Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-β aggregation

Journal of Medicinal Chemistry

Volumn 51, Issue 7, 2008, Pages 2027-2036

  Xie, Qiong ^a   Wang, Hao ^b   Xia, Zheng ^b   Lu, Meiyan ^a   Zhang, Weiwei ^b   Wang, Xinghai ^a   Fu, Wei ^a   Tang, Yun ^c   Sheng, Wei ^a   Li, Wei ^a   Zhou, Wei ^b   Zhu, Xu ^b   Qiu, Zhuibai ^a   Chen, Hongzhuan ^b  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DIMER; MEPTAZINOL; MONOMER; PROPIDIUM IODIDE; RIVASTIGMINE;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CATALYSIS; DRUG POTENCY; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHOBICITY; IC 50; MOLECULAR DOCKING; NONHUMAN; PROTEIN AGGREGATION; RAT;

ACETYLCHOLINESTERASE; AMYLOID BETA-PROTEIN; ANIMALS; BINDING SITES; BUTYRYLCHOLINESTERASE; CELL LINE, TUMOR; CELL SURVIVAL; CHOLINESTERASE INHIBITORS; DRUG DESIGN; ENZYME ACTIVATION; HUMANS; MEPTAZINOL; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TOXICITY TESTS;

EID: 41849142994     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070154q     Document Type: Article

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