUG TARGETING; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX; HUMAN; IN VITRO STUDY; INFLAMMATION; IONIZING RADIATION; OVERALL SURVIVAL; PRECANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION INDUCED NEOPLASM; REGULATORY MECHANISM; REVIEW; RISK ASSESSMENT; SECOND CANCER; STROMA CELL; TUMOR GROWTH;

BREAST NEOPLASMS; FEMALE; HUMANS; MATRIX METALLOPROTEINASE INHIBITORS; MATRIX METALLOPROTEINASES; MOLECULAR TARGETED THERAPY; NEOPLASMS, SECOND PRIMARY; TUMOR MICROENVIRONMENT;

EID: 84864658245     PISSN: 09607404     EISSN: 18793320     Source Type: Journal    
DOI: 10.1016/j.suronc.2012.06.001     Document Type: Review

References (109)

1. A. Artacho-Cordón, F. Artacho-Cordón, S. Ríos-Arrabal, I. Calvente, and M.I. Núñez Tumor microenvironment and breast cancer progression: a complex scenario Cancer Biol Ther 13 1 2012 14 24
2. V. Chabottaux, and A. Noel Breast cancer progression: insights into multifaceted matrix metalloproteinases Clin Exp Metastasis 24 8 2007 647 656
3. A. Jezierska, and T. Motyl Matrix metalloproteinase-2 involvement in breast cancer progression: a mini-review Med Sci Monit 15 2 2009 RA32 RA40
4. I. Ota, X.Y. Li, Y. Hu, and S.J. Weiss Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1 Proc Natl Acad Sci U S A 106 48 2009 20318 20323
5. J. Alcaraz, H. Mori, C.M. Ghajar, D. Brownfield, R. Galgoczy, and M.J. Bissell Collective epithelial cell invasion overcomes mechanical barriers of collagenous extracellular matrix by a narrow tube-like geometry and MMP14-dependent local softening Integr Biol (Camb) 3 12 2011 1153 1166
6. S.Q. Fan, Q.Y. Wei, M.R. Li, L.Q. Zhang, and Q.C. Liang Expression and clinical significance of MMP-2, MMP-9, TIMP-1, and TIMP-2 in breast carcinoma Ai Zheng 22 9 2003 968 973
7. I. Hoshino, and H. Matsubara Recent advances in histone deacetylase targeted cancer therapy Surg Today 40 9 2010 809 815
8. D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 5 2011 646 674
9. D.A. Young, R.L. Lakey, C.J. Pennington, D. Jones, L. Kevorkian, and D.R. Edwards Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption Arthritis Res Ther 7 3 2005 R503 R512
10. E.J. Mitmaker, N.J. Griff, R.H. Grogan, R. Sarkar, E. Kebebew, and Q.Y. Duh Modulation of matrix metalloproteinase activity in human thyroid cancer cell lines using demethylating agents and histone deacetylase inhibitors Surgery 149 4 2011 504 511
11. K.H. Lee, E.Y. Choi, M.K. Kim, K.O. Kim, B.I. Jang, and S.W. Kim Inhibition of histone deacetylase activity down-regulates urokinase plasminogen activator and matrix metalloproteinase-9 expression in gastric cancer Mol Cell Biochem 343 1-2 2010 163 171
12. H.W. Jeon, and Y.M. Lee Inhibition of histone deacetylase attenuates hypoxia-induced migration and invasion of cancer cells via the restoration of RECK expression Mol Cancer Ther 9 5 2010 1361 1370
13. M. Jordà, D. Olmeda, A. Vinyals, E. Valero, E. Cubillo, and A. Llorens Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the snail transcription factor J Cell Sci 118 Pt 15 2005 3371 3385
14. T. Tian, K.J. Nan, H. Guo, W.J. Wang, Z.P. Ruan, and S.H. Wang PTEN inhibits the migration and invasion of HepG2 cells by coordinately decreasing MMP expression via the PI3K/Akt pathway Oncol Rep 23 6 2010 1593 1600
15. A. Köhrmann, U. Kammerer, M. Kapp, J. Dietl, and J. Anacker Expression of matrix metalloproteinases (MMPs) in primary human breast cancer and breast cancer cell lines: new findings and review of the literature BMC Cancer 9 2009 188
16. Y. Kajiwara, H. Ueno, Y. Hashiguchi, E. Shinto, H. Shimazaki, and H. Mochizuki Heterogeneity of metalloproteinase expression in colorectal cancer - relation of molecular findings to basic morphology Anticancer Res 31 5 2011 1567 1575
17. I. Yana, and M. Seiki MT-MMPs play pivotal roles in cancer dissemination Clin Exp Metastasis 19 3 2002 209 215
18. G.E. Kim, J.H. Kim, K.H. Lee, Y.D. Choi, J.S. Lee, and J.H. Lee Stromal matrix metalloproteinase-14 expression correlates with the grade and biological behavior of mammary phyllodes tumors Appl Immunohistochem Mol Morphol 20 3 2012 298 303
19. P. Sena, F. Mariani, L. Marzona, M. Benincasa, M. Ponz de Leon, and C. Palumbo Matrix metalloproteinases 15 and 19 are stromal regulators of colorectal cancer development from the early stages Int J Oncol 41 1 2012 260 266
20. D. Liu, H. Guo, Y. Li, X. Xu, K. Yang, and Y. Bai Association between polymorphisms in the promoter regions of matrix metalloproteinases (MMPs) and risk of cancer metastasis: a meta-analysis PLoS One 7 2 2012 e31251
21. J.L. Johnson, S. Pillai, D. Pernazza, S.M. Sebti, N.J. Lawrence, and S.P. Chellappan Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease Cancer Res 72 2 2012 516 526
22. J.Y. Choi, Y.S. Jang, S.Y. Min, and J.Y. Song Overexpression of MMP-9 and HIF-1α in breast cancer cells under hypoxic conditions J Breast Cancer 14 2 2011 88 95
23. A. Page-McCaw, A.J. Ewald, and Z. Werb Matrix metalloproteinases and the regulation of tissue remodelling Nat Rev Mol Cell Biol 8 3 2007 221 233
24. H. Nagase, R. Visse, and G. Murphy Structure and function of matrix metalloproteinases and TIMPs Cardiovasc Res 69 3 2006 562 573
25. A.P. Burlaka, E.P. Sidorik, I.I. Ganusevich, and S.P. Osinsky Effects of radical oxygen species and NO: formation of intracellular hypoxia and activation of matrix metalloproteinases in tumor tissues Exp Oncol 28 1 2006 49 53
26. N.S. Brown, A. Jones, C. Fujiyama, A.L. Harris, and R. Bicknell Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors Cancer Res 60 22 2000 6298 6302
27. S. Rajagopalan, X.P. Meng, S. Ramasamy, D.G. Harrison, and Z.S. Galis Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability J Clin Invest 98 11 1996 2572 2579
28. G. Pani, T. Galeotti, and P. Chiarugi Metastasis: cancer cell's escape from oxidative stress Cancer Metastasis Rev 29 2 2010 351 378
29. F. Maupas-Schwalm, A. Bedel, N. Augé, M.H. Grazide, E. Mucher, and J.C. Thiers Integrin alpha(v)beta(3), metalloproteinases, and sphingomyelinase-2 mediate urokinase mitogenic effect Cell Signal 21 12 2009 1925 1934
30. E.I. Deryugina, B. Ratnikov, E. Monosov, T.I. Postnova, R. DiScipio, and J.W. Smith MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells Exp Cell Res 263 2 2001 209 223
31. M. Haraguchi, T. Okubo, Y. Miyashita, Y. Miyamoto, M. Hayashi, and T.N. Crotti Snail regulates cell-matrix adhesion by regulation of the expression of integrins and basement membrane proteins J Biol Chem 283 35 2008 23514 23523
32. N. Johansson, M. Ahonen, and V.M. Kähäri Matrix metalloproteinases in tumor invasion Cell Mol Life Sci 57 1 2000 5 15
33. S.M. Eck, J.S. Blackburn, A.C. Schmucker, P.S. Burrage, and C.E. Brinckerhoff Matrix metalloproteinase and G protein coupled receptors: co-conspirators in the pathogenesis of autoimmune disease and cancer J Autoimmun 33 3-4 2009 214 221
34. A. Boire, L. Covic, lA. Agarwa, S. Jacques, S. Sherifi, and A. Kuliopulos PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells Cell 120 3 2005 303 313
35. L.J. van't Veer, H. Dai, M.J. van de Vijver, Y.D. He, A.A.M. Hart, and M. Mao Gene expression profiling predicts clinical outcome of breast cancer Nature 415 6871 2002 530 536
36. K. Zarrabi, A. Dufour, J. Li, C. Kuscu, A. Pulkoski-Gross, and J. Zhi Inhibition of matrix metalloproteinase 14 (MMP-14)-mediated cancer cell migration J Biol Chem 286 38 2011 33167 33177
37. O. Tatti, M. Arjama, A. Ranki, S.J. Weiss, J. Keski-Oja, and K. Lehti Membrane-type-3 matrix metalloproteinase (MT3-MMP) functions as a matrix composition-dependent effector of melanoma cell invasion PLoS One 6 12 2011 e28325
38. C.J. Olsen, J. Moreira, E.M. Lukanidin, and N.S. Ambartsumian Human mammary fibroblasts stimulate invasion of breast cancer cells in a three-dimensional culture and increase stroma development in mouse xenografts BMC Cancer 10 2010 444
39. Y. Huang, A.E. Simms, A. Mazur, S. Wang, N.R. León, and B. Jones Fibroblast activation protein-α promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions Clin Exp Metastasis 28 6 2011 567 579
40. K. Kessenbrock, V. Plaks, and Z. Werb Matrix metalloproteinases: regulators of the tumor microenvironment Cell 141 1 2010 52 67
41. P. Nisticò, M.J. Bissell, and D.C. Radisky Epithelial-mesenchymal transition: general principles and pathological relevance with special emphasis on the role of matrix metalloproteinases Cold Spring Harb Perspect Biol 4 2 2012
42. E.S. Radisky, and D.C. Radisky Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer J Mammary Gland Biol Neoplasia 15 2 2010 201 212
43. S.A. Illman, K. Lehti, J. Keski-Oja, and J. Lohi Epilysin (MMP-28) induces TGF-beta mediated epithelial to mesenchymal transition in lung carcinoma cells J Cell Sci 119 Pt 18 2006 3856 3865
44. A. Dufour, N.S. Sampson, J. Li, C. Kuscu, R.C. Rizzo, and J.L. Deleon Small-molecule anticancer compounds selectively target the hemopexin domain of matrix metalloproteinase-9 Cancer Res 71 14 2011 4977 4988
45. J. Cao, and P. Kozarekar Induction of epithelial to mesenchymal transition (EMT) by membrane type 1-matrix metalloproteinase (MT1-MMP) is a prerequisite for cancer invasion Proc Am Assoc Cancer Res Annu Meet 47 2006 1023
46. D.S. Steinbrech, M.T. Longaker, B.J. Mehrara, P.B. Saadeh, G.S. Chin, and R.P. Gerrets Fibroblast response to hypoxia: the relationship between angiogenesis and matrix regulation J Surg Res 84 2 1999 127 133
47. V. Noë, B. Fingleton, K. Jacobs, H.C. Crawford, S. Vermeulen, and W. Steelant Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1 J Cell Sci 114 Pt 1 2001 111 118
48. D.C. Radisky, D.D. Levy, L.E. Littlepage, H. Liu, C.M. Nelson, and J.E. Fata Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability Nature 436 7047 2005 123 127
49. J. Fuxe, T. Vincent, and A. Garcia de Herreros Transcriptional crosstalk between TGF-β and stem cell pathways in tumor cell invasion: role of EMT promoting Smad complexes Cell Cycle 9 12 2010 2363 2374
50. Q. Yu, and I. Stamenkovic Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis Genes Dev 14 2 2000 163 176
51. A.M. Pendás, J.A. Uría, M.G. Jiménez, M. Balbín, J.P. Freije, and C. López-Otín An overview of collagenase-3 expression in malignant tumors and analysis of its potential value as a target in antitumor therapies Clin Chim Acta 291 2 2000 137 155
52. B.S. Nielsen, F. Rank, J.M. López, M. Balbin, F. Vizoso, and L.R. Lund Collagenase-3 expression in breast myofibroblasts as a molecular marker of transition of ductal carcinoma in situ lesions to invasive ductal carcinomas Cancer Res 61 19 2001 7091 7100
53. B. Zhang, X. Cao, Y. Liu, W. Cao, F. Zhang, and S. Zhang Tumor-derived matrix metalloproteinase-13 (MMP-13) correlates with poor prognoses of invasive breast cancer BMC Cancer 8 2008 83
54. H.J. Chang, M.J. Yang, Y.H. Yang, M.F. Hou, E.J. Hsueh, and S.R. Lin MMP13 is potentially a new tumor marker for breast cancer diagnosis Oncol Rep 22 5 2009 1119 1127
55. W.C. Powell, B. Fingleton, C.L. Wilson, M. Boothby, and L.M. Matrisian The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis Curr Biol 9 24 1999 1441 1447
56. H. Haro, H.C. Crawford, B. Fingleton, K. Shinomiya, D.M. Spengler, and L.M. Matrisian Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorption J Clin Invest 105 2 2000 143 150
57. T. Vargo-Gogola, B. Fingleton, H.C. Crawford, and L.M. Matrisian Matrilysin (matrix metalloproteinase-7) selects for apoptosis-resistant mammary cells in vivo Cancer Res 62 19 2002 5559 5563
58. B. Fingleton, T. Vargo-Gogola, H.C. Crawford, and L.M. Matrisian Matrilysin [MMP-7] expression selects for cells with reduced sensitivity to apoptosis Neoplasia 3 6 2001 459 468
59. N. Mitsiades, W.H. Yu, V. Poulaki, M. Tsokos, and I. Stamenkovic Matrix metalloproteinase-7-mediated cleavage of Fas ligand protects tumor cells from chemotherapeutic drug cytotoxicity Cancer Res 61 2 2001 577 581
60. M. Schulte, K. Reiss, M. Lettau, T. Maretzky, A. Ludwig, and D. Hartmann ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death Cell Death Differ 14 5 2007 1040 1049
61. D. Hanahan, and J. Folkman Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis Cell 86 3 1996 353 364
62. J.W. Pollard Macrophages define the invasive microenvironment in breast cancer J Leukoc Biol 84 3 2008 623 630
63. A.R. Nelson, B. Fingleton, M.L. Rothenberg, and L.M. Matrisian Matrix metalloproteinases: biologic activity and clinical implications J Clin Oncol 18 5 2000 1135 1149
64. A. Sparmann, and D. Bar-Sagi Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis Cancer Cell 6 5 2004 447 458
65. W.X. Zong, and C.B. Thompson Necrotic death as a cell fate Genes Dev 20 1 2006 1 15
66. V.C. Ardi, T.A. Kupriyanova, E.I. Deryugina, and J.P. Quigley Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis Proc Natl Acad Sci U S A 104 51 2007 20262 20267
67. G.O. Ahn, and J.M. Brown Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells Cancer Cell 13 3 2008 193 205
68. S.P. Tabruyn, and A.W. Griffioen Molecular pathways of angiogenesis inhibition Biochem Biophys Res Commun 355 1 2007 1 5
69. U.W. Nilsson, S. Garvin, and C. Dabrosin MMP-2 and MMP-9 activity is regulated by estradiol and tamoxifen in cultured human breast cancer cells Breast Cancer Res Treat 102 3 2007 253 261
70. U.W. Nilsson, and C. Dabrosin Estradiol and tamoxifen regulate endostatin generation via matrix metalloproteinase activity in breast cancer in vivo Cancer Res 66 9 2006 4789 4794
71. J. Sun Matrix metalloproteinases and tissue inhibitor of metalloproteinases are essential for the inflammatory response in cancer cells J Signal Transduct 2010 2010 985132
72. L.R. Patel, D.F. Camacho, Y. Shiozawa, K.J. Pienta, and R.S. Taichman Mechanisms of cancer cell metastasis to the bone: a multistep process Future Oncol 7 11 2011 1285 1297
73. Y. Drabsch, and P. ten Dijke TGF-β signaling in breast cancer cell invasion and bone metastasis J Mammary Gland Biol Neoplasia 16 2 2011 97 108
74. J.T. Erler, K.L. Bennewith, T.R. Cox, G. Lang, D. Bird, and A. Koong Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche Cancer Cell 15 1 2009 35 44
75. K. Tsujino, K. Kashihara, S. Kotani, K. Hayakawa, K. Imanaka, and Y. Takada A survey of patients with inflammatory skin recurrence corresponding to the area of previous irradiation after postoperative radiotherapy for breast cancer J Radiat Res 52 6 2011 797 803
76. M.H. Barcellos-Hoff, C. Park, and E.G. Wright Radiation and the microenvironment - tumorigenesis and therapy Nat Rev Cancer 5 11 2005 867 875
77. I. Madani, W. De Neve, and L.M. Maree Does ionizing radiation stimulate cancer invasion and metastasis? Bull Cancer 95 3 2008 292 300
78. S. Kunigal, S.S. Lakka, P. Joseph, N. Estes, and J.S. Rao Matrix metalloproteinase-9 inhibition down-regulates radiation-induced nuclear factor-kappa B activity leading to apoptosis in breast tumors Clin Cancer Res 14 11 2008 3617 3626
79. J.M. Brown, and A.J. Giaccia The unique physiology of solid tumors: opportunities (and problems) for cancer therapy Cancer Res 58 7 1998 1408 1416
80. I. Sofia Vala, L.R. Martins, N. Imaizumi, R.J. Nunes, J. Rino, and F. Kuonen Low doses of ionizing radiation promote tumor growth and metastasis by enhancing angiogenesis PLoS One 5 6 2010 e11222
81. C. Wild-Bode, M. Weller, A. Rimner, J. Dichgans, and W. Wick Sublethal irradiation promotes migration and invasiveness of glioma cells: implications for radiotherapy of human glioblastoma Cancer Res 61 6 2011 2744 2750
82. K. Tsutsumi, M. Tsuda, N. Yazawa, H. Nakamura, S. Ishihara, and H. Haga Increased motility and invasiveness in tumor cells that survive 10 Gy irradiation Cell Struct Funct 34 2 2009 89 96
83. M. Sassi, A. Jukkola, R. Riekki, M. Höyhtyä, L. Risteli, and A. Oikarinen Type I collagen turnover and cross-linking are increased in irradiated skin of breast cancer patients Radiother Oncol 58 3 2001 317 323
84. A. Kaliski, L. Maggiorella, K.A. Cengel, D. Mathe, V. Rouffiac, and P. Opolon Angiogenesis and tumor growth inhibition by a matrix metalloproteinase inhibitor targeting radiation-induced invasion Mol Cancer Ther 4 11 2005 1717 1728
85. B. Saltman, D.H. Kraus, H. Szeto, B. Parashar, R. Ghossein, and D. Felsen In vivo and in vitro models of ionizing radiation to the vocal folds Head Neck 32 5 2010 572 577
86. N. Cordes, B. Hansmeier, C. Beinke, V. Meineke, and D. van Beuningen Irradiation differentially affects substratum-dependent survival, adhesion, and invasion of glioblastoma cell lines Br J Cancer 89 11 2003 2122 2132
87. M. Martinou, E. Giannopoulou, G. Malatara, A.A. Argyriou, H.P. Kalofonos, and D. Kardamakis Ionizing radiation affects epidermal growth factor receptor signalling and metalloproteinase secretion in glioma cells Cancer Genomics Proteomics 8 1 2011 33 38
88. V.R. Gogineni, O. Kargiotis, J.D. Klopfenstein, M. Gujrati, D.H. Dinh, and J.S. Rao RNAi-mediated downregulation of radiation-induced MMP-9 leads to apoptosis via activation of ERK and Akt in IOMM-Lee cells Int J Oncol 34 1 2009 209 218
89. C. Strup-Perrot, M.C. Vozenin-Brotons, M. Vandamme, M. Benderitter, and D. Mathe Expression and activation of MMP-2, -3, -9, -14 are induced in rat colon after abdominal X-irradiation Scand J Gastroenterol 41 1 2006 60 70
90. W.H. Lee, J.P. Warrington, W.E. Sonntag, and Y.W. Lee Irradiation alters MMP-2/TIMP-2 system and collagen type IV degradation in brain Int J Radiat Oncol Biol Phys 82 5 2012 1559 1566
91. K.K.C. Tsai, E.Y.Y. Chuang, J.B. Little, and Z.M. Yuan Cellular mechanisms for low-dose ionizing radiation-induced perturbation of the breast tissue microenvironment Cancer Res 65 15 2005 6734 6744
92. B. Heissig, S. Rafii, H. Akiyama, Y. Ohki, Y. Sato, and T. Rafael Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization J Exp Med 202 6 2005 739 750
93. B. Paquette, C. Baptiste, H. Therriault, G. Arguin, B. Plouffe, and R. Lemay In vitro irradiation of basement membrane enhances the invasiveness of breast cancer cells Br J Cancer 97 11 2007 1505 1512
94. R.E. Kast, and M.E. Halatsch Matrix metalloproteinase-2 and -9 in glioblastoma: a trio of old drugs-captopril, disulfiram and nelfinavir-are inhibitors with potential as adjunctive treatments in glioblastoma Arch Med Res 2012
95. J.E. Klaunig, and L.M. Kamendulis The role of oxidative stress in carcinogenesis Annu Rev Pharmacol Toxicol 44 2004 239 267
96. M. Valko, C.J. Rhodes, lJ. Monco, M. Izakovic, and M. Mazur Free radicals, metals and antioxidants in oxidative stress-induced cancer Chem Biol Interact 160 1 2006 1 40
97. K.K. Shen, L.L. Ji, Y. Chen, Q.M. Yu, and Z.T. Wang Influence of glutathione levels and activity of glutathione-related enzymes in the brains of tumor-bearing mice Biosci Trends 5 1 2011 30 37
98. H. De Schutter, and S. Nuyts Radiosensitizing potential of epigenetic anticancer drugs Anticancer Agents Med Chem 9 1 2009 99 108
99. M. Jung, A. Kozikowski, and A. Dritschilo Rational design and development of radiation-sensitizing histone deacetylase inhibitors Chem Biodivers 2 11 2005 1452 1461
100. H.J. Cho, S.Y. Kim, K.H. Kim, W.K. Kang, J.I. Kim, and S.T. Oh The combination effect of sodium butyrate and 5-aza-2′-deoxycytidine on radiosensitivity in RKO colorectal cancer and MCF-7 breast cancer cell lines World J Surg Oncol 7 2003 49
101. Q. Cao, W. Cai, T. Li, Y. Yang, K. Chen, and L. Xing Combination of integrin siRNA and irradiation for breast cancer therapy Biochem Biophys Res Commun 351 3 2006 726 732
102. D. Yang, T. Gu, T. Wang, Q. Tang, and C. Ma Effects of osthole on migration and invasion in breast cancer cells Biosci Biotechnol Biochem 74 7 2010 1430 1434
103. S.Y. Park, J.A. Jun, K.J. Jeong, H.J. Heo, J.S. Sohn, and H.Y. Lee Histone deacetylases 1, 6 and 8 are critical for invasion in breast cancer Oncol Rep 25 6 2011 1677 1681
104. L.A. Liotta, K. Tryggvason, S. Garbisa, I. Hart, C.M. Foltz, and S. Shafie Metastatic potential correlates with enzymatic degradation of basement membrane collagen Nature 284 5751 1980 67 68
105. S. Zucker, J. Cao, and W.T. Chen Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment Oncogene 19 56 2000 6642 6650
106. L.M. Coussens, B. Fingleton, and L.M. Matrisian Matrix metalloproteinase inhibitors and cancer: trials and tribulations Science 295 5564 2002 2387 2392
107. C.M. Overall, and C. López-Otín Strategies for MMP inhibition in cancer: innovations for the post-trial era Nat Rev Cancer 2 9 2002 657 672
108. S. Zucker, and J. Cao Selective matrix metalloproteinase (MMP) inhibitors in cancer therapy: ready for prime time? Cancer Biol Ther 8 24 2009 2371 2373
109. C.M. Overall, and O. Kleifeld Towards third generation matrix metalloproteinase inhibitors for cancer therapy Br J Cancer 94 7 2006 941 946