In vivo rodent erythrocyte micronucleus assay. II. Some aspects of protocol design including repeated treatments, integration with toxicity testing, and automated scoring

Environmental and Molecular Mutagenesis

Volumn 35, Issue 3, 2000, Pages 234-252

  Hayashi, Makoto ^a   MacGregor, James T ^b   Gatehouse, David G ^c   Adler, Ilse Dore ^d   Blakey, David H ^e   Dertinger, Stephen D ^f   Krishna, Gopala ^g   Morita, Takeshi ^h   Russo, Antonella ⁱ   Sutou, Shizuyo ^j  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c GLAXOSMITHKLINE   (United Kingdom)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

^e HEALTH CANADA   (Canada)

^f LITRON LABORATORIES   (United States)

^g PFIZER INC   (United States)

^h GLAXOSMITHKLINE   (United States)

ⁱ UNIVERSITY OF INSUBRIA   (Italy)

^j NATL INST BIOSCI HUM TECHNOL   (Japan)

more..

Author keywords

Aneugen; Automation; Chronic treatment; Germ cell; Micronucleus assay; Somatic cell; Transplacental

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; CONFERENCE PAPER; ERYTHROCYTE MICRONUCLEUS TEST; GOOD LABORATORY PRACTICE; INTERMETHOD COMPARISON; LABORATORY AUTOMATION; MICRONUCLEUS TEST; NONHUMAN; OUTCOMES RESEARCH; RAT; SCORING SYSTEM; TISSUE SPECIFICITY; TOXICITY TESTING; VALIDATION PROCESS;

ANIMALS; ANIMALS, NEWBORN; AUTOMATION; CENTROMERE; ERYTHROCYTES; MICE; MICRONUCLEUS TESTS; ORGAN SPECIFICITY; RATS; REPRODUCIBILITY OF RESULTS; TOXICITY TESTS;

ANIMALIA; RODENTIA;

EID: 0034127726     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2280(2000)35:3<234::AID-EM10>3.0.CO;2-L     Document Type: Conference Paper

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