Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor

Biochemical Journal

Volumn 445, Issue 1, 2012, Pages 47-56

  Lamberto, Ilaria ^a   Qin, Haina ^b   Noberini, Roberta ^a   Premkumar, Lakshmanane ^a   Bourgin, Caroline ^a   Riedl, Stefan J ^a   Song, Jianxing ^b   Pasquale, Elena B ^c  

^a BURNHAM INSTITUTE   (United States)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antagonist; Cancer; EphA4; Ephrin; Imaging; Nerve regeneration; Receptor tyrosine kinase; Targeting

Indexed keywords

EPHRIN A5; EPHRIN RECEPTOR A4; PEPTIDE APY; PEPTIDE DERIVATIVE; PEPTIDE KYL; PEPTIDE VTM; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL CULTURE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; ISOTHERMAL TITRATION CALORIMETRY; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TARGETING; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; BRAIN; CALORIMETRY; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPHRINS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; NEUROBLASTOMA; PEPTIDE FRAGMENTS; PROSTATIC NEOPLASMS; PROTEIN BINDING; PROTEIN CONFORMATION; QUANTUM DOTS; RECEPTOR, EPHA4; SIGNAL TRANSDUCTION;

EID: 84862486945     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20120408     Document Type: Article

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