Structural, stability, dynamic and binding properties of the ALS-causing T46I mutant of the hVAPB MSP domain as revealed by NMR and MD simulations

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Lua, Shixiong ^a   Qin, Haina ^a   Lim, Liangzhong ^a   Shi, Jiahai ^a,c   Gupta, Garvita ^a   Song, Jianxing ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN RECEPTOR A4; MUTANT PROTEIN; PROTEIN P56; PROTEIN T46I; UNCLASSIFIED DRUG; UREA;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; GENE IDENTIFICATION; GENE MUTATION; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOGENESIS; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; TEMPERATURE SENSITIVITY; THERMODYNAMICS; WILD TYPE;

AMYOTROPHIC LATERAL SCLEROSIS; CALCIUM-BINDING PROTEINS; CIRCULAR DICHROISM; EYE PROTEINS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE PROTEINS; MOLECULAR DYNAMICS SIMULATION; MUTATION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPHA4; THERMODYNAMICS; VESICULAR TRANSPORT PROTEINS;

EID: 80055113691     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027072     Document Type: Article

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