A comparison of folic acid and 5-methyltetrahydrofolate for prevention of DNA damage and cell death in human lymphocytes in vitro

Mutagenesis

Volumn 18, Issue 1, 2003, Pages 81-86

  Wang, Xu ^b   Fenech, Michael ^a,b  

^a CSIRO   (Australia)

^b YUNNAN NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; CHOLINE; CYANOCOBALAMIN; CYTOCHALASIN B; DNA; FOLIC ACID; HOMOCYSTEINE; METHIONINE; METHIONINE SYNTHASE; METHYL GROUP; PHYTOHEMAGGLUTININ; POLYAMINE; S ADENOSYLMETHIONINE; VITAMIN RECEPTOR;

AMINO ACID SYNTHESIS; APOPTOSIS; ARTICLE; CELL DEATH; CELL DIVISION; CELL PROLIFERATION; CHROMOSOME DAMAGE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINESIS; CYTOSTASIS; DIET SUPPLEMENTATION; DNA DAMAGE; DNA METHYLATION; FEMALE; GENETIC DAMAGE; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE; LYMPHOCYTE PROLIFERATION; METHYLATION; MICRONUCLEUS TEST; MITOGENESIS; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; REDUCTION; VOLUNTEER;

ADULT; BIOLOGICAL AVAILABILITY; CARRIER PROTEINS; CELL DIVISION; CELLS, CULTURED; CHOLINE; CHROMOSOME BREAKAGE; CHROMOSOMES, HUMAN; DEOXYURACIL NUCLEOTIDES; DNA; DNA DAMAGE; DNA METHYLATION; DNA REPLICATION; FEMALE; FOLIC ACID; HUMANS; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MEMBRANE TRANSPORT PROTEINS; METHIONINE; MICRONUCLEUS TESTS; MIDDLE AGED; OXIDATION-REDUCTION; PHYTOHEMAGGLUTININS; PRODRUGS; RECEPTORS, CELL SURFACE; TETRAHYDROFOLATES; URACIL;

EID: 0037238069     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/18.1.81     Document Type: Article

References (29)

1. Antony,A.C. (1992) The biological chemistry of folate receptors. Blood, 79, 2808-2820.
2. Blount,B.C. and Ames,B.N. (1995) DNA damage in folate deficiency. Bailleres Clin. Haematol., 8, 461-475.
3. Blount,B.C., Mack,M.M., Wehr,C.M., MacGregor,J.T, Hiatt,R.A, Wang,G., Wickramasinghe,S.N., Everson,R.B. and Ames,B.N. (1997) Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc. Natl Acad. Sci. USA, 94, 3290-3295.
4. Cravo,M., Fidalgo,P., Pereira,A.D., Gouveia-Oliviera,A., Chaves,P., Selhub,J., Mason,J.B., Mira,F.C. and Leitao,C.N. (1994) DNA methylation as an intermediate biomarker in colorectal cancer: modulation by FA supplementation. Eur. J. Cancer. Prev, 3, 473-479.
5. Crott,J.W. and Fenech,M. (2001) Preliminary study of the genotoxic potential of homocysteine in human lymphocytes in vitro. Mutagenesis, 16, 213-217.
6. Crott,J.W., Mashiyama S.T., Ames,B.N. and Fenech,M. (2001a) MTHFR C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro. Carcinogenesis, 22, 1019-1025.
7. Crott,J.W., Mashiyama S.T., Ames,B.N. and Fenech,M. (2001b) The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes in vitro. Cancer Epidemiol. Biomarkers Prev., 10, 1089-1096.
8. Doucette,M.M. and Stevens,V.L. (2001) Folate receptor function is regulated in response to different cellular growth rates in cultured mammalian cells. J. Nutr., 131, 2819-2825.
9. Duthie,S.J., Narayanan,S., Blum,S., Pirie,L. and Brand,G.M. (2000) Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells. Nutr. Cancer, 37, 245-251.
10. Eto,I. and Krumdieck,C.L. (1986) Role of vitamine B-12 and folate deficiencies in carcinogenesis. In Poirier,L.A., Newberne,P.M. and Pariza,M.W. (ed.), Essential Nutrients in Carcinogenesis. Plenum Press, New York, NY, pp. 313-331.
11. Fenech,M. (2000) The in vitro micronucleus technique. Mutat. Res., 455, 81-95.
12. Fenech,M. (2001) The role of folic acid and vitamine B12 in genomic stability of human cells. Mutat. Res., 475, 56-67.
13. Fenech,M. and Crott,J.W. (2002) Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficient human lymphocytes-evidence for breakage-fusion-bridge cycles in the cytokinesis-block micronucleus assay. Mutat. Res., 504, 131-136.
14. Fenech,M., Dreosti,I.E. and Rinaldi,J.R. (1997) Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men. Carcinogenesis, 18, 1329-1336.
15. Fenech,M., Aitken,C. and Rinaldi,J. (1998) Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis, 19, 1163-1171.
16. Fowler,B.M., Giuliano,A.R., Piyathilake,C., Nour,M. and Hatch,K. (1998) Hypomethylation in cervical tissue - is there correlation with folate status. Cancer Epidemiol. Biomarkers Prev., 7, 901-906.
17. Jacob,R.A., Gretz,D.M., Taylor,P.C., James,S.J., Pogribny,I.R, Miller,B.J., Henning,S.M. and Swendseid,M.E. (1998) Moderate folate depletion increases plasma homocystein and decreases lymphocytes DNA methylation in post-menopausal women. J. Nutr., 128, 1204-1212.
18. Jacob,R.A., Jenden,D.J., Allman-Farinelli,M.A. and Swendseid,M.E. (1999) Folate nutrition alters choline status of women and men fed low choline diets. J. Nutr., 129, 712-717.
19. Kamen,B.A. and Capdevila,A. (1986) Receptor-mediated folate accumulation is regulated by cellular folate content. Proc. Natl Acad. Sci. USA, 83, 5983-5987.
20. Lindahl,T. and Wood,R.D. (1999) Quality control by DNA repair. Science, 286, 1897-1905.
21. Melnyk,S., Pogribna,M., Miller,B., Basnakian,A.G., Pogribny,I.P. and James,S.J. (1999) Uracil misincorporation, DNA strand breaks and gene amplification are associated with tumorigenic cell transformation in FA deficient/repleted Chinese hamster ovary cells. Cancer Lett., 146, 35-44.
22. Miele,M., Bonatti,S., Menichini,P, Ottaggio,L. and Abbondandolo,A. (1989) The presence of amplified regions affects the stability of chromosomes in drug-resistant Chinese hamster cells. Mutat. Res., 219, 171-178.
23. Pancharuniti,N., Lewis,C.A., Sauberlich,H.E. et al. (1994) Plasma homocysteine, folate and vitamin B12 concentrations and risk for early-onset coronary artery disease. Am. J. Clin. Nutr., 59, 940-948.
24. Poirier,L.A., Wise,C.K., Delongchamp,R.R. and Sinha,R. (2001) Blood determinations of S-adenosyl methionine, S-adenosyl homocysteine and homocysteine: correlations with diet. Cancer Epidemiol. Biomarkers Prev., 10, 649-655.
25. Shimizu,N., Itoh,N., Utiyama,H. and Wahl,G.M. (1998) Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronucleation during S phase. J. Cell Biol., 140, 1307-1320.
26. Shimizu,N., Shimuara,T. and Tanaka,T. (2000) Selective elimination of acentric double minutes from cancer cells through the extrusion of micronuclei. Mutat. Res., 448, 81-90.
27. Wagner,C. (1995) Biochemical role of folate in cellular metabolism. In Bailey,L.B. (ed.), Folate in Health and Disease. Marcel Dekker, New York, pp. 23-42.
28. Wang,J.A., Dudman,N.P., Lynch,J. and Wilcken,D.E. (1991) Betaine:homocysteine methyl transferase - a new assay for the liver enzyme and its absence from human skin fibroblasts and peripheral blood lymphocytes. Clin. Chim. Acta, 204, 239-249.
29. Zingg,J.M. and Jones,P.A. (1997) Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis. Carcinogenesis, 18, 869-882.