Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry

European Journal of Medicinal Chemistry

Volumn 53, Issue , 2012, Pages 356-363

  Zhang, Yikai ^a   Lv, Zhiliang ^a   Zhong, Hanyu ^a   Geng, Dongping ^a   Zhang, Mingfeng ^a   Zhang, Tao ^a   Li, Yongmei ^b   Li, Ke ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Anti cancer activity; Benzopyran 4 one derivative; Bioisosteric transformation; Click chemistry; Synthesis

Indexed keywords

3 [[4 [(4 OXO 4H CHROMEN 7 YLOXY)METHYL] 1H 1,2,3 TRIAZOL 1 YL]METHYL]BENZONITRILE; 4 [[4 [(4 OXO 4H CHROMEN 7 YLOXY)METHYL] 1H 1,2,3 TRIAZOL 1 YL]METHYL]BENZONITRILE; 7 [(1 BENZYL 1H 1,2,3 TRIAZOL 4 YL)METHOXY] 4H CHROMEN 4 ONE; 7 [[1 (2 BROMOBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 4H CHROMEN 4 ONE; 7 [[1 (2 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 4H CHROMEN 4 ONE; 7 [[1 (2 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOX] 4H CHROMEN 4 ONE; 7 [[1 (2 METHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHOXY) 4H CHROMEN 4 ONE; 7 [[1 (2,4 DICHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 4H CHROMEN 4 ONE; 7 [[1 (3 BROMOBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 4H CHROMEN 4 ONE; 7 [[1 (3 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 4H CHROMEN 4 ONE; 7 [[1 (3 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 4H CHROMEN 4 ONE; 7 [[1 (3 NITROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 4H CHROMEN 4 ONE; 7 [[1 (4 BROMOBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 4H CHROMEN 4 ONE; 7 [[1 (4 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 4H CHROMEN 4 ONE; 7 [[1 (4 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 4H CHROMEN 4 ONE; 7 [[1 (4 METHOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 4H CHROMEN 4 ONE; 7 [[1 (4 METHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 4H CHROMEN 4 ONE; 7 [[1 (4 NITROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 4H CHROMEN 4 ONE; 7 [[1 (4 TERT BUTYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 4H CHROMEN 4 ONE; 7 [[1(3 METHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 4H CHROMEN 4 ONE; ANTINEOPLASTIC AGENT; BENZOPYRAN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; CLICK CHEMISTRY; COUMARINS; HUMANS;

EID: 84861595329     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.04.026     Document Type: Article

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