Mismatch-repair protein MSH6 is associated with Ku70 and regulates DNA double-strand break repair

Nucleic Acids Research

Volumn 39, Issue 6, 2011, Pages 2130-2143

  Shahi, Ankita ^a   Lee, Jung Hee ^a   Kang, Yoonsung ^a   Lee, Sung Haeng ^a   Hyun, Jin Won ^b   Chang, In Youb ^a   Jun, Jae Yeoul ^a   You, Ho Jin ^a  

^a Chosun University   (South Korea)

^b Jeju National University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H2AX; KU ANTIGEN; MISMATCH REPAIR PROTEIN; MISMATCH REPAIR PROTEIN MSH6; UNCLASSIFIED DRUG; ZINOSTATIN;

ARTICLE; CELL ASSAY; CELL SURVIVAL; COMET ASSAY; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; GENETIC PARAMETERS; HUMAN; HUMAN CELL; IONIZING RADIATION; NON HOMOLOGOUS END JOINING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; TWO HYBRID SYSTEM; UPREGULATION;

ANTIGENS, NUCLEAR; CELL LINE; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-BINDING PROTEINS; HISTONES; HUMANS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 79953707633     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkq1095     Document Type: Article

References (59)

1. Khanna,K.K. and Jackson,S.P. (2001) DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet., 27, 247-254.
2. Zhang,Y., Rohde,L.H. and Wu,H. (2009) Involvement of nucleotide excision and mismatch repair mechanisms in double strand break repair. Curr. Genomics, 10, 250-258.
3. Lees-Miller,S.P. and Meek,K. (2003) Repair of DNA double strand breaks by non-homologous end joining. Biochimie, 85, 1161-1173. (Pubitemid 38142369)
4. Lieber,M.R., Ma,Y., Pannicke,U. and Schwarz,K. (2003) Mechanism and regulation of human non-homologous DNA end-joining. Nat. Rev. Mol. Cell Biol., 4, 712-720.
5. Downs,J.A. and Jackson,S.P. (2004) A means to a DNA end: the many roles of Ku. Nat. Rev. Mol. Cell Biol., 5, 367-378.
6. Burma,S., Chen,B.P. and Chen,D.J. (2006) Role of non-homologous end joining (NHEJ) in maintaining genomic integrity. DNA Repair (Amst), 5, 1042-1048. (Pubitemid 44291616)
7. Mimori,T., Hardin,J.A. and Steitz,J.A. (1986) Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders. J. Biol. Chem., 261, 2274-2278.
8. Koike,M., Shiomi,T. and Koike,A. (2001) Dimerization and nuclear localization of ku proteins. J. Biol. Chem., 276, 11167-11173.
9. Tuteja,R. and Tuteja,N. (2000) Ku autoantigen: a multifunctional DNA-binding protein. Crit. Rev. Biochem. Mol. Biol., 35, 1-33.
10. Nolens,G., Pignon,J.C., Koopmansch,B., Elmoualij,B., Zorzi,W., De Pauw,E. and Winkler,R. (2009) Ku proteins interact with activator protein-2 transcription factors and contribute to ERBB2 overexpression in breast cancer cell lines. Breast Cancer Res., 11, R83.
11. Yin,H. and Glass,J. (2006) In prostate cancer cells the interaction of C/EBPalpha with Ku70, Ku80, and poly(ADP-ribose) polymerase-1 increases sensitivity to DNA damage. J. Biol. Chem., 281, 11496-11505.
12. Amsel,A.D., Rathaus,M., Kronman,N. and Cohen,H.Y. (2008) Regulation of the proapoptotic factor Bax by Ku70-dependent deubiquitylation. Proc. Natl Acad. Sci. USA, 105, 5117-5122.
13. Ting,N.S., Yu,Y., Pohorelic,B., Lees-Miller,S.P. and Beattie,T.L. (2005) Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase. Nucleic Acids Res., 33, 2090-2098. (Pubitemid 41439877)
14. Chai,W., Ford,L.P., Lenertz,L., Wright,W.E. and Shay,J.W. (2002) Human Ku70/80 associates physically with telomerase through interaction with hTERT. J. Biol. Chem., 277, 47242-47247.
15. Cohen,H.Y., Lavu,S., Bitterman,K.J., Hekking,B., Imahiyerobo,T.A., Miller,C., Frye,R., Ploegh,H., Kessler,B.M. and Sinclair,D.A. (2004) Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol. Cell, 13, 627-638.
16. Mazumder,S., Plesca,D., Kinter,M. and Almasan,A. (2007) Interaction of a cyclin E fragment with Ku70 regulates Bax-mediated apoptosis. Mol. Cell Biol., 27, 3511-3520.
17. Tanaka,Y., Imamura,J., Kanai,F., Ichimura,T., Isobe,T., Koike,M., Kudo,Y., Tateishi,K., Ikenoue,T., Ijichi,H. et al. (2007) Runx3 interacts with DNA repair protein Ku70. Exp. Cell Res., 313, 3251-3260.
18. Li,B. and Comai,L. (2000) Functional interaction between Ku and the werner syndrome protein in DNA end processing. J. Biol. Chem., 275, 28349-28352.
19. Karmakar,P., Snowden,C.M., Ramsden,D.A. and Bohr,V.A. (2002) Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus. Nucleic Acids Res., 30, 3583-3591. (Pubitemid 34919214)
20. Fang,L., Wang,Y., Du,D., Yang,G., Tak Kwok,T., Kai Kong,S., Chen,B., Chen,D.J. and Chen,Z. (2007) Cell polarity protein Par3 complexes with DNA-PK via Ku70 and regulates DNA double-strand break repair. Cell Res., 17, 100-116. (Pubitemid 46279234)
21. Harfe,B.D. and Jinks-Robertson,S. (2000) DNA mismatch repair and genetic instability. Annu. Rev. Genet., 34, 359-399.
22. Sugawara,N., Paques,F., Colaiacovo,M. and Haber,J.E. (1997) Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination. Proc. Natl Acad. Sci. USA, 94, 9214-9219.
23. Elliott,B. and Jasin,M. (2001) Repair of double-strand breaks by homologous recombination in mismatch repair-defective mammalian cells. Mol. Cell Biol., 21, 2671-2682.
24. Bannister,L.A., Waldman,B.C. and Waldman,A.S. (2004) Modulation of error-prone double-strand break repair in mammalian chromosomes by DNA mismatch repair protein Mlh1. DNA Repair (Amst), 3, 465-474. (Pubitemid 38482021)
25. Smith,J.A., Waldman,B.C. and Waldman,A.S. (2005) A role for DNA mismatch repair protein Msh2 in error-prone double-strand-break repair in mammalian chromosomes. Genetics, 170, 355-363. (Pubitemid 40799997)
26. Kang,Y., Lee,J.H., Hoan,N.N., Sohn,H.M., Chang,I.Y. and You,H.J. (2009) Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin- induced DNA damage. J. Biol. Chem., 284, 9845-9853.
27. Gradia,S., Acharya,S. and Fishel,R. (1997) The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch. Cell, 91, 995-1005. (Pubitemid 28027832)
28. Collis,S.J., DeWeese,T.L., Jeggo,P.A. and Parker,A.R. (2005) The life and death of DNA-PK. Oncogene, 24, 949-961. (Pubitemid 40313872)
29. Li,Z., Otevrel,T., Gao,Y., Cheng,H.L., Seed,B., Stamato,T.D., Taccioli,G.E. and Alt,F.W. (1995) The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell, 83, 1079-1089. (Pubitemid 26007800)
30. Grawunder,U., Zimmer,D., Fugmann,S., Schwarz,K. and Lieber,M.R. (1998) DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. Mol. Cell, 2, 477-484.
31. Stewart,G.S., Wang,B., Bignell,C.R., Taylor,A.M. and Elledge,S.J. (2003) MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature, 421, 961-966. (Pubitemid 36288029)
32. Rogakou,E.P., Pilch,D.R., Orr,A.H., Ivanova,V.S. and Bonner,W.M. (1998) DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem., 273, 5858-5868.
33. Papadopoulos,N., Nicolaides,N.C., Liu,B., Parsons,R., Lengauer,C., Palombo,F., D'Arrigo,A., Markowitz,S., Willson,J.K., Kinzler,K.W. et al. (1995) Mutations of GTBP in genetically unstable cells. Science, 268, 1915-1917.
34. Jiricny,J. (2006) The multifaceted mismatch-repair system. Nat. Rev. Mol. Cell Biol., 7, 335-346.
35. Genschel,J., Littman,S.J., Drummond,J.T. and Modrich,P. (1998) Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha. J. Biol. Chem., 273, 19895-19901.
36. Kadyrov,F.A., Dzantiev,L., Constantin,N. and Modrich,P. (2006) Endonucleolytic function of MutLalpha in human mismatch repair. Cell, 126, 297-308. (Pubitemid 44092957)
37. Wang,Y., Cortez,D., Yazdi,P., Neff,N., Elledge,S.J. and Qin,J. (2000) BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev., 14, 927-939. (Pubitemid 30253002)
38. Wang,Y. and Qin,J. (2003) MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc. Natl Acad. Sci. USA, 100, 15387-15392.
39. Brown,K.D., Rathi,A., Kamath,R., Beardsley,D.I., Zhan,Q., Mannino,J.L. and Baskaran,R. (2003) The mismatch repair system is required for S-phase checkpoint activation. Nat. Genet., 33, 80-84.
40. Shimodaira,H., Yoshioka-Yamashita,A., Kolodner,R.D. and Wang,J.Y. (2003) Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin. Proc. Natl Acad. Sci. USA, 100, 2420-2425.
41. Kovtun,I.V. and McMurray,C.T. (2007) Crosstalk of DNA glycosylases with pathways other than base excision repair. DNA Repair (Amst), 6, 517-529. (Pubitemid 46357054)
42. Cannavo,E., Gerrits,B., Marra,G., Schlapbach,R. and Jiricny,J. (2007) Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2. J. Biol. Chem., 282, 2976-2986. (Pubitemid 47084306)
43. Villemure,J.F., Abaji,C., Cousineau,I. and Belmaaza,A. (2003) MSH2-deficient human cells exhibit a defect in the accurate termination of homology-directed repair of DNA double-strand breaks. Cancer Res., 63, 3334-3339. (Pubitemid 36735891)
44. Pichierri,P., Franchitto,A., Piergentili,R., Colussi,C. and Palitti,F. (2001) Hypersensitivity to camptothecin in MSH2 deficient cells is correlated with a role for MSH2 protein in recombinational repair. Carcinogenesis, 22, 1781-1787. (Pubitemid 33064842)
45. Franchitto,A., Pichierri,P., Piergentili,R., Crescenzi,M., Bignami,M. and Palitti,F. (2003) The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase. Oncogene, 22, 2110-2120. (Pubitemid 36539561)
46. Hong,Z., Jiang,J., Hashiguchi,K., Hoshi,M., Lan,L. and Yasui,A. (2008) Recruitment of mismatch repair proteins to the site of DNA damage in human cells. J. Cell Sci., 121, 3146-3154.
47. Koh,K.H., Kang,H.J., Li,L.S., Kim,N.G., You,K.T., Yang,E., Kim,H., Kim,H.J., Yun,C.O. and Kim,K.S. (2005) Impaired nonhomologous end-joining in mismatch repair-deficient colon carcinomas. Lab. Invest., 85, 1130-1138.
48. Kim,N.G., Choi,Y.R., Baek,M.J., Kim,Y.H., Kang,H., Kim,N.K., Min,J.S. and Kim,H. (2001) Frameshift mutations at coding mononucleotide repeats of the hRAD50 gene in gastrointestinal carcinomas with microsatellite instability. Cancer Res., 61, 36-38.
49. Giannini,G., Ristori,E., Cerignoli,F., Rinaldi,C., Zani,M., Viel,A., Ottini,L., Crescenzi,M., Martinotti,S., Bignami,M. et al. (2002) Human MRE11 is inactivated in mismatch repair-deficient cancers. EMBO Rep., 3, 248-254. (Pubitemid 34269518)
50. Jacob,S., Miquel,C., Sarasin,A. and Praz,F. (2005) Effects of camptothecin on double-strand break repair by non-homologous end-joining in DNA mismatch repair-deficient human colorectal cancer cell lines. Nucleic Acids Res., 33, 106-113. (Pubitemid 40276932)
51. Chang,C., Biedermann,K.A., Mezzina,M. and Brown,J.M. (1993) Characterization of the DNA double strand break repair defect in scid mice. Cancer Res., 53, 1244-1248. (Pubitemid 23097096)
52. Omori,S., Takiguchi,Y., Suda,A., Sugimoto,T., Miyazawa,H., Tanabe,N., Tatsumi,K., Kimura,H., Pardington,P.E., Chen,F. et al. (2002) Suppression of a DNA double-strand break repair gene, Ku70, increases radio- and chemosensitivity in a human lung carcinoma cell line. DNA Repair (Amst), 1, 299-310. (Pubitemid 38340226)
53. Ayene,I.S., Ford,L.P. and Koch,C.J. (2005) Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and gamma radiation. Mol. Cancer Ther., 4, 529-536.
54. Peng,Y., Zhang,Q., Nagasawa,H., Okayasu,R., Liber,H.L. and Bedford,J.S. (2002) Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation. Cancer Res., 62, 6400-6404. (Pubitemid 35364094)
55. Meyers,M., Hwang,A., Wagner,M.W. and Boothman,D.A. (2004) Role of DNA mismatch repair in apoptotic responses to therapeutic agents. Environ. Mol. Mutagen., 44, 249-264.
56. Stojic,L., Brun,R. and Jiricny,J. (2004) Mismatch repair and DNA damage signalling. DNA Repair (Amst), 3, 1091-1101. (Pubitemid 38997952)
57. Li,H.R., Shagisultanova,E.I., Yamashita,K., Piao,Z., Perucho,M. and Malkhosyan,S.R. (2004) Hypersensitivity of tumor cell lines with microsatellite instability to DNA double strand break producing chemotherapeutic agent bleomycin. Cancer Res., 64, 4760-4767. (Pubitemid 38924519)
58. Weterings,E. and Chen,D.J. (2008) The endless tale of non-homologous end-joining. Cell Res., 18, 114-124.
59. Walker,J.R., Corpina,R.A. and Goldberg,J. (2001) Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature, 412, 607-614. (Pubitemid 32772267)