Multifunctional tacrine-flavonoid hybrids with cholinergic, β-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease

European Journal of Medicinal Chemistry

Volumn 69, Issue , 2013, Pages 632-646

  Li, Su Yi ^a   Wang, Xiao Bing ^a   Xie, Sai Sai ^a   Jiang, Neng ^a   Wang, Kelvin D G ^a   Yao, He Quan ^a   Sun, Hong Bin ^a   Kong, Ling Yi ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Amyloid aggregation; Alzheimer's disease; Cholinesterase; Flavonoid; Metal chelator; Tacrine

Indexed keywords

2 (4 NITROPHENYL) 7 [3 [4 [3 (1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]PROPYL) 4H CHROMEN 4 ONE; 2 PHENYL 7 [2 [4 [2 ((1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]ETHYL]PIPERAZIN 1 YL]ETHYOXY] 4H CHROMEN 4 ONE; 2 PHENYL 7 [2 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]ETHOXY] 4H CHROMEN 4 ONE; 2 PHENYL 7 [3 [4 [2 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]ETHYL]PIPERAZIN 1 YL]PROPOXY] 4H CHROMEN 4 ONE; 2 PHENYL 7 [3 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]PROPOXY] 4H CHROMEN 4 ONE; 2 PHENYL 7 [4 [4 [2 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]ETHYL]PIPERAZIN 1 YL]BUTOXY] 4H CHROMEN 4 ONE; 2 PHENYL 7 [4 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]ETHYL]PIPERAZIN 1 YL]BUTOXY] 4H CHROMEN 4 ONE; 2 PHENYL 7 [5 [4 [2 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]ETHYL]PIPERAZIN 1 YL]PENTYL]OXY] 4H CHROMEN 4 ONE; 2 PHENYL 7 [[5 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]BUTOXY] 4H CHROMEN 4 ONE; 2 PHENYL 7 [[6 [4 [2 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]ETHYL]PIPERAZIN 1 YL]HEXYL]OXY] 4H CHROMEN 4 ONE; 2 PHENYL 7 [[6 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]HEXYL]OXY] 4H CHROMEN 4 ONE; 5 HYDROXY 2 PHENYL 7 [3 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]PROPOXY] 4H CHROMEN 4 ONE; 5 HYDROXY 7 [3 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL)PROPOXY) 2 (4 TOLYL) 4H CHROMEN 4 ONE; 5 METHOXY 2 PHENYL 7 [3 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]PROPOXY] 4H CHROMEN 4 ONEGENERAL; 5 METHOXY 7 [3 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL)PROPOXY) 2 (4 TOLYL) 4H CHROMEN 4 ONE; 7 [3 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL)PROPOXY) 4H CHROMEN 4 ONE; 7 [3 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]PROPOXY] 2 (4 TOLYL) 4H CHROMEN 4 ONE; AMYLOID BETA PROTEIN; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; FLAVONOID; METAL CHELATE; TACRINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOLECULAR MODEL; NONHUMAN; PROTEIN AGGREGATION; RAT;

ALZHEIMER'S DISEASE; ASNDIIUXKSSGTR-UHFFFAOYSA-N; CCSIEQWILAQNOJ-UHFFFAOYSA-N; CFTXWMALZMFVFR-UHFFFAOYSA-N; CHOLINESTERASE; DAQOTHBGIZARGM-UHFFFAOYSA-N; DDOHQRNJXWAFAL-UHFFFAOYSA-N; FLAVONOID; FYFPJPCNMIMCSI-UHFFFAOYSA-N; JBVVLTRVHVGZEU-UHFFFAOYSA-N; JBXYRSPJNIZSAT-UHFFFAOYSA-N; JFGPPVAZTXRZDC-UHFFFAOYSA-N; JWCIYSMFMZTUME-UHFFFAOYSA-N; LESFBJPJZADQHL-UHFFFAOYSA-N; MDVLYACOLMKYAL-UHFFFAOYSA-N; METAL CHELATOR; NHRHUIFWROFHGI-UHFFFAOYSA-N; NYSKQVVKHYVKTB-UHFFFAOYSA-N; OXTPOGAMUKLJIJ-UHFFFAOYSA-N; PDCBHYYTMYMYBE-UHFFFAOYSA-N; PGHRDQIVQWNEGD-UHFFFAOYSA-N; RQWXJZZQVBAPHB-UHFFFAOYSA-N; SXDGSJQISGFVLK-UHFFFAOYSA-N; TACRINE; TZWXGPOBAFCOHW-UHFFFAOYSA-N; VBAJECZQEAYMJO-UHFFFAOYSA-N; Β-AMYLOID AGGREGATION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANTIOXIDANTS; BIPHENYL COMPOUNDS; CELL LINE, TUMOR; CELL PROLIFERATION; CHELATING AGENTS; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FLAVONOIDS; FREE RADICAL SCAVENGERS; HUMANS; MICE; NEUROBLASTOMA; ORGANOMETALLIC COMPOUNDS; OXIDATION-REDUCTION; PEPTIDE FRAGMENTS; PICRATES; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE;

EID: 84884773453     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.09.024     Document Type: Article

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