Methionine concentration in the diet has a tissue-specific effect on chromosomal stability in female mice

Food and Chemical Toxicology

Volumn 62, Issue , 2013, Pages 456-462

  Aissa, Alexandre Ferro ^a   Gomes, Tarsila Daysy Ursula Hermogenes ^a   Almeida, Mara Ribeiro ^a   Hernandes, Lívia Cristina ^a   Darin, Joana D'arc Castania ^a   Bianchi, Maria Lourdes Pires ^a   Antunes, Lusânia Maria Greggi ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Chromosome instability; Genotoxicity; Methionine restriction; Methionine supplementation; Mutagenicity; Nutrigenomics

Indexed keywords

MESSENGER RNA; METHIONINE; PROTEIN MLH1; PROTEIN MSH2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHROMOSOMAL INSTABILITY; CHROMOSOME DAMAGE; COMET ASSAY; CONTROLLED STUDY; DIETARY INTAKE; DNA DAMAGE; DOWN REGULATION; FEMALE; GENE EXPRESSION REGULATION; GENOTOXICITY; MICRONUCLEUS TEST; MISMATCH REPAIR; MLH1 GENE; MOUSE; MSH2 GENE; NONHUMAN; TISSUE SPECIFICITY;

MUS;

CHROMOSOME INSTABILITY; GENOTOXICITY; METHIONINE RESTRICTION; METHIONINE SUPPLEMENTATION; MUTAGENICITY; NUTRIGENOMICS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BLOOD CELLS; BODY WEIGHT; CHROMOSOMAL INSTABILITY; COMET ASSAY; DIET; DIETARY SUPPLEMENTS; DNA DAMAGE; DNA REPAIR; FEMALE; GENE EXPRESSION REGULATION; HEART; LIVER; METHIONINE; MICE; MICRONUCLEUS TESTS; MUTS HOMOLOG 2 PROTEIN; NUCLEAR PROTEINS;

EID: 84884712586     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.09.004     Document Type: Article

References (67)

1. Aissa A.F., Bianchi M.L.P., Ribeiro J.C., Hernandes L.C., de Faria A.F., Mercadante A.Z., Antunes L.M.G. Comparative study of beta-carotene and microencapsulated beta-carotene: Evaluation of their genotoxic and antigenotoxic effects. Food Chem. Toxicol. 2012, 50:1418-1424.
2. Allione A., Russo A., Ricceri F., Vande Loock K., Guarrera S., Voglino F., Kirsch-Volders M., Matullo G. Validation of the nucleotide excision repair comet assay on cryopreserved PBMCs to measure inter-individual variation in DNA repair capacity. Mutagenesis 2013, 28:65-70.
3. Almeida M.R., Aissa A.F., Ursula Hermogenes Gomes T.D., Darin J.D., Chiste R.C., Mercadante A.Z., Antunes L.M., Bianchi M.L. In vivo genotoxicity and oxidative stress evaluation of an ethanolic extract from piquia (Caryocar villosum) pulp. J. Med. Food 2013, 16:268-271.
4. Amaral C.L.D., Bueno R.d.B.e.L., Burim R.V., Queiroz R.H.C., Bianchi M.d.L.P., Antunes L.M.G. The effects of dietary supplementation of methionine on genomic stability and p53 gene promoter methylation in rats. Mutat. Res./Genet. Toxicol. Environ. Mutagen. 2011, 722:78-83.
5. Arai E., Kanai Y. DNA methylation profiles in precancerous tissue and cancers: carcinogenetic risk estimation and prognostication based on DNA methylation status. Epigenomics 2010, 2:467-481.
6. Azqueta A., Collins A.R. The essential comet assay: a comprehensive guide to measuring DNA damage and repair. Arch. Toxicol. 2013, 87:949-968.
7. Bouzouf M., Martinez-Cruz F., Molinero P., Guerrero J.M., Osuna C. Melatonin prevents hyperhomocysteinemia and neural lipid peroxidation induced by methionine intake. Curr. Neurovasc. Res. 2005, 2:175-178.
8. Bull C.F., Mayrhofer G., Zeegers D., Mun G.L., Hande M.P., Fenech M.F. Folate deficiency is associated with the formation of complex nuclear anomalies in the cytokinesis-block micronucleus cytome assay. Environ. Mol. Mutagen. 2012, 53:311-323.
9. Calvisi D.F., Simile M.M., Ladu S., Pellegrino R., De Murtas V., Pinna F., Tomasi M.L., Frau M., Virdis P., De Miglio M.R., Muroni M.R., Pascale R.M., Feo F. Altered methionine metabolism and global DNA methylation in liver cancer: relationship with genomic instability and prognosis. Int. J. Cancer 2007, 121:2410-2420.
10. Campregher C., Schmid G., Ferk F., Knasmuller S., Khare V., Kortum B., Dammann K., Lang M., Scharl T., Spittler A., Roig A.I., Shay J.W., Gerner C., Gasche C. MSH3-Deficiency Initiates EMAST without Oncogenic Transformation of Human Colon Epithelial Cells. Plos One 2012, 7.
11. Cantoni G.L. Biological methylation: selected aspects. Annu. Rev. Biochem. 1975, 44:435-451.
12. Celik A., Ogenler O., Comelekoglu U. The evaluation of micronucleus frequency by acridine orange fluorescent staining in peripheral blood of rats treated with lead acetate. Mutagenesis 2005, 20:411-415.
13. Chambers J.C., Obeid O.A., Kooner J.S. Physiological increments in plasma homocysteine induce vascular endothelial dysfunction in normal human subjects. Arterioscl. Throm. Vas. 1999, 19:2922-2927.
14. Collins A.R. Investigating oxidative DNA damage and its repair using the comet assay. Mutat. Res. 2009, 681:24-32.
15. Collins A.R., Azqueta A. DNA repair as a biomarker in human biomonitoring studies; further applications of the comet assay. Mutat. Res. 2012, 736:122-129.
16. Duthie S.J., Grant G., Narayanan S. Increased uracil misincorporation in lymphocytes from folate-deficient rats. Br. J. Cancer 2000, 83:1532-1537.
17. Elshorbagy A.K., Valdivia-Garcia M., Refsum H., Smith A.D., Mattocks D.A.L., Perrone C.E. Sulfur amino acids in methionine-restricted rats: hyperhomocysteinemia. Nutrition 2010, 26:1201-1204.
18. Fenech M. Cytokinesis-block micronucleus cytome assay. Nat. Protoc. 2007, 2:1084-1104.
19. Fenech M. Folate (vitamin B9) and vitamin B12 and their function in the maintenance of nuclear and mitochondrial genome integrity. Mutat. Res. 2012, 733:21-33.
20. Fenech M., Aitken C., Rinaldi J. Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis 1998, 19:1163-1171.
21. Fenech M.F., Dreosti I.E., Rinaldi J.R. Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men. Carcinogenesis 1997, 18:1329-1336.
22. Ferguson L.R. Dietary influences on mutagenesis-where is this field going?. Environ. Mol. Mutagen. 2010, 51:909-918.
23. Finkelstein J.D., Martin J.J., Harris B.J. Methionine metabolism in mammals. The methionine-sparing effect of cystine. J. Biol. Chem. 1988, 263:11750-11754.
24. Fujimoto S., Togane Y., Matsuzaki C., Yamashina S., Nakano H., Yamazaki J., Yoshino G. Effects of long-term administration of methionine on vascular endothelium in rabbits. Nutr. Metab. Cardiovasc. 2003, 13:20-27.
25. Gahche J., Bailey R., Burt V., Hughes J., Yetley E., Dwyer J., Picciano M.F., McDowell M., Sempos C. Dietary supplement use among U.S. adults has increased since NHANES III (1988-1994). NCHS Data Brief 2010, 61:1-8.
26. Garibaldi F., Cicchini C., Conigliaro A., Santangelo L., Cozzolino A.M., Grassi G., Marchetti A., Tripodi M., Amicone L. An epistatic mini-circuitry between the transcription factors Snail and HNF4 alpha controls liver stem cell and hepatocyte features exhorting opposite regulation on stemness-inhibiting microRNAs. Cell Death Differ. 2012, 19:937-946.
27. Harper A.E., Beneveng N.J., Wohlhuet R.M. Effects of ingestion of disproportionate amounts of amino acids. Physiol. Rev. 1970, 50. p. 428.
28. Hayashi M., MacGregor J.T., Gatehouse D.G., Adler I.-D., Blakey D.H., Dertinger S.D., Krishna G., Morita T., Russo A., Sutou S. In vivo rodent erythrocyte micronucleus assay. II. Some aspects of protocol design including repeated treatments, integration with toxicity testing, and automated scoring. Environ. Mol. Mutagen. 2000, 35:234-252.
29. Humphrey L.L., Fu R.W., Rogers K., Freeman M., Helfand M. Homocysteine level and coronary heart disease incidence: a systematic review and meta-analysis. Mayo Clin. Proc. 2008, 83:1203-1212.
30. Jiang Y.D., Sun T., Xiong J.T., Cao J., Li G.Z., Wang S.R. Hyperhomocysteinemia-mediated DNA hypomethylation and its potential epigenetic role in rats. Acta Biochim. Biophys. Sin. 2007, 39:657-667.
31. Kanai Y. Genome-wide DNA methylation profiles in precancerous conditions and cancers. Cancer Sci. 2010, 101:36-45.
32. Khanna K.K., Jackson S.P. DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet. 2001, 27:247-254.
33. Kumagai H., Katoh S., Hirosawa K., Kimura M., Hishida A., Ikegaya N. Renal tubulointerstitial injury in weanling rats with hyperhomocysteinemia. Kidney Int. 2002, 62:1219-1228.
34. Lazalde-Ramos B.P., Zamora-Perez A.L., Sosa-Macias M., Guerrero-Velazquez C., Zuniga-Gonzalez G.M. DNA and oxidative damages decrease after ingestion of folic acid in patients with type 2 diabetes. Arch. Med. Res. 2012, 43:476-481.
35. Lopez-Torres M., Barja G. Lowered methionine ingestion as responsible for the decrease in rodent mitochondrial oxidative stress in protein and dietary restriction Possible implications for humans. Biochim. Biophys. Acta - Gen. Subj. 2008, 1780:1337-1347.
36. Malloy V.L., Krajcik R.A., Bailey S.J., Hristopoulos G., Plummer J.D., Orentreich N. Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction. Aging Cell 2006, 5:305-314.
37. Mastrocola A.S., Heinen C.D. Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage. DNA Repair (Amst) 2010, 9:120-133.
38. McCarty M.F., Barroso-Aranda J., Contreras F. The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy. Med. Hypotheses 2009, 72:125-128.
39. Miller R.A., Buehner G., Chang Y., Harper J.M., Sigler R., Smith-Wheelock M. Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell 2005, 4:119-125.
40. Mori N., Hirayama K. Long-term consumption of a methionine-supplemented diet increases iron and lipid peroxide levels in rat liver. J. Nutr. 2000, 130:2349-2355.
41. Niculescu M.D., Zeisel S.H. Diet, methyl donors and DNA methylation: Interactions between dietary folate, methionine and choline. J. Nutr. 2002, 132:2333s-2335s.
42. Ostling O., Johanson K.J. Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells. Biochem. Biophys. Res. Commun. 1984, 123:291-298.
43. Park C.M., Cho C.W., Rosenfeld M.E., Song Y.S. Methionine supplementation accelerates oxidative stress and nuclear factor kappaB activation in livers of C57BL/6 mice. J. Med. Food 2008, 11:667-674.
44. Paulitschke V., Schicher N., Szekeres T., Jager W., Elbling L., Riemer A.B., Scheiner O., Trimurtulu G., Venkateswarlu S., Mikula M., Swoboda A., Fiebiger E., Gerner C., Pehamberger H., Kunstfeld R. 3,3[prime],4,4[prime],5,5[prime]-hexahydroxystilbene impairs melanoma progression in a metastatic mouse model. J. Invest. Dermatol. 2010, 130:1668-1679.
45. Perrone C.E., Mattocks D.A.L., Jarvis-Morar M., Plummer J.D., Orentreich N. Methionine restriction effects on mitochondrial biogenesis and aerobic capacity in white adipose tissue, liver, and skeletal muscle of F344 rats. Metab.: Clin. Exp. 2010, 59:1000-1011.
46. Pogribny I.P., Basnakian A.G., Miller B.J., Lopatina N.G., Poirier L.A., James S.J. Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats. Cancer Res. 1995, 55:1894-1901.
47. Pogribny I.P., Shpyleva S.I., Muskhelishvili L., Bagnyukova T.V., James S.J., Beland F.A. Role of DNA damage and alterations in cytosine DNA methylation in rat liver carcinogenesis induced by a methyl-deficient diet. Mutat. Res. 2009, 669:56-62.
48. Razzak A.A., Oxentenko A.S., Vierkant R.A., Tillmans L.S., Wang A.H., Weisenberger D.J., Laird P.W., Lynch C.F., Anderson K.E., French A.J., Haile R.W., Harnack L.J., Potter J.D., Slager S.L., Smyrk T.C., Thibodeau S.N., Cerhan J.R., Limburg P.J. Associations between intake of folate and related micronutrients with molecularly defined colorectal cancer risks in the Iowa Women's Health Study. Nutr. Cancer 2012, 64:899-910.
49. Reeves P.G., Nielsen F.H., Fahey G.C. Ain-93 purified diets for laboratory rodents - final report of the American Institute of Nutrition Ad Hoc Writing Committee on the reformulation of the Ain-76a Rodent Diet. J. Nutr. 1993, 123:1939-1951.
50. Richie J.P., Leutzinger Y., Parthasarathy S., Malloy V., Orentreich N., Zimmerman J.A. Methionine restriction increases blood glutathione and longevity in F344 rats. Faseb J. 1994, 8:1302-1307.
51. Sawan C., Vaissiere T., Murr R., Herceg Z. Epigenetic drivers and genetic passengers on the road to cancer. Mutat. Res./Fund. Mol. Mech. Mutagen. 2008, 642:1-13.
52. Schmittgen T.D., Livak K.J. Analyzing real-time PCR data by the comparative C-T method. Nat. Protoc. 2008, 3:1101-1108.
53. Serpeloni J.M., Almeida M.R., Mercadante A.Z., Bianchi M.L., Antunes L.M. Effects of lutein and chlorophyll b on GSH depletion and DNA damage induced by cisplatin in vivo. Hum. Exp. Toxicol. 2013, 32:828-836.
54. Shahi A., Lee J.H., Kang Y., Lee S.H., Hyun J.W., Chang I.Y., Jun J.Y., You H.J. Mismatch-repair protein MSH6 is associated with Ku70 and regulates DNA double-strand break repair. Nucleic Acids Res. 2011, 39:2130-2143.
55. Sidelnikov E., Bostick R.M., Flanders W.D., Long Q., Fedirko V., Shaukat A., Daniel C.R., Rutherford R.E. Effects of calcium and vitamin D on MLH1 and MSH2 expression in rectal mucosa of sporadic colorectal adenoma patients. Cancer Epidemiol. Biomarkers Prevent. 2010, 19:1022-1032.
56. Singh N.P., Mccoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low-levels of DNA damage in individual cells. Exp. Cell Res. 1988, 175:184-191.
57. Sun L., Sadighi Akha A.A., Miller R.A., Harper J.M. Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age. J. Gerontol. A Biol. Sci. Med. Sci. 2009, 64:711-722.
58. Swayne B.G., Behan N.A., Williams A., Stover P.J., Yauk C.L., MacFarlane A.J. Supplemental dietary folic acid has no effect on chromosome damage in erythrocyte progenitor cells of mice. J. Nutr. 2012, 142:813-817.
59. Switzeny O.J., Müllner E., Wagner K.-H., Brath H., Aumüller E., Haslberger A.G. Vitamin and antioxidant rich diet increases MLH1 promoter DNA methylation in DMT2 subjects. Clin. Epigenet. 2012, 4:1-11.
60. Tang B., Mustafa A., Gupta S., Melnyk S., James S.J., Kruger W.D. Methionine-deficient diet induces post-transcriptional downregulation of cystathionine [beta]-synthase. Nutrition 2010, 26:1170-1175.
61. Thomas P., Wu J., Dhillon V., Fenech M. Effect of dietary intervention on human micronucleus frequency in lymphocytes and buccal cells. Mutagenesis 2011, 26:69-76.
62. Tice R.R., Agurell E., Anderson D., Burlinson B., Hartmann A., Kobayashi H., Miyamae Y., Rojas E., Ryu J.C., Sasaki Y.F. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 2000, 35:206-221.
63. Toborek M., Hennig B. Dietary methionine imbalance, endothelial cell dysfunction and atherosclerosis. Nutr. Res. 1996, 16:1251-1266.
64. Troen A.M., Lutgens E., Smith D.E., Rosenberg I.H., Selhub J. The atherogenic effect of excess methionine intake. Proc. Natl. Acad. Sci. USA 2003, 100:15089-15094.
65. Uccella S., Mariani A., Wang A.H., Vierkant R.A., Robien K., Anderson K.E., Cerhan J.R. Dietary and supplemental intake of one-carbon nutrients and the risk of type I and type II endometrial cancer: a prospective cohort study. Ann. Oncol. 2011, 22:2129-2136.
66. Wang X., Fenech M. A comparison of folic acid and 5-methyltetrahydrofolate for prevention of DNA damage and cell death in human lymphocytes in vitro. Mutagenesis 2003, 18:81-86.
67. Waterland R.A. Assessing the effects of high methionine intake on DNA methylation. J. Nutr. 2006, 136:1706s-1710s.