Cited1 Deficiency Suppresses Intestinal Tumorigenesis

PLoS Genetics

Volumn 9, Issue 8, 2013, Pages

  Méniel, Valérie ^a   Song, Fei ^b,c   Phesse, Toby ^d   Young, Madeleine ^a   Poetz, Oliver ^e   Parry, Lee ^a   Jenkins, John R ^b   Williams, Geraint T ^a   Dunwoodie, Sally L ^f,g   Watson, Alastair ^h   Clarke, Alan R ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

^d WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^e UNIVERSITY OF TÜBINGEN   (Germany)

^f VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^g UNIVERSITY OF NEW SOUTH WALES   (Australia)

^h UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; BETA CATENIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P53; TRANSCRIPTOME; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APC GENE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER SURVIVAL; CARCINOGENESIS; CELL COMPARTMENTALIZATION; CELL DEATH; CELL PROLIFERATION; CITED1 GENE; COLORECTAL TUMOR; CONTROLLED STUDY; GENE DELETION; GENE LOSS; HUMAN; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN DEPHOSPHORYLATION; TRANSCRIPTOMICS; TUMOR GENE; TUMOR GROWTH; UPREGULATION; WNT SIGNALING PATHWAY;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; APOPTOSIS; BETA CATENIN; CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; NEOPLASTIC STEM CELLS; NUCLEAR PROTEINS; PHOSPHATIDYLINOSITOL 3-KINASES; TRANSCRIPTION FACTORS; WNT SIGNALING PATHWAY;

EID: 84884653266     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003638     Document Type: Article

References (51)

1. Gryfe R, Swallow C, Bapat B, Redston M, Gallinger S, et al. (1997) Molecular biology of colorectal cancer. Curr Probl Cancer 21: 233-300.
2. Clarke AR, (2005) Studying the consequences of immediate loss of gene function in the intestine: APC. Biochem Soc Trans 33: 665-666.
3. Sansom OJ, Reed KR, Hayes AJ, Ireland H, Brinkmann H, et al. (2004) Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev 18: 1385-1390.
4. Yahata T, Shao W, Endoh H, Hur J, Coser KR, et al. (2001) Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein. Genes Dev 15: 2598-2612.
5. Plisov S, Tsang M, Shi G, Boyle S, Yoshino K, et al. (2005) Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning. J Am Soc Nephrol 16: 1632-1644.
6. Sansom OJ, Meniel VS, Muncan V, Phesse TJ, Wilkins JA, et al. (2007) Myc deletion rescues Apc deficiency in the small intestine. Nature 446: 676-679.
7. Shioda T, Fenner MH, Isselbacher KJ, (1996) msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation. Proc Natl Acad Sci USA 93: 12298-12303.
8. Dunwoodie SL, Rodriguez TA, Beddington RS, (1998) Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis. Mech Dev 72: 27-40.
9. Rodriguez TA, Sparrow DB, Scott AN, Withington SL, Preis JI, et al. (2004) Cited1 is required in trophoblasts for placental development and for embryo growth and survival. Mol Cell Biol 24: 228-244.
10. Howlin J, McBryan J, Napoletano S, Lambe T, McArdle E, et al. (2006) CITED1 homozygous null mice display aberrant pubertal mammary ductal morphogenesis. Oncogene 25: 1532-1542.
11. Yahata T, de Caestecker MP, Lechleider RJ, Andriole S, Roberts AB, et al. (2000) The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. J Biol Chem 275: 8825-8834.
12. Shioda T, Fenner MH, Isselbacher KJ, (1997) MSG1 and its related protein MRG1 share a transcription activating domain. Gene 204: 235-241.
13. Freedman SJ, Sun ZY, Kung AL, France DS, Wagner G, et al. (2003) Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2. Nat Struct Biol 10: 504-512.
14. Nair SS, Chaubal VA, Shioda T, Coser KR, Mojamdar M, (2001) Over-expression of MSG1 transcriptional co-activator increases melanin in B16 melanoma cells: a possible role for MSG1 in melanogenesis. Pigment Cell Res 14: 206-209.
15. Lovvorn HN 3rd, Boyle S, Shi G, Shyr Y, Wills ML, et al. (2007a) Wilms' tumorigenesis is altered by misexpression of the transcriptional co-activator, CITED1. J Pediatr Surg 42: 474-481.
16. Lovvorn HN, Westrup J, Opperman S, Boyle S, Shi G, et al. (2007b) CITED1 expression in Wilms' tumor and embryonic kidney. Neoplasia 9: 589-600.
17. Dillon RL, Brown ST, Ling C, Shioda, T.Muller WJ, (2007) An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer. Mol Cell Biol 27: 8648-8657.
18. Mugford JW, Yu J, Kobayashi A, McMahon AP, (2009) High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population. Dev Biol September 15; 333 (2):: 312-323.
19. Hendry C, Rumballe B, Moritz K, Little MH, (2011) Defining and redefining the nephron progenitor population. Pediatr Nephrol Sep;26 (9):: 1395-406 Epub 2011 Jan 14. Review.
20. Murphy AJ, Pierce J, de Caestecker C, Taylor C, Anderson JR, et al. (2012) SIX2 and CITED1, markers of nephronic progenitor self-renewal, remain active in primitive elements of Wilms' tumor. J Pediatr Surg Jun;47 (6):: 1239-49.
21. Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, et al. (2004) A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A Apr 20;101 (16):: 6062-7.
22. Andreu P, Colnot S, Godard C, Gad S, Chafey P, et al. (2005) Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine. Development Mar;132 (6):: 1443-51.
23. Batlle E, Henderson JT, Beghtel H, van den Born MM, Sancho E, et al. (2002) Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell 18;111 (2):: 251-63.
24. Phesse TJ, Parry L, Reed KR, Ewan KB, Dale TC, et al. (2008) Deficiency of Mbd2 attenuates Wnt signaling. Mol Cell Biol 28: 196094-103.
25. Shioda T, Lechleider RJ, Dunwoodie SL, Li H, Yahata T, et al. (1998) Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator. Proc Natl Acad Sci USA 95: 9785-90.
26. Smyth GK, (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: Article3.
27. Willert J, Epping M, Pollack JR, Brown PO, Nusse R, (2002) A transcriptional response to Wnt protein in human embryonic carcinoma cells. BMC Dev Biol Jul 2;2: 8.
28. González V, Hurley LH, (2010) The C-terminus of nucleolin promotes the formation of the c-MYC G-quadruplex and inhibits c-MYC promoter activity. Biochemistry Nov 16;49 (45):: 9706-14.
29. Clevers H, Nusse R, (2012) Wnt/β-catenin signaling and disease. Cell Jun 8;149 (6):: 1192-205.
30. van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, et al. (2002) The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111: 241-250.
31. Valenta T, Hausmann G, Basler K, (2012) The many faces and functions of beta-catenin. Embo J 31 (12):: 2714-2736.
32. Luckert K, Götschel F, Sorger PK, Hecht A, Joos TO, Pötz O, (2011) Snapshots of protein dynamics and post-translational modifications in one experiment-beta-catenin and its functions. Mol Cell Proteomics 10 (5):: M110.007377.
33. Hino S, Tanji C, Nakayama KI, Kikuchi A, (2005) Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination. Mol Cell Biol 25: 9063-72.
34. Buchert M, Athineos D, Abud HE, Burke ZD, Faux MC, et al. (2010) Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. PLoS Genet 15;6 (1):: e1000816.
35. Fevr T, Robine S, Louvard D, Huelsken J, (2007) Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells. Mol Cell Biol 27: 7551-9.
36. Li H, Ahmed NU, Fenner MH, Ueda M, Isselbacher KJ, et al. (1998) Regulation of expression of MSG1 melanocyte-specific nuclear protein in human melanocytes and melanoma cells. Exp Cell Res 242: 478-486.
37. Scognamiglio T, Hyjek E, Kao J, Chen YT, (2006) Diagnostic usefulness of HBME1, galectin-3, CK19, and CITED1 and evaluation of their expression in encapsulated lesions with questionable features of papillary thyroid carcinoma. Am J Clin Pathol 126: 700-708.
38. Su LK, Kinzler KW, Vogelstein B, Preisinger AC, Moser AR, et al. (1992) Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 256: 668-670.
39. Kim K, Pang KM, Evans M, Hay ED, (2000) Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators. Mol Biol Cell 11: 3509-3523.
40. Murphy DJ, Junttila MR, Pouyet L, Karnezis A, Shchors K, et al. (2008) Murphy Distinct thresholds govern Myc's biological output in vivo. Cancer Cell 14: 447-457.
41. Albuquerque C, Breukel C, van der Luijt R, Fidalgo P, Lage P, et al. (2002) The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade. Hum Mol Genet 11: 1549-1560.
42. Pollard P, Deheragoda M, Segditsas S, Lewis A, Rowan A, et al. (2009) The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression. Gastroenterology 136: 2204-2213.
43. Leedham SJ, Rodenas-Cuadrado P, Howarth K, Lewis A, Mallappa S, et al. (2013) A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts. Gut Jan;62 (1):: 83-93.
44. Barker N, van de Wetering M, Clevers H, 14. The intestinal stem cell. Genes Dev 2008 Jul 15;22 (14):: 1856-64 Review.
45. Ireland H, Kemp R, Houghton C, Howard L, Clarke AR, et al. (2004) Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. Gastroenterology 126: 1236-1246.
46. Shibata H, Toyama K, Shioya H, Ito M, Hirota M, et al. (1997) Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science 278: 120-123.
47. Brault V, Moore R, Kutsch S, Ishibashi M, Rowitch DH, et al. (2001) Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 128: 1253-1264.
48. Gregorieff A, Pinto D, Begthel H, Destrée O, Kielman M, Clevers H, (2005) Expression pattern of Wnt signaling components in the adult intestine. Gastroenterology 129 (2):: 626-38.
49. Smyth GK. (2005) Limma: linear models for microarray data. In: Bioinformatics and Computational Biology Solutions using R and Bioconductor, RGentleman, VCarey, SDudoit, RIrizarry, WHuber (eds.), Springer, New York, pages 397-420.
50. Wettenhall JM, Simpson KM, Satterley K, Smyth GK, (2006) AffylmGUI: a graphical user interface for linear modeling of single channel microarray data. Bioinformatics (7): 897-9.
51. Benjamini Y, Hochberg Y, (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society. Series B (57): 289-300.