In vivo genotoxicity and oxidative stress evaluation of an ethanolic extract from Piquiá (Caryocar villosum) pulp

Journal of Medicinal Food

Volumn 16, Issue 3, 2013, Pages 268-271

  Almeida, Mara Ribeiro ^a   Aissa, Alexandre Ferro ^a   Ursula Hermogenes Gomes, Tarsila Daysy ^a   Darin, Joana D'Arc Castania ^a   Chisté, Renan Campos ^b   Mercadante, Adriana Zerlotti ^b   Antunes, Lusânia Maria Greggi ^a   Bianchi, Maria Lourdes Pires ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Carotenoids; Comet assay; In vivo; Micronucleus test; Phenolic compounds; Wistar rats

Indexed keywords

ALCOHOL; CARYOCAR VILLOSUM EXTRACT; DOXORUBICIN; ELLAGIC ACID; GALLIC ACID; GLUTATHIONE; NEOXANTHIN; PLANT EXTRACT; QUERCETIN DERIVATIVE; QUINIC ACID; SODIUM CHLORIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG; VIOLAXANTHIN; XANTHINE DERIVATIVE; XANTHOPHYLL; ZEAXANTHIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW; CARYOCAR VILLOSUM; COMET ASSAY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EUTHANASIA; EVALUATION; GENOTOXICITY; HEART; KIDNEY; LIVER; MALE; MEDICINAL PLANT; MICRONUCLEUS TEST; NONHUMAN; OXIDATIVE STRESS; PHYTOCHEMISTRY; PRIORITY JOURNAL; RAT; TOXICITY TESTING; WOOD PULP;

ANIMALS; CATTLE; COMET ASSAY; FRUIT; GLUTATHIONE; HEART; HUMANS; MALE; MICE; MICRONUCLEUS TESTS; MUTAGENS; MYOCARDIUM; OXIDATIVE STRESS; PLANT EXTRACTS; RATS; RATS, WISTAR; THEALES; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 84875203987     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2012.0169     Document Type: Article

References (29)

1. Marx F, Andrade EHA, Maia JG: Chemical composition of the fruit pulp of Caryocar villosum. Z Lebensm Unters Forsch A 1997;204: 442-444 (Pubitemid 127788916)
2. Postescu ID, Chereches G, Tatomir C, Daicoviciu D, Filip GA: Modulation of doxorubicin-induced oxidative stress by a grape (Vitis vinifera L.) seed extract in normal and tumor cells. J Med Food 2012;15: 1-7
3. Grover P, Singh SP, Prabhakar PV, Reddy UA, Balasubramanyam A, Mahboob M, Rahman MF, Misra S: In vivo assessment of genotoxic effects of Annona squamosa seed extract in rats. Food Chem Toxicol 2009;47: 1964-1971
4. Inoue H, Akiyama S, Maeda-Yamamoto M, Nesumi A, Tanaka T, Murakami A: High-dose green tea polyphenols induce nephrotoxicity in dextran sulfate sodium-induced colitis mice by down-regulation of antioxidant enzymes and heat-shock protein expressions. Cell Stress Chaperones 2011;16: 653-662
5. Chiste RC, Freitas M, Mercadante AZ, Fernandes E: The potential of extracts of Caryocar villosum pulp to scavenge reactive oxygen and nitrogen species. Food Chem 2012;135: 1740-1749
6. Chiste RC, Mercadante AZ: Identification and quantification, by HPLC-DAD-MS/MS, of carotenoids and phenolic compounds from the Amazonian fruit Caryocar villosum. J Agric Food Chem 2012;60: 5884-5892
7. Ribeiro JC, Antunes LM, Aissa AF, Darin JD, De Rosso VV, Mercadante AZ, Bianchi Mde L: Evaluation of the genotoxic and antigenotoxic effects after acute and subacute treatments with acai pulp (Euterpe oleracea Mart.) on mice using the erythrocytes micronucleus test and the comet assay. Mutat Res 2010;695: 22-28
8. Aissa AF, Bianchi MLP, Ribeiro JC, Hernandes LC, de Faria AF, Mercadante AZ, Antunes LMG: Comparative study of beta-carotene and microencapsulated beta-carotene: Evaluation of their genotoxic and antigenotoxic effects. Food Chem Toxicol 2012;50: 1418-1424
9. Singh NP, McCoy MT, Tice RR, Schneider EL: A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988;175: 184-191
10. Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, Miyamae Y, Rojas E, Ryu JC, Sasaki YF: Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 2000;35: 206-221 (Pubitemid 30196665)
11. Schmid W: The micronucleus test. Mutat Res 1975;31: 9-15
12. Holden HE, Majeska JB, Studwell D: A direct comparison of mouse and rat bone marrow and blood as target tissues in the micronucleus assay. Mutat Res 1997;391: 87-89 (Pubitemid 27263455)
13. Titenko-Holland N, Windham G, Kolachana P, Reinisch F, Parvatham S, Osorio AM, Smith MT: Genotoxicity of malathion in human lymphocytes assessed using the micronucleus assay in vitro and in vivo: A study of malathion-exposed workers. Mutat Res 1997;388: 85-95 (Pubitemid 27226926)
14. Hayashi M, Morita T, Kodama Y, Sofuni T, Ishidate M: The micronucleus assay with mouse peripheral-blood reticulocytes using acridine orange-coated slides. Mutat Res 1990;245: 245
15. Buege JA, Aust SD: Microsomal lipid peroxidation. Methods Enzymol 1978;52: 302-310
16. Sedlak J, Lindsay RH: Estimation of total protein-bound and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem 1968;25: 192-205
17. Hartree EF: Determination of protein: A modification of the Lowry method that gives a linear photometric response. Anal Biochem 1972;48: 422-427
18. Almeida MR, Darin JD, Hernandes LC, Aissa AF, Chiste RC, Mercadante AZ, Antunes LM, Bianchi ML: Antigenotoxic effects of piquia (Caryocar villosum) in multiple rat organs. Plant Foods Hum Nutr 2012;67: 171-177
19. Chemat F, Zill-e-Huma, Khan MK: Applications of ultrasound in food technology: Processing, preservation and extraction. Ultrason Sonochem 2011;18: 813-835
20. Vieira PM, Veronezi E, Silva CR, Chen-Chen L: Detection of genotoxic, cytotoxic, and protective activities of Eugenia dysenterica DC. (Myrtaceae) in mice. J Med Food 2012;15: 563
21. Sanchez-Lamar A, Fonseca G, Fuentes JL, Cozzi R, Cundari E, Fiore M, Ricordy R, Perticone P, Degrassi F, De Salvia R: Assessment of the genotoxic risk of Punica granatum L. (Punicaceae) whole fruit extracts. J Ethnopharmacol 2008;115: 416-422
22. Boeira JM, Fenner R, Betti AH, Provensi G, Lacerda Lde A, Barbosa PR, Gonzalez FH, Correa AM, Driemeier D, Dall'Alba MP, Pedroso AP, Gosmann G, da Silva J, Rates SM: Toxicity and genotoxicity evaluation of Passiflora alata Curtis (Passifloraceae). J Ethnopharmacol 2010;128: 526-532
23. Dai J, Mumper RJ: Plant phenolics: Extraction, analysis and their antioxidant and anticancer properties. Molecules 2010;15: 7313
24. da Costa Lopes L, Albano F, Augusto Travassos Laranja G, Marques Alves L, Fernando Martins e Silva L, Poubel de Souza G, de Magalhaes Araujo I, Firmino Nogueira-Neto J, Felzenszwalb I, Kovary K: Toxicological evaluation by in vitro and in vivo assays of an aqueous extract prepared from Echinodorus macrophyllus leaves. Toxicol Lett 2000;116: 189-198
25. Kang YJ: The antioxidant function of metallothionein in the heart. Proc Soc Exp Biol Med 1999;222: 263-273 (Pubitemid 129784088)
26. Torres VM, Srdjenovic B, Jacevic V, Simic VD, Djordjevic A, Simplicio AL: Fullerenol C60(OH)24 prevents doxorubicin-induced acute cardiotoxicity in rats. Pharmacol Rep 2010;62: 707
27. Alpsoy S, Aktas C, Uygur R, Topcu B, Kanter M, Erboga M, Karakaya O, Gedikbasi A: Antioxidant and anti-apoptotic effects of onion (Allium cepa) extract on doxorubicin-induced cardiotoxicity in rats. J Appl Toxicol 2013;33: 202-208
28. Boutabet K, Kebsa W, Alyane M, Lahouel M: Polyphenolic fraction of Algerian propolis protects rat kidney against acute oxidative stress induced by doxorubicin. Indian J Nephrol 2011;21: 101-106
29. Hayashi M, MacGregor JT, Gatehouse DG, Adler ID, Blakey DH, Dertinger SD, Krishna G, Morita T, Russo A, Sutou S: In vivo rodent erythrocyte micronucleus assay. II. Some aspects of protocol design including repeated treatments, integration with toxicity testing, and automated scoring. Environ Mol Mutagen 2000;35: 234-252 (Pubitemid 30196667)