Structural and biophysical characterization of the EphB4·EphrinB2 protein-protein interaction and receptor specificity

Journal of Biological Chemistry

Volumn 281, Issue 38, 2006, Pages 28185-28192

  Chrencik, Jill E ^a   Brooun, Alexei ^a   Kraus, Michelle L ^a   Recht, Michael I ^b   Kolatkar, Anand R ^a   Gye, Won Han ^a   Seifert, Jan Marcus ^c   Widmer, Hans ^d   Auer, Manfred ^c   Kuhn, Peter ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b PALO ALTO RESEARCH CENTER   (United States)

^c Novartis Institutes for Biomedical Research GmbH and Co KG   (Austria)

^d NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; CALORIMETRY; CRYSTAL STRUCTURE; PATHOLOGY;

ANGIOGENESIS; LIGAND BINDING DOMAIN; PROTEIN PROTEIN INTERACTION; TUMORIGENESIS;

PROTEINS;

ARGININE; EPHRIN B2; EPHRIN RECEPTOR B4; LEUCINE;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; ENTHALPY; ENTROPY; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR AFFINITY;

BINDING SITES; CRYSTALLOGRAPHY; ENTROPY; EPHRIN-B2; HUMANS; RECEPTOR, EPHB4; THERMODYNAMICS;

EID: 33748781688     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M605766200     Document Type: Article

References (37)

1. Dodelet, V. C., and Pasquale, E. B. (2000) Oncogene 19, 5614-5619
2. Pasquale, E. B. (2005) Nat. Rev. Mol. Cell Biol. 6, 462-475
3. Wilkinson, D. G. (2001) Nat. Rev. Neurosci. 2, 155-164
4. Wilkinson, D. G. (2000) Int. Rev. Cytol. 196, 177-244
5. Blits-Huizinga, C. T., Nelersa, C. M., Malhotra, A., and Liebl, D. J. (2004) IUBMB Life 56, 257-265
6. Gale, N. W., Holland, S. J., Valenzuela, D. M., Flenniken, A., Pan, L., Ryan, T. E., Henkemeyer, M., Strebhardt, K., Hirai, H., Wilkinson, D. G., Pawson, T., Davis, S., and Yancopoulos, G. D. (1996) Neuron 17, 9-19
7. Committee, E. N. (1997) Cell 90, 403-404
8. Himanen, J. P., Chumley, M. J., Lackmann, M., Li, C., Barton, W. A., Jeffrey, P. D., Vearing, C., Geleick, D., Feldheim, D. A., Boyd, A. W., Henkemeyer, M., and Nikolov, D. B. (2004) Nat. Neurosci. 7, 501-509
9. Takemoto, M., Fukuda, T., Sonoda, R., Murakami, F., Tanaka, H., and Yamamoto, N. (2002) Eur. J. Neurosci. 16, 1168-1172
10. Himanen, J. P., Rajashankar, K. R., Lackmann, M., Cowan, C. A., Henkemeyer, M., and Nikolov, D. B. (2001) Nature 414, 933-938
11. Hopkins, A. L., Mason, J. S., and Overington, J. P. (2006) Curr. Opin. Struct. Biol. 16, 127-136
12. Holland, S. J., Gale, N. W., Mbamalu, G., Yancopoulos, G. D., Henkemeyer, M., and Pawson, T. (1996) Nature 383, 722-725
13. Schmucker, D., and Zipursky, S. L. (2001) Cell 105, 701-704
14. Smith, F. M., Vearing, C., Lackmann, M., Treutlein, H., Himanen, J., Chen, K., Saul, A., Nikolov, D., and Boyd, A. W. (2004) J. Biol. Chem. 279, 9522-9531
15. Ohtaka, H., Muzammil, S., Schon, A., Velazquez-Campoy, A., Vega, S., and Freire, E. (2004) Int. J. Biochem. Cell Biol. 36, 1787-1799
16. Wallace, A. C., Laskowski, R. A., and Thornton, J. M. (1995) Protein Eng. 8, 127-134
17. Toth, J., Cutforth, T., Gelinas, A. D., Bethoney, K. A., Bard, J., and Harrison, C. J. (2001) Dev. Cell 1, 83-92
18. Himanen, J. P., Henkemeyer, M., and Nikolov, D. B. (1998) Nature 396, 486-491
19. Chrencik, J. E., Brooun, A., Recht, M. I., Kraus, M. L., Koolpe, M., Kolatkar, A. R., Bruce, R. H., Martiny-Baron, G., Widmer, H., Pasquale, E. B., and Kuhn, P. (2006) Structure 14, 321-330
20. Nakamoto, M., and Bergemann, A. D. (2002) Microsc. Res. Tech. 59, 58-67
21. Liu, W., Ahmad, S. A., Jung, Y. D., Reinmuth, N., Fan, F., Bucana, C. D., and Ellis, L. M. (2002) Cancer 94, 934-939
22. Berclaz, G., Karamitopoulou, E., Mazzucchelli, L., Rohrbach, V., Dreher, E., Ziemiecki, A., and Andres, A. C. (2003) Ann. Oncol. 14, 220-226
23. Andres, A. C., Reid, H. H., Zurcher, G., Blaschke, R. J., Albrecht, D., and Ziemiecki, A. (1994) Oncogene 9, 1461-1467
24. Nikolova, Z., Djonov, V., Zuercher, G., Andres, A. C., and Ziemiecki, A. (1998) J. Cell Sci. 111, 2741-2751
25. Munarini, N., Jager, R., Abderhalden, S., Zuercher, G., Rohrbach, V., Loercher, S., Pfanner-Meyer, B., Andres, A. C., and Ziemiecki, A. (2002) J. Cell Sci. 115, 25-37
26. Berclaz, G., Andres, A. C., Albrecht, D., Dreher, E., Ziemiecki, A., Gusterson, B. A., and Crompton, M. R. (1996) Biochem. Biophys. Res. Commun. 226, 869-875
27. Noren, N. K., Lu, M., Freeman, A. L., Koolpe, M., and Pasquale, E. B. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 5583-5588
28. Kertesz, N., Krasnoperov, V., Reddy, R., Leshanski, L., Kumar, S. R., Zozulya, S., and Gill, P. S. (2006) Blood 107, 2330-2338
29. Martiny-Baron, G., Korff, T., Schaffner, F., Esser, N., Eggstein, S., Marme, D., and Augustin, H. G. (2004) Neoplasia 6, 248-257
30. Koolpe, M., Burgess, R., Dail, M., and Pasquale, E. B. (2005) J. Biol. Chem. 280, 17301-17311
31. Otwinowski, Z., and Minor, W. (1997) in Methods in Enzymology, Macromolecular Crystallography, Part A (Carter, C. W., Jr. and Sweet, R. M., eds) Vol. 276, pp. 307-326, Academic Press, Inc., New York
32. CCP4 (1994) Acta Crystallogr. D Biol. Crystallogr. 50, 760-763
33. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. A 47, 110-119
34. Turnbull, W. B., and Daranas, A. H. (2003) J. Am. Chem. Soc. 125, 14859-14866
35. Nikolov, D. B., Li, C., Barton, W. A., and Himanen, J. P. (2005) Biochemistry 44, 10947-10953
36. Himanen, J. P., and Nikolov, D. B. (2002) Acta Crystallogr. D Biol. Crystallogr. 58, 533-535
37. Day, B., To, C., Himanen, J. P., Smith, F. M., Nikolov, D. B., Boyd, A. W., and Lackmann, M. (2005) J. Biol. Chem. 280, 26526-26532