Studying the consequences of immediate loss of gene function in the intestine: APC

Biochemical Society Transactions

Volumn 33, Issue 4, 2005, Pages 665-666

  Clarke, A R ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

catenin; Adenomatous polyposis coli (APC); Colorectal cancer; Gene expression

Indexed keywords

APC PROTEIN; CRE RECOMBINASE; TRANSCRIPTOME;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; CELL DIFFERENTIATION; CELL FATE; CELL MIGRATION; CELL PROLIFERATION; COLON POLYPOSIS; COLORECTAL CANCER; CONFERENCE PAPER; CONTROLLED STUDY; DNA MICROARRAY; EPITHELIUM CELL; GENE FUNCTION; GENE INACTIVATION; GENE LOSS; GENETIC RECOMBINATION; HISTOPATHOLOGY; INTESTINE CRYPT; INTESTINE VILLUS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SMALL INTESTINE MUCOSA; TRANSCRIPTION INITIATION;

ADENOMATOUS POLYPOSIS COLI; ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; DISEASE MODELS, ANIMAL; GENES, APC; HUMANS; MICE; MUTATION;

MURINAE; PYRONIA TITHONUS;

EID: 23844537506     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0330665     Document Type: Conference Paper

References (10)

1. Kinzler, K.W., Nilbert, M.C., Su, L.K., Vogelstein, B., Bryan, T.M., Levy, D.B., Smith, K.J., Preisinger, A.C., Hedge, P., McKechnie, D. et al. (1991) Science 253, 661-665
2. Bienz, M. and Clevers, H. (2000) Cell 103, 311-320
3. Morin, P.J., Sparks, A.B., Korinek, V., Barker, N., Clevers, H., Vogelstein, B. and Kinzler, K.W. (1997) Science 275, 1787-1790
4. He, T.C., Sparks, A.B., Rago, C., Hermeking, H., Zawel, L., da Costa, L.T., Morin, P.J., Vogelstein, B. and Kinzler, K.W. (1998) Science 281, 1509-1512
5. Sansom, O.J., Reed, K.R., Hayes, A.J., Ireland, H., Brinkmann, H., Newton, I.P., Batlle, E., Simon-Assmann, P., Clevers, H., Nathke, I.S. et al. (2004) Genes Dev. 18, 1385-1390
6. Kemp, R., Ireland, H., Clayton, E., Houghton, C., Howard, L. and Winton, D.J. (2004) Nucleic Acids Res. 32, e92
7. Ireland, H., Kemp, R., Houghton, C., Howard, L., Clarke, A.R., Sansom, O.J. and Winton, D.J. (2004) Gastroenterology 126, 1236-1246
8. Shibata, H., Toyama, K., Shioya, H., Ito, M., Hirota, M., Hasegawa, S., Matsumoto, H., Takano, H., Akiyama, T., Toyoshima, K. et al. (1997) Science 278, 120-123
9. Batlle, E., Henderson, J.T., Beghtel, H., van den Born, M.M., Sancho, E., Huls, G., Meeldijk, J., Robertson, J., van de Wetering, M., Pawson, T. and Clevers, H. (2002) Cell 111, 251-263
10. Potten, C.S. (1998) Philos. Trans. R. Soc. London B. Ser. 353, 821-830