Deficiency of Mbd2 attenuates Wnt signaling

Molecular and Cellular Biology

Volumn 28, Issue 19, 2008, Pages 6094-6103

  Phesse, Toby J ^a,c   Parry, Lee ^a   Reed, Karen R ^a   Ewan, Kenneth B ^a   Dale, Trevor C ^a   Sansom, Owen J ^b   Clarke, Alan R ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^c ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; METHYL CPG BINDING PROTEIN 2; PROTEIN LECT2; PROTEIN NURD; REPRESSOR PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ADENOMA; ANIMAL CELL; ANIMAL TISSUE; APC GENE; ARTICLE; CONTROLLED STUDY; EPIGENETICS; GENE; GENE DELETION; GENE LECT2; GENE LOSS; HUMAN; HUMAN CELL; MALE; MBD2 GENE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PANETH CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SMALL INTESTINE;

DNA METHYLATION; DNA-BINDING PROTEINS; GENES, APC; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTESTINE, SMALL; PANETH CELLS; PROMOTER REGIONS (GENETICS); SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 52649117105     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00539-08     Document Type: Article

References (34)

1. Batlle, E., J. T. Henderson, H. Beghtel, M. M. van den Born, E. Sancho, G. Huls, J. Meeldijk, J. Robertson, M. van de Wetering, T. Pawson, and H. Clevers. 2002. Beta-catenin and TCF mediate cell positioning in the intestinal epithelium hy controlling the expression of EphB/ephrinB. Cell 111: 251-263.
2. Berger, J., O. Sansom, A. Clarke, and A. Bird. 2007. MBD2 is required for correct spatial gene expression in the gut. Mol. Cell. Biol. 27:4049-4057.
3. Breitling, R., P. Armengaud, A. Amtmann, and P. Herzyk. 2004. Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments. FEBS Lett. 573:83-92.
4. Brennan, K., J. M. Gonzalez-Sancho, L. A. Castelo-Soceio, L. R. Howe, and A. M. Brown. 2004. Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins. Oncogene 23:4873-4884.
5. Chang, W. W. 1982. Morphological basis of multistep process in experimental colonic carcinogenesis. Virchows Arch. B 41:17-37.
6. Eads, C. A., A. E. Nickel, and P. W. Laird. 2002. Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic mice. Cancer Res. 62:1296-1299.
7. Heath, J. P. 1996. Epithelial cell migration in the intestine. Cell Biol. Int. 20:139-146.
8. Hendrich, B., and A. Bird. 1998. Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol. Cell. Biol. 18:6538-6547.
9. Hendrich, B., J. Guy, B. Ramsahoye, V. A. Wilson, and A. Bird. 2001. Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development. Genes Dev. 15:710-723.
10. Hoppler, S., and C. L. Kavanagh. 2007. Wnt signalling: variety at the core. J. Cell Sci. 120:385-393.
11. Ireland, H., R. Kemp, C. Houghton, L. Howard, A. R. Clarke, O. J. Sansom, and D. J. Winton. 2004. Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. Gastroenterology 126:1236-1246.
12. Korinek, V., N. Barker, P. Moerer, E. van Donselaar, G. Huls, P. J. Peters, and H. Clevers. 1998. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat. Genet. 19:379-383.
13. Kuhnert, F., C. R. Davis, H. T. Wang, P. Chu, M. Lee, J. Yuan, R. Nusse, and C. J. Kuo. 2004. Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc. Natl. Acad. Sci. USA 101:266-271.
14. Laird, P. W., L. Jackson-Grusby, A. Fazeli, S. L. Dickinson, W. E. Jung, E. Li, R. A. Weinberg, and R. Jaenisch. 1995. Suppression of intestinal neoplasia by DNA hypomethylation. Cell 81:197-205.
15. Livak, K. J., and T. D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25:402-408.
16. Merritt, A. J., T. D. Allen, C. S. Potten, and J. A. Hickman. 1997. Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation. Oncogene 14:2759-2766.
17. Morin, P. J., A. B. Sparks, V. Korinek, N. Barker, H. Clevers, B. Vogelstein, and K. W. Kinzler. 1997. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275:1787-1790.
18. Muncan, V., O. J. Sansom, L. Tertoolen, T. J. Phesse, H. Begthel, E. Sancho, A. M. Cole, A. Gregorieff, I. M. de Alboran, H. Clevers, and A. R. Clarke. 2006. Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Mol. Cell. Biol. 26:8418-8426.
19. Munemitsu, S., I. Albert, B. Rubinfeld, and P. Polakis. 1996. Deletion of an amino-terminal sequence beta-catenin in vivo and promotes hyperphosporylation of the adenomatous polyposis coli tumor suppressor protein. Mol. Cell. Biol. 16:4088-4094.
20. Ng, H. H., Y. Zhang, B. Hendrich, C. A. Johnson, B. M. Turner, H. Erdjument-Bromage, P. Tempst, D. Reinberg, and A. Bird. 1999. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nat. Genet. 23:58-61.
21. Oshima, H., M. Oshima, M. Kobayashi, M. Tsutsumi, and M. M. Taketo. 1997. Morphological and molecular processes of polyp formation in Apc-(delta716) knockout mice. Cancer Res. 57:1644-1649.
22. Ovejero, C., C. Cavard, A. Perianin, T. Hakvoort, J. Vermeulen, C. Godard, M. Fahre, P. Chafey, K. Suzuki, B. Romagnolo, S. Yamagoe, and C. Perret. 2004. Identification of the leukocyte cell-derived ehemotaxin 2 as a direct target gene of beta-catenin in the liver. Hepatology 40:167-176.
23. Pinto, D., A. Gregorieff, H. Begthel, and H. Clevers. 2003. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev. 17:1709-1713.
24. Polakis, P. 1999. The oncogenic activation of beta-catenin. Curr. Opin. Genet. Dev. 9:15-21.
25. Sansom, O. J., J. Berger, S. M. Bishop, B. Hendrich, A. Bird, and A. R. Clarke. 2003. Deficiency of Mbd2 suppresses intestinal tumorigenesis. Nat. Genet. 34:145-147.
26. Sansom, O. J., V. S. Meniel, V. Muncan, T. J. Phesse, J. A. Wilkins, K. R. Reed, J. K. Vass, D. Athineos, H. Clevers, and A. R. Clarke. 2007. Myc deletion rescues Ape deficiency in the small intestine. Nature 446:676-679.
27. Sansom, O. J., K. R. Reed, A. J. Hayes, H. Ireland, H. Brinkmann, I. P. Newton, E. Batlle, P. Simon-Assmann, H. Clevers, I. S. Nathke, A. R. Clarke, and D. J. Winton. 2004. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev. 18:1385-1390.
28. Smalley, M. J., E. Sara, H. Paterson, S. Naylor, D. Cook, H. Jayatilake, L. G. Fryer, L. Hutchinson, M. J. Fry, and T. C. Dale. 1999. Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription. EMBO J. 18:2823-2835.
29. Su, L. K., K. W. Kinzler, B. Vogelstein, A. C. Preisinger, A. R. Moser, C. Luongo, K. A. Gould, and W. F. Dove. 1992. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 256:668-670.
30. Tusher, V. G., R. Tibshirani, and G. Chu. 2001. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. USA 98:5116-5121.
31. Wakita, K., O. Tetsu, and F. McCormick. 2001. A mammalian two-hybrid system for adenomatous polyposis coli-mutated colon cancer therapeutics. Cancer Res. 61:854-858.
32. Yamagoe, S., T. Akasaka, T. Uchida, T. Hachiya, T. Okabe, Y. Yamakawa, T. Arai, S. Mizuno, and K. Suzuki. 1997. Expression of a neutrophil chemotaetic protein LECT2 in human hepatocytes revealed by immunochemical studies using polyclonal and monoclonal antibodies to a recombinant LECT2. Biochem. Biophys. Res. Commun. 237:116-120.
33. Yamagoe, S., Y. Yamakawa, Y. Matsuo, J. Minowada, S. Mizuno, and K. Suzuki. 1996. Purification and primary amino acid sequence of a novel neutrophil chemotactic factor LECT2. Immunol. Lett. 52:9-13.
34. Zhang, Y., H. H. Ng, H. Erdjument-Bromage, P. Tempst, A. Bird, and D. Reinberg. 1999. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. 13:1924-1935.