Multiple diverse ligands binding at a single protein site: A matter of pre-existing populations

Protein Science

Volumn 11, Issue 2, 2002, Pages 184-197

  Ma, Buyong ^a   Shatsky, Maxim ^b   Wolfson, Haim J ^b   Nussinov, Ruth ^a,b,c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b TEL AVIV UNIVERSITY   (Israel)

^c SAIC FREDERICK INC   (United States)

Author keywords

Combinatorial libraries; Flexible docking; Flexible structural comparison; Hinge bending; Multiple ligand binding; Populations; Single site binding

Indexed keywords

LIGAND; PROTEIN;

BINDING SITE; COMBINATORIAL LIBRARY; CROSS RESISTANCE; DRUG DESIGN; ENZYME SPECIFICITY; LIGAND BINDING; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REVIEW;

BINDING SITES; COMBINATORIAL CHEMISTRY TECHNIQUES; LIGANDS; MODELS, MOLECULAR; MODELS, THEORETICAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEINS;

EID: 0036147568     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.21302     Document Type: Review

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