DNA repair as a biomarker in human biomonitoring studies; further applications of the comet assay

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 736, Issue 1-2, 2012, Pages 122-129

  Collins, Andrew R ^a   Azqueta, Amaya ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

Biomarker; Comet assay; DNA repair; Human biomonitoring; Review

Indexed keywords

8 HYDROXYGUANINE;

AGING; APE1 GENE; BIOLOGICAL MONITORING; COMET ASSAY; DIET SUPPLEMENTATION; DNA ADDUCT; DNA DAMAGE; ENVIRONMENTAL EXPOSURE; EXCISION REPAIR; GENE; GENE EXPRESSION; GENETIC POLYMORPHISM; GENOTOXICITY; HUMAN; IN VITRO STUDY; LIFESTYLE; MLH1 GENE; NBS1 GENE; OCCUPATIONAL EXPOSURE; OGG1 GENE; OXIDATION; PHENOTYPE; PHYTOCHEMISTRY; PRIORITY JOURNAL; RADIATION INJURY; REVIEW; ULTRAVIOLET IRRADIATION; XPA GENE; XPC GENE; XPD GENE; XRCC1 GENE; XRCC3 GENE;

AGING; BIOLOGICAL MARKERS; COMET ASSAY; DNA REPAIR; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION; HUMANS; LIFE STYLE; NUTRITIONAL STATUS; POLYMORPHISM, GENETIC;

EID: 84864518589     PISSN: 00275107     EISSN: 09218262     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2011.03.005     Document Type: Review

References (60)

1. G. Matullo, F. Ricceri, P. Vineis, Evidence of involvement of DNA repair polymorphisms in human cancer, under review.
2. Kiyohara C., Takayama K., Nakanishi Y. Lung cancer risk and genetic polymorphisms in DNA repair pathways: a meta-analysis. J. Nucleic Acids 2010, 10.4061/2010/701760.
3. Collins A.R. The comet assay for DNA damage and repair. Mol. Biotechnol. 2004, 26:249-261.
4. Au W.W., Giri A.K., Ruchirawat M. Challenge assay: a functional biomarker for exposure-induced DNA repair deficiency and for risk of cancer. Int. J. Hyg. Environ. Health 2010, 213:32-39.
5. Palyvoda O., Polanska J., Wygoda A., Rzeszowska-Wolny J. DNA damage and repair in lymphocytes of normal individuals and cancer patients: studies by the comet assay and micronucleus tests. Acta Biochim. Pol. 2003, 50:181-190.
6. Cebulska-Wasilewska A. Response to challenging dose of X-rays as a predictive assay for molecular epidemiology. Mutat. Res. 2003, 544:289-297.
7. Saha D.T., Davidson B.J., Wang A., Pollock A.J., Orden R.A., Goldman R. Quantification of DNA repair capacity in whole blood of patients with head and neck cancer and healthy donors by comet assay. Mutat. Res. 2008, 650:55-62.
8. Fracasso M.E., Doria D., Franceschetti P., Perbellini L., Romeo L. DNA damage and repair capacity by comet assay in lymphocytes of white-collar active smokers and passive smokers (non- and ex-smokers) at workplace. Toxicol. Lett. 2006, 167:131-141.
9. Touil N., Aka P.V., Buchet J.P., Thierens H., Kirsch-Volders M. Assessment of genotoxic effects related to chronic low level exposure to ionizing radiation using biomarkers for DNA damage and repair. Mutagenesis 2002, 17:223-232.
10. Aka P., Mateuca R., Buchet J.P., Thierens H., Kirsch-Volders M. Are genetic polymorphisms in OGG1 XRCC1 and XRCC3 genes predictive for the DNA strand break repair phenotype and genotoxicity in workers exposed to low dose ionising radiations?. Mutat. Res. 2004, 556:169-181.
11. Pool-Zobel B.L., Dornacher I., Lambertz R., Knoll M., Seitz H.K. Genetic damage and repair in human rectal cells for biomonitoring: sex differences, effects of alcohol exposure, and susceptibilities in comparison to peripheral blood lymphocytes. Mutat Res. 2004, 551:127-134.
12. Piperakis S.M., Kontogianni K., Piperakis M.M., Marcos R., Tsilimigaki S. Effects of pesticides on occupationally exposed humans. ScientificWorldJournal 2006, 6:1211-1220.
13. Collins A.R., Ma A., Duthie S.J. The kinetics of repair of oxidative DNA damage (strand breaks and oxidised pyrimidines) in human cells. Mutat. Res. 1995, 336:69-77.
14. Zhao X.H., Jia G., Liu Y.Q., Liu S.W., Yan L., Jin Y., Lj N. Association between polymorphisms of DNA repair gene XRCC1 and DNA damage in asbestos-exposed workers. Biomed. Environ. Sci. 2006, 19:232-238.
15. Keretetse G.S., Laubscher P.J., Du Plessis J.L., Pretorius P.J., Van Der Westhuizen F.H., Van Deventer E., Van Dyk E., Eloff F.C., Van Aarde M.N., Du Plessis L.H. DNA damage and repair detected by the comet assay in lymphocytes of african petrol attendants: a pilot study. Ann. Occup. Hyg. 2008, 52:653-662.
16. Vodicka P., Tuimala J., Stetina R., Kumar R., Manini P., Naccarati A., Maestri L., Vodickova L., Kuricova M., Jarventaus H., Majvaldova Z., Hirvonen A., Imbriani M., Mutti A., Migliore L., Norppa H., Hemminki K. Cytogenetic markers, DNA single-strand breaks, urinary metabolites, and DNA repair rates in styrene-exposed lamination workers. Environ. Health Perspect. 2004, 112:867-871.
17. Hanova M., Stetina R., Vodickova L., Vaclavikova R., Hlavac P., Smerhovsky Z., Naccarati A., Polakova V., Soucek P., Kuricova M., Manini P., Kumar R., Hemminki K., Vodicka P. Modulation of DNA repair capacity and mRNA expression levels of XRCC1, hOGG1 and XPC genes in styrene-exposed workers. Toxicol. Appl. Pharmacol. 2010, 248:194-200.
18. Vodicka P., Kumar R., Stetina R., Musak L., Soucek P., Haufroid V., Sasiadek M., Vodickova L., Naccarati A., Sedikova J., Sanyal S., Kuricova M., Brsiak V., Norppa H., Buchancova J., Hemminki K. Markers of individual susceptibility and DNA repair rate in workers exposed to xenobiotics in a tire plant. Environ. Mol. Mutagen. 2004, 44:283-292.
19. Virag P., Brie I., Postescu I.D., Perde-Schrepler M., Fischer-Fodor E., Soritau O., Irimie A., Cernea V. Comparative study of two evaluation methods for the genotoxic effects of environmental heavy metals on normal cells. Toxicol. Ind. Health 2009, 25:253-258.
20. Mendez-Gomez J., Garcia-Vargas G.G., Lopez-Carrillo L., Calderon-Aranda E.S., Gomez A., Vera E., Valverde M., Cebrian M.E., Rojas E. Genotoxic effects of environmental exposure to arsenic and lead on children in Region Lagunera, Mexico. Ann. NY Acad. Sci. 2008, 1140:358-367.
21. Mohankumar M.N., Janani S., Prabhu B.K., Kumar P.R.B., Jeevanram R.K. DNA damage and integrity of UV-induced DNA repair in lymphocytes of smokers analysed by the comet assay. Mutat. Res. 2002, 520:179-187.
22. Tyson J., Caple F., Spiers A., Burtle3 B., Daly A.K., Williams E.A., Hesketh J.E., Mathers J.C. Inter-individual variation in nucleotide excision repair in young adults: effects of age, adiposity, micronutrient supplementation and genotype. Brit. J. Nutr. 2009, 101:1316-1323.
23. Dusinska M., Collins A. Detection of oxidised purines and UV-induced photoproducts in DNA of single cells, by inclusion of lesion-specific enzymes in the comet assay. Altern. Lab. Anim. 1996, 24:405-411.
24. peit G.S., Schütz P., Hoffmann H. Enhancement of genotoxic effects in the comet assay with human blood samples by aphidicolin. Toxicol. Lett. 2004, 153:303-310.
25. Crebelli R., Carta P., Andreoli C., Aru G., Dobrowolny G., Rossi S., Zijno A. Biomonitoring of primary aluminium industry workers: detection of micronuclei and repairable DNA lesions by alkaline SCGE. Mutat. Res./Genet. Toxicol. Environ. Mutagen. 2002, 516:63-70.
26. Speit G., Witton-Davies T., Heepchantree W., Trenz K., Hoffmann H. Investigations on the effect of cigarette smoking in the comet assay. Mutat. Res. 2003, 542:33-42.
27. Green M.H.L., Waugh A.P.W., Lowe J.E., Harcourt S.A., Cole J., Arlett C.F. Effect of deoxyribonucleosides on the hypersensitivity of human peripheral blood lymphocytes to UV-B and UV-C irradiation. Mutat. Res. 1994, 315:25-32.
28. Cipollini M., He J., Rossi P., Baronti F., Micheli A., Rossi A.M., Barale R. Can individual repair kinetics of UVC-induced DNA damage in human lymphocytes be assessed through the comet assay?. Mutat. Res. 2006, 601:150-161.
29. Vande Loock K., Decordier I., Ciardelli R., Haumont D., Kirsch-Volders M. An aphidicolin-block nucleotide excision repair assay measuring DNA incision and repair capacity. Mutagenesis 2010, 25:25-32.
30. Paz-Elizur T., Elinger D., Leitner-Dagan Y., Blumenstein S., Krupsky M., Berrebi A., Schechtman E., Livneh Z. Development of an enzymatic DNA repair assay for molecular epidemiology studies: distribution of OGG activity in healthy individuals. DNA Repair 2007, 6:45-60.
31. Sauvaigo S., Guerniou V., Rapin D., Gasparutto D., Caillat S., Favier A. An oligonucleotide microarray for the monitoring of repair enzyme activity toward different DNA base damage. Anal. Biochem. 2004, 333:182-192.
32. Redaelli A., Magrassi R., Bonassi S., Abbondandolo A., Frosina G. AP endonuclease activity in humans: development of a simple assay and analysis of ten normal individuals. Teratog. Carcinog. Mutagen. 1998, 18:17-26.
33. Elliott R.M., Astley S., Southon S., Archer D.B. Measurement of cellular repair activities for oxidative DNA damage. Free Radic. Biol. Med. 2000, 28:1438-1446.
34. Collins A.R., Dusinska M., Horvathova E., Munro E., Savio M., Stetina R. Inter-individual differences in DNA base excision repair activity measured in vitro with the comet assay. Mutagenesis 2001, 16:297-301.
35. Langie S.A.S., Knaapen A.M., Brauers K.J.J., van Berlo D., van Schooten F.-J., Godschalk R.W.L. Development and validation of a modified comet assay to phenotypically assess nucleotide excision repair. Mutagenesis 2006, 21:153-158.
36. Gaivão I., Piasek A., Brevik A., Shaposhnikov S., Collins A.R. Comet assay-based methods for measuring DNA repair in vitro; estimates of inter- and intra-individual variation. Cell Biol. Toxicol. 2009, 25:45-52.
37. Herrera M., Dominguez G., Garcia J.M., Peña C., Jimenez C., Silva J., Garcia V., Gomez I., Diaz R., Martin P., Bonilla F. Differences in repair of DNA cross-links between lymphocytes and epithelial tumor cells from colon cancer patients measured in vitro with the comet assay. Clin. Cancer Res. 2009, 15:5466-5472.
38. Dusinska M., Collins A., Kazimirova A., Barancokova M., Harrington V., Volkovova K., Staruchova M., Horska A., Wsolova L., Kocan A. Genotoxic effects of asbestos in humans. Mutat. Res. 2004, 553:91-102.
39. Dusinska M., Barancokova M., Kazimirova A., Harrington V., Volkovova K., Staruchova M., Horska A., Wsolova L., Collins A. Does occupational exposure to mineral fibres cause DNA or chromosome damage?. Mutat. Res. 2004, 553:103-110.
40. Bräuner E.V., Forchhammer L., Møller P., Simonsen J., Glasius M., Wahlin P., Raaschou-Nielsen O., Loft S. Exposure to ultrafine particles from ambient air and oxidative stress-induced DNA damage. Environ. Health Perspect. 2007, 115:1177-1182.
41. Danielsen P.H., Bräuner E.V., Barregard L., Sällsten G., Wallin M., Olinski R., Rozalski R., Møller P., Loft S. Oxidatively damaged DNA and its repair after experimental exposure to wood smoke in healthy humans. Mutat. Res. 2008, 642:37-42.
42. Tomasetti M., Alleva R., Borghi B., Collins A.R. In vivo supplementation with coenzyme Q10 enhances the recovery of human lymphocytes from oxidative DNA damage. FASEB J. 2001, 10. 1096/fj.00-0694fje.
43. Collins A.R., Harrington V., Drew J., Melvin R. Nutritional modulation of DNA repair in a human intervention study. Carcinogenesis 2003, 24:511-515.
44. Brevik A., Karlsen A., Azqueta A., Tirado A., Blomhoff R. A.Collins, Both base excision repair and nucleotide excision repair in humans are influenced by nutritional factors. Cell. Biochem. Funct. 2011, 29:36-42.
45. Guarnieri S., Loft S., Riso P., Porrini M., Risom L., Poulsen H., Dragsted L.O., Møller P. DNA repair phenotype and dietary antioxidant supplementation. Brit. J. Nutr. 2008, 99:1018-1024.
46. Caple F., Williams E.A., Speirs A., Tyson J., Burtle B., Daly A.K., Mathers J.C., Hesketh J.E. Inter-individual variation in DNA damage and base excision repair in young, healthy non-smokers: effects of dietary supplementation and genotype. Brit. J. Nutr. 2010, 103:1585-1593.
47. Riso P., Martini D., Møller P., Loft S., Bonacina G., Moro M., Porrini M. DNA damage and repair activity after broccoli intake in young healthy smokers. Mutagenesis 2010, 25:595-602.
48. Langie S.A.S., Wilms L.C., Hämäläinen S., Kleinjans J.C.S., Godschalk R.W.L., van Schooten F.J. Modulation of nucleotide excision repair in human lymphocytes by genetic and dietary factors. Brit. J. Nutr. 2010, 103:490-501.
49. Vodicka P., Kumar R., Stetina R., Sanyal S., Soucek P., Haufroid V., Dusinska M., Kuricova M., Zamecnikova M., Musak L., Buchancova J., Norppa H., Hirvonen A., Vodickova L., Naccarati A., Matousu Z., Hemminki K. Genetic polymorphisms in DNA repair genes and possible links with DNA repair rates, chromosomal aberrations and single-strand breaks in DNA. Carcinogenesis 2004, 25:757-763.
50. Vodicka P, Stetina R., Polakova V., Tulupova E., Naccarati A., Vodickova L., Kumar R., Hanova M., Pardini B., Slyskova J., Musak L., De Palma G., Soucek P., Hemminki K. Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects. Carcinogenesis 2007, 28:657-664.
51. Ryk C., Routledge M.N., Allan J.M., Wild C.P., Kumar R., Lambert B., Hou S. Influence of DNA repair gene polymorphisms on the initial repair of MMS-induced DNA damage in human lymphocytes as measured by the alkaline comet assay. Environ. Mol. Mutagen. 2008, 49:669-675.
52. Dusinska M., Dzupinkova Z., Wsolova L., Harrington V., Collins A.R. Possible involvement of XPA in repair of oxidative DNA damage deduced from analysis of damage, repair and genotype in a human population study. Mutagenesis 2006, 21:205-211.
53. Meyer J.N QPCR: a tool for analysis of mitochondrial and nuclear DNA damage in ecotoxicology. Ecotoxicology 2010, 19:804-811.
54. Dusinska M., Collins A.R. DNA oxidation, antioxidant effects, and DNA repair measured with the comet assay. Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications 2010, 261-282. Blackwell Publishing Ltd. G. Aldini, K.-J. Yeum, E. Niki, R.M. Russell (Eds.).
55. Eiberger W., Volkmer B., Amouroux R., Dherin C., Radicella J.P., Epe B. Oxidative stress impairs the repair of oxidative DNA base modifications in human skin fibroblasts and melanoma cells. DNA Repair 2008, 7:912-921.
56. Langie S.A., Knaapen A.M., Houben J.M.J., van Kempen F.C., de Hoon J.P.J., Gottschalk R.W.H., Godschalk R.W.L., van Schooten F.J. The role of glutathione in the regulation of nucleotide excision repair during oxidative stress. Toxicol. Lett. 2007, 168:302-309.
57. Obtulowicz T., Swoboda M., Speina E., Gackowski D., Rozalski R., Siomek A., Janik J., Janowska B., Ciesla J.M., Jawien A., Banaszkiewicz Z., Guz J., Dziaman T., Szpila A., Olinski R., Tudek B. Oxidative stress and 8-oxoguanine repair are enhanced in colon adenoma and carcinoma patients. Mutagenesis 2010, 25:463-471.
58. Chen S.-K., Hsieh W.A., Tsai M.-H., Chen C.-C., Hong A.I.C., Wei Y.-H., Chang W.P. Age-associated decrease of oxidative repair enzymes, human 8-oxoguanine DNA glycosylases (hOgg1), in human aging. J. Radiat. Res. 2003, 44:31-35.
59. Pons B., Belmont A.-S., Masson-Genteuil G., Chapuis V., Oddos T., Sauvaigo S. Age-associated modifications of base excision repair activities in human skin fibroblast extracts. Mech. Ageing Dev. 2010, 131:661-665.
60. Janssen K., Schlink K., Götte W., Hippler B., Kaina B., Oesch F. DNA repair activity of 8-oxoguanine DNA glycosylase 1 (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser326/Cys326. Mutat. Res. 2001, 486:207-216.