Unique Structure and Dynamics of the EphA5 Ligand Binding Domain Mediate Its Binding Specificity as Revealed by X-ray Crystallography, NMR and MD Simulations

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Huan, Xuelu ^a   Shi, Jiahai ^b   Lim, Liangzhong ^b   Mitra, Sayantan ^c   Zhu, Wanlong ^b   Qin, Haina ^b   Pasquale, Elena B ^c,d   Song, Jianxing ^a,b,e  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c BURNHAM INSTITUTE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN RECEPTOR A5;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEUTERIUM HYDROGEN EXCHANGE; LIGAND BINDING; LIGAND BINDING DOMAIN; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; PROTEIN DOMAIN; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

BASE SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DNA PRIMERS; HUMANS; LIGANDS; MOLECULAR DYNAMICS SIMULATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; RECEPTOR, EPHA5;

EID: 84884549365     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074040     Document Type: Article

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