Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity Ephrin-binding channel of the EphA4 receptor

Journal of Biological Chemistry

Volumn 283, Issue 43, 2008, Pages 29473-29484

  Qin, Haina ^a   Shi, Jiahai ^a   Noberini, Roberta ^b,c   Pasquale, Elena B ^b,d   Song, Jianxing ^a,e  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b BURNHAM INSTITUTE   (United States)

^c UNIVERSITY OF PARMA   (Italy)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; DOCKING; DYES; LIGANDS; MOLECULES; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TITRATION; VOLUMETRIC ANALYSIS;

BINDING CHANNELS; BINDING DOMAINS; CANCER.; COMPUTATIONAL DOCKING; DRUG TARGETS; EPHRIN BINDINGS; HETERONUCLEAR; HIGH AFFINITIES; HYDROXYBENZOIC ACIDS; ISOTHERMAL TITRATION CALORIMETRIES; NMR SPECTROSCOPIES; PATHOLOGICAL PROCESSES; PLATELET AGGREGATIONS; RECEPTOR TYROSINE KINASES; SANDWICH ARCHITECTURES; SINGLE QUANTUM; SMALL MOLECULES; SMALL SIZES; SYNAPTIC PLASTICITIES; WEAK BINDINGS;

CRYSTAL STRUCTURE;

AMINO ACID; BENZOIC ACID DERIVATIVE; DISULFIDE; EPHRIN; EPHRIN RECEPTOR A4; EPHRIN RECEPTOR B2; EPHRIN RECEPTOR B4; HYDROGEN;

ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; CRYSTAL STRUCTURE; DISULFIDE BOND; HETERONUCLEAR SINGLE QUANTUM COHERENCE; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS; X RAY DIFFRACTION;

CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; EPHRIN-A4; HUMANS; KINETICS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPHA4; THERMODYNAMICS;

EID: 57649186979     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M804114200     Document Type: Article

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